IRONSperm: Sperm-templated soft magnetic microrobots
We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve...
Saved in:
| Published in | Science advances Vol. 6; no. 28; p. eaba5855 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Association for the Advancement of Science
01.07.2020
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve targeted drug delivery. We present a single-step electrostatic self-assembly technique to fabricate IRONSperms, soft magnetic microswimmers that emulate the motion of motile sperm cells. Our experiments and theoretical predictions show that the swimming speed of IRONSperms exceeds 0.2 body length/s (6.8 ± 4.1 µm/s) at an actuation frequency of 8 Hz and precision angle of 45°. We demonstrate that the nanoparticle coating increases the acoustic impedance of the sperm cells and enables localization of clusters of IRONSperm using ultrasound feedback. We also confirm the biocompatibility and drug loading ability of these microrobots, and their promise as biocompatible, controllable, and detectable biohybrid tools for in vivo targeted therapy. |
|---|---|
| AbstractList | We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve targeted drug delivery. We present a single-step electrostatic self-assembly technique to fabricate IRONSperms, soft magnetic microswimmers that emulate the motion of motile sperm cells. Our experiments and theoretical predictions show that the swimming speed of IRONSperms exceeds 0.2 body length/s (6.8 ± 4.1 µm/s) at an actuation frequency of 8 Hz and precision angle of 45°. We demonstrate that the nanoparticle coating increases the acoustic impedance of the sperm cells and enables localization of clusters of IRONSperm using ultrasound feedback. We also confirm the biocompatibility and drug loading ability of these microrobots, and their promise as biocompatible, controllable, and detectable biohybrid tools for in vivo targeted therapy. IRONSperms are microrobots templated by sperm cells, powered by magnetic fields, loaded with drugs, and localized by ultrasound. We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve targeted drug delivery. We present a single-step electrostatic self-assembly technique to fabricate IRONSperms, soft magnetic microswimmers that emulate the motion of motile sperm cells. Our experiments and theoretical predictions show that the swimming speed of IRONSperms exceeds 0.2 body length/s (6.8 ± 4.1 µm/s) at an actuation frequency of 8 Hz and precision angle of 45°. We demonstrate that the nanoparticle coating increases the acoustic impedance of the sperm cells and enables localization of clusters of IRONSperm using ultrasound feedback. We also confirm the biocompatibility and drug loading ability of these microrobots, and their promise as biocompatible, controllable, and detectable biohybrid tools for in vivo targeted therapy. |
| Author | Schmidt, Oliver G Magdanz, Veronika Xu, Haifeng Misra, Sarthak Medina-Sánchez, Mariana Khalil, Islam S M Mohanty, Sumit Simmchen, Juliane Furtado, Guilherme P Aziz, Azaam Gebauer, Johannes Klingner, Anke |
