Varicella Zoster Virus Impairs Expression of the Nonclassical Major Histocompatibility Complex Class I-Related Gene Protein (MR1)

• Published in: The Journal of infectious diseases Vol. 227; no. 3; pp. 391 - 401
• Main Authors: Purohit, Shivam K, Samer, Carolyn, McWilliam, Hamish E G, Traves, Renee, Steain, Megan, McSharry, Brian P, Kinchington, Paul R, Tscharke, David C, Villadangos, Jose A, Rossjohn, Jamie, Abendroth, Allison, Slobedman, Barry
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.02.2023
• Subjects: Animals; Herpesvirus 3, Human - genetics; Histocompatibility Antigens Class I; Ligands; Major; Major Histocompatibility Complex; Mammals; Minor Histocompatibility Antigens; varicella zoster virus; VZV; immune modulation; MR1

The antigen presentation molecule MR1 (major histocompatibility complex, class I-related) presents ligands derived from the riboflavin (vitamin B) synthesis pathway, which is not present in mammalian species or viruses, to mucosal-associated invariant T (MAIT) cells. In this study, we demonstrate th...