Postexercise cold water immersion modulates skeletal muscle PGC-1α mRNA expression in immersed and nonimmersed limbs: evidence of systemic regulation

• Published in: Journal of applied physiology (1985) Vol. 123; no. 2; pp. 451 - 459
• Main Authors: Allan, Robert, Sharples, Adam P., Close, Graeme L., Drust, Barry, Shepherd, Sam O., Dutton, John, Morton, James P., Gregson, Warren
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.08.2017
• Subjects: Adult; Body Temperature - physiology; Cold Temperature; Cold water; Cross-Over Studies; Exercise; Exercise - physiology; Extremities - physiology; Gene expression; Gene Expression Regulation - physiology; Glucose; Glucose monitoring; Humans; Male; Metformin; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiology; Muscles; Oxygen consumption; p38 Mitogen-Activated Protein Kinases - metabolism; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism; Phosphorylation - physiology; Prescription drugs; RNA, Messenger - metabolism; Skeletal muscle; Walking; Water - metabolism; Water immersion; Windows (intervals); normetanephrine; peroxisome proliferator-activated receptor-γ coactivator-1α; AMP-activated protein kinase; cold water immersion

Mechanisms mediating postexercise cold-induced increases in PGC-1α gene expression in human skeletal muscle are yet to be fully elucidated but may involve local cooling effects on AMPK and p38 MAPK-related signaling and/or increased systemic β-adrenergic stimulation. Therefore, we aimed to examine w...