Estrogen-receptor-β distribution in the human hypothalamus: Similarities and differences with ERα distribution
This study reports the first systematic rostrocaudal distribution of estrogen receptor beta immunoreactivity (ERβ‐ir) in the human hypothalamus and adjacent areas in five males and five females between 20–39 years of age and compares its distribution to previously reported ERα in the same patients....
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| Published in | Journal of comparative neurology (1911) Vol. 466; no. 2; pp. 251 - 277 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
10.11.2003
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| Online Access | Get full text |
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| Abstract | This study reports the first systematic rostrocaudal distribution of estrogen receptor beta immunoreactivity (ERβ‐ir) in the human hypothalamus and adjacent areas in five males and five females between 20–39 years of age and compares its distribution to previously reported ERα in the same patients. ERβ‐ir was generally observed more frequently in the cytoplasm than in the nucleus and appeared to be stronger in women. Basket‐like fiber stainings, suggestive for ERβ‐ir in synaptic terminals, were additionally observed in various areas. Men showed more robust nuclear ERβ‐ir than women in the medial part of the bed nucleus of the stria terminalis, paraventricular and paratenial nucleus of the thalamus, while less intense, but more nuclear, ERβ‐ir appeared to be present in, e.g., the BSTc, sexually dimorphic nucleus of the medial preoptic area, diagonal band of Broca and ventromedial nucleus. Women revealed more nuclear ERβ‐ir than men of a low to intermediate level, e.g., in the suprachiasmatic, supraoptic, paraventricular, infundibular, and medial mamillary nucleus. These data indicate potential sex differences in ERβ expression. ERβ‐ir expression patterns in subjects with abnormal hormone levels suggests that there may be sex differences in ERβ‐ir that are “activational” rather than “organizational” in nature. Similarities, differences, potential functional, and clinical implications of the observed ERα and ERβ distributions are discussed in relation to reproduction, autonomic‐function, mood, cognition, and neuroprotection in health and disease. J. Comp. Neurol. 466:251–277, 2003. © 2003 Wiley‐Liss, Inc. |
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| AbstractList | This study reports the first systematic rostrocaudal distribution of estrogen receptor beta immunoreactivity (ERβ‐ir) in the human hypothalamus and adjacent areas in five males and five females between 20–39 years of age and compares its distribution to previously reported ERα in the same patients. ERβ‐ir was generally observed more frequently in the cytoplasm than in the nucleus and appeared to be stronger in women. Basket‐like fiber stainings, suggestive for ERβ‐ir in synaptic terminals, were additionally observed in various areas. Men showed more robust nuclear ERβ‐ir than women in the medial part of the bed nucleus of the stria terminalis, paraventricular and paratenial nucleus of the thalamus, while less intense, but more nuclear, ERβ‐ir appeared to be present in, e.g., the BSTc, sexually dimorphic nucleus of the medial preoptic area, diagonal band of Broca and ventromedial nucleus. Women revealed more nuclear ERβ‐ir than men of a low to intermediate level, e.g., in the suprachiasmatic, supraoptic, paraventricular, infundibular, and medial mamillary nucleus. These data indicate potential sex differences in ERβ expression. ERβ‐ir expression patterns in subjects with abnormal hormone levels suggests that there may be sex differences in ERβ‐ir that are “activational” rather than “organizational” in nature. Similarities, differences, potential functional, and clinical implications of the observed ERα and ERβ distributions are discussed in relation to reproduction, autonomic‐function, mood, cognition, and neuroprotection in health and disease. J. Comp. Neurol. 466:251–277, 2003. © 2003 Wiley‐Liss, Inc. This study reports the first systematic rostrocaudal distribution of estrogen receptor beta immunoreactivity (ER beta -ir) in the human hypothalamus and adjacent areas in five males and five females between 20-39 years of age and compares its distribution to previously reported ER alpha in the same patients. ER beta -ir was generally observed more frequently in the cytoplasm than in the nucleus and appeared to be stronger in women. Basket-like fiber stainings, suggestive for ER beta -ir in synaptic terminals, were additionally observed in various areas. Men showed more robust nuclear ER beta -ir than women in the medial part of the bed nucleus of the stria terminalis, paraventricular and paratenial nucleus of the thalamus, while less intense, but more nuclear, ER beta -ir appeared to be present in, e.g. the BSTc, sexually dimorphic nucleus of the medial preoptic area, diagonal band of Broca and ventromedial nucleus. Women revealed more nuclear ER beta -ir than men of a low to intermediate level, e.g. in the suprachiasmatic, supraoptic, paraventricular, infundibular, and medial mamillary nucleus. These data indicate potential sex differences in ER beta expression. ER beta -ir expression patterns in subjects with abnormal hormone levels suggests that there may be sex differences in ER beta -ir that are "activational" rather than "organizational" in nature. Similarities, differences, potential functional, and clinical implications of the observed ER alpha and ER beta distributions are discussed in relation to reproduction, autonomic-function, mood, cognition, and neuroprotection in health and disease. This study reports the first systematic rostrocaudal distribution of estrogen receptor beta immunoreactivity (ER beta-ir) in the human hypothalamus and adjacent areas in five males and five females between 20-39 years of age and compares its distribution to previously reported ER alpha in the same patients. ER beta-ir was generally observed more frequently in the cytoplasm than in the nucleus and appeared to be stronger in women. Basket-like fiber stainings, suggestive for ER beta-ir in synaptic terminals, were additionally observed in various areas. Men showed more robust nuclear ER beta-ir than women in the medial part of the bed nucleus of the stria terminalis, paraventricular and paratenial nucleus of the thalamus, while less intense, but more nuclear, ER beta-ir appeared to be present in, e.g., the BSTc, sexually dimorphic nucleus of the medial preoptic area, diagonal band of Broca and ventromedial nucleus. Women revealed more nuclear ER beta-ir than men of a low to intermediate level, e.g., in the suprachiasmatic, supraoptic, paraventricular, infundibular, and medial mamillary nucleus. These data indicate potential sex differences in ER beta expression. ER beta-ir expression patterns in subjects with abnormal hormone levels suggests that there may be sex differences in ER beta-ir that are "activational" rather than "organizational" in nature. Similarities, differences, potential functional, and clinical implications of the observed ER alpha and ER beta distributions are discussed in relation to reproduction, autonomic-function, mood, cognition, and neuroprotection in health and disease.This study reports the first systematic rostrocaudal distribution of estrogen receptor beta immunoreactivity (ER beta-ir) in the human hypothalamus and adjacent areas in five males and five females between 20-39 years of age and compares its distribution to previously reported ER alpha in the same patients. ER beta-ir was generally observed more frequently in the cytoplasm than in the nucleus and appeared to be stronger in women. Basket-like fiber stainings, suggestive for ER beta-ir in synaptic terminals, were additionally observed in various areas. Men showed more robust nuclear ER beta-ir than women in the medial part of the bed nucleus of the stria terminalis, paraventricular and paratenial nucleus of the thalamus, while less intense, but more nuclear, ER beta-ir appeared to be present in, e.g., the BSTc, sexually dimorphic nucleus of the medial preoptic area, diagonal band of Broca and ventromedial nucleus. Women revealed more nuclear ER beta-ir than men of a low to intermediate level, e.g., in the suprachiasmatic, supraoptic, paraventricular, infundibular, and medial mamillary nucleus. These data indicate potential sex differences in ER beta expression. ER beta-ir expression patterns in subjects with abnormal hormone levels suggests that there may be sex differences in ER beta-ir that are "activational" rather than "organizational" in nature. Similarities, differences, potential functional, and clinical implications of the observed ER alpha and ER beta distributions are discussed in relation to reproduction, autonomic-function, mood, cognition, and neuroprotection in health and disease. |
| Author | Balesar, Rawien Kruijver, Frank P.M. Unmehopa, Unga A. Espila, Ana M. Swaab, Dick F. |
| Author_xml | – sequence: 1 givenname: Frank P.M. surname: Kruijver fullname: Kruijver, Frank P.M. email: fkruijver@Rijngeestgroep.nl organization: Graduate School of Neurosciences, Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands – sequence: 2 givenname: Rawien surname: Balesar fullname: Balesar, Rawien organization: Graduate School of Neurosciences, Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands – sequence: 3 givenname: Ana M. surname: Espila fullname: Espila, Ana M. organization: Graduate School of Neurosciences, Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands – sequence: 4 givenname: Unga A. surname: Unmehopa fullname: Unmehopa, Unga A. organization: Graduate School of Neurosciences, Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands – sequence: 5 givenname: Dick F. surname: Swaab fullname: Swaab, Dick F. email: d.swaab@nih.knaw.nl organization: Graduate School of Neurosciences, Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/14528452$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0006-8993(99)02475-0 10.1046/j.1365-2826.2003.01055.x 10.1073/pnas.96.22.12887 10.1016/S1043-2760(01)00377-0 10.1016/S0893-133X(01)00351-7 10.1002/cne.1054 10.1016/S0301-0082(00)00059-9 10.1016/0031-9384(82)90365-1 10.1016/0006-8993(94)90689-0 10.1159/000057339 10.1093/schbul/16.2.185 10.1002/(SICI)1097-0185(199710)249:2<259::AID-AR14>3.0.CO;2-N 10.1006/bbrc.2000.3827 10.1016/S0006-8993(98)00809-9 10.1016/0306-4530(91)90068-5 10.1210/jcem.83.12.5471 10.1002/(SICI)1098-1136(199905)26:3<260::AID-GLIA7>3.0.CO;2-R 10.1210/en.139.9.3976 10.1016/S0303-7207(01)00414-2 10.1126/science.3992248 10.1002/(SICI)1096-9861(19980713)396:4<544::AID-CNE10>3.0.CO;2-G 10.1210/jc.86.2.818 10.1159/000126778 10.1016/0006-8993(90)90350-K 10.1073/pnas.90.23.11162 10.1006/hbeh.1998.1451 10.1016/S0361-9230(97)00210-4 10.1073/pnas.052707299 10.1016/0165-3806(88)90231-3 10.1016/S0197-4580(03)00059-9 10.1095/biolreprod60.6.1279 10.1016/0306-4522(95)00602-8 10.1073/pnas.95.26.15635 10.1016/S0169-328X(02)00130-4 10.1002/cne.901700302 10.1016/0026-0495(95)90168-X 10.1016/S0306-4530(02)00036-7 10.1002/(SICI)1096-9861(19971201)388:4<507::AID-CNE1>3.0.CO;2-6 10.1023/A:1007152904926 10.1212/WNL.53.1.91 10.1097/00075197-200111000-00006 10.1046/j.1365-2826.1997.00659.x 10.1016/S0278-5846(00)00150-0 10.1016/0091-3057(94)90254-2 10.1016/S0006-8993(96)01400-X 10.1210/en.131.3.1336 10.1001/archpsyc.58.6.529 10.1001/archpsyc.58.7.655 10.1210/endo.142.12.8560 10.1073/pnas.221449798 10.1210/en.141.8.2951 10.1210/me.13.2.307 10.1016/0304-3940(91)90316-L 10.1016/S0169-328X(02)00544-2 10.1016/S0304-3940(01)01545-2 10.1523/JNEUROSCI.23-13-05771.2003 10.1159/000054518 10.1530/ror.0.0030164 10.1016/S8756-3282(01)00703-7 10.1016/0306-4522(96)00183-2 10.1006/hbeh.1997.1419 10.1172/JCI0215736 10.1016/0304-3940(76)90027-6 10.1016/0166-2236(95)80007-O 10.1016/S0303-7207(01)00557-3 10.1016/S0306-3623(02)00129-5 10.1046/j.1365-2826.2001.00719.x 10.1073/pnas.93.12.5925 10.1159/000127221 10.1523/JNEUROSCI.22-03-01027.2002 10.1002/1096-9861(20010212)430:3<396::AID-CNE1039>3.0.CO;2-0 10.1016/S0006-3223(00)00995-1 10.1016/0304-3940(95)11659-K 10.1016/0165-0173(93)90007-M 10.1210/endo.140.12.7179 10.1016/S0165-6147(99)01392-9 10.1002/cne.903590204 10.1002/cne.901510204 10.1126/science.279.5348.242 10.1007/s00401-003-0720-3 10.1530/eje.0.1480227 10.1006/frne.1998.0170 10.1016/S0303-7207(98)00197-X 10.1016/0006-8993(89)90012-7 10.1159/000122742 10.1002/(SICI)1097-4695(19980905)36:3<357::AID-NEU5>3.0.CO;2-V 10.1016/S0303-7207(97)00133-0 10.1016/0197-4580(95)02016-0 10.1016/S0169-328X(00)00135-2 10.1210/jc.82.12.4258 10.1016/S0006-8993(99)02458-0 10.1159/000048217 10.1016/S0165-0327(98)00203-1 10.1016/S0895-7061(98)00096-X 10.1210/jc.85.12.4835 10.1016/S0047-6374(01)00406-7 10.1016/S0197-4580(00)00151-2 10.1016/0960-0760(95)00165-V 10.1016/S0006-8993(01)02610-5 10.1016/S0039-128X(96)00222-X 10.1001/jama.288.3.321 10.1111/j.1365-2826.1994.tb00635.x 10.1002/elps.1150091006 10.1016/S0306-4530(00)00043-3 10.1016/S0079-6123(00)26025-1 10.1002/(SICI)1096-9861(19980316)392:3<330::AID-CNE4>3.0.CO;2-2 10.1523/JNEUROSCI.09-02-00497.1989 10.1073/pnas.121146898 10.1046/j.1365-2869.2001.00236.x 10.1016/S0006-8993(00)02993-0 10.1210/jc.85.10.3840 10.1210/endo.140.6.6928 10.1006/frne.1998.0171 10.1111/j.1365-2826.1993.tb00364.x 10.1176/appi.ajp.159.5.713 10.1016/0361-9230(89)90194-9 10.1097/00019442-199721520-00002 10.1016/S0140-6736(00)02628-3 10.1016/S1043-2760(02)00611-2 10.1073/pnas.95.26.15677 10.1523/JNEUROSCI.16-17-05555.1996 10.1073/pnas.221451898 10.1038/13453 10.1523/JNEUROSCI.15-05-03526.1995 10.1016/S0361-9230(97)00217-7 10.1002/1096-9861(20000925)425:3<422::AID-CNE7>3.0.CO;2-H 10.1006/hbeh.2001.1682 10.1002/mds.10139 10.1210/me.11.3.353 10.1161/01.CIR.94.4.727 10.1016/S0006-8993(02)02460-5 10.1002/1096-9861(20010115)429:3<355::AID-CNE1>3.0.CO;2-# 10.1016/S0960-0760(00)00114-X 10.1046/j.0007-1331.2001.00743.x 10.1016/S0006-8993(00)02870-5 10.1016/S0306-4530(02)00022-7 10.1016/S0196-9781(01)00398-9 10.1016/S0306-4522(00)00245-1 10.1073/pnas.242735799 10.1212/WNL.57.4.605 10.1016/S0197-4580(00)00255-4 10.1210/en.2003-0004 10.1210/jcem.84.6.5761 10.1523/JNEUROSCI.20-22-08620.2000 10.1097/00001756-200107030-00036 10.1016/S0149-7634(99)00053-6 10.1677/jme.0.0240145 10.1016/S0166-2236(02)02182-3 10.1056/NEJM199906103402306 10.1016/S0079-6123(08)64027-3 10.1210/en.2002-211438 10.1073/pnas.250473597 10.1159/000127191 10.1016/S0006-8993(97)00617-3 10.1159/000127154 10.1038/378068a0 10.1006/hbeh.2002.1773 10.1006/frne.1999.0177 10.1016/S0301-0082(00)00025-3 10.1073/pnas.96.19.10905 10.1016/0006-8993(78)90723-0 10.1016/S0006-8993(02)02590-8 10.1016/S0006-8993(99)01960-5 10.1073/pnas.041617498 10.1111/j.1365-2826.2001.00598.x 10.1001/archneur.59.3.385 10.1016/S0925-4773(98)00223-8 10.1016/S0896-6273(01)00390-7 10.1210/edrv.20.3.0370 10.1161/01.CIR.94.6.1402 10.1002/cne.10393 10.1677/joe.0.1690241 10.1159/000054370 10.1210/jc.86.3.1379 10.1016/S0166-4328(05)80019-1 10.1073/pnas.041483198 10.1002/cne.10124 10.1093/geronb/55.1.P47 10.1073/pnas.97.23.12729 10.1210/jcem.87.2.8230 10.1016/S0920-9964(00)00088-8 10.1016/S0306-4530(99)00020-7 10.1046/j.0007-1331.2001.00751.x 10.1176/appi.ajp.157.9.1445 10.1002/(SICI)1096-9861(19981130)401:4<480::AID-CNE4>3.0.CO;2-F 10.1002/(SICI)1097-4695(19990605)39:3<359::AID-NEU3>3.0.CO;2-W 10.1002/cne.903350104 10.1210/en.140.10.4530 10.1016/S0006-8993(99)02413-0 10.1038/sj.ijo.0802054 10.1126/science.277.5331.1508 10.1096/fj.01-0504com 10.1016/0306-4530(85)90009-5 10.1006/hbeh.2001.1680 10.1210/jc.85.9.3283 10.1073/pnas.95.19.11445 10.1016/0168-0102(96)81278-8 10.1038/35081582 10.1016/S0301-0082(00)00039-3 10.1002/cne.10416 10.1007/BF03347808 10.1038/nm0597-545 10.1016/S0924-8196(97)80004-8 10.1016/S0006-8993(01)03283-8 10.1093/jnen/59.4.314 10.1002/neu.480240706 10.1002/(SICI)1097-4695(19990915)40:4<574::AID-NEU12>3.0.CO;2-8 10.1016/0006-8993(89)91219-5 10.1212/WNL.54.12.2292 10.1210/jcem.85.5.6564 10.1210/jc.83.11.3965 10.1523/JNEUROSCI.12-11-04133.1992 10.1139/y89-013 10.1210/er.20.3.279 10.1016/S0140-6736(96)03356-9 10.1016/0361-9230(80)90266-X 10.1212/WNL.48.5_Suppl_7.16S 10.1073/pnas.97.1.337 10.1007/BF01967291 10.1002/cne.10175 10.1161/01.CIR.89.5.1943 10.1016/S0079-6123(00)26005-6 10.1016/S0531-5565(99)00044-3 10.1016/S0006-8993(01)02060-1 10.1002/jemt.1151 10.1006/bbrc.1998.8590 10.1073/pnas.89.15.7199 10.1002/cne.902140206 10.1007/s004290050236 10.1016/0306-4522(94)00384-H 10.1126/science.1887219 10.1146/annurev.neuro.25.112701.142745 10.1016/0014-5793(96)00782-X |
