Reversed-phase high-performance liquid chromatography behavior of chaotropic counteranions

• Published in: Journal of Chromatography A Vol. 1064; no. 1; pp. 9 - 18
• Main Authors: Kazakevich, Y.V., LoBrutto, R., Vivilecchia, R.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 28.01.2005; Elsevier
• Subjects: Adsorbed layer; Adsorption; Analytical chemistry; Anions - chemistry; Chaotropic counteranions; Chemistry; Chromatographic methods and physical methods associated with chromatography; Chromatography, High Pressure Liquid - methods; Exact sciences and technology; Osmolar Concentration; Other chromatographic methods; Retention mechanism; Reversed-phase HPLC; Salt effect; Reversed-phase HPLC; Adsorbed layer; Salt effect; Retention mechanism; Chaotropic counteranions; Property composition relationship; Chromatographic retention; Adsorption isotherm; HPLC chromatography; Hexafluophosphates; Mobile phase; Modeling; Electrospray; Mechanism; Tetrafluoborates; Chaotropic anion; Mathematical model; Phase composition; Coupled method; Perchlorates; Reversed phase chromatography; Inorganic anion; Ionic strength; Mass spectrometry; Bonded stationary phase

The retention behavior of inorganic liophilic anions in reversed-phase HPLC columns was studied. Usually, the addition of these ions to the mobile phase influences the retention of protonated basic analytes similar to the effect of amphiphilic ions (ion-pairing agents). The nature of this influence...