Effect of acute treatment with YM992 on extracellular serotonin levels in the rat frontal cortex

• Published in: European journal of pharmacology Vol. 395; no. 1; pp. 23 - 29
• Main Authors: Hatanaka, Ken-ichi, Yatsugi, Shin-ichi, Yamaguchi, Tokio
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 21.04.2000; Elsevier
• Subjects: Analysis of Variance; Animals; Antidepressant; Antidepressive Agents - pharmacology; Biological and medical sciences; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Citalopram - pharmacology; Cyclohexanols - pharmacology; Dose-Response Relationship, Drug; Extracellular Space - chemistry; Extracellular Space - drug effects; Fluorobenzenes - pharmacology; Fluoxetine - pharmacology; Frontal Lobe - drug effects; Frontal Lobe - metabolism; Male; Medical sciences; Microdialysis; Morpholines - pharmacology; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; p-Chloroamphetamine - pharmacology; Pharmacology. Drug treatments; Piperidines - pharmacology; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Rats; Rats, Wistar; Selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor; Serotonin (5-hydroxytryptamine, 5-HT); Serotonin - metabolism; Serotonin Agents - pharmacology; Serotonin Antagonists - pharmacology; Serotoninergic system; Synaptosomes - drug effects; Synaptosomes - metabolism; Tritium; Venlafaxine; Venlafaxine Hydrochloride; YM992; Antidepressant; Venlafaxine; Microdialysis; Serotonin (5-hydroxytryptamine, 5-HT); YM992; Selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor; Short term; Intraperitoneal administration; Rat; Serotonin; Psychotropic; Rodentia; Central nervous system; Frontal cortex; Reuptake inhibitor; Biological activity; 5-HT2 Serotonine receptor; Vertebrata; Mammalia; Animal; Neurotransmitter; Antidepressant agent; Antagonist; Mechanism of action; Comparative study; Brain (vertebrata)

( S)-2-[[(7-fluoroindan-4-yl)oxy]methyl]morpholine monohydrochloride (YM992) is a novel putative antidepressant exhibiting both selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibition and 5-HT 2A receptor antagonism. In vivo microdialysis revealed that a single treatment with YM992 (3, 1...