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| References | Swaab DF, Fliers E, Hoogendijk WJ, Veltman DJ, Zhou JN. 2000. Interaction of prefrontal cortical and hypothalamic systems in the pathogenesis of depression. Prog Brain Res 126: 369-396. Salehi A, Dubelaar EJ, Mulder M, Swaab DF. 1998. Aggravated decrease in the activity of nucleus basalis neurons in Alzheimer's disease is apolipoprotein E-type dependent. Proc Natl Acad Sci U S A 95: 11445-11449. Zhang L, Li B, Zhao W, Chang YH, Ma W, Dragan M, Barker JL, Hu Q, Rubinow DR. 2002b. Sex-related differences in MAPKs activation in rat astrocytes: effects of estrogen on cell death. Mol Brain Res 103: 1-11. Buijs RM, Kalsbeek A, van der Woude TP, van Heerikhuize JJ, Shinn S. 1993a. Suprachiasmatic nucleus lesion increases corticosterone secretion. Am J Physiol 264(6 Pt 2): R1186-1192. Gahr M. 2001. Distribution of sex steroid hormone receptors in the avian brain: functional implications for neural sex differences and sexual behaviors. Microsc Res Tech 55: 1-11. Savaskan E, Olivieri G, Meier F, Ravid R, Muller-Spahn F. 2001. Hippocampal estrogen beta-receptor immunoreactivity is increased in Alzheimer's disease. Brain Res 908: 113-119. Luine VN, Jacome LF, Maclusky NJ. 2003. Rapid enhancement of visual and place memory by estrogens in rats. Endocrinology 144: 2836-2844. Mallick BN, Joseph MM. 1997. Role of cholinergic inputs to the medial preoptic area in regulation of sleep-wakefulness and body temperature in freely moving rats. Brain Res 750: 311-317. Swaab DF, Hofman MA. 1990. An enlarged suprachiasmatic nucleus in homosexual men. Brain Res 537: 141-148. Shughrue PJ, Komm B, Merchenthaler I. 1996. The distribution of estrogen receptor-beta mRNA in the rat hypothalamus. Steroids 61: 678-681. Laflamme N, Nappi RE, Drolet G, Labrie C, Rivest S. 1998. Expression and neuropeptidergic characterization of estrogen receptors (ERα and ERβ) throughout the rat brain: anatomical evidence of distinct roles of each subtype. J Neurobiol 36: 357-378. Saper CB. 2000. Hypothalamic connections with the cerebral cortex. Prog Brain Res 126: 39-48. Österlund MK, Hurd XL. 2001. Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders. Prog Neurobiol 64: 251-267. Byne W, Tobet S, Mattiace LA, Lasco MS, Kemether E, Edgar MA, Morgello S, Buchsbaum MS, Jones LB. 2001. The interstitial nuclei of the human anterior hypothalamus: an investigation of variation with sex, sexual orientation, and HIV status. Horm Behav 40: 86-92. Swaab DF, Chung WCJ, Kruijver FPM, Hofman MA, Ishunina TA. 2001. Structural and functional sex differences in the human hypothalamus. Horm Behav 40: 93-98. Rosenkranz K, Hinney A, Ziegler A, Hermann H, Fichter M, Mayer H, Siegfried W, Young JK, Remschmidt H, Hebebrand J. 1998. Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: identification of several genetic variants. J Clin Endocrinol Metab 83: 4524-4527. Halbreich U. 1997. Role of estrogen in postmenopausal depression. Neurology 48: S116-S119. Abraham IM, Han SK, Todman MG, Korach KS, Herbison AE. 2003. Estrogen receptor beta mediates rapid estrogen actions on gonadotropin-releasing hormone neurons in vivo. J Neurosci 23: 5771-5777. Schumacher M, Akwa Y, Guennoun R, Robert F, Labombarda F, Desarnaud F, Robel P, De Nicola AF, Beaulieu EE. 2000. Steroid synthesis and metabolism in the nervous system: trophic and protective effects. J Neurocytol 29: 307-326. Kawata M. 1995. Roles of steroid hormones and their receptors in structural organization in the nervous system. Neurosci Res 24: 1-46. Asthana S, Baker LD, Craft S, Stanczyk FZ, Veith RC, Raskind MA, Plymate SR. 2001. High-dose estradiol improves cognition for women with AD: results of a randomized study. Neurology 57: 605-612. Hofman MA, Swaab DF. 1994. Alterations in circadian rhythmicity of the vasopressin-producing neurons of the human suprachiasmatic nucleus (SCN) with aging. Brain Res 651: 134-142. Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J-A. 1996. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci U S A 93: 5925-5930. Paech K, Webb P, Kuiper GG, Nilsson S, Gustafsson JA, Kushner PJ, Scanlan TS. 1997. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 277: 1508-1510. Collins P, Webb C. 1999. Estrogen hits the surface. Nat Med 5: 1130-1131. Byne W, Lasco MS, Kemether E, Shinwari A, Edgar MA, Morgello S, Jones LB, Tobet S. 2000. The interstitial nuclei of the human anterior hypothalamus: an investigation of sexual variation in volume and cell size, number and density. Brain Res 856: 254-258. Pfaff D, Keiner M. 1973. Atlas of estradiol-concentrating cells in the central nervous system of the female rat. J Comp Neurol 151: 121-158. Jakab RL, Wong JK, Belcher SM. 2001. Estrogen receptor β immunoreactivity in differentiating cells of the developing rat cerebellum. J Comp Neurol 430: 396-409. Schneider LS, Small GW, Hamilton SH, Bystritsky A, Nemeroff CB, Meyers BS. 1997. Estrogen replacement and response to fluoxetine in a multicenter geriatric depression trial. Fluoxetine Collaborative Study Group. Am J Geriatr Psychiatry 5: 97-106. Fernández-Guasti A, Kruijver FPM, Fodor M, Swaab DF. 2000. Sex differences in the distribution of androgen receptors in the human hypothalamus. J Comp Neurol 425: 422-435. Webster JC, Jewell CM, Sar M, Cidlowski JA. 1994. The glucocorticoid receptor: maybe not all steroid receptors are nuclear. Endocrine 2: 967-969. Moga MM, Weis RP, Moore RY. 1995. Efferent projections of the paraventricular thalamic nucleus in the rat. J Comp Neurol 359: 221-238. Swaab DF, Chung WCJ, Kruijver FPM, Hofman MA. Hestiantoro A. 2003. Sex differences in the human hypothalamus in the different stages of human life. Neurobiol Aging 24: S1-S16. Vasudevan N, Kow LM, Pfaff DW. 2001. Early membrane estrogenic effects required for full expression of slower genomic actions in a nerve cell line. Proc Natl Acad Sci U S A 98: 12267-12271. Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjold M, Gustafsson JA. 1997. Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab 82: 4258-4265. Garcia-Segura LM, Naftolin F, Hutchinson JB, Azcoita I, Chowen JA. 1999. Role of astroglia in estrogen regulation of synaptic plasticity and brain repair. J Neurobiol 40: 574-584. Scammell TE, Estabrooke IV, McCarthy MT, Chemelli RM, Yanagisawa M, Miller MS, Saper CB. 2000. Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J Neurosci 20: 8620-8628. Segovia S, Guillamón A. 1993. Sexual dimorphism in the vomeronasal pathway and sex differences in reproductive behaviors. Brain Res Rev 18: 51-74. Dijk DJ, Czeisler CA. 1995. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. J Neurosci 15: 3526-3538. Shupnik MA, Pitt LK, Soh AY, Anderson A, Lopes MB, Laws ER Jr. 1998. Selective expression of estrogen receptor alpha and beta isoforms in human pituitary tumors. J Clin Endocrinol Metab 83: 3965-3972. Mendelsohn ME, Karas RH. 1999. The protective effects of estrogen on the cardiovascular system. N Engl J Med 340: 1801-1811. Kim SH, Cairns N, Fountoulakisc M, Lubec G. 2001. Decreased brain histamine-releasing factor protein in patients with Down syndrome and Alzheimer's disease. Neurosci Lett 300: 41-44. Kruijver FPM, Balesar R, Espila AM, Unmehopa UA, Swaab DF. 2002. Estrogen-receptor-alpha distribution in the human hypothalamus in relation to sex and endocrine status. J Comp Neurol 454: 115-139. Lecce G, Meduri G, Ancelin M, Bergeron C, Perrot-Applanat M. 2001. Presence of estrogen receptor beta in the human endometrium through the cycle: expression in glandular, stromal, and vascular cells. J Clin Endocrinol Metab 86: 1379-1386. Lasco MS, Jordan TJ, Edgar MA, Petito CK, Byne W. 2002. A lack of dimorphism of sex or sexual orientation in the human anterior commissure. Brain Res 936: 95-98. Seeman MV, Lang M. 1990. The role of estrogens in schizophrenia gender differences. Schizophr Bull 106: 185-194. Sherwin BB, Gelfand MM. 1985. Sex steroids and affect in the surgical menopause: a double-blind, cross-over study. Psychoneuroendocrinology 10: 325-335. Blaustein JD, Greco B. 2002. A progestin antagonist blocks vaginocervical stimulation-induced fos expression in neurones containing progestin receptors in the rostral medial preoptic area. J Neuroendocrinol 14: 109-115. Koutcherov Y, Mai JK, Ashwell KW, Paxinos G. 2002. Organization of human hypothalamus in fetal development. J Comp Neurol 446: 301-324. Prell GD, Khandelwal JK, Burns RS, Green JP. 1989. Diurnal fluctuation in levels of histamine metabolites in cerebrospinal fluid of rhesus monkey. Agents Actions 26: 79-286. Van Leeuwen FW, de Kleijn DP, van den Hurk HH, Neubauer A, Sonnemans MA, Sluijs JA, Koycu S, Ramdjielal RD, Salehi A, Martens GJ, Grosveld FG, Burbach JP, Hol EM. 1998. Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. Science 279: 242-247. Nandi D, Aziz TZ, Liu X, Stein JF. 2002. Brainstem motor loops in the control of movement. Mov Disord 17(Suppl 3): S22-27. Goldsmith PC, Boggan JE, Thind KK. 1997. Estrogen and progesterone receptor expression in neuroendocrine and related neurons of the pubertal female monkey hypothalamus. Neuroendocrinology 65: 325-334. Wagner CK, Silverman AJ, Morell JI. 1998. Evidence for estrogen receptor in cell nuclei and axon terminals within the lateral habenula of the rat: regulation during pregnancy. J Comp Neurol 392: 330-342 Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS. 2000. Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci U S A 97: 12729-12734. Tsang KL, Ho SL, Lo SK. 2000. Estrogen improves motor disability in parkinsonian postmenopausal women with 1991; 16 1990; 106 2001; 142 2002; 99 1996; 72 2001; 48 2001; 49 1998; 279 1999; 40 1997; 5 1998; 396 1997; 3 2001; 40 1997; 9 1996; 75 1998; 392 1998; 19 2000; 883 1993a; 264 1995; 24 2002; 87 1996; 61 1999; 55 1999; 53 2000; 880 2001; 55 2001; 57 2001; 58 1998; 11 1996; 64 2002; 75 1999; 26 1989; 495 1995; 55 1999; 24 1996; 94 1999; 340 1996; 93 1999; 20 2001; 26 1998; 139 2001; 22 2001; 25 2001; 169 1992; 131 1989; 489 1999; 39 1995; 44 1999; 34 1998; 3 1998; 146 2001; 31 2002; 59 1997; 82 2002; 110 2000; 856 1997; 750 2001; 908 1996; 348 1990; 537 1997; II 2002; 41 1991; 44 1973; 151 1999; 13 1998; 401 1978; 25 2001; 12 2001; 13 1992; 89 2001; 10 2002; 38 2002a; 935 1989; 23 2000; 157 1997; 66 2000; 278 2002; 30 1997; 65 1995; 16 1995; 15 2002b; 103 2002; 454 2002; 452 1995; 359 1999; 140 2003a; 15 1993; 90 1985; 228 1995; 18 2002 1989; 26 2002; 28 2002; 25 2002; 26 1997; 767 2002; 443 1989; 164 2002; 22 1980; 5 2002; 446 2000; 141 1994; 651 2002; 16 2002; 17 2002; 14 2001; 300 1999; 849 1993; 24 1991; 235 1997; 44 1997; 48 2002; 13 2000; 85 1997; 277 2002; 159 1995; 378 2003b 1998; 83 2001; 429 1994; 60 1997; 388 2002; 143 1982; 60 2000; 126 2000; 97 1978; 148 1998; 95 1985; 10 2001; 895 1989; 67 2000; 356 1989; 9 1994; 89 1976; 2 1997 2002; 4 2000; 71 2002; 936 1996; 16 1998; 68 1999 2001; 430 2003; 106 1997; 32 2000; 76 2000; 74 2002; 123 2003; 24 2003; 28 2002; 925 2000; 80 1999; 199 2000; 100 2003; 100 2001; 436 2003; 23 2002; 198 2001; 182 1999; 84 1998; 117 1999; 81 1976; 170 1992; 12 2003; 110 1993; 5 2001; 86 1995; 64 2001; 178 1982; 29 1997; 11 1998; 808 2000; 59 2000; 54 2000; 55 1997; 13 1988; 44 1998; 246 1999; 96 2001; 98 1991; 132 1983; 214 2000; 29 1993b; 335 2000; 26 2000; 24 2000; 21 1997; 132 2000; 20 1994; 49 1999; 60 1999; 5 1995; 193 2001; 63 2001; 64 1997; 249 1993; 18 1988; 9 2001; 4 2000; 425 2002; 288 1996; 392 2001; 2 2003; 148 1994; 2 1998; 34 2003; 144 1998; 36 1994; 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| References_xml | – reference: Fernández-Guasti A, Kruijver FPM, Fodor M, Swaab DF. 2000. Sex differences in the distribution of androgen receptors in the human hypothalamus. J Comp Neurol 425: 422-435. – reference: Scammell TE, Estabrooke IV, McCarthy MT, Chemelli RM, Yanagisawa M, Miller MS, Saper CB. 2000. Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J Neurosci 20: 8620-8628. – reference: Liang YQ, Akishita M, Kim S, Ako J, Hashimoto M, Iijima K, Ohike Y, Watanabe T, Sudoh N, Toba K, Yoshizumi M, Ouchi Y. 2002. Estrogen receptor β is involved in the anorectic action of estrogen. Int J Obes Relat Metab Disord 26: 1103-1109. – reference: Swaab DF, Raadsheer FC, Endert E, Hofman MA, Kamphorst W, Ravid R. 1994. Increased cortisol levels in aging and Alzheimer's disease in postmortem cerebrospinal fluid. J Neuroendocrinol 6: 681-687. – reference: Garcia-Segura LM, Naftolin F, Hutchinson JB, Azcoita I, Chowen JA. 1999. Role of astroglia in estrogen regulation of synaptic plasticity and brain repair. J Neurobiol 40: 574-584. – reference: Chung WCJ, De Vries GJ, Swaab DF. 2002. Sexual differentiation of the bed nucleus of the stria terminalis in humans may extend into adulthood. J Neurosci 22: 1027-1033. – reference: Simerly RB. 2002. Wired for reproduction: organization and development of sexually dimorphic circuits in the mammalian forebrain. Annu Rev Neurosci 25: 507-536. – reference: Price RH Jr, Lorenzon N, Handa RJ. 2000. Differential expression of estrogen receptor beta splice variants in rat brain: identification and characterization of a novel variant missing exon 4. Mol Brain Res 80: 260-268. – reference: Gooren LJG, Kruijver FPM. 2002. Androgens and male behaviour. Mol Cell Endocrinol 198: 1-40. – reference: Saji S, Jensen EV, Nilsson S, Rylander T, Warner M, Gustafsson JA. 2000. Estrogen receptors alpha and beta in the rodent mammary gland. Proc Natl Acad Sci U S A 97: 337-342. – reference: Matsumoto A, Arai Y. 1976. Effect of estrogen on early postnatal development of synaptic formation in the hypothalamic arcuate nucleus of female rats. Neurosci Lett 2: 79-82. – reference: Ogawa S, Chester AE, Hewitt SC, Walker VR, Gustafsson JA, Smithies O, Korach KS, Pfaff DW. 2000. From the cover: abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO). Proc Natl Acad Sci U S A 97: 14737-14741. – reference: Seeman TE, Singer B, Wilkinson CW, McEwen B. 2001. Gender differences in age-related changes in HPA axis reactivity. Psychoneuroendocrinology 26: 225-240. – reference: Heeb MM, Yahr P. 1996. c-Fos immunoreactivity in the sexually dimorphic area of the hypothalamus and related brain regions of male gerbils after exposure to sex-related stimuli or performance of specific sexual behaviors. Neuroscience 72: 1049-1071. – reference: Najimi M, Bennis M, Moyse E, Miachon S, Kopp N, Chigr F. 2001. Regional distribution of benzodiazepine binding sites in the human newborn and infant hypothalamus. A quantitative autoradiographic study. Brain Res 895: 129-138. – reference: Puy L, MacLusky NJ, Becker L, Karzan N, Trachtenberg J, Brown TJ. 1995. Immunocytochemical detection of androgen receptor in human temporal cortex: characterization and application of polyclonal androgen receptor antibodies in frozen and paraffin embedded tissues. J Steroid Biochem Mol Biol 55: 197-209. – reference: Senanarong V, Vannasaeng S, Poungvarin N, Ploybutr S, Udompunthurak S, Jamjumras P, Fairbanks L, Cummings JL. 2002. Endogenous estradiol in elderly individuals: cognitive and noncognitive associations. Arch Neurol 59: 385-389. – reference: Kulkarni J, Riedel A, de Castella AR, Fitzgerald PB, Rolfe TJ, Taffe J, Burger H. 2001. Estrogen - a potential treatment for schizophrenia. Schizophr Res 48: 137-144. – reference: Kaiser S, Kruijver FP, Straub RH, Sachser N, Swaab DF. 2003a. Early social stress in male guinea-pigs changes social behaviour, and autonomic and neuroendocrine functions. J Neuroendocrinol 15: 761-769. – reference: Goldstone AP, Unmehopa UA, Bloom SR, Swaab DF. 2002. Hypothalamic NPY and agouti-related protein are increased in human illness but not in Prader-Willi syndrome and other obese subjects. J Clin Endocrinol Metab 87: 927-937. – reference: Van Leeuwen FW, de Kleijn DP, van den Hurk HH, Neubauer A, Sonnemans MA, Sluijs JA, Koycu S, Ramdjielal RD, Salehi A, Martens GJ, Grosveld FG, Burbach JP, Hol EM. 1998. Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. Science 279: 242-247. – reference: Wersinger SR, Sannen K, Villalba C, Lubahn DB, Rissman EF, De Vries GJ. 1997. Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene. Horm Behav 32: 176-183. – reference: Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjold M, Gustafsson JA. 1997. Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab 82: 4258-4265. – reference: Salehi A, Heyn S, Gonatas NK, Swaab DF. 1995. Decreased protein synthetic activity of the hypothalamic tuberomamillary nucleus in Alzheimer's disease as suggested by smaller Golgi apparatus. Neurosci Lett 193: 29-32. – reference: Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J-A. 1996. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci U S A 93: 5925-5930. – reference: Vasudevan N, Kow LM, Pfaff DW. 2001. Early membrane estrogenic effects required for full expression of slower genomic actions in a nerve cell line. Proc Natl Acad Sci U S A 98: 12267-12271. – reference: Hofman MA, Swaab DF. 1989. The sexually dimorphic nucleus of the preoptic area in the human brain: a comparative morphometric study. J Anat 164: 55-72. – reference: Lafrati MD, Karas RH, Arnowitz M. 1997. Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice. Nat Med 3: 545-548. – reference: O'Brien ML, Park K, In Y, Park-Sarge OK. 1999. Characterization of estrogen receptor-beta (ERbeta) messenger ribonucleic acid and protein expression in rat granulosa cells. Endocrinology 140: 4530-4541. – reference: Donahue JE, Stopa EG, Chorsky RL, King JC, Schipper HM, Tobet SA, Blaustein JD, Reichlin S. 2000. Cells containing estrogen receptor-α in the human basal forebrain. Brain Res 856: 142-151. – reference: Passani MB, Bacciottini L, Mannaioni PF, Blandina P. 2000. Central histaminergic system and cognition. Neurosci Biobehav Rev 24: 107-113. – reference: Pfaff DW, Gerlach JL, McEwen BS, Ferin M, Carmel P, Zimmerman EA. 1976. Autoradiographic localization of hormone-concentrating cells in the brain of the female rhesus monkey. J Comp Neurol 170: 279-293. – reference: Gregg TR, Siegel A. 2001. Brain structures and neurotransmitters regulating aggression in cats: implications for human aggression. Prog Neuropsychopharmacol Biol Psychiatry 25: 91-140. – reference: Wise PM. 2002. Estrogens and neuroprotection. Trends Endocrinol Metab 13: 229-230. – reference: Zhang JQ, Cai WQ, Zhou de S, Su BY. 2002a. Distribution and differences of estrogen receptor beta immunoreactivity in the brain of adult male and female rats. Brain Res 935: 73-80. – reference: Collins P, Webb C. 1999. Estrogen hits the surface. Nat Med 5: 1130-1131. – reference: Fernández-Guasti A, Swaab DF, Rodríguez-Manzo G. 2002. Sexual behavior reduces hypothalamic androgen receptor immunoreactivity. Psychoneuroendocrinology 28: 501-512. – reference: Beyer C. 1999. Estrogen and the developing mammalian brain. Anat Embryol 199: 279-390. – reference: Wang L, Andersson S, Warner M, Gustafsson JA. 2001. Morphological abnormalities in the brains of estrogen receptor beta knockout mice. Proc Natl Acad Sci U S A 98: 2792-2796. – reference: Ogawa S, Chan J, Chester AE, Gustafsson JA, Korach KS, Pfaff DW. 1999. Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice. Proc Natl Acad Sci USA 96: 12887-12892. – reference: Swaab DF, Hofman MA. 1990. An enlarged suprachiasmatic nucleus in homosexual men. Brain Res 537: 141-148. – reference: Paech K, Webb P, Kuiper GG, Nilsson S, Gustafsson JA, Kushner PJ, Scanlan TS. 1997. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 277: 1508-1510. – reference: Pfaff D, Keiner M. 1973. Atlas of estradiol-concentrating cells in the central nervous system of the female rat. J Comp Neurol 151: 121-158. – reference: Dubal DB, Zhu H, Yu J, Rau SW, Shughrue PJ, Merchenthaler I, Kindy MS, Wise PM. 2001. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Proc Natl Acad Sci USA 98: 1952-1957. – reference: Ma TP, Johnson JC, Hoskins GA. 1997. Organization of the zona incerta in the macaque: an electron microscopic study. Anat Rec 249: 259-275. – reference: Tchernof A, Poehlman ET, Despres JP. 2000. Body fat distribution, the menopause transition, and hormone replacement therapy. Diabetes Metab 26: 12-20. – reference: Gorski RA, Gordon JH, Shryne JE, Southam AM. 1978. Evidence for a morphological sex difference within the medial preoptic area of the rat brain. Brain Res 148: 333-346. – reference: Savaskan E, Olivieri G, Meier F, Ravid R, Muller-Spahn F. 2001. Hippocampal estrogen beta-receptor immunoreactivity is increased in Alzheimer's disease. Brain Res 908: 113-119. – reference: Mercuro G, Zoncu S, Piano D, Pilia I, Lao A, Melis GB, Cherchi A. 1998. Estradiol-17beta reduces blood pressure and restores the normal amplitude of the circadian blood pressure rhythm in postmenopausal hypertension. Am J Hypertens 11(8 Pt 1): 909-913. – reference: Halbreich U. 1997. Role of estrogen in postmenopausal depression. Neurology 48: S116-S119. – reference: Savic I, Berglund H, Gulyas B, Roland P. 2001. Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans. Neuron 31: 661-668. – reference: Blaustein JD, Turcotte JC. 1989. Estrogen receptor-immunostaining of neuronal cytoplasmic processes as well as cell nuclei in guinea pig brain. Brain Res 495: 75-82. – reference: Kim-Schulze S, McGowan KA, Hubchak SC. 1996. Expression of an estrogen receptor by human coronary artery and umbilical vein endothelial cells. Circulation 94: 1402-1407. – reference: Bao AM, Liu RY, van Someren EJ, Hofman MA, Cao YX, Zhou JN. 2003. Diurnal rhythm of free estradiol during the menstrual cycle. Eur J Endocrinol 148: 227-232. – reference: Krezel W, Dupont S, Krust A, Chambon P, Chapman PF. 2001. Increased anxiety and synaptic plasticity in estrogen receptor beta-deficient mice. Proc Natl Acad Sci U S A 98: 12278-12282. – reference: Mitchner NA, Garlick C, Ben-Jonathan N. 1998. Cellular distribution and gene regulation of estrogen receptors alpha and beta in the rat pituitary gland. Endocrinology 139: 3976-3983. – reference: Chu S, Fuller PJ. 1997. Identification of a splice variant of the rat estrogen receptor beta gene. Mol Cell Endocrinol 132: 195-199. – reference: Kelly MJ, Moss RL, Dudley CA. 1978. The effect of ovariectomy on the responsiveness of preoptic-septal neurons to microelectrophoresed estrogen. Neuroendocrinology 25: 204-211. – reference: Asthana S, Craft S, Baker LD, Raskind MA, Birnbaum RS, Lofgreen CP, Veith RC, Plymate SR. 1999. Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study. Psychoneuroendocrinology 24: 657-677. – reference: Quadros PS, Pfau JL, Goldstein AY, De Vries GJ, Wagner CK. 2002. Sex differences in progesterone receptor expression: a potential mechanism for estradiol-mediated sexual differentiation. Endocrinology 143: 3727-3739. – reference: Balthazart J, Baillien M, Ball GF. 2001. Rapid and reversible inhibition of brain aromatase activity. J Neuroendocrinol 13: 63-73. – reference: Prinz P, Bailey S, Moe K, Wilkinson C, Scanlan J. 2001. Urinary free cortisol and sleep under baseline and stressed conditions in healthy senior women: effects of estrogen replacement therapy. J Sleep Res 10: 19-26. – reference: Swaab DF, Fliers E, Hoogendijk WJ, Veltman DJ, Zhou JN. 2000. Interaction of prefrontal cortical and hypothalamic systems in the pathogenesis of depression. Prog Brain Res 126: 369-396. – reference: Orikasa C, Kondo Y, Hayashi S, McEwen BS, Sakuma Y. 2002. Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: implication in luteinizing hormone surge. Proc Natl Acad Sci U S A 99: 3306-3311. – reference: Fitzpatrick SL, Funkhouser JM, Sindoni DM, Stevis PS, Deecher DC, Bapat AR, Merchentaler I, Trail DE. 1999. Expression of estrogen receptor-β protein in rodent ovary. Endocrinology 140: 2581-2591. – reference: Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, Sar M, Korach KS, Gustafsson JA, Smithies O. 1998. Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci U S A 95: 15677-15682. – reference: Buijs RM, Kalsbeek A, van der Woude TP, van Heerikhuize JJ, Shinn S. 1993a. Suprachiasmatic nucleus lesion increases corticosterone secretion. Am J Physiol 264(6 Pt 2): R1186-1192. – reference: Hall JM, McDonnell DP. 1999. The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 140: 5566-5578. – reference: Writing Group for the Women's Health Initiative Investigators. 2002. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. JAMA 288: 321-333. – reference: Zhou JN, Riemerema RF, Unmehopa UA, Hoogendijk WJ, van Heerikhuize JJ, Hofman MA, Swaab DF. 2001. Alterations in arginine vasopressin neurons in the suprachiasmatic nucleus in depression. Arch Gen Psychiatry 58: 655-662. – reference: Pau CY, Pau KY, Spies HG. 1998. Putative estrogen receptor beta and alpha mRNA expression in male and female rhesus macaques. Mol Cell Endocrinol 146: 59-68. – reference: Maruyama K, Endoh H, Sasaki-Iwaoka H, Kanou H, Shimaya E, Hashimoto S, Kato S, Kawashima H. 1998. A novel isoform of rat estrogen receptor beta with 18 amino acid insertion in the ligand binding domain as a putative dominant negative regulator of estrogen action. Biochem Biophys Res Commun 246: 142-147. – reference: Azcoitia I, Sierra A, Garcia-Segura LM. 1999. Localization of estrogen receptor beta-immunoreactivity in astrocytes of the adult rat brain. Glia 26: 260-267. – reference: Nomura M, Durbak L, Chan J, Smithies O, Gustafsson JA, Korach KS, Pfaff DW, Ogawa S. 2002. Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice. Horm Behav 41: 288-296. – reference: Herbison AE. 1997. Estrogen regulation of GABA transmission in rat preoptic area. Brain Res Bull 44: 321-326. – reference: Österlund MK, Hurd XL. 2001. Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders. Prog Neurobiol 64: 251-267. – reference: Amsterdam J, Garcia-Espana F, Fawcett J, Quitkin F, Reimherr F, Rosenbaum J, Beasley C. 1999. Fluoxetine efficacy in menopausal women with and without estrogen replacement. J Affect Disord 55: 11-17. – reference: Kornstein SG, Schatzberg AF, Thase ME, Yonkers KA, McCullough JP, Keitner GI, Gelenberg AJ, Davis SM, Harrison WM, Keller MB. 2000. Gender differences in treatment response to sertraline versus imipramine in chronic depression. Am J Psychiatry 157: 1445-14452. – reference: Garcia-Segura LM, Azcoitia I, DonCarlos LL. 2001. Neuroprotection by estradiol. Prog Neurobiol 63: 29-60. – reference: Moga MM, Weis RP, Moore RY. 1995. Efferent projections of the paraventricular thalamic nucleus in the rat. J Comp Neurol 359: 221-238. – reference: Andersson C, Lydrup ML, Ferno M, Idvall I, Gustafsson J, Nilsson BO. 2001. Immunocytochemical demonstration of oestrogen receptor beta in blood vessels of the female rat. J Endocrinol 169: 241-247. – reference: Saunders PT. 1998. Oestrogen receptor beta (ER beta). Rev Reprod 3: 164-171. – reference: Breedlove SM. 1992. Sexual dimorphism in the vertebrate nervous system. J Neurosci 12: 4133-4142. – reference: Swaab DF, Lucassen PJ, Salehi A, Scherder EJA, van Someren EJW, Verwer RWH. 1998. Reduced neuronal activity and reactivation in Alzheimer's disease. Prog Brain Res 117: 343-377. – reference: Kruijver FPM, Balesar R, Espila AM, Unmehopa UA, Swaab DF. 2002. Estrogen-receptor-alpha distribution in the human hypothalamus in relation to sex and endocrine status. J Comp Neurol 454: 115-139. – reference: Rahman Q, Wilson GD. 2003. Sexual orientation and the 2nd to 4th finger length ratio: evidence for organising effects of sex hormones or developmental instability? Psychoneuroendocrinology 28: 288-303. – reference: Rosenkranz K, Hinney A, Ziegler A, Hermann H, Fichter M, Mayer H, Siegfried W, Young JK, Remschmidt H, Hebebrand J. 1998. Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: identification of several genetic variants. J Clin Endocrinol Metab 83: 4524-4527. – reference: Mungarndee SS, Baldwin BA, Chindadoungratana C, Kotchabhakdi N. 2002. Hypothalamic and zona incerta neurons in sheep, initially only responding to the sight of food, also respond to the sight of water after intracerebroventricular injection of hypertonic saline or angiotensin II. Brain Res 925: 204-212. – reference: Prell GD, Khandelwal JK, Burns RS, Green JP. 1989. Diurnal fluctuation in levels of histamine metabolites in cerebrospinal fluid of rhesus monkey. Agents Actions 26: 79-286. – reference: Lemmen JG, Broekhof JL, Kuiper GG, Gustafsson JA, van der Saag PT, van der Burg B. 1999. Expression of estrogen receptor alpha and beta during mouse embryogenesis. Mech Dev 81: 163-167. – reference: Byne W, Lasco MS, Kemether E, Shinwari A, Edgar MA, Morgello S, Jones LB, Tobet S. 2000. The interstitial nuclei of the human anterior hypothalamus: an investigation of sexual variation in volume and cell size, number and density. Brain Res 856: 254-258. – reference: Wang L, Andersson S, Warner M, Gustafsson JA. 2003. Estrogen receptor (ER) β knockout mice reveal a role for ERβ in migration of cortical neurons in the developing brain beta knockout mice. Proc Natl Acad Sci USA 100: 703-708. – reference: White RE. 2002. Estrogen and vascular function. Vascul Pharmacol 38: 73-80. – reference: Blaustein JD, Olster DH. 1993. Colchicine-induced accumulation of estrogen receptor and progestin receptor immunoreactivity in atypical areas in guinea-pig brain. J Neuroendocrinol 5: 63-70. – reference: Greco B, Edwards DA, Michael RP, Clancy AN. 1996. Androgen receptor immunoreactivity and mating-induced Fos expression in forebrain and midbrain structures in the male rat. Neuroscience 75: 161-171. – reference: Lindamer LA, Buse DC, Lohr JB, Jeste DV. 2001. Hormone replacement therapy in postmenopausal women with schizophrenia: positive effect on negative symptoms? Biol Psychiatry 49: 47-51. – reference: Ongur D, An X, Price JL. 1998. Prefrontal cortical projections to the hypothalamus in macaque monkeys. J Comp Neurol 401: 480-505. – reference: McCarthy MM, Auger AP, Perrot-Sinal TS. 2002. Getting excited about GABA and sex differences in the brain. Trends Neurosci 25: 307-312. – reference: Hofman MA, Swaab DF. 1994. Alterations in circadian rhythmicity of the vasopressin-producing neurons of the human suprachiasmatic nucleus (SCN) with aging. Brain Res 651: 134-142. – reference: Lecce G, Meduri G, Ancelin M, Bergeron C, Perrot-Applanat M. 2001. Presence of estrogen receptor beta in the human endometrium through the cycle: expression in glandular, stromal, and vascular cells. J Clin Endocrinol Metab 86: 1379-1386. – reference: Blaak E. 2001. Gender differences in fat metabolism. Curr Opin Clin Nutr Metab Care 4: 499-502. – reference: Bakker J, Woodley SK, Kelliher KR, Baum MJ. 2002. Sexually dimorphic activation of galanin neurones in the ferret's dorsomedial preoptic area/anterior hypothalamus after mating. J Neuroendocrinol 14: 116-125. – reference: Mufson EJ, Cai WJ, Jaffar S, Chen EY, Stebbins G, Sendera T, Kordower JH. 1999. Estrogen receptor immunoreactivity within subregions of the rat forebrain: neuronal distribution and association with perikarya containing choline acetyltransferase. Brain Res 849: 253-274. – reference: Taylor AH, Al-Azzawi F. 2000. Immunolocalisation of oestrogen receptor beta in human tissues. J Mol Endocrinol 24: 145-155. – reference: Brown B, Grossman SP. 1980. Evidence that nerve cell bodies in the zona incerta influence ingestive behavior. Brain Res Bull 5: 593-597. – reference: Venkov CD, Rankin AB, Vaughan DE. 1996. Identification of authentic estrogen receptor in cultured endothelial cells: a potential mechanism for steroid hormone regulation of endothelial function. Circulation 94: 727-733. – reference: Wood RI, Newman SW. 1999. Androgen receptor immunoreactivity in the male and female Syrian hamster brain. J Neurobiol 39: 359-370. – reference: Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O. 1993. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci U S A 90: 11162-11166. – reference: Schumacher M, Akwa Y, Guennoun R, Robert F, Labombarda F, Desarnaud F, Robel P, De Nicola AF, Beaulieu EE. 2000. Steroid synthesis and metabolism in the nervous system: trophic and protective effects. J Neurocytol 29: 307-326. – reference: Cheung S, Ballew JR, Moore KE, Lookingland KJ. 1998. Contribution of dopamine neurons in the medial zona incerta to the innervation of the central nucleus of the amygdala, horizontal diagonal band of Broca and hypothalamic paraventricular nucleus. Brain Res 808: 174-181. – reference: Kaiser S, Kruijver FPM, Swaab DF, Sachser N. 2003b. Early social stress in female guinea pigs induces a masculinization of adult behavior and corresponding changes in brain and neuroendocrine function. Behav Brain Res (in press). – reference: Milner TA, McEwen BS, Hayashi S, Li CJ, Reagan LP, Alves SE. 2001. Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites. J Comp Neurol 429: 355-371. – reference: Mai JK, Assheuer J, Paxinos G. 1997. Atlas of the human brain. London: Academic Press. – reference: Brown RE, Stevens DR, Haas HL. 2001. The physiology of brain histamine. Prog Neurobiol 63: 637-72. – reference: Yaffe K, Liu LY, Grady D, Cauley J, Kramer J, Cummings SR. 2000. Cognitive decline in women in relation to non-protein-bound oestradiol concentrations. Lancet 356: 708-712. – reference: Laflamme N, Nappi RE, Drolet G, Labrie C, Rivest S. 1998. Expression and neuropeptidergic characterization of estrogen receptors (ERα and ERβ) throughout the rat brain: anatomical evidence of distinct roles of each subtype. J Neurobiol 36: 357-378. – reference: Panzica GC, Aste N, Viglietti-Panzica C, Ottinger MA. 1995. Structural sex differences in the brain: influence of gonadal steroids and behavioral correlates. J Endocrinol Invest 18: 232-252. – reference: Buijs RM, Kalsbeek A. 2001. Hypothalamic integration of central and peripheral clocks. Nat Rev 2: 521-526. – reference: Blaustein JD. 1992. Cytoplasmic estrogen receptors in rat brain: immunocytochemical evidence using three antibodies with distinct epitopes. Endocrinology 131: 1336-1342. – reference: Wagner CK, Silverman AJ, Morell JI. 1998. Evidence for estrogen receptor in cell nuclei and axon terminals within the lateral habenula of the rat: regulation during pregnancy. J Comp Neurol 392: 330-342 – reference: Sherwin BB, Gelfand MM. 1985. Sex steroids and affect in the surgical menopause: a double-blind, cross-over study. Psychoneuroendocrinology 10: 325-335. – reference: Kim SH, Cairns N, Fountoulakisc M, Lubec G. 2001. Decreased brain histamine-releasing factor protein in patients with Down syndrome and Alzheimer's disease. Neurosci Lett 300: 41-44. – reference: Cooke PS, Heine PA, Taylor JA, Lubahn DB. 2001. The role of estrogen and estrogen receptor-alpha in male adipose tissue. Mol Cell Endocrinol 178: 147-154. – reference: Stevens JR. 2002. Schizophrenia: reproductive hormones and the brain. Am J Psychiatry 159: 713-719. – reference: Pedersen SB, Bruun JM, Hube F, Kristensen K, Hauner H, Richelsen B. 2001. Demonstration of estrogen receptor subtypes alpha and beta in human adipose tissue: influences of adipose cell differentiation and fat depot localization. Mol Cell Endocrinol 182: 27-37. – reference: Mazurkiewicz-Kwilecki IM, Nsonwah S. 1989. Changes in the regional brain histamine and histidine levels in postmortem brains of Alzheimer patients. Can J Physiol Pharmacol 67: 75-78. – reference: Swaab DF, Hofman MA. 1988. Sexual differentiation of the human hypothalamus: ontogeny of the sexually dimorphic nucleus of the preoptic area. Dev Brain Res 44: 314-318. – reference: Zhou JN, Hofman MA, Gooren LJG, Swaab DF. 1995. A sex difference in the human brain and its relation to transsexuality. Nature 378: 68-70. – reference: Schneider LS, Small GW, Hamilton SH, Bystritsky A, Nemeroff CB, Meyers BS. 1997. Estrogen replacement and response to fluoxetine in a multicenter geriatric depression trial. Fluoxetine Collaborative Study Group. Am J Geriatr Psychiatry 5: 97-106. – reference: Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS. 2000. Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci U S A 97: 12729-12734. – reference: Greco B, Allegretto EA, Tetel MJ, Blaustein JD. 2001. Coexpression of ER beta with ER alpha and progestin receptor proteins in the female rat forebrain: effects of estradiol treatment. Endocrinology 142: 5172-5181. – reference: Mendelsohn ME, Karas RH. 1999. The protective effects of estrogen on the cardiovascular system. N Engl J Med 340: 1801-1811. – reference: McEwen BS, Alves SE. 1999. Estrogen actions in the central nervous system. Endocr Rev 20: 279-307. – reference: Edwards DA, Isaacs S. 1991. Zona incerta lesions: effects on copulation, partner-preference and other socio-sexual behaviors. Behav Brain Res 44: 145-150. – reference: Wang Z, Hulihan TJ, Insel TR. 1997. Sexual and social experience is associated with different patterns of behavior and neural activation in male prairie voles. Brain Res 767: 321-332. – reference: Tsang KL, Ho SL, Lo SK. 2000. Estrogen improves motor disability in parkinsonian postmenopausal women with motor fluctuations. Neurology 54: 2292-2298. – reference: Lasco MS, Jordan TJ, Edgar MA, Petito CK, Byne W. 2002. A lack of dimorphism of sex or sexual orientation in the human anterior commissure. Brain Res 936: 95-98. – reference: Kreier F, Fliers E, Voshol PJ, v. Eden CG, Havekes LM, Kalsbeek A, v. Heijningen, Sluiter AJ, Mettenleiter TC, Romijn JA, Sauerwein HP, Buijs, RM. 2002. Selective parasympathetic innervation of subcutaneous and intra-abdominal fat - functional implications. J Clin Invest 110: 1243-1250. – reference: Gudmundsson A, Goodman B, Lent S, Barczi S, Grace A, Boyle L, Ershler WB, Carnes M. 1999. Effects of estrogen replacement therapy on the circadian rhythms of serum cortisol and body temperature in postmenopausal women. Exp Gerontol 34: 809-818. – reference: Mallick BN, Joseph MM. 1997. Role of cholinergic inputs to the medial preoptic area in regulation of sleep-wakefulness and body temperature in freely moving rats. Brain Res 750: 311-317. – reference: Hu XY, Qin S, Lu YP, Ravid R, Swaab DF, Zhou JN. 2003. Decreased estrogen receptor-alpha expression in hippocampal neurons in relation to hyperphosphorylated tau in Alzheimer patients. Acta Neuropathol (Berl) 106: 213-220. – reference: Swaab DF, Hofman MA. 1995. Sexual differentiation of the human hypothalamus in relation to gender and sexual orientation. Trends Neurosci 18: 264-270. – reference: Webster JC, Jewell CM, Sar M, Cidlowski JA. 1994. The glucocorticoid receptor: maybe not all steroid receptors are nuclear. Endocrine 2: 967-969. – reference: Koutcherov Y, Mai JK, Ashwell KW, Paxinos G. 2002. Organization of human hypothalamus in fetal development. J Comp Neurol 446: 301-324. – reference: Tang M-X, Jacobs D, Stern Y, Marder K, Schofield P, Gurland B, Andrews H, Mayeux R. 1996. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 348: 429-432. – reference: Swaab DF, Chung WCJ, Kruijver FPM, Hofman MA. Hestiantoro A. 2003. Sex differences in the human hypothalamus in the different stages of human life. Neurobiol Aging 24: S1-S16. – reference: Carlson LE, Sherwin BB, Chertkow HM. 2000. Relationships between mood and estradiol (E2) levels in Alzheimer's disease (AD) patients. J Gerontol B Psychol Sci Soc Sci 55: P47-53. – reference: Soares CN, Almeida OP, Joffe H, Cohen LS. 2001. Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial. Arch Gen Psychiatry 58: 529-534. – reference: Buijs RM, Markman M, Nunes-Cardoso B, Hou YX, Shinn S. 1993b. Projections of the suprachiasmatic nucleus to stress-related areas in the rat hypothalamus: a light and electron microscopic study. J Comp Neurol 335: 42-54. – reference: Couse JF, Korach KS. 1999. Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev 20: 358-417. – reference: Hofman MA, Swaab DF. 1995. Influence of aging on the seasonal rhythm of the vasopressin-expressing neurons in the human suprachiasmatic nucleus. Neurobiol Aging 16: 965-971. – reference: Goldsmith PC, Boggan JE, Thind KK. 1997. Estrogen and progesterone receptor expression in neuroendocrine and related neurons of the pubertal female monkey hypothalamus. Neuroendocrinology 65: 325-334. – reference: Tuomisto L, Tuomisto J. 1982. Diurnal variations in brain and pituitary histamine and histamine-N-methyltransferase in the rat and guinea pig. Med Biol 60: 204-209. – reference: Nandi D, Aziz TZ, Liu X, Stein JF. 2002. Brainstem motor loops in the control of movement. Mov Disord 17(Suppl 3): S22-27. – reference: Blanchet PJ, Fang J, Hyland K, Arnold LA, Mouradian MM, Chase TN. 1999. Short-term effects of high-dose 17beta-estradiol in postmenopausal PD patients: a crossover study. Neurology 53: 91-95. – reference: Segovia S, Guillamón A. 1993. Sexual dimorphism in the vomeronasal pathway and sex differences in reproductive behaviors. Brain Res Rev 18: 51-74. – reference: McEwen BS. 1999. The molecular and neuroanatomical basis for estrogen effects in the central nervous system. J Clin Endocrinol Metab 84: 1790-1797. – reference: Van Eerdenburg FJ, Daemen IA, van der Beek EM, van Leeuwen FW. 2000. Changes in estrogen-alpha receptor immunoreactivity during the estrous cycle in lactating dairy cattle. Brain Res 880: 219-223. – reference: Clarke CH, Norfleet AM, Clarke MSF, Watson CS, Cunningham KA, Thomas ML. 2000. Perimembrane localization of the estrogen receptor α protein in neuronal processes of cultured hippocampal neurons. Neuroendocrinology 71: 34-42. – reference: Mesulam MM, Mufson EJ, Levey AI, Wainer BH. 1983. Cholinergic innervation of cortex by basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey. J Comp Neurol 214: 170-197. – reference: Jakab RL, Wong JK, Belcher SM. 2001. Estrogen receptor β immunoreactivity in differentiating cells of the developing rat cerebellum. J Comp Neurol 430: 396-409. – reference: Mosselman S, Polman J, Dijkema R. 1996. ERβ: identification and characterization of a novel human receptor. FEBS Lett 392: 49-53. – reference: Seeman MV, Lang M. 1990. The role of estrogens in schizophrenia gender differences. Schizophr Bull 106: 185-194. – reference: Ji RR, Schlaepfer TE, Aizenman CD, Epstein CM, Qiu D, Huang JC, Rupp F. 1998. Repetitive transcranial magnetic stimulation activates specific regions in rat brain. Proc Natl Acad Sci U S A 95: 15635-15640. – reference: Nomura M, Korach KS, Pfaff DW, Ogawa S. 2003. Estrogen receptor beta (ERbeta) protein levels in neurons depend on estrogen receptor alpha (ERalpha) gene expression and on its ligand in a brain region-specific manner. Mol Brain Res 110: 7-14. – reference: Swaab DF, Chung WCJ, Kruijver FPM, Hofman MA, Ishunina TA. 2001. Structural and functional sex differences in the human hypothalamus. Horm Behav 40: 93-98. – reference: Dalton LD, Grossman SP. 1982. Responses to dietary alterations in rats with zona incerta lesions. Physiol Behav 29: 51-60. – reference: Gundlah C, Kohama SG, Mirkes SJ, Garyfallou VT, Urbanski HF, and Bethea CL. 2000. Distribution of estrogen receptor beta (ERbeta) mRNA in hypothalamus, midbrain and temporal lobe of spayed macaque: continued expression with hormone replacement. Mol Brain Res 76: 191-204. – reference: Kawata M. 1995. Roles of steroid hormones and their receptors in structural organization in the nervous system. Neurosci Res 24: 1-46. – reference: Luine VN, Jacome LF, Maclusky NJ. 2003. Rapid enhancement of visual and place memory by estrogens in rats. Endocrinology 144: 2836-2844. – reference: Karas RH, Patterson BL, Mendelsohn ME. 1994. Human vascular smooth muscle cells contain functional estrogen receptor. Circulation 89: 1943-1950. – reference: Li X, Schwartz PE, Rissman EF. 1997. Distribution of estrogen receptor-β-like immunoreactivity in rat forebrain. Neuroendocrinology 66: 63-67. – reference: Karolczak M, Beyer C. 1998. Developmental sex differences in estrogen receptor-beta mRNA expression in the mouse hypothalamus/preoptic region. Neuroendocrinology 68: 229-234. – reference: Kolmac CI, Power BD, Mitrofanis J. 1998. Patterns of connections between zona incerta and brainstem in rats. J Comp Neurol 396: 544-555. – reference: Hileman SM, Handa RJ, Jackson GL. 1999. Distribution of estrogen receptor-beta messenger ribonucleic acid in the male sheep hypothalamus. Biol Reprod 60: 1279-1284. – reference: Gibbs RB, Aggarwal P. 1998. Estrogen and basal forebrain cholinergic neurons: implications for brain ageing and Alzheimer's disease-related cognitive decline. Horm Behav 34: 98-111. – reference: Kametani H, Kawamura H. 1991. Circadian rhythm of cortical acetylcholine release as measured by in vivo microdialysis in freely moving rats. Neurosci Lett 132: 263-266. – reference: LeVay S. 1991. A difference in hypothalamic structure between heterosexual and homosexual men. Science 235: 1034-1037. – reference: Simonian SX, Herbison AE. 1997. Differential expression of estrogen receptor α and β immunoreactivity by oxytocin neurons of rat paraventricular nucleus. J Neuroendocrinol 9: 803-806. – reference: Kelly MJ, Levin ER. 2001. Rapid actions of plasma membrane estrogen receptors. Trends Endocrinol Metab 12: 152-156. – reference: Shupnik MA, Pitt LK, Soh AY, Anderson A, Lopes MB, Laws ER Jr. 1998. Selective expression of estrogen receptor alpha and beta isoforms in human pituitary tumors. J Clin Endocrinol Metab 83: 3965-3972. – reference: van der Sluis PJ, Pool CW, Sluiter AA. 1988. Immunochemical detection of peptides and proteins on press-blots after direct tissue gel isoelectric focusing. Electrophoresis 9: 654-661. – reference: Wood RI, Newman SW. 1993. Intracellular partitioning of androgen receptor immunoreactivity in the brain of the male Syrian hamster: effects of castration and steroid replacement. J Neurobiol 24: 925-938. – reference: Abraham IM, Han SK, Todman MG, Korach KS, Herbison AE. 2003. Estrogen receptor beta mediates rapid estrogen actions on gonadotropin-releasing hormone neurons in vivo. J Neurosci 23: 5771-5777. – reference: Ohlsson C, Hellberg N, Parini P, Vidal O, Bohlooly M, Rudling M, Lindberg MK, Warner M, Angelin B, Gustafsson JA. 2000. Obesity and disturbed lipoprotein profile in estrogen receptor-alpha-deficient male mice. Biochem Biophys Res Commun 278: 640-645. – reference: Toran-Allerand CD. 1991. Organotypic culture of the developing cerebral cortex and hypothalamus relevance to sexual differentiation. Psychoneuroendocrinology 16: 7-24. – reference: Ogawa S, Taylor JA, Lubahn DB, Korach KS, Pfaff DW. 1996. Reversal of sex roles in genetic female mice by disruption of estrogen receptor gene. Neuroendocrinology 64: 467-470. – reference: Swaab DF, Fliers E, 1985. A sexually dimorphic nucleus in the human brain. Science 228: 11132-1115. – reference: Pfaff DW, Vasudevan N, Kia HK, Zhu YS, Chan J, Garey J, Morgan M, Ogawa S. 2000. Estrogens, brain and behavior: studies in fundamental neurobiology and observations related to women's health. J Steroid Biochem Mol Biol 74: 365-373. – reference: Patrone C, Andersson S, Korhonen L, Lindholm D. 1999. Estrogen receptor-dependent regulation of sensory neuron survival in developing dorsal root ganglion. Proc Natl Acad Sci U S A 96: 10905-10910. – reference: Kiviranta T, Tuomisto L, Airaksinen EM. 1994. Diurnal and age-related changes in cerebrospinal fluid tele-methylhistamine levels during infancy and childhood. Pharmacol Biochem Behav 49: 997-1000. – reference: Van Leeuwen FW, Chouham S, Axelson JF, Swaab DF, Van Eerdenburg FJ. 1995. Sex differences in the distribution of estrogen receptors in the septal area and hypothalamus of the domestic pig (Sus scrofa). Neuroscience 64: 261-275. – reference: Goncharuk VD, Van Heerikhuize J, Swaab DF, Buijs RM. 2002. Paraventricular nucleus of the human hypothalamus in primary hypertension: activation of corticotropin-releasing hormone neurons. J Comp Neurol 443: 321-331. – reference: Kruijver FPM, Swaab DF. 2002. Sex hormone receptors are present in the human suprachiasmatic nucleus. Neuroendocrinology 75: 296-305. – reference: Sheehan T, Numan M. 2002. Estrogen, progesterone, and pregnancy termination alter neural activity in brain regions that control maternal behavior in rats. Neuroendocrinology 75: 12-23. – reference: McEwen B, Akama K, Alves S, Brake WG, Bulloch K, Lee S, Li C, Yuen G, Milner TA. 2001. Tracking the estrogen receptor in neurons: implications for estrogen-induced synapse formation. Proc Natl Acad Sci USA 98: 7093-7100. – reference: Raadsheer FC, Hoogendijk WJ, Stam FC, Tilders FJ, Swaab DF. 1994. Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocrinology 60: 436-444. – reference: Svendsen OL, Hassager C, Christiansen C. 1995. Age- and menopause-associated variations in body composition and fat distribution in healthy women as measured by dual-energy X-ray absorptiometry. Metabolism 44: 369-373. – reference: Van der Eerden BC, Gevers EF, Lowik CW, Karperien M, Wit JM. 2002. Expression of estrogen receptor alpha and beta in the epiphyseal plate of the rat. Bone 30: 478-485. – reference: Blaustein JD, Greco B. 2002. A progestin antagonist blocks vaginocervical stimulation-induced fos expression in neurones containing progestin receptors in the rostral medial preoptic area. J Neuroendocrinol 14: 109-115. – reference: Ishunina TA, Swaab DF. 2001. Increased expression of estrogen receptor α and β in the nucleus basalis of Meynert in Alzheimer's disease. Neurobiol Aging 22: 417-426. – reference: Dijk DJ, Czeisler CA. 1995. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. J Neurosci 15: 3526-3538. – reference: Scott CJ, Tilbrook AJ, Simmons DM, Rawson JA, Chu S, Fuller PJ, Ing NH, Clarke IJ. 2000. The distribution of cells containing estrogen receptor-alpha (ERalpha) and ERbeta messenger ribonucleic acid in the preoptic area and hypothalamus of the sheep: comparison of males and females. Endocrinology 141: 2951-2962. – reference: Gahr M. 2001. Distribution of sex steroid hormone receptors in the avian brain: functional implications for neural sex differences and sexual behaviors. Microsc Res Tech 55: 1-11. – reference: Wilson ME, Rosewell KL, Kashon ML, Shughrue PJ, Merchenthaler I, Wise PM. 2002. Age differentially influences estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) gene expression in specific regions of the rat brain. Mech Ageing Dev 123: 593-601. – reference: Keck ME, Wigger A, Welt T, Muller MB, Gesing A, Reul JM, Holsboer F, Landgraf R, Neumann ID. 2002. Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders. Neuropsychopharmacology 26: 94-105. – reference: De Lacalle S, Saper CB. 2000. Calcitonin gene-related peptide-like immunoreactivity marks putative visceral sensory pathways in human brain. Neuroscience 100: 115-130. – reference: Byne W, Tobet S, Mattiace LA, Lasco MS, Kemether E, Edgar MA, Morgello S, Buchsbaum MS, Jones LB. 2001. The interstitial nuclei of the human anterior hypothalamus: an investigation of variation with sex, sexual orientation, and HIV status. Horm Behav 40: 86-92. – reference: Kuiper GG, Shughrue PJ, Merchenthaler I, Gustafsson JA. 1998. The estrogen receptor beta subtype: a novel mediator of estrogen action in neuroendocrine systems. Front Neuroendocrinol 19: 253-286. – reference: Kalsbeek A, van Heerikhuize JJ, Wortel J, Buijs RM. 1996. A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V1 antagonist. J Neurosci 16: 5555-5565. – reference: Allen LS, Hines M, Shryne JE, Gorski RA. 1989. Two sexually dimorphic nuclei in the human brain. J Neurosci 9: 467-502. – reference: Zhang L, Li B, Zhao W, Chang YH, Ma W, Dragan M, Barker JL, Hu Q, Rubinow DR. 2002b. Sex-related differences in MAPKs activation in rat astrocytes: effects of estrogen on cell death. Mol Brain Res 103: 1-11. – reference: Shughrue PJ, Komm B, Merchenthaler I. 1996. The distribution of estrogen receptor-beta mRNA in the rat hypothalamus. Steroids 61: 678-681. – reference: Kruijver FPM, Fernández-Guasti A, Fodor M, Kraan EM, Swaab DF. 2001. Sex differences in androgen receptors of the human mamillary bodies are related to endocrine status rather than to sexual orientation or transsexuality. J Clin Endocrinol Metab 86: 818-827. – reference: Koch M, Ehret G. 1989. Immunocytochemical localization and quantitation of estrogen-binding cells in the male and female (virgin, pregnant, lactating) mouse brain. Brain Res 489: 101-112. – reference: Iqbal J, Pompolo S, Sakurai T, Clarke IJ. 2001. Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus. J Neuroendocrinol 13: 1033-1041. – reference: Fugger HN, Foster TC, Gustafsson J, Rissman EF. 2000. Novel effects of estradiol and estrogen receptor alpha and beta on cognitive function. Brain Res 883: 258-264. – reference: Blurton-Jones M, Tuszynski MH. 2002. Estrogen receptor-beta colocalizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats. J Comp Neurol 452: 276-287. – reference: Toran-Allerand CD, Singh M, Sétáló G Jr. 1999. Novel mechanisms of estrogen action in the brain: new players in an old story. Front Neuroendocrinol 20: 97-121. – reference: Österlund MK, Gustafsson JA, Keller E, Hurd YL. 2000. Estrogen receptor beta (ERbeta) messenger ribonucleic acid (mRNA) expression within the human forebrain: distinct distribution pattern to ERalpha mRNA. J Clin Endocrinol Metab 85: 3840-3846. – reference: Van Leeuwen FW, Fischer DF, Kamel D, Sluijs JA, Sonnemans MA, Benne R, Swaab DF, Salehi A, Hol EM. 2000. Molecular misreading: a new type of transcript mutation expressed during aging. Neurobiol Aging 21: 879-891. – reference: Cooke B, Hegstrom CD, Villeneuve LS, Breedlove SM. 1998. Sexual differentiation of the vertebrate brain: principles and mechanisms. Front Neuroendocrinol 19: 323-362. – reference: Su JD, Qiu J, Zhong YP, Chen YZ. 2001. Expression of estrogen receptor-alpha and -beta immunoreactivity in the cultured neonatal suprachiasmatic nucleus: with special attention to GABAergic neurons. Neuroreport 12: 1955-1959. – reference: Tremblay GB, Tremblay A, Copeland NG, Gilbert DJ, Jenkins NA, Labrie F, Giguere V. 1997. