Evaluation of Target Attainment of Vancomycin Area Under the Curve in Children With Methicillin-Resistant Staphylococcus Aureus Bacteremia

• Published in: Therapeutic drug monitoring Vol. 37; no. 5; p. 619
• Main Authors: Hahn, Andrea, Frenck, Jr, Robert W, Allen-Staat, Mary, Zou, Yuanshu, Vinks, Alexander A
• Format: Journal Article
• Language: English
• Published: United States 01.10.2015
• Subjects: Anti-Bacterial Agents - pharmacokinetics; Area Under Curve; Bacteremia - drug therapy; Child; Child, Preschool; Female; Humans; Infant; Male; Methicillin-Resistant Staphylococcus aureus - drug effects; Vancomycin - pharmacokinetics

Vancomycin is often required to treat methicillin-resistant Staphylococcus aureus bacteremia in children. Treatment failure occurs in up to 50% of adults and is associated with a 24-hour area under the curve/minimum inhibitory concentration (AUC24h/MIC) <400. We sought to identify patient factors...