Vancomycin-Nonsusceptible Enterococci Mediated by vanC at a Large Children’s Hospital: Prevalence, Susceptibility, and Impact on Care of Enterococcal Bacteremia
Abstract Enterococcus gallinarum and casseliflavus have inherent vancomycin resistance and, though known as pathogens, have not been well characterized in pediatric patients. We identified a significant prevalence of these enterococcal species among immunocompromised patients at a large pediatric in...
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Published in | Open forum infectious diseases Vol. 7; no. 5; p. ofaa160 |
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Main Authors | , , , , |
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Language | English |
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Oxford University Press
01.05.2020
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Abstract | Abstract
Enterococcus gallinarum and casseliflavus have inherent vancomycin resistance and, though known as pathogens, have not been well characterized in pediatric patients. We identified a significant prevalence of these enterococcal species among immunocompromised patients at a large pediatric institution and describe the impact on patient care, antibiotic stewardship, and infection control. |
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AbstractList | Abstract
Enterococcus gallinarum and casseliflavus have inherent vancomycin resistance and, though known as pathogens, have not been well characterized in pediatric patients. We identified a significant prevalence of these enterococcal species among immunocompromised patients at a large pediatric institution and describe the impact on patient care, antibiotic stewardship, and infection control. Enterococcus gallinarum and casseliflavus have inherent vancomycin resistance and, though known as pathogens, have not been well characterized in pediatric patients. We identified a significant prevalence of these enterococcal species among immunocompromised patients at a large pediatric institution and describe the impact on patient care, antibiotic stewardship, and infection control. |
Author | Parker, Sarah K Dominguez, Samuel R Williams, Manon C Dodson, Daniel S MacBrayne, Christine E |
AuthorAffiliation | Section of Infectious Diseases, Children’s Hospital Colorado , Aurora, Colorado, USA |
AuthorAffiliation_xml | – name: Section of Infectious Diseases, Children’s Hospital Colorado , Aurora, Colorado, USA |
Author_xml | – sequence: 1 givenname: Daniel S surname: Dodson fullname: Dodson, Daniel S email: daniel.dodson@childrenscolorado.org organization: Section of Infectious Diseases, Children’s Hospital Colorado, Aurora, Colorado, USA – sequence: 2 givenname: Samuel R surname: Dominguez fullname: Dominguez, Samuel R organization: Section of Infectious Diseases, Children’s Hospital Colorado, Aurora, Colorado, USA – sequence: 3 givenname: Christine E surname: MacBrayne fullname: MacBrayne, Christine E organization: Section of Infectious Diseases, Children’s Hospital Colorado, Aurora, Colorado, USA – sequence: 4 givenname: Manon C surname: Williams fullname: Williams, Manon C organization: Section of Infectious Diseases, Children’s Hospital Colorado, Aurora, Colorado, USA – sequence: 5 givenname: Sarah K surname: Parker fullname: Parker, Sarah K organization: Section of Infectious Diseases, Children’s Hospital Colorado, Aurora, Colorado, USA |
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References | Friedman (2020052504095028900_CIT0007) 2020; 39 de Perio (2020052504095028900_CIT0006) 2006; 27 Batistão (2020052504095028900_CIT0009) 2012; 107 Contreras (2020052504095028900_CIT0013) 2008; 70 CLSI. (2020052504095028900_CIT0008) 2018 Choi (2020052504095028900_CIT0003) 2004; 38 Ahmed (2020052504095028900_CIT0001) 2018; 24 Miller (2020052504095028900_CIT0002) 2014; 12 Tschudin Sutter (2020052504095028900_CIT0011) 2010; 51 Britt (2020052504095028900_CIT0004) 2016; 5 Cooper (2020052504095028900_CIT0012) 2008; 29 Reid (2020052504095028900_CIT0010) 2001; 32 Koganemaru (2020052504095028900_CIT0005) 2008; 14 |