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol Endocrinol 11: 353-365. – reference: Shughrue PJ, Lane MV, Merchentaler I. 1997. Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J Comp Neurol 388: 507-525. – reference: DeJonge FH, Louwerse AL, Ooms MP, Evers P, Endert E, van de Poll NE. 1989. Lesions of the SDN-POA inhibit sexual behavior of male wistar rats. Brain Res Bull 23: 483-492. – reference: Saper CB. 2000. Hypothalamic connections with the cerebral cortex. Prog Brain Res 126: 39-48. – reference: Behl C, Holsboer F. 1999. The female sex hormone oestrogen as a neuroprotectant. Trends Pharmacol Sci 20: 441-444. – reference: Keck ME, Holsboer F. 2001. Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders. Peptides 22: 835-844. – reference: Salehi A, Dubelaar EJ, Mulder M, Swaab DF. 1998. Aggravated decrease in the activity of nucleus basalis neurons in Alzheimer's disease is apolipoprotein E-type dependent. Proc Natl Acad Sci U S A 95: 11445-11449. – reference: Liu RY, Zhou JN, Hoogendijk WJ, van Heerikhuize J, Kamphorst W, Unmehopa UA, Hofman MA, Swaab DF. 2000. Decreased vasopressin gene expression in the biological clock of Alzheimer disease patients with and without depression. J Neuropathol Exp Neurol 59: 314-322. – reference: Allen LS, Gorski RA. 1992. Sexual orientation and the size of the anterior commissure in the human brain. Proc Natl Acad Sci U S A 89: 7199-7202. – reference: Razandi M, Pedram A, Kehrl J, Levin ER. 1999. Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells. Mol Endocrinol 13: 307-319. – reference: Shughrue PJ, Merchenthaler I. 2001. Distribution of estrogen receptor beta immunoreactivity in the rat central nervous system. J Comp Neurol 436: 64-81. – reference: Guillamón A, Segovia S. 1997. Sex differences in the vomeronasal system. Brain Res Bull 44: 377-382. – reference: Pelletier G, El-Alfy M. 2000. Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs. J Clin Endocrinol Metab 85: 4835-4840. – reference: Kruijver FPM, Zhou JN, Pool CW, Hofman MA, Gooren LJG, Swaab DF. 2000. Male-to-female transsexuals have female neuron numbers in a limbic nucleus. J Clin Endocrinol Metab 85: 2034-2041. – reference: Asthana S, Baker LD, Craft S, Stanczyk FZ, Veith RC, Raskind MA, Plymate SR. 2001. High-dose estradiol improves cognition for women with AD: results of a randomized study. Neurology 57: 605-612. – reference: Ishunina TA, Kruijver FPM, Balesar R, Swaab DF. 2000. Differential expression of estrogen receptor α and β immunoreactivity in the human supraoptic nucleus in relation to sex and ageing. J Clin Endocrinol Metab 85: 3283-3291. – reference: Verwer RW, Hermens WT, Dijkhuizen P, Ter Brake O, Baker RE, Salehi A, Sluiter AA, Kok MJ, Muller LJ, Verhaagen J, Swaab DF. 2002. Cells in human postmortem brain tissue slices remain alive for several weeks in culture. FASEB J 16: 54-60. – volume: 24 start-page: S1 year: 2003 end-page: S16 article-title: Sex differences in the human hypothalamus in the different stages of human life publication-title: Neurobiol Aging – volume: 20 start-page: 97 year: 1999 end-page: 121 article-title: Novel mechanisms of estrogen action in the brain: new players in an old story publication-title: Front Neuroendocrinol – volume: 66 start-page: 63 year: 1997 end-page: 67 article-title: Distribution of estrogen receptor‐β‐like immunoreactivity in rat forebrain publication-title: Neuroendocrinology – volume: 19 start-page: 253 year: 1998 end-page: 286 article-title: The estrogen receptor beta subtype: a novel mediator of estrogen action in neuroendocrine systems publication-title: Front Neuroendocrinol – volume: 26 start-page: 1103 year: 2002 end-page: 1109 article-title: Estrogen receptor β is involved in the anorectic action of estrogen publication-title: Int J Obes Relat Metab Disord – volume: 90 start-page: 11162 year: 1993 end-page: 11166 article-title: Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene publication-title: Proc Natl Acad Sci U S A – volume: 99 start-page: 3306 year: 2002 end-page: 3311 article-title: Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: implication in luteinizing hormone surge publication-title: Proc Natl Acad Sci U S A – volume: 16 start-page: 54 year: 2002 end-page: 60 article-title: Cells in human postmortem brain tissue slices remain alive for several weeks in culture publication-title: FASEB J – volume: 5 start-page: 1130 year: 1999 end-page: 1131 article-title: Estrogen hits the surface publication-title: Nat Med – volume: 12 start-page: 1955 year: 2001 end-page: 1959 article-title: Expression of estrogen receptor‐alpha and ‐beta immunoreactivity in the cultured neonatal suprachiasmatic nucleus: with special attention to GABAergic neurons publication-title: Neuroreport – volume: 16 start-page: 965 year: 1995 end-page: 971 article-title: Influence of aging on the seasonal rhythm of the vasopressin‐expressing neurons in the human suprachiasmatic nucleus publication-title: Neurobiol Aging – volume: II start-page: 425 year: 1997 end-page: 501 – volume: 96 start-page: 10905 year: 1999 end-page: 10910 article-title: Estrogen receptor‐dependent regulation of sensory neuron survival in developing dorsal root ganglion publication-title: Proc Natl Acad Sci U S A – volume: 182 start-page: 27 year: 2001 end-page: 37 article-title: Demonstration of estrogen receptor subtypes alpha and beta in human adipose tissue: influences of adipose cell differentiation and fat depot localization publication-title: Mol Cell Endocrinol – volume: 49 start-page: 47 year: 2001 end-page: 51 article-title: Hormone replacement therapy in postmenopausal women with schizophrenia: positive effect on negative symptoms? publication-title: Biol Psychiatry – volume: 4 start-page: 499 year: 2001 end-page: 502 article-title: Gender differences in fat metabolism publication-title: Curr Opin Clin Nutr Metab Care – volume: 264 start-page: R1186 issue: 6 Pt 2 year: 1993a end-page: 1192 article-title: Suprachiasmatic nucleus lesion increases corticosterone secretion publication-title: Am J Physiol – volume: 83 start-page: 3965 year: 1998 end-page: 3972 article-title: Selective expression of estrogen receptor alpha and beta isoforms in human pituitary tumors publication-title: J Clin Endocrinol Metab – volume: 430 start-page: 396 year: 2001 end-page: 409 article-title: Estrogen receptor β immunoreactivity in differentiating cells of the developing rat cerebellum publication-title: J Comp Neurol – volume: 86 start-page: 818 year: 2001 end-page: 827 article-title: Sex differences in androgen receptors of the human mamillary bodies are related to endocrine status rather than to sexual orientation or transsexuality publication-title: J Clin Endocrinol Metab – volume: 170 start-page: 279 year: 1976 end-page: 293 article-title: Autoradiographic localization of hormone‐concentrating cells in the brain of the female rhesus monkey publication-title: J Comp Neurol – volume: 9 start-page: 803 year: 1997 end-page: 806 article-title: Differential expression of estrogen receptor α and β immunoreactivity by oxytocin neurons of rat paraventricular nucleus publication-title: J Neuroendocrinol – volume: 489 start-page: 101 year: 1989 end-page: 112 article-title: Immunocytochemical localization and quantitation of estrogen‐binding cells in the male and female (virgin, pregnant, lactating) mouse brain publication-title: Brain Res – volume: 249 start-page: 259 year: 1997 end-page: 275 article-title: Organization of the zona incerta in the macaque: an electron microscopic study publication-title: Anat Rec – volume: 3 start-page: 164 year: 1998 end-page: 171 article-title: Oestrogen receptor beta (ER beta) publication-title: Rev Reprod – volume: 452 start-page: 276 year: 2002 end-page: 287 article-title: Estrogen receptor‐beta colocalizes extensively with parvalbumin‐labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats publication-title: J Comp Neurol – volume: 18 start-page: 232 year: 1995 end-page: 252 article-title: Structural sex differences in the brain: influence of gonadal steroids and behavioral correlates publication-title: J Endocrinol Invest – volume: 55 start-page: 197 year: 1995 end-page: 209 article-title: Immunocytochemical detection of androgen receptor in human temporal cortex: characterization and application of polyclonal androgen receptor antibodies in frozen and paraffin embedded tissues publication-title: J Steroid Biochem Mol Biol – volume: 58 start-page: 655 year: 2001 end-page: 662 article-title: Alterations in arginine vasopressin neurons in the suprachiasmatic nucleus in depression publication-title: Arch Gen Psychiatry – volume: 392 start-page: 49 year: 1996 end-page: 53 article-title: ERβ: identification and characterization of a novel human receptor publication-title: FEBS Lett – volume: 64 start-page: 251 year: 2001 end-page: 267 article-title: Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders publication-title: Prog Neurobiol – volume: 59 start-page: 385 year: 2002 end-page: 389 article-title: Endogenous estradiol in elderly individuals: cognitive and noncognitive associations publication-title: Arch Neurol – volume: 31 start-page: 661 year: 2001 end-page: 668 article-title: Smelling of odorous sex hormone‐like compounds causes sex‐differentiated hypothalamic activations in humans publication-title: Neuron – volume: 126 start-page: 369 year: 2000 end-page: 396 article-title: Interaction of prefrontal cortical and hypothalamic systems in the pathogenesis of depression publication-title: Prog Brain Res – volume: 110 start-page: 7 year: 2003 end-page: 14 article-title: Estrogen receptor beta (ERbeta) protein levels in neurons depend on estrogen receptor alpha (ERalpha) gene expression and on its ligand in a brain region‐specific manner publication-title: Mol Brain Res – volume: 151 start-page: 121 year: 1973 end-page: 158 article-title: Atlas of estradiol‐concentrating cells in the central nervous system of the female rat publication-title: J Comp Neurol – volume: 20 start-page: 279 year: 1999 end-page: 307 article-title: Estrogen actions in the central nervous system publication-title: Endocr Rev – volume: 85 start-page: 3283 year: 2000 end-page: 3291 article-title: Differential expression of estrogen receptor α and β immunoreactivity in the human supraoptic nucleus in relation to sex and ageing publication-title: J Clin Endocrinol Metab – volume: 750 start-page: 311 year: 1997 end-page: 317 article-title: Role of cholinergic inputs to the medial preoptic area in regulation of sleep‐wakefulness and body temperature in freely moving rats publication-title: Brain Res – volume: 288 start-page: 321 year: 2002 end-page: 333 article-title: Risks and benefits of estrogen plus progestin in healthy postmenopausal women publication-title: JAMA – volume: 85 start-page: 2034 year: 2000 end-page: 2041 article-title: Male‐to‐female transsexuals have female neuron numbers in a limbic nucleus publication-title: J Clin Endocrinol Metab – volume: 856 start-page: 254 year: 2000 end-page: 258 article-title: The interstitial nuclei of the human anterior hypothalamus: an investigation of sexual variation in volume and cell size, number and density publication-title: Brain Res – volume: 883 start-page: 258 year: 2000 end-page: 264 article-title: Novel effects of estradiol and estrogen receptor alpha and beta on cognitive function publication-title: Brain Res – year: 2002 – volume: 85 start-page: 4835 year: 2000 end-page: 4840 article-title: Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs publication-title: J Clin Endocrinol Metab – volume: 9 start-page: 467 year: 1989 end-page: 502 article-title: Two sexually dimorphic nuclei in the human brain publication-title: J Neurosci – volume: 436 start-page: 64 year: 2001 end-page: 81 article-title: Distribution of estrogen receptor beta immunoreactivity in the rat central nervous system publication-title: J Comp Neurol – volume: 58 start-page: 529 year: 2001 end-page: 534 article-title: Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double‐blind, randomized, placebo‐controlled trial publication-title: Arch Gen Psychiatry – volume: 651 start-page: 134 year: 1994 end-page: 142 article-title: Alterations in circadian rhythmicity of the vasopressin‐producing neurons of the human suprachiasmatic nucleus (SCN) with aging publication-title: Brain Res – volume: 443 start-page: 321 year: 2002 end-page: 331 article-title: Paraventricular nucleus of the human hypothalamus in primary hypertension: activation of corticotropin‐releasing hormone neurons publication-title: J Comp Neurol – volume: 142 start-page: 5172 year: 2001 end-page: 5181 article-title: Coexpression of ER beta with ER alpha and progestin receptor proteins in the female rat forebrain: effects of estradiol treatment publication-title: Endocrinology – volume: 396 start-page: 544 year: 1998 end-page: 555 article-title: Patterns of connections between zona incerta and brainstem in rats publication-title: J Comp Neurol – volume: 85 start-page: 3840 year: 2000 end-page: 3846 article-title: Estrogen receptor beta (ERbeta) messenger ribonucleic acid (mRNA) expression within the human forebrain: distinct distribution pattern to ERalpha mRNA publication-title: J Clin Endocrinol Metab – volume: 95 start-page: 11445 year: 1998 end-page: 11449 article-title: Aggravated decrease in the activity of nucleus basalis neurons in Alzheimer's disease is apolipoprotein E‐type dependent publication-title: Proc Natl Acad Sci U S A – volume: 13 start-page: 1033 year: 2001 end-page: 1041 article-title: Evidence that orexin‐containing neurones provide direct input to gonadotropin‐releasing hormone neurones in the ovine hypothalamus publication-title: J Neuroendocrinol – volume: 38 start-page: 73 year: 2002 end-page: 80 article-title: Estrogen and vascular function publication-title: Vascul Pharmacol – volume: 22 start-page: 417 year: 2001 end-page: 426 article-title: Increased expression of estrogen receptor α and β in the nucleus basalis of Meynert in Alzheimer's disease publication-title: Neurobiol Aging – volume: 100 start-page: 703 year: 2003 end-page: 708 article-title: Estrogen receptor (ER) β knockout mice reveal a role for ERβ in migration of cortical neurons in the developing brain beta knockout mice publication-title: Proc Natl Acad Sci USA – volume: 86 start-page: 1379 year: 2001 end-page: 1386 article-title: Presence of estrogen receptor beta in the human endometrium through the cycle: expression in glandular, stromal, and vascular cells publication-title: J Clin Endocrinol Metab – volume: 25 start-page: 507 year: 2002 end-page: 536 article-title: Wired for reproduction: organization and development of sexually dimorphic circuits in the mammalian forebrain publication-title: Annu Rev Neurosci – volume: 21 start-page: 879 year: 2000 end-page: 891 article-title: Molecular misreading: a new type of transcript mutation expressed during aging publication-title: Neurobiol Aging – volume: 936 start-page: 95 year: 2002 end-page: 98 article-title: A lack of dimorphism of sex or sexual orientation in the human anterior commissure publication-title: Brain Res – volume: 98 start-page: 12278 year: 2001 end-page: 12282 article-title: Increased anxiety and synaptic plasticity in estrogen receptor beta‐deficient mice publication-title: Proc Natl Acad Sci U S A – volume: 32 start-page: 176 year: 1997 end-page: 183 article-title: Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene publication-title: Horm Behav – volume: 75 start-page: 12 year: 2002 end-page: 23 article-title: Estrogen, progesterone, and pregnancy termination alter neural activity in brain regions that control maternal behavior in rats publication-title: Neuroendocrinology – volume: 25 start-page: 91 year: 2001 end-page: 140 article-title: Brain structures and neurotransmitters regulating aggression in cats: implications for human aggression publication-title: Prog Neuropsychopharmacol Biol Psychiatry – volume: 24 start-page: 657 year: 1999 end-page: 677 article-title: Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo‐controlled, double‐blind, pilot study publication-title: Psychoneuroendocrinology – volume: 401 start-page: 480 year: 1998 end-page: 505 article-title: Prefrontal cortical projections to the hypothalamus in macaque monkeys publication-title: J Comp Neurol – volume: 2 start-page: 967 year: 1994 end-page: 969 article-title: The glucocorticoid receptor: maybe not all steroid receptors are nuclear publication-title: Endocrine – start-page: 467 year: 1999 end-page: 521 – volume: 63 start-page: 637 year: 2001 end-page: 72 article-title: The physiology of brain histamine publication-title: Prog Neurobiol – volume: 13 start-page: 63 year: 2001 end-page: 73 article-title: Rapid and reversible inhibition of brain aromatase activity publication-title: J Neuroendocrinol – volume: 335 start-page: 42 year: 1993b end-page: 54 article-title: Projections of the suprachiasmatic nucleus to stress‐related areas in the rat