GABA levels within the medial preoptic area: effects of chronic administration of sodium valproic acid

• Published in: Psychoneuroendocrinology Vol. 25; no. 5; pp. 519 - 534
• Main Authors: Dodge, James C., Illig, Amanda M., Snyder, Peter J., Badura, Lori L.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.07.2000; Elsevier
• Subjects: Animals; Behavioral psychophysiology; Biological and medical sciences; Chromatography, High Pressure Liquid; Estrous cyclicity; Estrus; Female; Fundamental and applied biological sciences. Psychology; GABA Agents - administration & dosage; GABA Agents - pharmacology; gamma-Aminobutyric Acid - metabolism; GnRH; HPLC; Male; Mice; Mice, Inbred DBA; Microdialysis; Neurotransmission and behavior; Preoptic Area - drug effects; Preoptic Area - metabolism; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Seizures; Valproic Acid - administration & dosage; Valproic Acid - pharmacology; Microdialysis; GnRH; HPLC; Seizures; Estrous cyclicity; Rodentia; Gonadotropin RH; Anticonvulsant; Valproic acid; Gabaergic pathway; Vertebrata; Reproduction; Mammalia; Mouse; Animal; Preoptic nucleus; Development; Estrous cycle; Reproductive cycle; Brain (vertebrata)

Sodium valproic acid (VPA) is a widely prescribed anticonvulsant medication that has been shown to interfere with pubertal maturation of the reproductive system, and induce endocrine abnormalities in adults, within a subset of the clinical population. While VPA's mechanism of action is still po...