Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis

All flaviviruses, including Zika virus, produce noncoding subgenomic flaviviral RNA (sfRNA), which plays an important role in viral pathogenesis. However, the exact mechanism of how sfRNA enables viral evasion of antiviral response is not well defined. Here, we show that sfRNA is required for transp...

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Published inScience advances Vol. 8; no. 48; p. eadd8095
Main Authors Slonchak, Andrii, Wang, Xiaohui, Aguado, Julio, Sng, Julian D J, Chaggar, Harman, Freney, Morgan E, Yan, Kexin, Torres, Francisco J, Amarilla, Alberto A, Balea, Rickyle, Setoh, Yin Xiang, Peng, Nias, Watterson, Daniel, Wolvetang, Ernst, Suhrbier, Andreas, Khromykh, Alexander A
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 02.12.2022
Subjects
Animals
Antiviral Agents
Biomedicine and Life Sciences
Female
Humans
Mice
Molecular Biology
Phosphorylation
Placenta
Pregnancy
RNA, Untranslated - genetics
RNA, Viral - genetics
SciAdv r-articles
STAT1 Transcription Factor - genetics
Viral Proteins
Virology
Zika Virus
Zika Virus Infection - genetics
Online AccessGet full text

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Abstract All flaviviruses, including Zika virus, produce noncoding subgenomic flaviviral RNA (sfRNA), which plays an important role in viral pathogenesis. However, the exact mechanism of how sfRNA enables viral evasion of antiviral response is not well defined. Here, we show that sfRNA is required for transplacental virus dissemination in pregnant mice and subsequent fetal brain infection. We also show that sfRNA promotes apoptosis of neural progenitor cells in human brain organoids, leading to their disintegration. In infected human placental cells, sfRNA inhibits multiple antiviral pathways and promotes apoptosis, with signal transducer and activator of transcription 1 (STAT1) identified as a key shared factor. We further show that the production of sfRNA leads to reduced phosphorylation and nuclear translocation of STAT1 via a mechanism that involves sfRNA binding to and stabilizing viral protein NS5. Our results suggest the cooperation between viral noncoding RNA and a viral protein as a novel strategy for counteracting antiviral responses.
AbstractList All flaviviruses, including Zika virus, produce noncoding subgenomic flaviviral RNA (sfRNA), which plays an important role in viral pathogenesis. However, the exact mechanism of how sfRNA enables viral evasion of antiviral response is not well defined. Here, we show that sfRNA is required for transplacental virus dissemination in pregnant mice and subsequent fetal brain infection. We also show that sfRNA promotes apoptosis of neural progenitor cells in human brain organoids, leading to their disintegration. In infected human placental cells, sfRNA inhibits multiple antiviral pathways and promotes apoptosis, with signal transducer and activator of transcription 1 (STAT1) identified as a key shared factor. We further show that the production of sfRNA leads to reduced phosphorylation and nuclear translocation of STAT1 via a mechanism that involves sfRNA binding to and stabilizing viral protein NS5. Our results suggest the cooperation between viral noncoding RNA and a viral protein as a novel strategy for counteracting antiviral responses.
All flaviviruses, including Zika virus, produce noncoding subgenomic flaviviral RNA (sfRNA), which plays an important role in viral pathogenesis. However, the exact mechanism of how sfRNA enables viral evasion of antiviral response is not well defined. Here, we show that sfRNA is required for transplacental virus dissemination in pregnant mice and subsequent fetal brain infection. We also show that sfRNA promotes apoptosis of neural progenitor cells in human brain organoids, leading to their disintegration. In infected human placental cells, sfRNA inhibits multiple antiviral pathways and promotes apoptosis, with signal transducer and activator of transcription 1 (STAT1) identified as a key shared factor. We further show that the production of sfRNA leads to reduced phosphorylation and nuclear translocation of STAT1 via a mechanism that involves sfRNA binding to and stabilizing viral protein NS5. Our results suggest the cooperation between viral noncoding RNA and a viral protein as a novel strategy for counteracting antiviral responses. A mechanism by which Zika virus noncoding RNA enables viral evasion of antiviral response in vertebrates.
