BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI
AKI is a major cause of morbidity and mortality and an important contributor to the development and progression of CKD. Molecular biomarkers that improve the detection and prognostication of AKI are therefore required. We assessed the utility as such of BPI fold-containing family A member 2 (BPIFA2)...
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Published in | Journal of the American Society of Nephrology Vol. 28; no. 12; pp. 3473 - 3478 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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American Society of Nephrology
01.12.2017
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Abstract | AKI is a major cause of morbidity and mortality and an important contributor to the development and progression of CKD. Molecular biomarkers that improve the detection and prognostication of AKI are therefore required. We assessed the utility as such of BPI fold-containing family A member 2 (BPIFA2), also known as parotid secretory protein, which we identified
a multiplex quantitative proteomics screen of acutely injured murine kidneys. In physiologic conditions, BPIFA2 is expressed specifically in the parotid glands and is abundant in salivary secretions. In our study, AKI induced
expression in the kidneys of mice within 3 hours. Furthermore, we detected BPIFA2 protein in plasma and urine in these models as early as 6 hours after injury. However, renal injury did not induce the expression of
in mice lacking
, an immediate early gene expressed in the kidneys during AKI. Notably, patients with AKI had higher blood and urine levels of BPIFA2 than did healthy individuals. Together, our results reveal that BPIFA2 is a potential early biomarker of AKI. |
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AbstractList | AKI is a major cause of morbidity and mortality and an important contributor to the development and progression of CKD. Molecular biomarkers that improve the detection and prognostication of AKI are therefore required. We assessed the utility as such of BPI fold-containing family A member 2 (BPIFA2), also known as parotid secretory protein, which we identified
via
a multiplex quantitative proteomics screen of acutely injured murine kidneys. In physiologic conditions, BPIFA2 is expressed specifically in the parotid glands and is abundant in salivary secretions. In our study, AKI induced
Bpifa2
expression in the kidneys of mice within 3 hours. Furthermore, we detected BPIFA2 protein in plasma and urine in these models as early as 6 hours after injury. However, renal injury did not induce the expression of
Bpifa2
in mice lacking
Nur77
, an immediate early gene expressed in the kidneys during AKI. Notably, patients with AKI had higher blood and urine levels of BPIFA2 than did healthy individuals. Together, our results reveal that BPIFA2 is a potential early biomarker of AKI. AKI is a major cause of morbidity and mortality and an important contributor to the development and progression of CKD. Molecular biomarkers that improve the detection and prognostication of AKI are therefore required. We assessed the utility as such of BPI fold-containing family A member 2 (BPIFA2), also known as parotid secretory protein, which we identified a multiplex quantitative proteomics screen of acutely injured murine kidneys. In physiologic conditions, BPIFA2 is expressed specifically in the parotid glands and is abundant in salivary secretions. In our study, AKI induced expression in the kidneys of mice within 3 hours. Furthermore, we detected BPIFA2 protein in plasma and urine in these models as early as 6 hours after injury. However, renal injury did not induce the expression of in mice lacking , an immediate early gene expressed in the kidneys during AKI. Notably, patients with AKI had higher blood and urine levels of BPIFA2 than did healthy individuals. Together, our results reveal that BPIFA2 is a potential early biomarker of AKI. AKI is a major cause of morbidity and mortality and an important contributor to the development and progression of CKD. Molecular biomarkers that improve the detection and prognostication of AKI are therefore required. We assessed the utility as such of BPI fold-containing family A member 2 (BPIFA2), also known as parotid secretory protein, which we identified via a multiplex quantitative proteomics screen of acutely injured murine kidneys. In physiologic conditions, BPIFA2 is expressed specifically in the parotid glands and is abundant in salivary secretions. In our study, AKI induced Bpifa2 expression in the kidneys of mice within 3 hours. Furthermore, we detected BPIFA2 protein in plasma and urine in these models as early as 6 hours after injury. However, renal injury did not induce the expression of Bpifa2 in mice lacking Nur77, an immediate early gene expressed in the kidneys during AKI. Notably, patients with AKI had higher blood and urine levels of BPIFA2 than did healthy individuals. Together, our results reveal that BPIFA2 is a potential early biomarker of AKI. |
Author | Kota, Satya K Pernicone, Elizabeth Leaf, David E Kota, Savithri Balasubramanian Stillman, Isaac E Waikar, Sushrut S |
Author_xml | – sequence: 1 givenname: Satya K surname: Kota fullname: Kota, Satya K organization: Harvard Stem Cell Institute, Cambridge, Massachusetts – sequence: 2 givenname: Elizabeth surname: Pernicone fullname: Pernicone, Elizabeth organization: Division of Nephrology, Department of Medicine and – sequence: 3 givenname: David E surname: Leaf fullname: Leaf, David E organization: Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts – sequence: 4 givenname: Isaac E surname: Stillman fullname: Stillman, Isaac E organization: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; and – sequence: 5 givenname: Sushrut S surname: Waikar fullname: Waikar, Sushrut S organization: Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts – sequence: 6 givenname: Savithri Balasubramanian surname: Kota fullname: Kota, Savithri Balasubramanian email: skota@bidmc.harvard.edu organization: Division of Nephrology, Department of Medicine and |
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Cites_doi | 10.1126/scisignal.2003200 10.1681/ASN.2012080800 10.1152/ajprenal.2000.278.5.F726 10.1177/154405910508400208 10.1038/ki.2012.410 10.1093/hmg/11.8.937 10.1172/JCI114502 10.1016/j.jprot.2016.07.005 10.1016/S1570-9639(04)00003-2 10.1007/s00467-009-1279-6 10.1681/ASN.2004090740 10.1681/ASN.2016010038 10.1038/nrneph.2015.105 10.1021/ac502040v 10.1093/genetics/95.1.129 10.2217/bmm.10.12 10.1021/pr050492k 10.1371/journal.pone.0147255 10.1046/j.1523-1755.2002.00433.x 10.1016/j.cell.2014.04.028 10.1093/ndt/gfq498 10.1681/ASN.2011070646 10.1016/0022-2836(86)90277-9 10.1042/BST0391028 10.1681/ASN.2011121147 10.1097/01.ASN.0000088027.54400.C6 |
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Title | BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI |
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