Effects of transdermal estrogen on collagen turnover at rest and in response to exercise in postmenopausal women

• Published in: Journal of applied physiology (1985) Vol. 113; no. 7; pp. 1040 - 1047
• Main Authors: Pingel, J., Langberg, H., Skovgård, D., Koskinen, S., Flyvbjerg, A., Frystyk, J., Kjær, M., Hansen, M.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.10.2012
• Subjects: Aged; Collagen; Collagen Type I - biosynthesis; Collagen Type I - metabolism; Cross-Over Studies; Estradiol - blood; Estradiol - metabolism; Estrogen replacement therapy; Estrogen Replacement Therapy - methods; Estrogens; Estrogens - administration & dosage; Exercise; Exercise - physiology; Female; Hormones; Humans; Insulin-Like Growth Factor I - metabolism; Interleukin-6 - metabolism; Menopause; Microdialysis - methods; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiology; Musculoskeletal system; Patellar Ligament - drug effects; Patellar Ligament - metabolism; Patellar Ligament - physiology; Peptide Fragments - metabolism; Physiology; Postmenopause - drug effects; Postmenopause - metabolism; Postmenopause - physiology; Procollagen - metabolism; Quadriceps Muscle - drug effects; Quadriceps Muscle - metabolism; Quadriceps Muscle - physiology; Rest - physiology; Skin - metabolism; Transdermal Patch; Womens health

Menopause is associated with loss of collagen content in the skin and tendon as well as accumulation of noncontractile tissue in skeletal muscle. The relative role of hormones and physical activity on these changes is not known. Accordingly, in a randomized, controlled, crossover study we investigat...