Teriparatide (rh [1-34] PTH) improved osteointegration of a hemiarthroplasty with signs of aseptic loosening

• Published in: Orthopedics (Thorofare, N.J.) Vol. 34; no. 9; pp. e574 - e577
• Main Authors: Oteo-Álvaro, Ángel, Matas, José A, Alonso-Farto, Juan C
• Format: Journal Article
• Language: English
• Published: United States SLACK INCORPORATED 09.09.2011
• Subjects: Aged, 80 and over; Arthroplasty, Replacement, Hip; Bone Density Conservation Agents - therapeutic use; Humans; Male; Osseointegration - drug effects; Osteoporosis - complications; Osteoporosis - drug therapy; Postoperative Complications - prevention & control; Prosthesis Failure - drug effects; Prosthesis Failure - etiology; Retrospective Studies; Teriparatide - therapeutic use
• ISSN: 0147-7447; 1938-2367
• DOI: 10.3928/01477447-20110714-50

Incidences of osteoporosis and fragility fractures are constantly increasing, which are associated with increased morbidity and mortality. When these patients undergo surgery, a higher number of postoperative complications may be expected because of poor bone quality and delayed healing. As a result, poorer primary stability of the implant, initial loosening, and impaired fixation strength in different regions may be seen. In these patients, we can choose the most advanced implants, but it is necessary to stimulate bone biology to increase the stability of the implant. This article reports the result obtained in a patient diagnosed with osteoporosis with aseptic loosening of a hip hemiarthroplasty after treatment with teriparatide (rh [1-34] PTH). This drug is indicated for the treatment of osteoporosis in men and postmenopausal women with high fracture risk and glucocorticoid-induced osteoporosis, and is administered subcutaneously for 2 years. It has an anabolic effect through stimulation of the osteoblast population that increases trabecular connectivity, cortical thickness, and bone mineral content. In animal models, teriparatide improved implant fixation 2 to 4 weeks after administration, resulting in the thickening of bone trabeculae and increased bone mass in the peri-implant area. In this retrospective analysis of clinical data and radiographic and scintigraphic images, after 24 months of treatment, the patient experienced clinical improvement associated with the disappearance of radiographic signs of loosening and a decrease in pathological radiotracer uptake in the bone scan, which are signs of osteointegration after treatment with teriparatide.