The association between concurrent psychotropic medications and self-reported adherence with taking a mood stabilizer in bipolar disorder

Objective Multiple psychotropic medications are routinely prescribed to treat bipolar disorder, creating complex medication regimens. This study investigated whether the daily number of psychotropic medications or the daily number of pills were associated with self‐reported adherence with taking a m...

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Published inHuman psychopharmacology Vol. 25; no. 1; pp. 47 - 54
Main Authors Bauer, Michael, Glenn, Tasha, Grof, Paul, Marsh, Wendy, Sagduyu, Kemal, Alda, Martin, Murray, Greg, Lewitzka, Ute, Schmid, Rita, Haack, Sara, Whybrow, Peter C.
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.01.2010
Subjects
adherence
Adult
Affect
Antimanic Agents - therapeutic use
Antipsychotic Agents - therapeutic use
Attitude to Health
bipolar disorder
Bipolar Disorder - drug therapy
Bipolar Disorder - psychology
Female
Humans
Male
Middle Aged
mood stabilizer
Patient Compliance
polypharmacy
Psychiatric Status Rating Scales
Self Concept
Surveys and Questionnaires
Online AccessGet full text

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Abstract Objective Multiple psychotropic medications are routinely prescribed to treat bipolar disorder, creating complex medication regimens. This study investigated whether the daily number of psychotropic medications or the daily number of pills were associated with self‐reported adherence with taking a mood stabilizer. Methods Patients self‐reported their mood and medications taken daily for about 6 months. Adherence was defined as taking at least one pill of any mood stabilizer daily. Univariate general linear models (GLMs) were used to estimate if adherence was associated with the number of daily medications and the number of pills, controlling for age. The association between mean daily dosage of mood stabilizer and adherence was also estimated using a GLM. Results Three hundred and twelve patients (mean age 38.4 ± 10.9 years) returned 58,106 days of data and took a mean of 3.1 ± 1.6 psychotropic medications daily (7.0 ± 4.2 pills). No significant association was found between either the daily number of medications or the daily number of pills and adherence. For most mood stabilizers, patients with lower adherence took a significantly smaller mean daily dosage. Conclusions The number of concurrent psychotropic medications may not be associated with adherence in bipolar disorder. Patients with lower adherence may be taking smaller dosages of mood stabilizers. Copyright © 2009 John Wiley & Sons, Ltd.
AbstractList Multiple psychotropic medications are routinely prescribed to treat bipolar disorder, creating complex medication regimens. This study investigated whether the daily number of psychotropic medications or the daily number of pills were associated with self-reported adherence with taking a mood stabilizer. Patients self-reported their mood and medications taken daily for about 6 months. Adherence was defined as taking at least one pill of any mood stabilizer daily. Univariate general linear models (GLMs) were used to estimate if adherence was associated with the number of daily medications and the number of pills, controlling for age. The association between mean daily dosage of mood stabilizer and adherence was also estimated using a GLM. Three hundred and twelve patients (mean age 38.4 +/- 10.9 years) returned 58,106 days of data and took a mean of 3.1 +/- 1.6 psychotropic medications daily (7.0 +/- 4.2 pills). No significant association was found between either the daily number of medications or the daily number of pills and adherence. For most mood stabilizers, patients with lower adherence took a significantly smaller mean daily dosage. The number of concurrent psychotropic medications may not be associated with adherence in bipolar disorder. Patients with lower adherence may be taking smaller dosages of mood stabilizers.
Objective Multiple psychotropic medications are routinely prescribed to treat bipolar disorder, creating complex medication regimens. This study investigated whether the daily number of psychotropic medications or the daily number of pills were associated with self-reported adherence with taking a mood stabilizer. Methods Patients self-reported their mood and medications taken daily for about 6 months. Adherence was defined as taking at least one pill of any mood stabilizer daily. Univariate general linear models (GLMs) were used to estimate if adherence was associated with the number of daily medications and the number of pills, controlling for age. The association between mean daily dosage of mood stabilizer and adherence was also estimated using a GLM. Results Three hundred and twelve patients (mean age 38.4 c 10.9 years) returned 58,106 days of data and took a mean of 3.1 c 1.6 psychotropic medications daily (7.0 c 4.2 pills). No significant association was found between either the daily number of medications or the daily number of pills and adherence. For most mood stabilizers, patients with lower adherence took a significantly smaller mean daily dosage. Conclusions The number of concurrent psychotropic medications may not be associated with adherence in bipolar disorder. Patients with lower adherence may be taking smaller dosages of mood stabilizers.
