Elevated interleukin-35 suppresses liver inflammation by regulation of T helper 17 cells in acute hepatitis B virus infection

• Published in: International immunopharmacology Vol. 70; pp. 252 - 259
• Main Authors: Teng, Deng-Ke, Liu, Yi, Lv, Yi-Fei, Wang, Li, Zhang, Wei, Wang, Jiu-Ping, Li, Yu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2019; Elsevier BV
• Subjects: Acute Disease; Acute infection; Adult; Animals; Antigens; Antigens, Viral - immunology; Blood cells; CD4 antigen; Cells, Cultured; Chemokines; Cytokines; Disease Models, Animal; Female; Helper cells; Hepatitis; Hepatitis B; Hepatitis B - immunology; Hepatitis B virus; Hepatitis B virus - physiology; Hepatocytes; Humans; Immunomodulation; Immunoregulation; Immunosuppression; Infections; Inflammation; Inflammatory response; Interleukin 17; Interleukin 22; Interleukin-17 - metabolism; Interleukin-35; Interleukins - metabolism; Liver; Liver - drug effects; Liver - pathology; Liver inflammation; Lymphocytes; Lymphocytes T; Male; Mice; Mice, Inbred BALB C; Natural killer cells; Peptides; Peptides - immunology; Peripheral blood; Phenotypes; T helper 17 cells; Th17 Cells - immunology; Up-Regulation; Viruses; Young Adult; Acute infection; Hepatitis B virus; T helper 17 cells; Liver inflammation; Interleukin-35

Interleukin (IL)-35 is a responsive anti-inflammatory cytokine implicated in different diseases processes. It has been reported that elevated IL-35 contributed to immunosuppression in chronic hepatitis by modulation of T helper 17 (Th17) and regulatory T cells. However, the role of IL-35 in acute he...