Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis

• Published in: Science advances Vol. 8; no. 48; p. eadd8095
• Main Authors: Slonchak, Andrii, Wang, Xiaohui, Aguado, Julio, Sng, Julian D J, Chaggar, Harman, Freney, Morgan E, Yan, Kexin, Torres, Francisco J, Amarilla, Alberto A, Balea, Rickyle, Setoh, Yin Xiang, Peng, Nias, Watterson, Daniel, Wolvetang, Ernst, Suhrbier, Andreas, Khromykh, Alexander A
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 02.12.2022
• Subjects: Animals; Antiviral Agents; Biomedicine and Life Sciences; Female; Humans; Mice; Molecular Biology; Phosphorylation; Placenta; Pregnancy; RNA, Untranslated - genetics; RNA, Viral - genetics; SciAdv r-articles; STAT1 Transcription Factor - genetics; Viral Proteins; Virology; Zika Virus; Zika Virus Infection - genetics

All flaviviruses, including Zika virus, produce noncoding subgenomic flaviviral RNA (sfRNA), which plays an important role in viral pathogenesis. However, the exact mechanism of how sfRNA enables viral evasion of antiviral response is not well defined. Here, we show that sfRNA is required for transp...