| Author_xml | – sequence: 1 givenname: Veronika orcidid: 0000-0001-7522-033X surname: Magdanz fullname: Magdanz, Veronika organization: Applied Zoology, Faculty of Biology, Technical University of Dresden, Dresden, Germany – sequence: 2 givenname: Islam S M orcidid: 0000-0003-0617-088X surname: Khalil fullname: Khalil, Islam S M organization: Department of Biomechanical Engineering, University of Twente, Enschede, Netherlands – sequence: 3 givenname: Juliane orcidid: 0000-0001-9073-9770 surname: Simmchen fullname: Simmchen, Juliane organization: Physical Chemistry, Technical University of Dresden, Dresden, Germany – sequence: 4 givenname: Guilherme P surname: Furtado fullname: Furtado, Guilherme P organization: Department of Biomechanical Engineering, University of Twente, Enschede, Netherlands – sequence: 5 givenname: Sumit orcidid: 0000-0002-7423-3611 surname: Mohanty fullname: Mohanty, Sumit organization: Department of Biomechanical Engineering, University of Twente, Enschede, Netherlands – sequence: 6 givenname: Johannes surname: Gebauer fullname: Gebauer, Johannes organization: Applied Zoology, Faculty of Biology, Technical University of Dresden, Dresden, Germany – sequence: 7 givenname: Haifeng orcidid: 0000-0002-7999-0814 surname: Xu fullname: Xu, Haifeng organization: Institute for Integrative Nanosciences, Leibniz Institute for Solid State and Materials Research, Dresden, Germany – sequence: 8 givenname: Anke orcidid: 0000-0002-2426-433X surname: Klingner fullname: Klingner, Anke organization: Department of Physics, German University in Cairo, New Cairo City, Egypt – sequence: 9 givenname: Azaam orcidid: 0000-0001-8230-3424 surname: Aziz fullname: Aziz, Azaam organization: Institute for Integrative Nanosciences, Leibniz Institute for Solid State and Materials Research, Dresden, Germany – sequence: 10 givenname: Mariana surname: Medina-Sánchez fullname: Medina-Sánchez, Mariana organization: Institute for Integrative Nanosciences, Leibniz Institute for Solid State and Materials Research, Dresden, Germany – sequence: 11 givenname: Oliver G orcidid: 0000-0001-9503-8367 surname: Schmidt fullname: Schmidt, Oliver G organization: School of Science, Technical University of Dresden, Dresden, Germany – sequence: 12 givenname: Sarthak orcidid: 0000-0003-4961-0144 surname: Misra fullname: Misra, Sarthak organization: Department of Biomedical Engineering, University of Groningen and University Medical Center Groningen, Groningen, Netherlands |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32923590$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVkM1Lw0AQxRep2Fp79Sg5ekndnf3KehCk-FEoFrT3ZbPZ1EiSjdm04H9vtLXU0xuYN29mfudoUPvaIXRJ8JQQEDfBFibbTk1qeML5CRoBlTwGzpLBUT1EkxA-MMaECcGJOkNDCgooV3iE2Px1-fLWuLa6jX4l7lzVlKZzWRR83kWVWdeuK2xUFbb1rU99Fy7QaW7K4CZ7HaPV48Nq9hwvlk_z2f0itlThLgZQUuQiBZxgZgE4yY10VgolbcYIUAUJVSbB4DgBJylgkxlGM8ES2esY3e1im01aucy6umtNqZu2qEz7pb0p9P9OXbzrtd9qyTgWmPcB1_uA1n9uXOh0VQTrytLUzm-CBsZAYCIE7a3TnbV_MoTW5Yc1BOsf2HoHW-9h9wNXx8cd7H9o6Tdkhn2U |