Author Wolvetang, Ernst
Suhrbier, Andreas
Khromykh, Alexander A
Wang, Xiaohui
Watterson, Daniel
Setoh, Yin Xiang
Slonchak, Andrii
Freney, Morgan E
Chaggar, Harman
Torres, Francisco J
Aguado, Julio
Amarilla, Alberto A
Sng, Julian D J
Balea, Rickyle
Yan, Kexin
Peng, Nias
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Cites_doi 10.1128/JVI.79.3.1934-1942.2005
10.1126/science.aab3369
10.1016/j.cell.2016.04.032
10.1210/jc.2004-1113
10.1038/s41467-018-03662-6
10.1128/JVI.06743-11
10.1093/nar/gkt956
10.1038/s41467-020-16086-y
10.1128/JVI.00354-15
10.1126/scitranslmed.aax7888
10.1016/j.stem.2016.04.017
10.1016/j.chom.2016.03.008
10.1128/JVI.01159-10
10.1099/vir.0.83391-0
10.1038/s41564-019-0399-4
10.1371/journal.ppat.1004242
10.1371/journal.ppat.1006265
10.1371/journal.pntd.0005135
10.1128/mBio.02506-18
10.1056/NEJMoa1600651
10.3389/fimmu.2018.03047
10.3390/v12101177
10.1128/JVI.00274-06
10.1016/j.antiviral.2018.09.006
10.1099/0022-1317-43-1-247
10.1016/j.celrep.2017.09.047
10.1016/j.immuni.2019.03.025
10.1016/j.chom.2008.10.007
10.7554/eLife.39023
10.1038/nri1604
10.1128/mBio.01865-15
10.1016/S1473-3099(17)30727-2
10.3389/fgene.2018.00595
10.1128/JVI.00343-20
10.1080/10428190400018398
10.3390/cells9040899
10.1016/j.virol.2010.08.008
10.1038/s41467-022-28977-3
10.1126/science.aah3963
10.1073/pnas.1905617116
10.3390/pathogens9100848
10.1080/22221751.2019.1637283
10.1016/j.chom.2016.03.010
10.1093/infdis/jiy572
10.1128/JVI.00930-16
10.1128/mSphereDirect.00190-17
10.1128/JVI.02714-05
10.1038/nature12517
10.1128/JVI.00207-12
10.1128/JVI.01104-12
10.1038/sj.onc.1203525
10.1128/JVI.02608-15
10.1073/pnas.88.24.11455
10.1016/j.virusres.2015.01.026
10.1128/JVI.00163-17
10.1038/s41598-017-03120-1
10.1016/j.chom.2016.05.009
10.1128/JVI.80.6.2987-2999.2006
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content type line 23
These authors contributed equally to this work as co–senior authors.
Present address: Health and Biosecurity, Commonwealth Scientific and Industrial Research Organization, Acton, ACT, Australia.
Present address: Microbiology and Molecular Epidemiology Division, Environmental Health Institute, National Environmental Agency, Singapore, Singapore.
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References e_1_3_3_50_2
Bradley M. P. (e_1_3_3_19_2) 2017; 67
e_1_3_3_16_2
e_1_3_3_18_2
e_1_3_3_39_2
e_1_3_3_12_2
e_1_3_3_37_2
e_1_3_3_58_2
e_1_3_3_14_2
e_1_3_3_35_2
e_1_3_3_56_2
e_1_3_3_33_2
e_1_3_3_54_2
e_1_3_3_10_2
e_1_3_3_31_2
e_1_3_3_52_2
e_1_3_3_40_2
e_1_3_3_61_2
e_1_3_3_5_2
e_1_3_3_7_2
e_1_3_3_9_2
e_1_3_3_27_2
e_1_3_3_29_2
e_1_3_3_23_2
e_1_3_3_48_2
e_1_3_3_25_2
e_1_3_3_46_2
e_1_3_3_44_2
e_1_3_3_3_2
e_1_3_3_21_2
e_1_3_3_42_2
e_1_3_3_51_2
e_1_3_3_17_2
e_1_3_3_38_2
e_1_3_3_13_2
e_1_3_3_36_2
e_1_3_3_59_2
e_1_3_3_15_2
e_1_3_3_34_2
e_1_3_3_57_2
e_1_3_3_32_2
e_1_3_3_55_2
e_1_3_3_11_2
e_1_3_3_30_2
e_1_3_3_53_2
e_1_3_3_60_2
e_1_3_3_6_2
e_1_3_3_8_2
e_1_3_3_28_2
e_1_3_3_49_2
e_1_3_3_24_2
e_1_3_3_47_2
e_1_3_3_26_2
e_1_3_3_45_2
e_1_3_3_2_2
e_1_3_3_20_2
e_1_3_3_43_2
e_1_3_3_4_2
e_1_3_3_22_2
e_1_3_3_41_2
References_xml – ident: e_1_3_3_34_2
  doi: 10.1128/JVI.79.3.1934-1942.2005
– ident: e_1_3_3_9_2
  doi: 10.1126/science.aab3369
– ident: e_1_3_3_24_2
  doi: 10.1016/j.cell.2016.04.032
– ident: e_1_3_3_45_2
  doi: 10.1210/jc.2004-1113
– ident: e_1_3_3_20_2
  doi: 10.1038/s41467-018-03662-6
– ident: e_1_3_3_47_2
  doi: 10.1128/JVI.06743-11
– ident: e_1_3_3_60_2
  doi: 10.1093/nar/gkt956
– ident: e_1_3_3_16_2
  doi: 10.1038/s41467-020-16086-y
– ident: e_1_3_3_48_2
  doi: 10.1128/JVI.00354-15
– ident: e_1_3_3_21_2
