Characterization of antihistamine–human serum protein interactions by capillary electrophoresis

• Published in: Journal of Chromatography A Vol. 1147; no. 2; pp. 261 - 269
• Main Authors: Martínez-Gómez, M.A., Carril-Avilés, M.M., Sagrado, S., Villanueva-Camañas, R.M., Medina-Hernández, M.J.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 20.04.2007; Elsevier
• Subjects: Antihistamine–protein interactions; Biological and medical sciences; Blood Proteins - metabolism; Capillary electrophoresis; Electrophoresis, Capillary - methods; Frontal analysis; Histamine and antagonists. Allergy; Histamine H1 Antagonists - metabolism; Human serum albumin; Humans; Medical sciences; Pharmacology. Drug treatments; Protein Binding; Whole plasma; α 1-Acid glycoprotein; Whole plasma; Human serum albumin; Capillary electrophoresis; Antihistamine–protein interactions; Frontal analysis; α 1-Acid glycoprotein; Human; Biological fluid; Molecular interaction; Serum albumin; Serum protein; Antihistamine-protein interactions; Antihistaminic; Blood; Blood plasma; Biological fixation; Binding capacity; Ultraviolet detector; α1-Acid glycoprotein; α1-acid-Glycoprotein; Antagonist; Histamine receptor

An important topic in the drug discovery and development process is the role of drug binding to plasma proteins. In this paper the characterization of the interaction between antihistamines (cationic drugs) towards human serum albumin (HSA) and α 1-acid glycoprotein (AGP) under physiological conditi...