| CitedBy_id | crossref_primary_10_1038_s41467_021_26607_y crossref_primary_10_1021_acsami_4c02836 crossref_primary_10_1021_acs_chemrev_1c00481 crossref_primary_10_1021_acsnano_3c01609 crossref_primary_10_1002_admt_202101256 crossref_primary_10_1021_acsomega_3c07033 crossref_primary_10_3390_nano13101590 crossref_primary_10_1016_j_ijengsci_2023_103827 crossref_primary_10_1017_jfm_2023_1085 crossref_primary_10_1016_j_mtchem_2021_100609 crossref_primary_10_1002_advs_202002203 crossref_primary_10_1002_smll_202107888 crossref_primary_10_1016_j_mtbio_2024_101119 crossref_primary_10_1002_smsc_202300211 crossref_primary_10_1007_s11431_022_2169_6 crossref_primary_10_1021_acsami_4c02325 crossref_primary_10_1007_s42235_023_00421_2 crossref_primary_10_1016_j_csbj_2024_06_008 crossref_primary_10_1016_j_jcp_2024_113004 crossref_primary_10_1002_smll_202005185 crossref_primary_10_1021_acs_chemrev_2c00062 crossref_primary_10_1002_admt_202400239 crossref_primary_10_1021_accountsmr_3c00227 crossref_primary_10_1021_acsami_3c09701 crossref_primary_10_1038_s41467_024_49043_0 crossref_primary_10_1002_adma_202312340 crossref_primary_10_1021_acsami_1c18597 crossref_primary_10_1080_00914037_2022_2132248 crossref_primary_10_1039_D3NR03516F crossref_primary_10_1002_adma_202201051 crossref_primary_10_1002_admt_202200450 crossref_primary_10_1039_D4MH00114A crossref_primary_10_1109_TASE_2022_3207289 crossref_primary_10_1002_aisy_202300093 crossref_primary_10_3390_fluids6110411 crossref_primary_10_1038_s41578_021_00389_7 crossref_primary_10_34133_cbsystems_0101 crossref_primary_10_1109_LRA_2024_3349810 crossref_primary_10_1002_smll_202400408 crossref_primary_10_1039_D3NR00502J crossref_primary_10_1109_JPROC_2022_3165713 crossref_primary_10_1016_j_bios_2022_114960 crossref_primary_10_1063_5_0032969 crossref_primary_10_1109_LRA_2023_3264746 crossref_primary_10_1016_j_isci_2022_104507 crossref_primary_10_1039_D2NR00152G crossref_primary_10_1002_adma_202204257 crossref_primary_10_1002_aisy_202200208 crossref_primary_10_1371_journal_pone_0253222 crossref_primary_10_1515_rams_2023_0119 crossref_primary_10_2147_IJN_S465548 crossref_primary_10_1016_j_jmmm_2023_171160 crossref_primary_10_1016_j_mtbio_2020_100085 crossref_primary_10_1038_s41467_024_47639_0 crossref_primary_10_1088_1361_6528_ac43e6 crossref_primary_10_1016_j_bioactmat_2022_01_002 crossref_primary_10_1039_D3BM01095C crossref_primary_10_1016_j_repbio_2024_100920 crossref_primary_10_1016_j_sna_2024_115229 crossref_primary_10_1002_admt_202201928 crossref_primary_10_3390_mi15040510 crossref_primary_10_1017_jfm_2021_1081 crossref_primary_10_3390_bioengineering11040311 crossref_primary_10_1002_adma_202203613 crossref_primary_10_1021_acsnano_1c07431 crossref_primary_10_1021_acs_chemrev_0c01234 crossref_primary_10_3389_fphys_2021_753686 crossref_primary_10_1002_adfm_202201800 