Raised LIGHT Levels in Pulmonary Arterial Hypertension: Potential Role in Thrombus Formation

• Published in: American journal of respiratory and critical care medicine Vol. 177; no. 2; pp. 202 - 207
• Main Authors: Otterdal, Kari, Andreassen, Arne K, Yndestad, Arne, Oie, Erik, Sandberg, Wiggo J, Dahl, Christen P, Pedersen, Turid M, Ueland, Thor, Gullestad, Lars, Brosstad, Frank R, Aukrust, Pal, Damas, Jan K
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 15.01.2008; American Lung Association; American Thoracic Society
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Biomarkers - blood; Blood and lymphatic vessels; Blood clots; Blood platelets; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Disease Progression; Endothelium; Enzymes; Glycoproteins; Heart; Hemodynamics; Herpes viruses; Humans; Hypertension, Pulmonary - etiology; Immunoassay; Inflammation; Intensive care medicine; Ligands; Light; Medical sciences; Pathogenesis; Pneumology; Pulmonary arteries; Pulmonary hypertension; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases; Thromboembolism; Thrombosis - etiology; Tumor Necrosis Factor Ligand Superfamily Member 14 - analysis; Tumor Necrosis Factor Ligand Superfamily Member 14 - blood; Tumor Necrosis Factor Ligand Superfamily Member 14 - physiology; Tumor necrosis factor-TNF; Umbilical Veins - cytology; Veins & arteries; Intensive care; Prostaglandin I2; Respiratory disease; prostacyclin; Cardiovascular disease; Inflammation; Pulmonary hypertension; platelets; Endothelium; Arterial disease; Vascular disease; Platelet; Artery thrombosis; Resuscitation

Thrombus formation and inflammation are involved in the pathogenesis of pulmonary arterial hypertension (PAH), and LIGHT (Lymphotoxin-like Inducible protein that competes with Glycoprotein D for Herpesvirus entry mediator on T lymphocytes) has been shown to promote vascular inflammation. We sought t...