Levetiracetam Attenuates Adolescent Stress-induced Behavioral and Electrophysiological Changes Associated With Schizophrenia in Adult Rats

• Published in: Schizophrenia bulletin Vol. 49; no. 1; pp. 68 - 77
• Main Authors: Cavichioli, Andreza M, Santos-Silva, Thamyris, Grace, Anthony A, Guimarães, Francisco S, Gomes, Felipe V
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 03.01.2023
• Subjects: Action Potentials - physiology; Animals; Dopamine; Dopaminergic Neurons - physiology; Levetiracetam - pharmacology; Male; Rats; Rats, Sprague-Dawley; Regular; Schizophrenia - etiology; Ventral Tegmental Area; adolescence; dopamine system; ventral hippocampus; psychosis; levetiracetam

Stress during adolescence is a major risk factor for schizophrenia. We have found previously in rats that adolescent stress caused, in adulthood, behavioral changes and enhanced ventral tegmental area (VTA) dopamine system activity, which were associated with dysregulation of the excitatory-inhibito...