crossref_primary_10_1016_j_snb_2021_130589 crossref_primary_10_3390_pharmaceutics14061132 crossref_primary_10_1002_adma_202205746 crossref_primary_10_1002_aisy_202300311 crossref_primary_10_1039_D1NR07172F crossref_primary_10_1016_j_matt_2023_09_013 crossref_primary_10_1016_j_jddst_2024_105356 crossref_primary_10_1016_j_apmt_2023_101887 crossref_primary_10_1007_s43154_021_00066_1 crossref_primary_10_3390_mi15040468 crossref_primary_10_1063_5_0048891 crossref_primary_10_3390_mi11121107 crossref_primary_10_3390_mi13030481 crossref_primary_10_1002_adma_202200671 crossref_primary_10_1098_rsif_2023_0021 crossref_primary_10_3390_app122211542 crossref_primary_10_1002_advs_202003177 crossref_primary_10_1002_aisy_202100052 crossref_primary_10_1002_advs_202306901 crossref_primary_10_1002_aisy_202100178 crossref_primary_10_32607_actanaturae_15681 crossref_primary_10_1039_D0CS01062F crossref_primary_10_1002_chem_202203913 crossref_primary_10_1038_s41467_023_35905_6 crossref_primary_10_3390_mi14050983 crossref_primary_10_1002_anbr_202100152 crossref_primary_10_1002_adma_202203959 crossref_primary_10_1002_adma_202006237 crossref_primary_10_1002_adhm_202101991 crossref_primary_10_1002_advs_202200342 crossref_primary_10_1039_D2SM00891B crossref_primary_10_1038_s41427_022_00425_0 crossref_primary_10_1002_adma_202101758 crossref_primary_10_3389_fbioe_2023_1327441 crossref_primary_10_1002_advs_202004037 crossref_primary_10_1109_LRA_2023_3280814 crossref_primary_10_1021_acs_chemrev_0c00999 crossref_primary_10_1002_smll_202207035 crossref_primary_10_1002_smll_202310288 crossref_primary_10_1002_adma_202304825 crossref_primary_10_1109_TMECH_2021_3109346 crossref_primary_10_1021_acsnano_2c01979 crossref_primary_10_1063_5_0189185 crossref_primary_10_1039_D2CS00112H crossref_primary_10_1109_TMECH_2022_3201012 crossref_primary_10_1038_s41598_021_00902_6 crossref_primary_10_1088_1748_605X_ac8b4b crossref_primary_10_3390_mi11121048 crossref_primary_10_1002_sstr_202200356 crossref_primary_10_1016_j_jconrel_2022_06_020 crossref_primary_10_21923_jesd_1318257 crossref_primary_10_1021_acsnano_3c09753 crossref_primary_10_1002_nano_202000169 crossref_primary_10_1002_smll_202304607 crossref_primary_10_1016_j_pmatsci_2023_101204 crossref_primary_10_1021_acs_jpcc_1c01906 crossref_primary_10_1016_j_nantod_2022_101560 crossref_primary_10_3389_frobt_2022_1027415 crossref_primary_10_1038_s41598_021_02553_z crossref_primary_10_1126_sciadv_adj0883 crossref_primary_10_3390_mi14091710 crossref_primary_10_1002_smll_202202685 crossref_primary_10_1007_s12213_023_00158_5 crossref_primary_10_1021_acs_nanolett_4c00047 crossref_primary_10_1016_j_actbio_2023_08_005 crossref_primary_10_1016_j_colcom_2022_100600 crossref_primary_10_1021_acs_chemmater_2c01960 crossref_primary_10_1021_acsnano_2c01908 crossref_primary_10_1016_j_engreg_2023_08_001 crossref_primary_10_1109_TRO_2024_3410096 crossref_primary_10_1039_D3CS00564J crossref_primary_10_1002_adts_202100438 |
