Morphine–nicotine interaction in conditioned place preference in mice after chronic nicotine exposure

• Published in: European journal of pharmacology Vol. 587; no. 1; pp. 169 - 174
• Main Authors: Vihavainen, Tanja, Piltonen, Marjo, Tuominen, Raimo K., Korpi, Esa R., Ahtee, Liisa
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 10.06.2008; Elsevier
• Subjects: [ 35S]GTPγS; [ 3H]DAMGO; Analgesics, Opioid - pharmacology; Animals; Autoradiography; Biological and medical sciences; Conditioned place preference; Conditioning, Operant - drug effects; Cross-sensitization; Enkephalin, Ala-MePhe-Gly- - pharmacology; Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology; Male; Medical sciences; Mice; Morphine; Morphine - pharmacology; Naltrexone - pharmacology; Narcotic Antagonists - pharmacology; Nicotine; Nicotine - pharmacology; Nicotinic Agonists - pharmacology; Pharmacology. Drug treatments; Receptors, Opioid, mu - drug effects; [ 3H]DAMGO; [ 35S]GTPγS; Morphine; Conditioned place preference; Cross-sensitization; Nicotine; Interaction; Rodentia; Opiates; Narcotic analgesic; Nicotine;Morphine;Cross-sensitization;Conditioned place preference;[3H]DAMGO;[35S]GTPγS; Alkaloid; Vertebrata; Chronic; Mammalia; Mouse; Animal

Previously we found that morphine's effects on locomotor activity and brain dopamine metabolism were enhanced in mice after cessation of 7-week oral nicotine treatment. In the present experiments we show that such chronic nicotine exposure cross-sensitizes NMRI mice to the reinforcing effect of...