Intranasal delivery of MSC-derived exosomes attenuates allergic asthma via expanding IL-10 producing lung interstitial macrophages in mice - Ren, Jiling; Liu, Yongzhe; Yao, Ye; Feng, Lifeng; Zhao, Xiaotong; Li, Zongjin; Yang, Liang (International immunopharmacology, 2021)
Keywords: Alveoli; Animal models; Animals; Asthma; Asthma - chemically induced; Asthma - immunology; Asthma - metabolism; Asthma - prevention & control; Bisphosphonates; CCR2 protein; Cell Proliferation; Cells, Cultured; Clodronic acid; CX3C Chemokine Receptor 1 - genetics; CX3C Chemokine Receptor 1 - metabolism; CX3CR1 protein; Disease Models, Animal; Exosome; Exosomes; Exosomes - immunology; Exosomes - metabolism; Exosomes - transplantation; Flow cytometry; IL-10; Immunomodulation; Inflammation; Interleukin 10; Interleukin-10 - genetics; Interleukin-10 - metabolism; Lung - immunology; Lung - metabolism; Lung interstitial macrophages; Lungs; Macrophages; Macrophages, Alveolar - immunology; Macrophages, Alveolar - metabolism; Mesenchymal Stem Cell Transplantation; Mesenchyme; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Monocyte chemoattractant protein 1; MSC; Ovalbumin; Respiratory tract diseases; Spleen; Spleen - immunology; Spleen - metabolism; Splenectomy; Stem cell transplantation; Stem cells; MSC; Exosome; Lung interstitial macrophages; IL-10; Asthma