| Cites_doi | 10.1242/jeb.35.4.796 10.1038/nnano.2016.137 10.1038/srep04919 10.1109/JPROC.2014.2385105 10.1021/acs.nanolett.5b04221 10.1038/nmat4569 10.1063/1.2431454 10.1126/scirobotics.aaq1155 10.1021/acsnano.7b06398 10.1109/TRO.2007.910775 10.1063/1.5142470 10.1021/nl404044d 10.1039/b925568k 10.1103/PhysRevLett.80.3879 10.1038/srep11403 10.1126/scirobotics.aam6431 10.1021/nn301312z 10.1163/016918611X568620 10.1126/scirobotics.aat8829 10.1038/ncomms4081 10.1137/S106482750038146X 10.1063/1.4958737 10.1002/adma.201404444 10.1002/admi.201500505 10.1039/C6FD00008H 10.1002/adbi.201900061 10.1007/s10544-014-9876-y 10.1002/adfm.201707228 10.1063/1.1830486 10.1021/acs.nanolett.9b02869 10.1063/1.2349585 10.1530/jrf.0.0750153 10.1002/adma.201302544 10.1021/ja047697z 10.1002/adma.201504327 10.1126/sciadv.aau1532 10.2976/1.2773861 10.1016/0021-9797(92)90229-F 10.1146/annurev-bioeng-010510-103409 10.1021/nn101861n 10.1119/1.10903 10.1039/C9NR06221A 10.1242/jeb.039800 10.1146/annurev.fl.09.010177.002011 10.1002/adma.201606301 10.1109/TRO.2010.2073030 10.1126/scirobotics.aav8006 10.1126/scirobotics.aaq0495 10.1002/adma.201804130 10.1242/jeb.204.7.1333 10.1371/journal.pone.0223576 10.1021/acs.nanolett.5b01945 10.3923/pjbs.2010.802.808 10.1002/adhm.201900213 10.1016/j.jcp.2017.12.008 10.1146/annurev-control-053018-023803 10.1039/c4sm00026a |
| ContentType | Journal Article |
| Copyright | Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). 2020 The Authors |
| Copyright_xml | – notice: Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). – notice: Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). 2020 The Authors |
| DBID | NPM AAYXX CITATION 7X8 5PM |
| DOI | 10.1126/sciadv.aba5855 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| EISSN | 2375-2548 |
| EndPage | eaba5855 |
| ExternalDocumentID | 10_1126_sciadv_aba5855 32923590 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: ; grantid: CMMI-1635443 – fundername: ; grantid: 853609 – fundername: ; grantid: 91619 – fundername: ; grantid: 835268 – fundername: ; grantid: Excellence Initiative TU Dresden – fundername: ; grantid: SPP 1726 – fundername: ; grantid: SAMURAI project # 14855 |
| GroupedDBID | 53G 5VS AAFWJ ACGFS ADAXU ADBBV ADPDF ADRAZ AENVI AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BBORY BCGUY BCNDV BKF EBS EJD FRP GROUPED_DOAJ HYE KQ8 M48 M~E NPM OK1 OVD OVEED RHF RHI RPM TEORI AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c390t-22976f6b20804c2251fa7ec7697cd412392839a802e512e7320ada43d6487a43 |
| IEDL.DBID | RPM |
| ISSN | 2375-2548 |
| IngestDate | Tue Apr 09 21:47:42 EDT 2024 Fri Jun 28 20:08:46 EDT 2024 Fri Aug 23 01:46:28 EDT 2024 Tue Oct 29 09:29:11 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 28 |
| Language | English |
| License | Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c390t-22976f6b20804c2251fa7ec7697cd412392839a802e512e7320ada43d6487a43 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-7999-0814 0000-0001-9503-8367 0000-0001-7522-033X 0000-0001-8230-3424 0000-0002-2426-433X 0000-0003-0617-088X 0000-0001-9073-9770 0000-0003-4961-0144 0000-0002-7423-3611 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450605/ |
