Changing sensitivity to cell death during development of retinal photoreceptors

• Published in: Journal of neuroscience research Vol. 74; no. 6; pp. 875 - 883
• Main Authors: Chiarini, Luciana B., Leal-Ferreira, Mona Lisa, de Freitas, Fabíola G., Linden, Rafael
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.12.2003
• Subjects: Animals; apoptosis; Apoptosis - drug effects; Apoptosis - physiology; Cell Death - drug effects; Cell Death - physiology; cell differentiation; Cell Differentiation - drug effects; Cell Differentiation - physiology; cell proliferation; Cells, Cultured; Okadaic Acid - pharmacology; Photoreceptor Cells - cytology; Photoreceptor Cells - drug effects; Photoreceptor Cells - growth & development; Rats; retinal degeneration; rods

Photoreceptor cell death occurs during both normal and pathological retinal development. We tested for selective induction and blockade of cell death in either retinal photoreceptors or their precursors. Organotypical retinal explants from rats at postnatal days 3–11 were treated in vitro for 24 hr...