hypothalamus: a light and electron microscopic study publication-title: J Comp Neurol – volume: 14 start-page: 116 year: 2002 end-page: 125 article-title: Sexually dimorphic activation of galanin neurones in the ferret's dorsomedial preoptic area/anterior hypothalamus after mating publication-title: J Neuroendocrinol – volume: 23 start-page: 483 year: 1989 end-page: 492 article-title: Lesions of the SDN‐POA inhibit sexual behavior of male wistar rats publication-title: Brain Res Bull – volume: 214 start-page: 170 year: 1983 end-page: 197 article-title: Cholinergic innervation of cortex by basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey publication-title: J Comp Neurol – volume: 12 start-page: 152 year: 2001 end-page: 156 article-title: Rapid actions of plasma membrane estrogen receptors publication-title: Trends Endocrinol Metab – volume: 98 start-page: 12267 year: 2001 end-page: 12271 article-title: Early membrane estrogenic effects required for full expression of slower genomic actions in a nerve cell line publication-title: Proc Natl Acad Sci U S A – year: 1997 – volume: 378 start-page: 68 year: 1995 end-page: 70 article-title: A sex difference in the human brain and its relation to transsexuality publication-title: Nature – volume: 348 start-page: 429 year: 1996 end-page: 432 article-title: Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease publication-title: Lancet – volume: 140 start-page: 5566 year: 1999 end-page: 5578 article-title: The estrogen receptor beta‐isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens publication-title: Endocrinology – volume: 159 start-page: 713 year: 2002 end-page: 719 article-title: Schizophrenia: reproductive hormones and the brain publication-title: Am J Psychiatry – volume: 97 start-page: 14737 year: 2000 end-page: 14741 article-title: From the cover: abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO) publication-title: Proc Natl Acad Sci U S A – volume: 22 start-page: 1027 year: 2002 end-page: 1033 article-title: Sexual differentiation of the bed nucleus of the stria terminalis in humans may extend into adulthood publication-title: J Neurosci – volume: 65 start-page: 325 year: 1997 end-page: 334 article-title: Estrogen and progesterone receptor expression in neuroendocrine and related neurons of the pubertal female monkey hypothalamus publication-title: Neuroendocrinology – volume: 5 start-page: 593 year: 1980 end-page: 597 article-title: Evidence that nerve cell bodies in the zona incerta influence ingestive behavior publication-title: Brain Res Bull – volume: 71 start-page: 34 year: 2000 end-page: 42 article-title: Perimembrane localization of the estrogen receptor α protein in neuronal processes of cultured hippocampal neurons publication-title: Neuroendocrinology – volume: 87 start-page: 927 year: 2002 end-page: 937 article-title: Hypothalamic NPY and agouti‐related protein are increased in human illness but not in Prader‐Willi syndrome and other obese subjects publication-title: J Clin Endocrinol Metab – volume: 24 start-page: 107 year: 2000 end-page: 113 article-title: Central histaminergic system and cognition publication-title: Neurosci Biobehav Rev – volume: 28 start-page: 288 year: 2003 end-page: 303 article-title: Sexual orientation and the 2nd to 4th finger length ratio: evidence for organising effects of sex hormones or developmental instability? publication-title: Psychoneuroendocrinology – volume: 81 start-page: 163 year: 1999 end-page: 167 article-title: Expression of estrogen receptor alpha and beta during mouse embryogenesis publication-title: Mech Dev – volume: 26 start-page: 260 year: 1999 end-page: 267 article-title: Localization of estrogen receptor beta‐immunoreactivity in astrocytes of the adult rat brain publication-title: Glia – volume: 106 start-page: 185 year: 1990 end-page: 194 article-title: The role of estrogens in schizophrenia gender differences publication-title: Schizophr Bull – volume: 9 start-page: 654 year: 1988 end-page: 661 article-title: Immunochemical detection of peptides and proteins on press‐blots after direct tissue gel isoelectric focusing publication-title: Electrophoresis – volume: 60 start-page: 436 year: 1994 end-page: 444 article-title: Increased numbers of corticotropin‐releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients publication-title: Neuroendocrinology – volume: 44 start-page: 321 year: 1997 end-page: 326 article-title: Estrogen regulation of GABA transmission in rat preoptic area publication-title: Brain Res Bull – volume: 388 start-page: 507 year: 1997 end-page: 525 article-title: Comparative distribution of estrogen receptor‐α and ‐β mRNA in the rat central nervous system publication-title: J Comp Neurol – volume: 193 start-page: 29 year: 1995 end-page: 32 article-title: Decreased protein synthetic activity of the hypothalamic tuberomamillary nucleus in Alzheimer's disease as suggested by smaller Golgi apparatus publication-title: Neurosci Lett – volume: 53 start-page: 91 year: 1999 end-page: 95 article-title: Short‐term effects of high‐dose 17beta‐estradiol in postmenopausal PD patients: a crossover study publication-title: Neurology – volume: 4 start-page: 289 year: 2002 end-page: 308 – volume: 67 start-page: 75 year: 1989 end-page: 78 article-title: Changes in the regional brain histamine and histidine levels in postmortem brains of Alzheimer patients publication-title: Can J Physiol Pharmacol – volume: 29 start-page: 51 year: 1982 end-page: 60 article-title: Responses to dietary alterations in rats with zona incerta lesions publication-title: Physiol Behav – volume: 157 start-page: 1445 year: 2000 end-page: 14452 article-title: Gender differences in treatment response to sertraline versus imipramine in chronic depression publication-title: Am J Psychiatry – volume: 75 start-page: 296 year: 2002 end-page: 305 article-title: Sex hormone receptors are present in the human suprachiasmatic nucleus publication-title: Neuroendocrinology – volume: 148 start-page: 227 year: 2003 end-page: 232 article-title: Diurnal rhythm of free estradiol during the menstrual cycle publication-title: Eur J Endocrinol – volume: 808 start-page: 174 year: 1998 end-page: 181 article-title: Contribution of dopamine neurons in the medial zona incerta to the innervation of the central nucleus of the amygdala, horizontal diagonal band of Broca and hypothalamic paraventricular nucleus publication-title: Brain Res – volume: 26 start-page: 12 year: 2000 end-page: 20 article-title: Body fat distribution, the menopause transition, and hormone replacement therapy publication-title: Diabetes Metab – volume: 41 start-page: 288 year: 2002 end-page: 296 article-title: Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice publication-title: Horm Behav – volume: 429 start-page: 355 year: 2001 end-page: 371 article-title: Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites publication-title: J Comp Neurol – volume: 98 start-page: 2792 year: 2001 end-page: 2796 article-title: Morphological abnormalities in the brains of estrogen receptor beta knockout mice publication-title: Proc Natl Acad Sci U S A – volume: 106 start-page: 213 year: 2003 end-page: 220 article-title: Decreased estrogen receptor‐alpha expression in hippocampal neurons in relation to hyperphosphorylated tau in Alzheimer patients publication-title: Acta Neuropathol (Berl) – volume: 199 start-page: 279 year: 1999 end-page: 390 article-title: Estrogen and the developing mammalian brain publication-title: Anat Embryol – volume: 908 start-page: 113 year: 2001 end-page: 119 article-title: Hippocampal estrogen beta‐receptor immunoreactivity is increased in Alzheimer's disease publication-title: Brain Res – volume: 26 start-page: 225 year: 2001 end-page: 240 article-title: Gender differences in age‐related changes in HPA axis reactivity publication-title: Psychoneuroendocrinology – volume: 40 start-page: 574 year: 1999 end-page: 584 article-title: Role of astroglia in estrogen regulation of synaptic plasticity and brain repair publication-title: J Neurobiol – volume: 856 start-page: 142 year: 2000 end-page: 151 article-title: Cells containing estrogen receptor‐α in the human basal forebrain publication-title: Brain Res – volume: 26 start-page: 94 year: 2002 end-page: 105 article-title: Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper‐anxious rats: implications for pathogenesis of affective disorders publication-title: Neuropsychopharmacology – volume: 235 start-page: 1034 year: 1991 end-page: 1037 article-title: A difference in hypothalamic structure between heterosexual and homosexual men publication-title: Science – volume: 59 start-page: 314 year: 2000 end-page: 322 article-title: Decreased vasopressin gene expression in the biological clock of Alzheimer disease patients with and without depression publication-title: J Neuropathol Exp Neurol – volume: 279 start-page: 242 year: 1998 end-page: 247 article-title: Frameshift mutants of beta amyloid precursor protein and ubiquitin‐B in Alzheimer's and Down patients publication-title: Science – volume: 140 start-page: 4530 year: 1999 end-page: 4541 article-title: Characterization of estrogen receptor‐beta (ERbeta) messenger ribonucleic acid and protein expression in rat granulosa cells publication-title: Endocrinology – volume: 55 start-page: 11 year: 1999 end-page: 17 article-title: Fluoxetine efficacy in menopausal women with and without estrogen replacement publication-title: J Affect Disord – volume: 849 start-page: 253 year: 1999 end-page: 274 article-title: Estrogen receptor immunoreactivity within subregions of the rat forebrain: neuronal distribution and association with perikarya containing choline acetyltransferase publication-title: Brain Res – volume: 76 start-page: 191 year: 2000 end-page: 204 article-title: Distribution of estrogen receptor beta (ERbeta) mRNA in hypothalamus, midbrain and temporal lobe of spayed macaque: continued expression with hormone replacement publication-title: Mol Brain Res – volume: 2 start-page: 79 year: 1976 end-page: 82 article-title: Effect of estrogen on early postnatal development of synaptic formation in the hypothalamic arcuate nucleus of female rats publication-title: Neurosci Lett – volume: 64 start-page: 261 year: 1995 end-page: 275 article-title: Sex differences in the distribution of estrogen receptors in the septal area and hypothalamus of the domestic pig (Sus scrofa) publication-title: Neuroscience – volume: 36 start-page: 357 year: 1998 end-page: 378 article-title: Expression and neuropeptidergic characterization of estrogen receptors (ERα and ERβ) throughout the rat brain: anatomical evidence of distinct roles of each subtype publication-title: J Neurobiol – volume: 925 start-page: 204 year: 2002 end-page: 212 article-title: Hypothalamic and zona incerta neurons in sheep, initially only responding to the sight of food, also respond to the sight of water after intracerebroventricular injection of hypertonic saline or angiotensin II publication-title: Brain Res – volume: 18 start-page: 264 year: 1995 end-page: 270 article-title: Sexual differentiation of the human hypothalamus in relation to gender and sexual orientation publication-title: Trends Neurosci – volume: 24 start-page: 925 year: 1993 end-page: 938 article-title: Intracellular partitioning of androgen receptor immunoreactivity in the brain of the male Syrian hamster: effects of castration and steroid replacement publication-title: J Neurobiol – volume: 537 start-page: 141 year: 1990 end-page: 148 article-title: An enlarged suprachiasmatic nucleus in homosexual men publication-title: Brain Res – volume: 143 start-page: 3727 year: 2002 end-page: 3739 article-title: Sex differences in progesterone receptor expression: a potential mechanism for estradiol‐mediated sexual differentiation publication-title: Endocrinology – volume: 25 start-page: 204 year: 1978 end-page: 211 article-title: The effect of ovariectomy on the responsiveness of preoptic‐septal neurons to microelectrophoresed estrogen publication-title: Neuroendocrinology – volume: 44 start-page: 314 year: 1988 end-page: 318 article-title: Sexual differentiation of the human hypothalamus: ontogeny of the sexually dimorphic nucleus of the preoptic area publication-title: Dev Brain Res – volume: 228 start-page: 11132 year: 1985 end-page: 1115 article-title: A sexually dimorphic nucleus in the human brain publication-title: Science – volume: 246 start-page: 142 year: 1998 end-page: 147 article-title: A novel isoform of rat estrogen receptor beta with 18 amino acid insertion in the ligand binding domain as a putative dominant negative regulator of estrogen action publication-title: Biochem Biophys Res Commun – volume: 44 start-page: 377 year: 1997 end-page: 382 article-title: Sex differences in the vomeronasal system publication-title: Brain Res Bull – volume: 28 start-page: 501 year: 2002 end-page: 512 article-title: Sexual behavior reduces hypothalamic androgen receptor immunoreactivity publication-title: Psychoneuroendocrinology – volume: 95 start-page: 15677 year: 1998 end-page: 15682 article-title: Generation and reproductive phenotypes of mice lacking estrogen receptor beta publication-title: Proc Natl Acad Sci U S A – volume: 49 start-page: 997 year: 1994 end-page: 1000 article-title: Diurnal and age‐related changes in cerebrospinal fluid tele‐methylhistamine levels during infancy and childhood publication-title: Pharmacol Biochem Behav – volume: 98 start-page: 1952 year: 2001 end-page: 1957 article-title: Estrogen receptor alpha, not beta, is a critical link in estradiol‐mediated protection against brain injury publication-title: Proc Natl Acad Sci USA – volume: 93 start-page: 5925 year: 1996 end-page: 5930 article-title: Cloning of a novel estrogen receptor expressed in rat prostate and ovary publication-title: Proc Natl Acad Sci U S A – volume: 98 start-page: 7093 year: 2001 end-page: 7100 article-title: Tracking the estrogen receptor in neurons: implications for estrogen‐induced synapse formation publication-title: Proc Natl Acad Sci USA – volume: 55 start-page: 1 year: 2001 end-page: 11 article-title: Distribution of sex steroid hormone receptors in the avian brain: functional implications for neural sex differences and sexual behaviors publication-title: Microsc Res Tech – volume: 97 start-page: 12729 year: 2000 end-page: 12734 article-title: Increased adipose tissue in male and female estrogen receptor‐alpha knockout mice publication-title: Proc Natl Acad Sci U S A – volume: 40 start-page: 93 year: 2001 end-page: 98 article-title: Structural and functional sex differences in the human hypothalamus publication-title: Horm Behav – volume: 34 start-page: 98 year: 1998 end-page: 111 article-title: Estrogen and basal forebrain cholinergic neurons: implications for brain ageing and Alzheimer's disease‐related cognitive decline publication-title: Horm Behav – volume: 57 start-page: 605 year: 2001 end-page: 612 article-title: High‐dose estradiol improves cognition for women with AD: results of a randomized study publication-title: Neurology – volume: 95 start-page: 15635 year: 1998 end-page: 15640 article-title: Repetitive transcranial magnetic stimulation activates specific regions in rat brain publication-title: Proc Natl Acad Sci U S A – volume: 767 start-page: 321 year: 1997 end-page: 332 article-title: Sexual and social experience is associated with different patterns of behavior and neural activation in male prairie voles publication-title: Brain Res – volume: 44 start-page: 145 year: 1991 end-page: 150 article-title: Zona incerta lesions: effects on copulation, partner‐preference and other socio‐sexual behaviors publication-title: Behav Brain Res – volume: 61 start-page: 678 year: 1996 end-page: 681 article-title: The distribution of estrogen receptor‐beta mRNA in the rat hypothalamus publication-title: Steroids – volume: 277 start-page: 1508 year: 1997 end-page: 1510 article-title: Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites publication-title: Science – volume: 110 start-page: 1243 year: 2002 end-page: 1250 article-title: Selective parasympathetic innervation of subcutaneous and intra‐abdominal fat — functional implications publication-title: J Clin Invest – volume: 14 start-page: 109 year: 2002 end-page: 115 article-title: A progestin antagonist blocks vaginocervical stimulation‐induced fos expression in neurones containing progestin receptors in the rostral medial preoptic area publication-title: J Neuroendocrinol – volume: 24 start-page: 145 year: 2000 end-page: 155 article-title: Immunolocalisation of oestrogen receptor beta in human tissues publication-title: J Mol Endocrinol – volume: 11 start-page: 909 issue: 8 Pt 1 year: 1998 end-page: 913 article-title: Estradiol‐17beta reduces blood pressure and restores the normal amplitude of the circadian blood pressure rhythm in postmenopausal hypertension publication-title: Am J Hypertens – volume: 454 start-page: 115 year: 2002 end-page: 139 article-title: Estrogen‐receptor‐alpha distribution in the human hypothalamus in relation to sex and endocrine status publication-title: J Comp Neurol – volume: 89 start-page: 7199 year: 1992 end-page: 7202 article-title: Sexual orientation and the size of the anterior commissure in the human brain publication-title: Proc Natl Acad Sci U S A – volume: 72 start-page: 1049 year: 1996 end-page: 1071 article-title: c‐Fos immunoreactivity in the sexually dimorphic area of the hypothalamus and related brain regions of male