| PMID | 32923590 |
| PQID | 2442601663 |
| PQPubID | 23479 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7450605 proquest_miscellaneous_2442601663 crossref_primary_10_1126_sciadv_aba5855 pubmed_primary_32923590 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-07-01 |
| PublicationDateYYYYMMDD | 2020-07-01 |
| PublicationDate_xml | – month: 07 year: 2020 text: 2020-07-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Science advances |
| PublicationTitleAlternate | Sci Adv |
| PublicationYear | 2020 |
| Publisher | American Association for the Advancement of Science |
| Publisher_xml | – name: American Association for the Advancement of Science |
| References | e_1_3_2_26_2 e_1_3_2_49_2 e_1_3_2_28_2 e_1_3_2_41_2 e_1_3_2_20_2 e_1_3_2_43_2 e_1_3_2_22_2 e_1_3_2_45_2 e_1_3_2_24_2 e_1_3_2_47_2 e_1_3_2_60_2 Gadêlha H. (e_1_3_2_52_2) 2019 e_1_3_2_9_2 e_1_3_2_16_2 e_1_3_2_37_2 e_1_3_2_7_2 e_1_3_2_18_2 e_1_3_2_39_2 e_1_3_2_54_2 e_1_3_2_10_2 e_1_3_2_31_2 e_1_3_2_5_2 e_1_3_2_12_2 e_1_3_2_33_2 e_1_3_2_58_2 e_1_3_2_3_2 e_1_3_2_14_2 e_1_3_2_35_2 e_1_3_2_56_2 e_1_3_2_50_2 e_1_3_2_27_2 e_1_3_2_48_2 e_1_3_2_29_2 e_1_3_2_40_2 e_1_3_2_21_2 e_1_3_2_42_2 e_1_3_2_23_2 e_1_3_2_44_2 e_1_3_2_25_2 e_1_3_2_46_2 e_1_3_2_61_2 e_1_3_2_15_2 e_1_3_2_38_2 e_1_3_2_8_2 e_1_3_2_17_2 e_1_3_2_59_2 e_1_3_2_6_2 e_1_3_2_19_2 e_1_3_2_30_2 e_1_3_2_53_2 e_1_3_2_32_2 e_1_3_2_51_2 e_1_3_2_11_2 e_1_3_2_34_2 e_1_3_2_57_2 e_1_3_2_4_2 e_1_3_2_13_2 e_1_3_2_36_2 e_1_3_2_55_2 e_1_3_2_2_2 |
| References_xml | – ident: e_1_3_2_45_2 doi: 10.1242/jeb.35.4.796 – ident: e_1_3_2_29_2 doi: 10.1038/nnano.2016.137 – ident: e_1_3_2_32_2 doi: 10.1038/srep04919 – ident: e_1_3_2_3_2 doi: 10.1109/JPROC.2014.2385105 – ident: e_1_3_2_7_2 doi: 10.1021/acs.nanolett.5b04221 – ident: e_1_3_2_13_2 doi: 10.1038/nmat4569 – ident: e_1_3_2_22_2 doi: 10.1063/1.2431454 – ident: e_1_3_2_15_2 doi: 10.1126/scirobotics.aaq1155 – ident: e_1_3_2_42_2 – ident: e_1_3_2_30_2 doi: 10.1021/acsnano.7b06398 – ident: e_1_3_2_46_2 doi: 10.1109/TRO.2007.910775 – ident: e_1_3_2_53_2 doi: 10.1063/1.5142470 – ident: e_1_3_2_31_2 doi: 10.1021/nl404044d – ident: e_1_3_2_12_2 doi: 10.1039/b925568k – ident: e_1_3_2_43_2 doi: 10.1103/PhysRevLett.80.3879 – ident: e_1_3_2_27_2 doi: 10.1038/srep11403 – ident: e_1_3_2_4_2 doi: 10.1126/scirobotics.aam6431 – start-page: 795245 year: 2019 ident: e_1_3_2_52_2 article-title: The human sperm beats anisotropically and asymmetrically in 3D publication-title: bioRxiv contributor: fullname: Gadêlha H. – ident: e_1_3_2_10_2 doi: 10.1021/nn301312z – ident: e_1_3_2_54_2 doi: 10.1163/016918611X568620 – ident: e_1_3_2_17_2 doi: 10.1126/scirobotics.aat8829 – ident: e_1_3_2_20_2 doi: 10.1038/ncomms4081 – ident: e_1_3_2_59_2 doi: 10.1137/S106482750038146X – ident: e_1_3_2_37_2 doi: 10.1063/1.4958737 – ident: e_1_3_2_14_2 doi: 10.1002/adma.201404444 – ident: e_1_3_2_23_2 doi: 10.1002/admi.201500505 – ident: e_1_3_2_40_2 doi: 10.1039/C6FD00008H – ident: e_1_3_2_39_2 doi: 10.1002/adbi.201900061 – ident: e_1_3_2_28_2 doi: 10.1007/s10544-014-9876-y – ident: e_1_3_2_36_2 doi: 10.1002/adfm.201707228 – ident: e_1_3_2_60_2 doi: 10.1063/1.1830486 – ident: e_1_3_2_16_2 doi: 10.1021/acs.nanolett.9b02869 – ident: e_1_3_2_44_2 doi: 10.1063/1.2349585 – ident: e_1_3_2_56_2 doi: 10.1530/jrf.0.0750153 – ident: e_1_3_2_21_2 doi: 10.1002/adma.201302544 – ident: e_1_3_2_38_2 – ident: e_1_3_2_9_2 doi: 10.1021/ja047697z – ident: e_1_3_2_33_2 doi: 10.1002/adma.201504327 – ident: e_1_3_2_35_2 doi: 10.1126/sciadv.aau1532 – ident: e_1_3_2_50_2 doi: 10.2976/1.2773861 – ident: e_1_3_2_55_2 doi: 10.1016/0021-9797(92)90229-F – ident: e_1_3_2_2_2 doi: 10.1146/annurev-bioeng-010510-103409 – ident: e_1_3_2_5_2 doi: 10.1021/nn101861n – ident: e_1_3_2_49_2 doi: 10.1119/1.10903 – ident: e_1_3_2_34_2 doi: 10.1039/C9NR06221A – ident: e_1_3_2_51_2 doi: 10.1242/jeb.039800 – ident: e_1_3_2_47_2 doi: 10.1146/annurev.fl.09.010177.002011 – ident: e_1_3_2_24_2 doi: 10.1002/adma.201606301 – ident: e_1_3_2_6_2 doi: 10.1109/TRO.2010.2073030 – ident: e_1_3_2_8_2 doi: 10.1126/scirobotics.aav8006 – ident: e_1_3_2_19_2 doi: 10.1126/scirobotics.aaq0495 – ident: e_1_3_2_26_2 doi: 10.1002/adma.201804130 – ident: e_1_3_2_48_2 doi: 10.1242/jeb.204.7.1333 – ident: e_1_3_2_58_2 doi: 10.1371/journal.pone.0223576 – ident: e_1_3_2_11_2 doi: 10.1021/acs.nanolett.5b01945 – ident: e_1_3_2_57_2 doi: 10.3923/pjbs.2010.802.808 – ident: e_1_3_2_18_2 doi: 10.1002/adhm.201900213 – ident: e_1_3_2_61_2 doi: 10.1016/j.jcp.2017.12.008 – ident: e_1_3_2_25_2 doi: 10.1146/annurev-control-053018-023803 – ident: e_1_3_2_41_2 doi: 10.1039/c4sm00026a |
| SSID | ssj0001466519 |
| Score | 2.568658 |
| Snippet | We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity... IRONSperms are microrobots templated by sperm cells, powered by magnetic fields, loaded with drugs, and localized by ultrasound. We develop biohybrid magnetic... |
| SourceID | pubmedcentral proquest crossref pubmed |
| SourceType | Open Access Repository Aggregation Database Index Database |
| StartPage | eaba5855 |
| SubjectTerms | Applied Sciences and Engineering SciAdv r-articles |
| SummonAdditionalLinks | – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3PS8MwFA46L17E-bP-ooKgHjraNG0aQUTEMQUn6Aa7lbRNVdjauXai_70vaTY358FTDi2hfMnL-17z3vcQOuHUjWIacQvCH2aRJAabw2CPAXHsIE1tnjiy3vmh7be65L7n9X7ynzSAxZ-hnewn1R31G5_vX1dg8JczBTA8-WjwiAP39ZbRCpaiXDKNT1N99b-F-L6n-nxgl3oWxEWB1nBcnGLeRy0Qz9_5kzMOqbmO1jSTNK-rpa-jJZFtoLq21cI804LS55uI3D09tp-HcAZfmGqwpCBVH1hmYhZwDJsD_pLJYkZzINPzRnmUl8UW6jRvOzctS3dLsGKX2aWFMTCL1I8wcEASg5k6Kacipj6jcULAQTFgEowHNhbg5AV1MSwEJ27iQ8wC4zaqZXkmdpEZpy7mDI4ymjry4pOJRDb-Y3HKcBQ4noFOJ_CEw0oTI1SxBPbDCshQA2mg4wl6IWxbeRfBM5GPixBYhRIz810D7VRoTudyMbBOj9kGonM4T1-QktjzT7K3VyWNTYkUTPT2_v2F-2gVywhaJeAeoFo5GotDoBlldKT2zzfuoNHB priority: 102 providerName: Scholars Portal |
