CCR2 Influences T Regulatory Cell Migration to Tumors and Serves as a Biomarker of Cyclophosphamide Sensitivity

• Published in: Cancer research (Chicago, Ill.) Vol. 76; no. 22; pp. 6483 - 6494
• Main Authors: Loyher, Pierre-Louis, Rochefort, Juliette, Baudesson de Chanville, Camille, Hamon, Pauline, Lescaille, Géraldine, Bertolus, Chloé, Guillot-Delost, Maude, Krummel, Matthew F., Lemoine, François M., Combadière, Christophe, Boissonnas, Alexandre
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 15.11.2016
• Subjects: Animals; Biomarkers; Cancer; Cell Movement; Cellular Biology; Cyclophosphamide - administration & dosage; Cyclophosphamide - pharmacology; Cyclophosphamide - therapeutic use; Female; Humans; Life Sciences; Male; Mice; Middle Aged; Receptors, CCR2 - metabolism; T-Lymphocytes, Regulatory - immunology; Chemokine; Immunossuppression; Chemotherapy; cells; T regulatory; Cancer Immunology

The CCL2 chemokine receptor CCR2 drives cancer by mediating the recruitment of monocytes and myeloid-derived suppressor cells to the tumor microenvironment. In this study, we extend the significance of CCR2 in this setting by identifying a new role for it in mediating recruitment of CD4+ T regulator...