gerbils after exposure to sex‐related stimuli or performance of specific sexual behaviors publication-title: Neuroscience – volume: 16 start-page: 5555 year: 1996 end-page: 5565 article-title: A diurnal rhythm of stimulatory input to the hypothalamo‐pituitary‐adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V1 antagonist publication-title: J Neurosci – volume: 84 start-page: 1790 year: 1999 end-page: 1797 article-title: The molecular and neuroanatomical basis for estrogen effects in the central nervous system publication-title: J Clin Endocrinol Metab – volume: 425 start-page: 422 year: 2000 end-page: 435 article-title: Sex differences in the distribution of androgen receptors in the human hypothalamus publication-title: J Comp Neurol – volume: 75 start-page: 161 year: 1996 end-page: 171 article-title: Androgen receptor immunoreactivity and mating‐induced Fos expression in forebrain and midbrain structures in the male rat publication-title: Neuroscience – volume: 94 start-page: 1402 year: 1996 end-page: 1407 article-title: Expression of an estrogen receptor by human coronary artery and umbilical vein endothelial cells publication-title: Circulation – volume: 60 start-page: 204 year: 1982 end-page: 209 article-title: Diurnal variations in brain and pituitary histamine and histamine‐N‐methyltransferase in the rat and guinea pig publication-title: Med Biol – volume: 54 start-page: 2292 year: 2000 end-page: 2298 article-title: Estrogen improves motor disability in parkinsonian postmenopausal women with motor fluctuations publication-title: Neurology – volume: 29 start-page: 307 year: 2000 end-page: 326 article-title: Steroid synthesis and metabolism in the nervous system: trophic and protective effects publication-title: J Neurocytol – volume: 935 start-page: 73 year: 2002a end-page: 80 article-title: Distribution and differences of estrogen receptor beta immunoreactivity in the brain of adult male and female rats publication-title: Brain Res – volume: 2 start-page: 521 year: 2001 end-page: 526 article-title: Hypothalamic integration of central and peripheral clocks publication-title: Nat Rev – volume: 10 start-page: 19 year: 2001 end-page: 26 article-title: Urinary free cortisol and sleep under baseline and stressed conditions in healthy senior women: effects of estrogen replacement therapy publication-title: J Sleep Res – volume: 895 start-page: 129 year: 2001 end-page: 138 article-title: Regional distribution of benzodiazepine binding sites in the human newborn and infant hypothalamus. A quantitative autoradiographic study publication-title: Brain Res – volume: 100 start-page: 115 year: 2000 end-page: 130 article-title: Calcitonin gene‐related peptide‐like immunoreactivity marks putative visceral sensory pathways in human brain publication-title: Neuroscience – volume: 20 start-page: 441 year: 1999 end-page: 444 article-title: The female sex hormone oestrogen as a neuroprotectant publication-title: Trends Pharmacol Sci – volume: 126 start-page: 39 year: 2000 end-page: 48 article-title: Hypothalamic connections with the cerebral cortex publication-title: Prog Brain Res – volume: 15 start-page: 3526 year: 1995 end-page: 3538 article-title: Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans publication-title: J Neurosci – volume: 82 start-page: 4258 year: 1997 end-page: 4265 article-title: Human estrogen receptor beta‐gene structure, chromosomal localization, and expression pattern publication-title: J Clin Endocrinol Metab – volume: 97 start-page: 337 year: 2000 end-page: 342 article-title: Estrogen receptors alpha and beta in the rodent mammary gland publication-title: Proc Natl Acad Sci U S A – volume: 48 start-page: S116 year: 1997 end-page: S119 article-title: Role of estrogen in postmenopausal depression publication-title: Neurology – volume: 340 start-page: 1801 year: 1999 end-page: 1811 article-title: The protective effects of estrogen on the cardiovascular system publication-title: N Engl J Med – volume: 94 start-page: 727 year: 1996 end-page: 733 article-title: Identification of authentic estrogen receptor in cultured endothelial cells: a potential mechanism for steroid hormone regulation of endothelial function publication-title: Circulation – volume: 25 start-page: 307 year: 2002 end-page: 312 article-title: Getting excited about GABA and sex differences in the brain publication-title: Trends Neurosci – volume: 140 start-page: 2581 year: 1999 end-page: 2591 article-title: Expression of estrogen receptor‐β protein in rodent ovary publication-title: Endocrinology – volume: 13 start-page: 307 year: 1999 end-page: 319 article-title: Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells publication-title: Mol Endocrinol – volume: 3 start-page: 545 year: 1997 end-page: 548 article-title: Estrogen inhibits the vascular injury response in estrogen receptor α‐deficient mice publication-title: Nat Med – volume: 63 start-page: 29 year: 2001 end-page: 60 article-title: Neuroprotection by estradiol publication-title: Prog Neurobiol – volume: 40 start-page: 86 year: 2001 end-page: 92 article-title: The interstitial nuclei of the human anterior hypothalamus: an investigation of variation with sex, sexual orientation, and HIV status publication-title: Horm Behav – volume: 89 start-page: 1943 year: 1994 end-page: 1950 article-title: Human vascular smooth muscle cells contain functional estrogen receptor publication-title: Circulation – volume: 146 start-page: 59 year: 1998 end-page: 68 article-title: Putative estrogen receptor beta and alpha mRNA expression in male and female rhesus macaques publication-title: Mol Cell Endocrinol – volume: 446 start-page: 301 year: 2002 end-page: 324 article-title: Organization of human hypothalamus in fetal development publication-title: J Comp Neurol – volume: 23 start-page: 5771 year: 2003 end-page: 5777 article-title: Estrogen receptor beta mediates rapid estrogen actions on gonadotropin‐releasing hormone neurons in vivo publication-title: J Neurosci – volume: 131 start-page: 1336 year: 1992 end-page: 1342 article-title: Cytoplasmic estrogen receptors in rat brain: immunocytochemical evidence using three antibodies with distinct epitopes publication-title: Endocrinology – volume: 44 start-page: 369 year: 1995 end-page: 373 article-title: Age‐ and menopause‐associated variations in body composition and fat distribution in healthy women as measured by dual‐energy X‐ray absorptiometry publication-title: Metabolism – volume: 117 start-page: 343 year: 1998 end-page: 377 article-title: Reduced neuronal activity and reactivation in Alzheimer's disease publication-title: Prog Brain Res – volume: 96 start-page: 12887 year: 1999 end-page: 12892 article-title: Survival of reproductive behaviors in estrogen receptor beta gene‐deficient (betaERKO) male and female mice publication-title: Proc Natl Acad Sci USA – volume: 20 start-page: 8620 year: 2000 end-page: 8628 article-title: Hypothalamic arousal regions are activated during modafinil‐induced wakefulness publication-title: J Neurosci – volume: 392 start-page: 330 year: 1998 end-page: 342 article-title: Evidence for estrogen receptor in cell nuclei and axon terminals within the lateral habenula of the rat: regulation during pregnancy publication-title: J Comp Neurol – volume: 80 start-page: 260 year: 2000 end-page: 268 article-title: Differential expression of estrogen receptor beta splice variants in rat brain: identification and characterization of a novel variant missing exon 4 publication-title: Mol Brain Res – volume: 148 start-page: 333 year: 1978 end-page: 346 article-title: Evidence for a morphological sex difference within the medial preoptic area of the rat brain publication-title: Brain Res – volume: 17 start-page: S22 issue: Suppl 3 year: 2002 end-page: 27 article-title: Brainstem motor loops in the control of movement publication-title: Mov Disord – volume: 55 start-page: P47 year: 2000 end-page: 53 article-title: Relationships between mood and estradiol (E2) levels in Alzheimer's disease (AD) patients publication-title: J Gerontol B Psychol Sci Soc Sci – volume: 6 start-page: 681 year: 1994 end-page: 687 article-title: Increased cortisol levels in aging and Alzheimer's disease in postmortem cerebrospinal fluid publication-title: J Neuroendocrinol – volume: 26 start-page: 79 year: 1989 end-page: 286 article-title: Diurnal fluctuation in levels of histamine metabolites in cerebrospinal fluid of rhesus monkey publication-title: Agents Actions – volume: 34 start-page: 809 year: 1999 end-page: 818 article-title: Effects of estrogen replacement therapy on the circadian rhythms of serum cortisol and body temperature in postmenopausal women publication-title: Exp Gerontol – volume: 164 start-page: 55 year: 1989 end-page: 72 article-title: The sexually dimorphic nucleus of the preoptic area in the human brain: a comparative morphometric study publication-title: J Anat – volume: 495 start-page: 75 year: 1989 end-page: 82 article-title: Estrogen receptor‐immunostaining of neuronal cytoplasmic processes as well as cell nuclei in guinea pig brain publication-title: Brain Res – volume: 178 start-page: 147 year: 2001 end-page: 154 article-title: The role of estrogen and estrogen receptor‐alpha in male adipose tissue publication-title: Mol Cell Endocrinol – volume: 132 start-page: 195 year: 1997 end-page: 199 article-title: Identification of a splice variant of the rat estrogen receptor beta gene publication-title: Mol Cell Endocrinol – volume: 60 start-page: 1279 year: 1999 end-page: 1284 article-title: Distribution of estrogen receptor‐beta messenger ribonucleic acid in the male sheep hypothalamus publication-title: Biol Reprod – volume: 198 start-page: 1 year: 2002 end-page: 40 article-title: Androgens and male behaviour publication-title: Mol Cell Endocrinol – volume: 13 start-page: 229 year: 2002 end-page: 230 article-title: Estrogens and neuroprotection publication-title: Trends Endocrinol Metab – volume: 19 start-page: 323 year: 1998 end-page: 362 article-title: Sexual differentiation of the vertebrate brain: principles and mechanisms publication-title: Front Neuroendocrinol – volume: 22 start-page: 835 year: 2001 end-page: 844 article-title: Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders publication-title: Peptides – volume: 123 start-page: 593 year: 2002 end-page: 601 article-title: Age differentially influences estrogen receptor‐alpha (ERalpha) and estrogen receptor‐beta (ERbeta) gene expression in specific regions of the rat brain publication-title: Mech Ageing Dev – volume: 5 start-page: 63 year: 1993 end-page: 70 article-title: Colchicine‐induced accumulation of estrogen receptor and progestin receptor immunoreactivity in atypical areas in guinea‐pig brain publication-title: J Neuroendocrinol – volume: 144 start-page: 2836 year: 2003 end-page: 2844 article-title: Rapid enhancement of visual and place memory by estrogens in rats publication-title: Endocrinology – volume: 68 start-page: 229 year: 1998 end-page: 234 article-title: Developmental sex differences in estrogen receptor‐beta mRNA expression in the mouse hypothalamus/preoptic region publication-title: Neuroendocrinology – volume: 278 start-page: 640 year: 2000 end-page: 645 article-title: Obesity and disturbed lipoprotein profile in estrogen receptor‐alpha‐deficient male mice publication-title: Biochem Biophys Res Commun – volume: 30 start-page: 478 year: 2002 end-page: 485 article-title: Expression of estrogen receptor alpha and beta in the epiphyseal plate of the rat publication-title: Bone – volume: 169 start-page: 241 year: 2001 end-page: 247 article-title: Immunocytochemical demonstration of oestrogen receptor beta in blood vessels of the female rat publication-title: J Endocrinol – volume: 16 start-page: 7 year: 1991 end-page: 24 article-title: Organotypic culture of the developing cerebral cortex and hypothalamus relevance to sexual differentiation publication-title: Psychoneuroendocrinology – volume: 103 start-page: 1 year: 2002b end-page: 11 article-title: Sex‐related differences in MAPKs activation in rat astrocytes: effects of estrogen on cell death publication-title: Mol Brain Res – volume: 880 start-page: 219 year: 2000 end-page: 223 article-title: Changes in estrogen‐alpha receptor immunoreactivity during the estrous cycle in lactating dairy cattle publication-title: Brain Res – volume: 74 start-page: 365 year: 2000 end-page: 373 article-title: Estrogens, brain and behavior: studies in fundamental neurobiology and observations related to women's health publication-title: J Steroid Biochem Mol Biol – volume: 39 start-page: 359 year: 1999 end-page: 370 article-title: Androgen receptor immunoreactivity in the male and female Syrian hamster brain publication-title: J Neurobiol – volume: 132 start-page: 263 year: 1991 end-page: 266 article-title: Circadian rhythm of cortical acetylcholine release as measured by in vivo microdialysis in freely moving rats publication-title: Neurosci Lett – volume: 18 start-page: 51 year: 1993 end-page: 74 article-title: Sexual dimorphism in the vomeronasal pathway and sex differences in reproductive behaviors publication-title: Brain Res Rev – volume: 356 start-page: 708 year: 2000 end-page: 712 article-title: Cognitive decline in women in relation to non‐protein‐bound oestradiol concentrations publication-title: Lancet – volume: 5 start-page: 97 year: 1997 end-page: 106 article-title: Estrogen replacement and response to fluoxetine in a multicenter geriatric depression trial. Fluoxetine Collaborative Study Group publication-title: Am J Geriatr Psychiatry – volume: 48 start-page: 137 year: 2001 end-page: 144 article-title: Estrogen — a potential treatment for schizophrenia publication-title: Schizophr Res – volume: 139 start-page: 3976 year: 1998 end-page: 3983 article-title: Cellular distribution and gene regulation of estrogen receptors alpha and beta in the rat pituitary gland publication-title: Endocrinology – volume: 12 start-page: 4133 year: 1992 end-page: 4142 article-title: Sexual dimorphism in the vertebrate nervous system publication-title: J Neurosci – year: 2003b article-title: Early social stress in female guinea pigs induces a masculinization of adult behavior and corresponding changes in brain and neuroendocrine function publication-title: Behav Brain Res – volume: 64 start-page: 467 year: 1996 end-page: 470 article-title: Reversal of sex roles in genetic female mice by disruption of estrogen receptor gene publication-title: Neuroendocrinology – volume: 13 start-page: 39 year: 1997 end-page: 137 – volume: 11 start-page: 353 year: 1997 end-page: 365 article-title: Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta publication-title: Mol Endocrinol – volume: 24 start-page: 1 year: 1995 end-page: 46 article-title: Roles of steroid hormones and their receptors in structural organization in the nervous system publication-title: Neurosci Res – volume: 83 start-page: 4524 year: 1998 end-page: 4527 article-title: Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: identification of several genetic variants publication-title: J Clin Endocrinol Metab – volume: 300 start-page: 41 year: 2001 end-page: 44 article-title: Decreased brain histamine‐releasing factor protein in patients with Down syndrome and Alzheimer's disease publication-title: Neurosci Lett – volume: 10 start-page: 325 year: 1985 end-page: 335 article-title: Sex steroids and affect in the surgical menopause: a double‐blind, cross‐over study publication-title: Psychoneuroendocrinology – volume: 359 start-page: 221 year: 1995 end-page: 238 article-title: Efferent projections of the paraventricular thalamic nucleus in the rat publication-title: J Comp Neurol – volume: 20 start-page: 358 year: 1999 end-page: 417 article-title: Estrogen receptor null mice: what have we learned and where will they lead us? publication-title: Endocr Rev – volume: 141 start-page: 2951 year: 2000 end-page: 2962 article-title: The distribution of cells containing estrogen receptor‐alpha (ERalpha) and ERbeta messenger ribonucleic acid in the preoptic area and hypothalamus of the sheep: comparison of males and females publication-title: Endocrinology – volume: 15 start-page: 761 year: 2003a end-page: 769 article-title: Early social stress in male guinea‐pigs changes social behaviour, and autonomic and neuroendocrine functions publication-title: J Neuroendocrinol – ident: e_1_2_7_66_1 doi: 10.1016/S0006-8993(99)02475-0 – ident: e_1_2_7_83_1 doi: 10.1046/j.1365-2826.2003.01055.x – ident: e_1_2_7_148_1 doi: 10.1073/pnas.96.22.12887 – ident: e_1_2_7_92_1 doi: 10.1016/S1043-2760(01)00377-0 – volume: 26 start-page: 94 year: 2002 ident: e_1_2_7_91_1 article-title: Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper‐anxious rats: implications for pathogenesis of affective disorders publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(01)00351-7 – ident: e_1_2_7_193_1 doi: 10.1002/cne.1054 – ident: e_1_2_7_153_1 doi: 10.1016/S0301-0082(00)00059-9 – volume: 29 start-page: 51 year: 1982 ident: e_1_2_7_40_1 article-title: Responses to dietary alterations in rats with zona incerta lesions publication-title: Physiol Behav doi: 10.1016/0031-9384(82)90365-1 – ident: e_1_2_7_74_1 doi: 10.1016/0006-8993(94)90689-0 – ident: e_1_2_7_104_1 doi: 10.1159/000057339 – volume: 106 start-page: 185 year: 1990 ident: e_1_2_7_185_1 article-title: The role of estrogens in schizophrenia gender differences publication-title: Schizophr Bull doi: 10.1093/schbul/16.2.185 – ident: e_1_2_7_123_1 