| Title | IRONSperm: Sperm-templated soft magnetic microrobots |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32923590 https://search.proquest.com/docview/2442601663 https://pubmed.ncbi.nlm.nih.gov/PMC7450605 |
| Volume | 6 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT8JAEJ4gJy9GfOKD1MREPRTodrvb9WaIBE1Ao5hwa7bbVkloIRT8_c4uLQG9eeke-kgzncc33ZlvAK4ld0PFQ2lj-iNsGim0OYL26FOn7SdJW0aO7nfuD1jvgz6PvFEFvLIXxhTtq3DczCZpMxt_mdrKWapaZZ1Y67Xf4VTT4nmtHdhBBd1I0c2PFcoYwpKCoLFokJHRd1OGErGxHlXjEoQ1nnbDm7HoD8D8XSe5EXi6-7BXIEbrYfVmNajE2QHUCpvMrduCOPruEOjT28vgfYa-9t4yi62JpyaIJiMrR3drpfIz002LVqrL8ObTcLrIj2DYfRx2enYxFcFWrmgvbEIQQSQsJIj1qEJzdBLJY8WZ4CqiGIgEIgYh_TaJMZjH3CUocEndiGFugusxVLNpFp-CpRKXSIEuiyeO3uAUcaQH_AmVCBL6jleHm1I8wWzFfRGYnIGwYCXToJBpHa5K6QWonnrPQWbxdJkHiB4MaRlz63Cykub6WeVnqAPfkvP6Ak19vX0GNcJQYBcacPbvO89hl-jM2RTeXkB1MV_GlwgvFmHDpOV47FO_YVTrB7if0mU |
| link.rule.ids | 230,315,730,783,787,867,888,24332,27938,27939,53806,53808 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PT9swFH4qcBgXfmxjFBhk0iTGIWniOHbNDaGhltGCWIe4RbaTjIo2rWjKgb-eZydBhZ3YyQcnUZLP7_l79nufAb5LHirNlXQx_BEuTTTaHEF7bNPAb2eZL5PA1Dv3-qzzh57fRrcNiOpaGJu0r9XQy0djLx_e2dzK6Vi36jyx1lXvlFMjixe1lmAF7dVnC0G6XVqhjCExqSQaqxIZmTx6Uklkx-awmpAgsYmMI16cjf6hmG8zJRemnrN1uKlfusw4uffmhfL00xs9x3d_1QasVWTUOSm7N6GR5h9hszL3mfOj0qQ--gS0e33Z_z1FN37s2MY1mlYjJKqJM0NP7ozl39zUQzpjk-H3MFGTYvYZBmc_B6cdtzpwwdWh8AuXECQnGVMEaSTVaOlBJnmqORNcJxTnOIFkRMi2T1LkCSkPCWIpaZgwDHuw3YLlfJKn2-DoLCRSoDfkWWD2TkWamLMDhc4EUe0gasJh_d_jaSmrEdtwhLC4BCuuwGrCtxqWGEe-2c6QeTqZz2IkJlYPjYVN-FLC9PKsGt8m8FcAvlxgVLVf9yAsVl27gmHnv-88gA-dQe8ivuj2f-3CKjEBus3v3YPl4mGefkUWU6h9O2afAUd18ok |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT4QwEJ7omhgvvh_rExMT9QALpUupN6NufK7GR2K8kLaAGl12s8t68Nc7LWBWvXnqgUKAj5l-Q2e-AdgRzJeKSWFj-MNtGiu0OYL2GFLPDdPUFbGn652v2sHpAz1_bD6OtPoySftKvjrZe8fJXl9MbmWvoxpVnljj5uqIUS2L12z04rQxDhNos244Eqib3ys0CJCclDKNZZmMiD8cIQUyZN2wxidIbpraGY-uSH9o5u9syZHlpzUDT9WNF1knb84wl476_KXp-K8nm4XpkpRah8WUORhLsnmYK81-YO2V2tT7C0DPbq_bdz105weWGWytbfWOhDW2BujRrY54znRdpNXRmX79ruzmg0W4b53cH53aZeMFW_nczW1CkKSkgSRIJ6lCi_dSwRLFAs5UTHGt40hKuAhdkiBfSJhPEFNB_TjA8AfHJahl3SxZAUulPhEcvSJLPb2HypNY9xDkKuVEhl6zDrvVu496hbxGZMISEkQFYFEJWB22K2gitAC9rSGypDscREhQjC5a4NdhuYDq-1oVxnVgP0D8nqDVtX8eQWiMynYJxeq_z9yCyZvjVnR51r5Ygymi43ST5rsOtbw_TDaQzORy03y2X_Mn9Qk |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=IRONSperm%3A+Sperm-templated+soft+magnetic+microrobots&rft.jtitle=Science+advances&rft.au=Magdanz%2C+Veronika&rft.au=Khalil%2C+Islam+S.+M.&rft.au=Simmchen%2C+Juliane&rft.au=Furtado%2C+Guilherme+P.&rft.date=2020-07-01&rft.issn=2375-2548&rft.eissn=2375-2548&rft.volume=6&rft.issue=28&rft_id=info:doi/10.1126%2Fsciadv.aba5855&rft.externalDBID=n%2Fa&rft.externalDocID=10_1126_sciadv_aba5855 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2375-2548&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2375-2548&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2375-2548&client=summon |