  doi: 10.1126/scitranslmed.aax7888
– ident: e_1_3_3_26_2
  doi: 10.1016/j.stem.2016.04.017
– ident: e_1_3_3_27_2
  doi: 10.1016/j.chom.2016.03.008
– ident: e_1_3_3_5_2
  doi: 10.1128/JVI.01159-10
– ident: e_1_3_3_44_2
  doi: 10.1099/vir.0.83391-0
– ident: e_1_3_3_55_2
  doi: 10.1038/s41564-019-0399-4
– ident: e_1_3_3_10_2
  doi: 10.1371/journal.ppat.1004242
– ident: e_1_3_3_8_2
  doi: 10.1371/journal.ppat.1006265
– ident: e_1_3_3_12_2
  doi: 10.1371/journal.pntd.0005135
– ident: e_1_3_3_18_2
  doi: 10.1128/mBio.02506-18
– ident: e_1_3_3_13_2
  doi: 10.1056/NEJMoa1600651
– ident: e_1_3_3_49_2
  doi: 10.3389/fimmu.2018.03047
– ident: e_1_3_3_42_2
  doi: 10.3390/v12101177
– ident: e_1_3_3_46_2
  doi: 10.1128/JVI.00274-06
– ident: e_1_3_3_11_2
  doi: 10.1016/j.antiviral.2018.09.006
– ident: e_1_3_3_17_2
  doi: 10.1099/0022-1317-43-1-247
– ident: e_1_3_3_23_2
  doi: 10.1016/j.celrep.2017.09.047
– ident: e_1_3_3_43_2
  doi: 10.1016/j.immuni.2019.03.025
– ident: e_1_3_3_15_2
  doi: 10.1016/j.chom.2008.10.007
– ident: e_1_3_3_31_2
  doi: 10.7554/eLife.39023
– ident: e_1_3_3_29_2
  doi: 10.1038/nri1604
– ident: e_1_3_3_32_2
  doi: 10.1128/mBio.01865-15
– ident: e_1_3_3_14_2
  doi: 10.1016/S1473-3099(17)30727-2
– ident: e_1_3_3_2_2
  doi: 10.3389/fgene.2018.00595
– volume: 67
  start-page: 242
  year: 2017
  ident: e_1_3_3_19_2
  article-title: Animal models of Zika virus
  publication-title: Comp. Med.
  contributor:
    fullname: Bradley M. P.
– ident: e_1_3_3_37_2
  doi: 10.1128/JVI.00343-20
– ident: e_1_3_3_30_2
  doi: 10.1080/10428190400018398
– ident: e_1_3_3_36_2
  doi: 10.3390/cells9040899
– ident: e_1_3_3_53_2
  doi: 10.1016/j.virol.2010.08.008
– ident: e_1_3_3_38_2
  doi: 10.1038/s41467-022-28977-3
– ident: e_1_3_3_6_2
  doi: 10.1126/science.aah3963
– ident: e_1_3_3_33_2
  doi: 10.1073/pnas.1905617116
– ident: e_1_3_3_61_2
  doi: 10.3390/pathogens9100848
– ident: e_1_3_3_25_2
  doi: 10.1080/22221751.2019.1637283
– ident: e_1_3_3_57_2
  doi: 10.1016/j.chom.2016.03.010
– ident: e_1_3_3_41_2
– ident: e_1_3_3_22_2
  doi: 10.1093/infdis/jiy572
– ident: e_1_3_3_40_2
  doi: 10.1128/JVI.00930-16
– ident: e_1_3_3_54_2
  doi: 10.1128/mSphereDirect.00190-17
– ident: e_1_3_3_35_2
  doi: 10.1128/JVI.02714-05
– ident: e_1_3_3_58_2
  doi: 10.1038/nature12517
– ident: e_1_3_3_7_2
  doi: 10.1128/JVI.00207-12
– ident: e_1_3_3_39_2
  doi: 10.1128/JVI.01104-12
– ident: e_1_3_3_50_2
  doi: 10.1038/sj.onc.1203525
– ident: e_1_3_3_59_2
  doi: 10.1128/JVI.02608-15
– ident: e_1_3_3_52_2
  doi: 10.1073/pnas.88.24.11455
– ident: e_1_3_3_3_2
  doi: 10.1016/j.virusres.2015.01.026
– ident: e_1_3_3_51_2
  doi: 10.1128/JVI.00163-17
– ident: e_1_3_3_56_2
  doi: 10.1038/s41598-017-03120-1
– ident: e_1_3_3_28_2
  doi: 10.1016/j.chom.2016.05.009
– ident: e_1_3_3_4_2
  doi: 10.1128/JVI.80.6.2987-2999.2006
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Snippet All flaviviruses, including Zika virus, produce noncoding subgenomic flaviviral RNA (sfRNA), which plays an important role in viral pathogenesis. However, the...
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SubjectTerms Animals
Antiviral Agents
Biomedicine and Life Sciences
Female
Humans
Mice
Molecular Biology
Phosphorylation
Placenta
Pregnancy
RNA, Untranslated - genetics
RNA, Viral - genetics
SciAdv r-articles
STAT1 Transcription Factor - genetics
Viral Proteins
Virology
Zika Virus
Zika Virus Infection - genetics
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Title Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis
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