References_xml | – volume: 107 start-page: 57 year: 2012 ident: 2020052504095028900_CIT0009 article-title: Risk factors for vancomycin-resistant enterococci colonisation in critically ill patients publication-title: Mem Inst Oswaldo Cruz doi: 10.1590/S0074-02762012000100008 contributor: fullname: Batistão – volume: 14 start-page: 413 year: 2008 ident: 2020052504095028900_CIT0005 article-title: Bacteremia caused by VanC-type enterococci in a university hospital in Japan: a 6-year survey publication-title: J Infect Chemother doi: 10.1007/s10156-008-0644-X contributor: fullname: Koganemaru – volume: 51 start-page: 678 year: 2010 ident: 2020052504095028900_CIT0011 article-title: Not all patients with vancomycin-resistant enterococci need to be isolated publication-title: Clin Infect Dis doi: 10.1086/655824 contributor: fullname: Tschudin Sutter – volume: 27 start-page: 28 year: 2006 ident: 2020052504095028900_CIT0006 article-title: Risk factors and outcomes associated with non-Enterococcus faecalis, non-Enterococcus faecium enterococcal bacteremia publication-title: Infect Control Hosp Epidemiol doi: 10.1086/500000 contributor: fullname: de Perio – volume: 39 start-page: 318 year: 2020 ident: 2020052504095028900_CIT0007 article-title: Enterococcal bacteremia in children with malignancies and following hematopoietic stem cell transplantation: a 15-year single-center experience publication-title: Pediatr Infect Dis J doi: 10.1097/INF.0000000000002579 contributor: fullname: Friedman – volume: 24 start-page: 590 year: 2018 ident: 2020052504095028900_CIT0001 article-title: Vancomycin-resistant enterococci: a review of antimicrobial resistance mechanisms and perspectives of human and animal health publication-title: Microb Drug Resist doi: 10.1089/mdr.2017.0147 contributor: fullname: Ahmed – volume: 38 start-page: 53 year: 2004 ident: 2020052504095028900_CIT0003 article-title: Clinical features and outcomes of bacteremia caused by Enterococcus casseliflavus and Enterococcus gallinarum: analysis of 56 cases publication-title: Clin Infect Dis doi: 10.1086/380452 contributor: fullname: Choi – volume: 32 start-page: 1540 year: 2001 ident: 2020052504095028900_CIT0010 article-title: Clinical and epidemiological features of Enterococcus casseliflavus/flavescens and Enterococcus gallinarum bacteremia: a report of 20 cases publication-title: Clin Infect Dis doi: 10.1086/320542 contributor: fullname: Reid – volume: 70 start-page: 346 year: 2008 ident: 2020052504095028900_CIT0013 article-title: Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci publication-title: J Hosp Infect doi: 10.1016/j.jhin.2008.07.012 contributor: fullname: Contreras – volume-title: CLSI Supplement M100 year: 2018 ident: 2020052504095028900_CIT0008 article-title: Performance standards for Antimicrobial Susceptibility Testing. Clinical and Laboratory Standards Institute contributor: fullname: CLSI. – volume: 29 start-page: 361 year: 2008 ident: 2020052504095028900_CIT0012 article-title: Outbreak of Enterococcus gallinarum infections after total knee arthroplasty publication-title: Infect Control Hosp Epidemiol doi: 10.1086/529213 contributor: fullname: Cooper – volume: 5 start-page: 57 year: 2016 ident: 2020052504095028900_CIT0004 article-title: Clinical epidemiology of vancomycin-resistant Enterococcus gallinarum and Enterococcus casseliflavus bloodstream infections publication-title: J Glob Antimicrob Resist doi: 10.1016/j.jgar.2015.12.002 contributor: fullname: Britt – volume: 12 start-page: 1221 year: 2014 ident: 2020052504095028900_CIT0002 article-title: Mechanisms of antibiotic resistance in enterococci publication-title: Expert Rev Anti Infect Ther doi: 10.1586/14787210.2014.956092 contributor: fullname: Miller |
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Enterococcus gallinarum and casseliflavus have inherent vancomycin resistance and, though known as pathogens, have not been well characterized in... Enterococcus gallinarum and casseliflavus have inherent vancomycin resistance and, though known as pathogens, have not been well characterized in pediatric... |
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Title | Vancomycin-Nonsusceptible Enterococci Mediated by vanC at a Large Children’s Hospital: Prevalence, Susceptibility, and Impact on Care of Enterococcal Bacteremia |
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