doi: 10.1002/(SICI)1097-0185(199710)249:2<259::AID-AR14>3.0.CO;2-N – start-page: 425 volume-title: Experimental and clinical aspects year: 1997 ident: e_1_2_7_82_1 – ident: e_1_2_7_150_1 doi: 10.1006/bbrc.2000.3827 – ident: e_1_2_7_32_1 doi: 10.1016/S0006-8993(98)00809-9 – ident: e_1_2_7_216_1 doi: 10.1016/0306-4530(91)90068-5 – volume: 83 start-page: 4524 year: 1998 ident: e_1_2_7_173_1 article-title: Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: identification of several genetic variants publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.83.12.5471 – ident: e_1_2_7_10_1 doi: 10.1002/(SICI)1098-1136(199905)26:3<260::AID-GLIA7>3.0.CO;2-R – ident: e_1_2_7_137_1 doi: 10.1210/en.139.9.3976 – ident: e_1_2_7_38_1 doi: 10.1016/S0303-7207(01)00414-2 – volume: 228 start-page: 11132 year: 1985 ident: e_1_2_7_204_1 article-title: A sexually dimorphic nucleus in the human brain publication-title: Science doi: 10.1126/science.3992248 – ident: e_1_2_7_98_1 doi: 10.1002/(SICI)1096-9861(19980713)396:4<544::AID-CNE10>3.0.CO;2-G – ident: e_1_2_7_106_1 doi: 10.1210/jc.86.2.818 – ident: e_1_2_7_170_1 doi: 10.1159/000126778 – volume-title: Textbook of biological psychiatry, part I: basic principles year: 2002 ident: e_1_2_7_203_1 – ident: e_1_2_7_206_1 doi: 10.1016/0006-8993(90)90350-K – ident: e_1_2_7_121_1 doi: 10.1073/pnas.90.23.11162 – ident: e_1_2_7_55_1 doi: 10.1006/hbeh.1998.1451 – ident: e_1_2_7_71_1 doi: 10.1016/S0361-9230(97)00210-4 – ident: e_1_2_7_152_1 doi: 10.1073/pnas.052707299 – ident: e_1_2_7_205_1 doi: 10.1016/0165-3806(88)90231-3 – ident: e_1_2_7_212_1 doi: 10.1016/S0197-4580(03)00059-9 – ident: e_1_2_7_72_1 doi: 10.1095/biolreprod60.6.1279 – ident: e_1_2_7_69_1 doi: 10.1016/0306-4522(95)00602-8 – ident: e_1_2_7_81_1 doi: 10.1073/pnas.95.26.15635 – ident: e_1_2_7_244_1 doi: 10.1016/S0169-328X(02)00130-4 – ident: e_1_2_7_163_1 doi: 10.1002/cne.901700302 – ident: e_1_2_7_200_1 doi: 10.1016/0026-0495(95)90168-X – volume: 28 start-page: 501 year: 2002 ident: e_1_2_7_49_1 article-title: Sexual behavior reduces hypothalamic androgen receptor immunoreactivity publication-title: Psychoneuroendocrinology doi: 10.1016/S0306-4530(02)00036-7 – ident: e_1_2_7_192_1 doi: 10.1002/(SICI)1096-9861(19971201)388:4<507::AID-CNE1>3.0.CO;2-6 – ident: e_1_2_7_183_1 doi: 10.1023/A:1007152904926 – volume: 60 start-page: 204 year: 1982 ident: e_1_2_7_220_1 article-title: Diurnal variations in brain and pituitary histamine and histamine‐N‐methyltransferase in the rat and guinea pig publication-title: Med Biol – ident: e_1_2_7_17_1 doi: 10.1212/WNL.53.1.91 – ident: e_1_2_7_16_1 doi: 10.1097/00075197-200111000-00006 – ident: e_1_2_7_196_1 doi: 10.1046/j.1365-2826.1997.00659.x – ident: e_1_2_7_63_1 doi: 10.1016/S0278-5846(00)00150-0 – ident: e_1_2_7_96_1 doi: 10.1016/0091-3057(94)90254-2 – ident: e_1_2_7_125_1 doi: 10.1016/S0006-8993(96)01400-X – ident: e_1_2_7_18_1 doi: 10.1210/en.131.3.1336 – ident: e_1_2_7_197_1 doi: 10.1001/archpsyc.58.6.529 – ident: e_1_2_7_246_1 doi: 10.1001/archpsyc.58.7.655 – ident: e_1_2_7_62_1 doi: 10.1210/endo.142.12.8560 – ident: e_1_2_7_227_1 doi: 10.1073/pnas.221449798 – ident: e_1_2_7_184_1 doi: 10.1210/en.141.8.2951 – ident: e_1_2_7_172_1 doi: 10.1210/me.13.2.307 – ident: e_1_2_7_86_1 doi: 10.1016/0304-3940(91)90316-L – ident: e_1_2_7_145_1 doi: 10.1016/S0169-328X(02)00544-2 – ident: e_1_2_7_94_1 doi: 10.1016/S0304-3940(01)01545-2 – ident: e_1_2_7_2_1 doi: 10.1523/JNEUROSCI.23-13-05771.2003 – ident: e_1_2_7_35_1 doi: 10.1159/000054518 – ident: e_1_2_7_178_1 doi: 10.1530/ror.0.0030164 – ident: e_1_2_7_221_1 doi: 10.1016/S8756-3282(01)00703-7 – ident: e_1_2_7_61_1 doi: 10.1016/0306-4522(96)00183-2 – ident: e_1_2_7_235_1 doi: 10.1006/hbeh.1997.1419 – ident: e_1_2_7_102_1 doi: 10.1172/JCI0215736 – ident: e_1_2_7_127_1 doi: 10.1016/0304-3940(76)90027-6 – ident: e_1_2_7_207_1 doi: 10.1016/0166-2236(95)80007-O – ident: e_1_2_7_160_1 doi: 10.1016/S0303-7207(01)00557-3 – ident: e_1_2_7_236_1 doi: 10.1016/S0306-3623(02)00129-5 – ident: e_1_2_7_77_1 doi: 10.1046/j.1365-2826.2001.00719.x – ident: e_1_2_7_108_1 doi: 10.1073/pnas.93.12.5925 – ident: e_1_2_7_117_1 doi: 10.1159/000127221 – volume-title: Atlas of the human brain year: 1997 ident: e_1_2_7_124_1 – ident: e_1_2_7_34_1 doi: 10.1523/JNEUROSCI.22-03-01027.2002 – ident: e_1_2_7_80_1 doi: 10.1002/1096-9861(20010212)430:3<396::AID-CNE1039>3.0.CO;2-0 – ident: e_1_2_7_119_1 doi: 10.1016/S0006-3223(00)00995-1 – ident: e_1_2_7_175_1 doi: 10.1016/0304-3940(95)11659-K – ident: e_1_2_7_187_1 doi: 10.1016/0165-0173(93)90007-M – ident: e_1_2_7_68_1 doi: 10.1210/endo.140.12.7179 – ident: e_1_2_7_14_1 doi: 10.1016/S0165-6147(99)01392-9 – ident: e_1_2_7_138_1 doi: 10.1002/cne.903590204 – ident: e_1_2_7_162_1 doi: 10.1002/cne.901510204 – ident: e_1_2_7_225_1 doi: 10.1126/science.279.5348.242 – ident: e_1_2_7_76_1 doi: 10.1007/s00401-003-0720-3 – ident: e_1_2_7_13_1 doi: 10.1530/eje.0.1480227 – ident: e_1_2_7_109_1 doi: 10.1006/frne.1998.0170 – ident: e_1_2_7_159_1 doi: 10.1016/S0303-7207(98)00197-X – ident: e_1_2_7_97_1 doi: 10.1016/0006-8993(89)90012-7 – ident: e_1_2_7_93_1 doi: 10.1159/000122742 – ident: e_1_2_7_111_1 doi: 10.1002/(SICI)1097-4695(19980905)36:3<357::AID-NEU5>3.0.CO;2-V – ident: e_1_2_7_33_1 doi: 10.1016/S0303-7207(97)00133-0 – start-page: 467 volume-title: Handbook of clinical neurology year: 1999 ident: e_1_2_7_202_1 – ident: e_1_2_7_75_1 doi: 10.1016/0197-4580(95)02016-0 – ident: e_1_2_7_166_1 doi: 10.1016/S0169-328X(00)00135-2 – ident: e_1_2_7_47_1 doi: 10.1210/jc.82.12.4258 – ident: e_1_2_7_29_1 doi: 10.1016/S0006-8993(99)02458-0 – ident: e_1_2_7_189_1 doi: 10.1159/000048217 – ident: e_1_2_7_6_1 doi: 10.1016/S0165-0327(98)00203-1 – volume: 11 start-page: 909 issue: 8 year: 1998 ident: e_1_2_7_134_1 article-title: Estradiol‐17beta reduces blood pressure and restores the normal amplitude of the circadian blood pressure rhythm in postmenopausal hypertension publication-title: Am J Hypertens doi: 10.1016/S0895-7061(98)00096-X – ident: e_1_2_7_161_1 doi: 10.1210/jc.85.12.4835 – ident: e_1_2_7_237_1 doi: 10.1016/S0047-6374(01)00406-7 – volume: 26 start-page: 12 year: 2000 ident: e_1_2_7_215_1 article-title: Body fat distribution, the menopause transition, and hormone replacement therapy publication-title: Diabetes Metab – ident: e_1_2_7_226_1 doi: 10.1016/S0197-4580(00)00151-2 – ident: e_1_2_7_168_1 doi: 10.1016/0960-0760(95)00165-V – ident: e_1_2_7_179_1 doi: 10.1016/S0006-8993(01)02610-5 – ident: e_1_2_7_191_1 doi: 10.1016/S0039-128X(96)00222-X – ident: e_1_2_7_241_1 doi: 10.1001/jama.288.3.321 – ident: e_1_2_7_208_1 doi: 10.1111/j.1365-2826.1994.tb00635.x – ident: e_1_2_7_222_1 doi: 10.1002/elps.1150091006 – ident: e_1_2_7_186_1 doi: 10.1016/S0306-4530(00)00043-3 – ident: e_1_2_7_210_1 doi: 10.1016/S0079-6123(00)26025-1 – ident: e_1_2_7_230_1 doi: 10.1002/(SICI)1096-9861(19980316)392:3<330::AID-CNE4>3.0.CO;2-2 – volume: 9 start-page: 467 year: 1989 ident: e_1_2_7_5_1 article-title: Two sexually dimorphic nuclei in the human brain publication-title: J Neurosci doi: 10.1523/JNEUROSCI.09-02-00497.1989 – ident: e_1_2_7_132_1 doi: 10.1073/pnas.121146898 – ident: e_1_2_7_167_1 doi: 10.1046/j.1365-2869.2001.00236.x – ident: e_1_2_7_51_1 doi: 10.1016/S0006-8993(00)02993-0 – ident: e_1_2_7_154_1 doi: 10.1210/jc.85.10.3840 – ident: e_1_2_7_50_1 doi: 10.1210/endo.140.6.6928 – ident: e_1_2_7_37_1 doi: 10.1006/frne.1998.0171 – ident: e_1_2_7_20_1 doi: 10.1111/j.1365-2826.1993.tb00364.x – ident: e_1_2_7_198_1 doi: 10.1176/appi.ajp.159.5.713 – volume: 23 start-page: 483 year: 1989 ident: e_1_2_7_41_1 article-title: Lesions of the SDN‐POA inhibit sexual behavior of male wistar rats publication-title: Brain Res Bull doi: 10.1016/0361-9230(89)90194-9 – ident: e_1_2_7_182_1 doi: 10.1097/00019442-199721520-00002 – ident: e_1_2_7_242_1 doi: 10.1016/S0140-6736(00)02628-3 – ident: e_1_2_7_238_1 doi: 10.1016/S1043-2760(02)00611-2 – ident: e_1_2_7_101_1 doi: 10.1073/pnas.95.26.15677 – ident: e_1_2_7_85_1 doi: 10.1523/JNEUROSCI.16-17-05555.1996 – ident: e_1_2_7_103_1 doi: 10.1073/pnas.221451898 – volume: 264 start-page: R1186 issue: 6 year: 1993 ident: e_1_2_7_27_1 article-title: Suprachiasmatic nucleus lesion increases corticosterone secretion publication-title: Am J Physiol – ident: e_1_2_7_36_1 doi: 10.1038/13453 – ident: e_1_2_7_43_1 doi: 10.1523/JNEUROSCI.15-05-03526.1995 – ident: e_1_2_7_65_1 doi: 10.1016/S0361-9230(97)00217-7 – ident: e_1_2_7_48_1 doi: 10.1002/1096-9861(20000925)425:3<422::AID-CNE7>3.0.CO;2-H – ident: e_1_2_7_211_1 doi: 10.1006/hbeh.2001.1682 – ident: e_1_2_7_143_1 doi: 10.1002/mds.10139 – ident: e_1_2_7_218_1 doi: 10.1210/me.11.3.353 – ident: e_1_2_7_228_1 doi: 10.1161/01.CIR.94.4.727 – ident: e_1_2_7_243_1 doi: 10.1016/S0006-8993(02)02460-5 – ident: e_1_2_7_136_1 doi: 10.1002/1096-9861(20010115)429:3<355::AID-CNE1>3.0.CO;2-# – ident: e_1_2_7_164_1 doi: 10.1016/S0960-0760(00)00114-X – ident: e_1_2_7_19_1 doi: 10.1046/j.0007-1331.2001.00743.x – ident: e_1_2_7_223_1 doi: 10.1016/S0006-8993(00)02870-5 – ident: e_1_2_7_171_1 doi: 10.1016/S0306-4530(02)00022-7 – ident: e_1_2_7_90_1 doi: 10.1016/S0196-9781(01)00398-9 – ident: e_1_2_7_42_1 doi: 10.1016/S0306-4522(00)00245-1 – ident: e_1_2_7_233_1 doi: 10.1073/pnas.242735799 – ident: e_1_2_7_9_1 doi: 10.1212/WNL.57.4.605 – ident: e_1_2_7_78_1 doi: 10.1016/S0197-4580(00)00255-4 – ident: e_1_2_7_122_1 doi: 10.1210/en.2003-0004 – volume: 84 start-page: 1790 year: 1999 ident: e_1_2_7_130_1 article-title: The molecular and neuroanatomical basis for estrogen effects in the central nervous system publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.84.6.5761 – ident: e_1_2_7_181_1 doi: 10.1523/JNEUROSCI.20-22-08620.2000 – ident: e_1_2_7_199_1 doi: 10.1097/00001756-200107030-00036 – ident: e_1_2_7_157_1 doi: 10.1016/S0149-7634(99)00053-6 – ident: e_1_2_7_214_1 doi: 10.1677/jme.0.0240145 – ident: e_1_2_7_129_1 doi: 10.1016/S0166-2236(02)02182-3 – ident: e_1_2_7_133_1 doi: 10.1056/NEJM199906103402306 – ident: e_1_2_7_209_1 doi: 10.1016/S0079-6123(08)64027-3 – ident: e_1_2_7_169_1 doi: 10.1210/en.2002-211438 – ident: e_1_2_7_149_1 doi: 10.1073/pnas.250473597 – ident: e_1_2_7_56_1 doi: 10.1159/000127191 – ident: e_1_2_7_231_1 doi: 10.1016/S0006-8993(97)00617-3 – ident: e_1_2_7_147_1 doi: 10.1159/000127154 – ident: e_1_2_7_245_1 doi: 10.1038/378068a0 – ident: e_1_2_7_144_1 doi: 10.1006/hbeh.2002.1773 – ident: e_1_2_7_217_1 doi: 10.1006/frne.1999.0177 – ident: e_1_2_7_54_1 doi: 10.1016/S0301-0082(00)00025-3 – ident: e_1_2_7_158_1 doi: 10.1073/pnas.96.19.10905 – ident: e_1_2_7_60_1 doi: 10.1016/0006-8993(78)90723-0 – ident: e_1_2_7_113_1 doi: 10.1016/S0006-8993(02)02590-8 – ident: e_1_2_7_140_1 doi: 10.1016/S0006-8993(99)01960-5 – ident: e_1_2_7_232_1 doi: 10.1073/pnas.041617498 – ident: e_1_2_7_12_1 doi: 10.1111/j.1365-2826.2001.00598.x – ident: e_1_2_7_188_1 doi: 10.1001/archneur.59.3.385 – ident: e_1_2_7_115_1 doi: 10.1016/S0925-4773(98)00223-8 – ident: e_1_2_7_180_1 doi: 10.1016/S0896-6273(01)00390-7 – ident: e_1_2_7_39_1 doi: 10.1210/edrv.20.3.0370 – ident: e_1_2_7_95_1 doi: 10.1161/01.CIR.94.6.1402 – ident: e_1_2_7_22_1 doi: 10.1002/cne.10393 – ident: e_1_2_7_7_1 doi: 10.1677/joe.0.1690241 – ident: e_1_2_7_88_1 doi: 10.1159/000054370 – ident: e_1_2_7_114_1 doi: 10.1210/jc.86.3.1379 – ident: e_1_2_7_46_1 doi: 10.1016/S0166-4328(05)80019-1 – ident: e_1_2_7_45_1 doi: 10.1073/pnas.041483198 – ident: e_1_2_7_58_1 doi: 10.1002/cne.10124 – volume: 198 start-page: 1 year: 2002 ident: e_1_2_7_59_1 article-title: Androgens and male behaviour publication-title: Mol Cell Endocrinol – start-page: 289 year: 2002 ident: e_1_2_7_4_1 – ident: e_1_2_7_31_1 doi: 10.1093/geronb/55.1.P47 – ident: e_1_2_7_70_1 doi: 10.1073/pnas.97.23.12729 – ident: e_1_2_7_57_1 doi: 10.1210/jcem.87.2.8230 – ident: e_1_2_7_110_1 doi: 10.1016/S0920-9964(00)00088-8 – ident: e_1_2_7_8_1 doi: 10.1016/S0306-4530(99)00020-7 – ident: e_1_2_7_11_1 doi: 10.1046/j.0007-1331.2001.00751.x – ident: e_1_2_7_99_1 doi: 10.1176/appi.ajp.157.9.1445 – ident: e_1_2_7_151_1 doi: 10.1002/(SICI)1096-9861(19981130)401:4<480::AID-CNE4>3.0.CO;2-F – ident: e_1_2_7_240_1 doi: 10.1002/(SICI)1097-4695(19990605)39:3<359::AID-NEU3>3.0.CO;2-W – ident: e_1_2_7_28_1 doi: 10.1002/cne.903350104 – ident: e_1_2_7_146_1 doi: 10.1210/en.140.10.4530 – ident: e_1_2_7_44_1 doi: 10.1016/S0006-8993(99)02413-0 – ident: e_1_2_7_118_1 doi: 10.1038/sj.ijo.0802054 – ident: e_1_2_7_155_1 doi: 10.1126/science.277.5331.1508 – ident: e_1_2_7_229_1 doi: 10.1096/fj.01-0504com – ident: e_1_2_7_190_1 doi: 10.1016/0306-4530(85)90009-5 – ident: e_1_2_7_30_1 doi: 10.1006/hbeh.2001.1680 – ident: e_1_2_7_79_1 doi: 10.1210/jc.85.9.3283 – ident: e_1_2_7_176_1 doi: 10.1073/pnas.95.19.11445 – ident: e_1_2_7_89_1 doi: 10.1016/0168-0102(96)81278-8 – ident: e_1_2_7_26_1 doi: 10.1038/35081582 – ident: e_1_2_7_25_1 doi: 10.1016/S0301-0082(00)00039-3 – ident: e_1_2_7_107_1 doi: 10.1002/cne.10416 – ident: e_1_2_7_156_1 doi: 10.1007/BF03347808 – volume: 3 start-page: 545 year: 1997 ident: e_1_2_7_112_1 article-title: Estrogen inhibits the vascular injury response in estrogen receptor α‐deficient mice publication-title: Nat Med doi: 10.1038/nm0597-545 – start-page: 39 volume-title: The primate nervous system, part I year: 1997 ident: e_1_2_7_201_1 doi: 10.1016/S0924-8196(97)80004-8 – ident: e_1_2_7_141_1 doi: 10.1016/S0006-8993(01)03283-8 – volume: 164 start-page: 55 year: 1989 ident: e_1_2_7_73_1 article-title: The sexually dimorphic nucleus of the preoptic area in the human brain: a comparative morphometric study publication-title: J Anat – year: 2003 ident: e_1_2_7_84_1 article-title: Early social stress in female guinea pigs induces a masculinization of adult behavior and corresponding changes in brain and neuroendocrine function publication-title: Behav Brain Res – ident: e_1_2_7_120_1 doi: 10.1093/jnen/59.4.314 – ident: e_1_2_7_239_1 doi: 10.1002/neu.480240706 – ident: e_1_2_7_53_1 doi: 10.1002/(SICI)1097-4695(19990915)40:4<574::AID-NEU12>3.0.CO;2-8 – ident: e_1_2_7_21_1 doi: 10.1016/0006-8993(89)91219-5 – ident: e_1_2_7_219_1 doi: 10.1212/WNL.54.12.2292 – ident: e_1_2_7_105_1 doi: 10.1210/jcem.85.5.6564 – ident: e_1_2_7_194_1 doi: 10.1210/jc.83.11.3965 – volume: 2 start-page: 967 year: 1994 ident: e_1_2_7_234_1 article-title: The glucocorticoid receptor: maybe not all steroid receptors are nuclear publication-title: Endocrine – volume: 12 start-page: 4133 year: 1992 ident: e_1_2_7_23_1 article-title: Sexual dimorphism in the vertebrate nervous system publication-title: J Neurosci doi: 10.1523/JNEUROSCI.12-11-04133.1992 – ident: e_1_2_7_128_1 doi: 10.1139/y89-013 – ident: e_1_2_7_131_1 doi: 10.1210/er.20.3.279 – ident: e_1_2_7_213_1 doi: 10.1016/S0140-6736(96)03356-9 – ident: e_1_2_7_24_1 doi: 10.1016/0361-9230(80)90266-X – volume: 48 start-page: S116 year: 1997 ident: e_1_2_7_67_1 article-title: Role of estrogen in postmenopausal depression publication-title: Neurology doi: 10.1212/WNL.48.5_Suppl_7.16S – ident: e_1_2_7_174_1 doi: 10.1073/pnas.97.1.337 – volume: 26 start-page: 79 year: 1989 ident: e_1_2_7_165_1 article-title: Diurnal fluctuation in levels of histamine metabolites in cerebrospinal fluid of rhesus monkey publication-title: Agents Actions doi: 10.1007/BF01967291 – ident: e_1_2_7_100_1 doi: 10.1002/cne.10175 – ident: e_1_2_7_87_1 doi: 10.1161/01.CIR.89.5.1943 – ident: e_1_2_7_177_1 doi: 10.1016/S0079-6123(00)26005-6 – ident: e_1_2_7_64_1 doi: 10.1016/S0531-5565(99)00044-3 – ident: e_1_2_7_142_1 doi: 10.1016/S0006-8993(01)02060-1 – ident: e_1_2_7_52_1 doi: 10.1002/jemt.1151 – ident: e_1_2_7_126_1 doi: 10.1006/bbrc.1998.8590 – ident: e_1_2_7_3_1 doi: 10.1073/pnas.89.15.7199 – ident: e_1_2_7_135_1 doi: 10.1002/cne.902140206 – volume: 199 start-page: 279 year: 1999 ident: e_1_2_7_15_1 article-title: Estrogen and the developing mammalian brain publication-title: Anat Embryol doi: 10.1007/s004290050236 – ident: e_1_2_7_224_1 doi: 10.1016/0306-4522(94)00384-H – volume: 235 start-page: 1034 year: 1991 ident: e_1_2_7_116_1 article-title: A difference in hypothalamic structure between heterosexual and homosexual men publication-title: Science doi: 10.1126/science.1887219 – ident: e_1_2_7_195_1 doi: 10.1146/annurev.neuro.25.112701.142745 – ident: e_1_2_7_139_1 doi: 10.1016/0014-5793(96)00782-X |
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| Snippet | This study reports the first systematic rostrocaudal distribution of estrogen receptor beta immunoreactivity (ERβ‐ir) in the human hypothalamus and adjacent... This study reports the first systematic rostrocaudal distribution of estrogen receptor beta immunoreactivity (ER beta-ir) in the human hypothalamus and... This study reports the first systematic rostrocaudal distribution of estrogen receptor beta immunoreactivity (ER beta -ir) in the human hypothalamus and... |
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| SubjectTerms | Adult Alzheimer's disease Estrogen Receptor beta estrogen receptor-α immunoreactivity (ERα-ir) estrogen receptor-β immunoreactivity (ERβ-ir) Female Gene Expression Regulation - physiology human hypothalamus Humans Hypothalamus - chemistry Hypothalamus - metabolism Male neuroprotection Receptors, Estrogen - analysis Receptors, Estrogen - biosynthesis Sex Characteristics sex differences sexual orientation Statistics, Nonparametric transsexuality |
| Title | Estrogen-receptor-β distribution in the human hypothalamus: Similarities and differences with ERα distribution |
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