Changing sensitivity to cell death during development of retinal photoreceptors
Photoreceptor cell death occurs during both normal and pathological retinal development. We tested for selective induction and blockade of cell death in either retinal photoreceptors or their precursors. Organotypical retinal explants from rats at postnatal days 3–11 were treated in vitro for 24 hr...
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| Published in | Journal of neuroscience research Vol. 74; no. 6; pp. 875 - 883 |
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| Format | Journal Article |
| Language | English |
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| Abstract | Photoreceptor cell death occurs during both normal and pathological retinal development. We tested for selective induction and blockade of cell death in either retinal photoreceptors or their precursors. Organotypical retinal explants from rats at postnatal days 3–11 were treated in vitro for 24 hr with thapsigargin, okadaic acid, etoposide, anisomycin, or forskolin. Explant sections were examined for cell death, and identification of either photoreceptors or proliferating/immediate postmitotic cells followed imunohistochemistry for either rhodopsin or bromodeoxyuridine and proliferating cell nuclear antigen, respectively. Photoreceptor cell death was selectively induced by either thapsigargin or okadaic acid, whereas death of proliferating/immediate postmitotic cells was induced by etoposide. Prelabeling of proliferating precursors allowed direct demonstration of changing sensitivity of photoreceptors to various chemicals. Degeneration of both photoreceptors and proliferating/immediate postmitotic cells depended on protein synthesis. Increase of intracellular cyclic AMP blocked degeneration of postmitotic, but not of proliferating, photoreceptor precursors. The selective induction and blockade of cell death show that developing photoreceptors undergo progressive changes in mechanisms of programmed cell death associated with phenotypic differentiation. © 2003 Wiley‐Liss, Inc. |
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| AbstractList | Photoreceptor cell death occurs during both normal and pathological retinal development. We tested for selective induction and blockade of cell death in either retinal photoreceptors or their precursors. Organotypical retinal explants from rats at postnatal days 3-11 were treated in vitro for 24 hr with thapsigargin, okadaic acid, etoposide, anisomycin, or forskolin. Explant sections were examined for cell death, and identification of either photoreceptors or proliferating/immediate postmitotic cells followed imunohistochemistry for either rhodopsin or bromodeoxyuridine and proliferating cell nuclear antigen, respectively. Photoreceptor cell death was selectively induced by either thapsigargin or okadaic acid, whereas death of proliferating/immediate postmitotic cells was induced by etoposide. Prelabeling of proliferating precursors allowed direct demonstration of changing sensitivity of photoreceptors to various chemicals. Degeneration of both photoreceptors and proliferating/immediate postmitotic cells depended on protein synthesis. Increase of intracellular cyclic AMP blocked degeneration of postmitotic, but not of proliferating, photoreceptor precursors. The selective induction and blockade of cell death show that developing photoreceptors undergo progressive changes in mechanisms of programmed cell death associated with phenotypic differentiation. Photoreceptor cell death occurs during both normal and pathological retinal development. We tested for selective induction and blockade of cell death in either retinal photoreceptors or their precursors. Organotypical retinal explants from rats at postnatal days 3–11 were treated in vitro for 24 hr with thapsigargin, okadaic acid, etoposide, anisomycin, or forskolin. Explant sections were examined for cell death, and identification of either photoreceptors or proliferating/immediate postmitotic cells followed imunohistochemistry for either rhodopsin or bromodeoxyuridine and proliferating cell nuclear antigen, respectively. Photoreceptor cell death was selectively induced by either thapsigargin or okadaic acid, whereas death of proliferating/immediate postmitotic cells was induced by etoposide. Prelabeling of proliferating precursors allowed direct demonstration of changing sensitivity of photoreceptors to various chemicals. Degeneration of both photoreceptors and proliferating/immediate postmitotic cells depended on protein synthesis. Increase of intracellular cyclic AMP blocked degeneration of postmitotic, but not of proliferating, photoreceptor precursors. The selective induction and blockade of cell death show that developing photoreceptors undergo progressive changes in mechanisms of programmed cell death associated with phenotypic differentiation. © 2003 Wiley‐Liss, Inc. |
| Author | Linden, Rafael Chiarini, Luciana B. Leal-Ferreira, Mona Lisa de Freitas, Fabíola G. |
| Author_xml | – sequence: 1 givenname: Luciana B. surname: Chiarini fullname: Chiarini, Luciana B. email: chiarini@biof.ufrj.br organization: Instituto de Biofisica Carlos Chagas Filho, UFRJ, Rio de Janeiro, Brazil – sequence: 2 givenname: Mona Lisa surname: Leal-Ferreira fullname: Leal-Ferreira, Mona Lisa organization: Instituto de Biofisica Carlos Chagas Filho, UFRJ, Rio de Janeiro, Brazil – sequence: 3 givenname: Fabíola G. surname: de Freitas fullname: de Freitas, Fabíola G. organization: Instituto de Biofisica Carlos Chagas Filho, UFRJ, Rio de Janeiro, Brazil – sequence: 4 givenname: Rafael surname: Linden fullname: Linden, Rafael organization: Instituto de Biofisica Carlos Chagas Filho, UFRJ, Rio de Janeiro, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/14648592$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1371_journal_pone_0006723 crossref_primary_10_1371_journal_pone_0155093 crossref_primary_10_1016_j_cub_2014_03_061 crossref_primary_10_1016_j_neuroscience_2018_06_008 crossref_primary_10_1002_jnr_22026 crossref_primary_10_1017_S0952523807070587 crossref_primary_10_1113_jphysiol_2012_234641 crossref_primary_10_1016_j_neuroscience_2006_03_054 crossref_primary_10_1016_j_freeradbiomed_2006_08_009 crossref_primary_10_1016_j_neuint_2006_03_011 crossref_primary_10_1016_j_bbrc_2007_07_038 crossref_primary_10_1016_j_neuint_2010_04_021 crossref_primary_10_1016_j_preteyeres_2004_10_001 crossref_primary_10_1016_j_exer_2005_04_007 crossref_primary_10_1113_jphysiol_2008_160051 |
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| Snippet | Photoreceptor cell death occurs during both normal and pathological retinal development. We tested for selective induction and blockade of cell death in either... |
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| SubjectTerms | Animals apoptosis Apoptosis - drug effects Apoptosis - physiology Cell Death - drug effects Cell Death - physiology cell differentiation Cell Differentiation - drug effects Cell Differentiation - physiology cell proliferation Cells, Cultured Okadaic Acid - pharmacology Photoreceptor Cells - cytology Photoreceptor Cells - drug effects Photoreceptor Cells - growth & development Rats retinal degeneration rods |
| Title | Changing sensitivity to cell death during development of retinal photoreceptors |
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