Chronic restraint stress increases angiotensin II potency in the rat carotid: role of cyclooxygenases and reactive oxygen species

• Published in: Journal of pharmacy and pharmacology Vol. 69; no. 1; p. 52
• Main Authors: Côco, Hariane, Pernomian, Larissa, Pereira, Priscila C, Gomes, Mayara S, Marchi, Katia C, Lopes, Alexandre H, Cunha, Thiago M, Tirapelli, Carlos R, de Oliveira, Ana M
• Format: Journal Article
• Language: English
• Published: England 01.01.2017
• Subjects: 6-Ketoprostaglandin F1 alpha - metabolism; Angiotensin II - metabolism; Animals; Carotid Arteries - metabolism; Catalase - metabolism; Corticosterone - blood; Cyclooxygenase 1 - metabolism; Cyclooxygenase 2 - metabolism; Cyclooxygenase Inhibitors; Endothelium, Vascular - metabolism; Hydrogen Peroxide - metabolism; Male; Muscle Contraction; Muscle, Smooth, Vascular - physiology; NADPH Oxidase 4; NADPH Oxidases - metabolism; Oxadiazoles - metabolism; Phosphatidylinositol 3-Kinases - metabolism; Prostaglandin-Endoperoxide Synthases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Rats, Wistar; Reactive Oxygen Species - metabolism; Restraint, Physical; Stress, Psychological - etiology; Stress, Psychological - metabolism; Stress, Psychological - physiopathology; Vasoconstriction; chronic restraint stress; Akt; prostacyclin; angiotensin II; hydrogen peroxide

To investigate the mechanisms underlying the effects of chronic restraint stress on the vascular contractile response induced by angiotensin (Ang) II in rat carotid. Concentration-response curves for AngII were obtained in endothelium-intact or endothelium-denuded carotid rings, in the absence or pr...