Objective Multiple psychotropic medications are routinely prescribed to treat bipolar disorder, creating complex medication regimens. This study investigated whether the daily number of psychotropic medications or the daily number of pills were associated with self‐reported adherence with taking a mood stabilizer. Methods Patients self‐reported their mood and medications taken daily for about 6 months. Adherence was defined as taking at least one pill of any mood stabilizer daily. Univariate general linear models (GLMs) were used to estimate if adherence was associated with the number of daily medications and the number of pills, controlling for age. The association between mean daily dosage of mood stabilizer and adherence was also estimated using a GLM. Results Three hundred and twelve patients (mean age 38.4 ± 10.9 years) returned 58,106 days of data and took a mean of 3.1 ± 1.6 psychotropic medications daily (7.0 ± 4.2 pills). No significant association was found between either the daily number of medications or the daily number of pills and adherence. For most mood stabilizers, patients with lower adherence took a significantly smaller mean daily dosage. Conclusions The number of concurrent psychotropic medications may not be associated with adherence in bipolar disorder. Patients with lower adherence may be taking smaller dosages of mood stabilizers. Copyright © 2009 John Wiley & Sons, Ltd.
OBJECTIVEMultiple psychotropic medications are routinely prescribed to treat bipolar disorder, creating complex medication regimens. This study investigated whether the daily number of psychotropic medications or the daily number of pills were associated with self-reported adherence with taking a mood stabilizer.METHODSPatients self-reported their mood and medications taken daily for about 6 months. Adherence was defined as taking at least one pill of any mood stabilizer daily. Univariate general linear models (GLMs) were used to estimate if adherence was associated with the number of daily medications and the number of pills, controlling for age. The association between mean daily dosage of mood stabilizer and adherence was also estimated using a GLM.RESULTSThree hundred and twelve patients (mean age 38.4 +/- 10.9 years) returned 58,106 days of data and took a mean of 3.1 +/- 1.6 psychotropic medications daily (7.0 +/- 4.2 pills). No significant association was found between either the daily number of medications or the daily number of pills and adherence. For most mood stabilizers, patients with lower adherence took a significantly smaller mean daily dosage.CONCLUSIONSThe number of concurrent psychotropic medications may not be associated with adherence in bipolar disorder. Patients with lower adherence may be taking smaller dosages of mood stabilizers.
Abstract Objective Multiple psychotropic medications are routinely prescribed to treat bipolar disorder, creating complex medication regimens. This study investigated whether the daily number of psychotropic medications or the daily number of pills were associated with self‐reported adherence with taking a mood stabilizer. Methods Patients self‐reported their mood and medications taken daily for about 6 months. Adherence was defined as taking at least one pill of any mood stabilizer daily. Univariate general linear models (GLMs) were used to estimate if adherence was associated with the number of daily medications and the number of pills, controlling for age. The association between mean daily dosage of mood stabilizer and adherence was also estimated using a GLM. Results Three hundred and twelve patients (mean age 38.4 ± 10.9 years) returned 58,106 days of data and took a mean of 3.1 ± 1.6 psychotropic medications daily (7.0 ± 4.2 pills). No significant association was found between either the daily number of medications or the daily number of pills and adherence. For most mood stabilizers, patients with lower adherence took a significantly smaller mean daily dosage. Conclusions The number of concurrent psychotropic medications may not be associated with adherence in bipolar disorder. Patients with lower adherence may be taking smaller dosages of mood stabilizers. Copyright © 2009 John Wiley & Sons, Ltd.
Author Murray, Greg
Lewitzka, Ute
Haack, Sara
Schmid, Rita
Glenn, Tasha
Alda, Martin
Marsh, Wendy
Sagduyu, Kemal
Bauer, Michael
Grof, Paul
Whybrow, Peter C.
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  surname: Schmid
  fullname: Schmid, Rita
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  givenname: Peter C.
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  organization: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles (UCLA), Los Angeles, California, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20033908$$D View this record in MEDLINE/PubMed
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2009; 44
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SSID ssj0009909
Score 2.0231338
Snippet Objective Multiple psychotropic medications are routinely prescribed to treat bipolar disorder, creating complex medication regimens. This study investigated...
Multiple psychotropic medications are routinely prescribed to treat bipolar disorder, creating complex medication regimens. This study investigated whether the...
Abstract Objective Multiple psychotropic medications are routinely prescribed to treat bipolar disorder, creating complex medication regimens. This study...
OBJECTIVEMultiple psychotropic medications are routinely prescribed to treat bipolar disorder, creating complex medication regimens. This study investigated...
Objective Multiple psychotropic medications are routinely prescribed to treat bipolar disorder, creating complex medication regimens. This study investigated...
SourceID proquest
crossref
pubmed
wiley
istex
SourceType Aggregation Database
Index Database
Publisher
StartPage 47
SubjectTerms adherence
Adult
Affect
Antimanic Agents - therapeutic use
Antipsychotic Agents - therapeutic use
Attitude to Health
bipolar disorder
Bipolar Disorder - drug therapy
Bipolar Disorder - psychology
Female
Humans
Male
Middle Aged
mood stabilizer
Patient Compliance
polypharmacy
Psychiatric Status Rating Scales
Self Concept
Surveys and Questionnaires
Title The association between concurrent psychotropic medications and self-reported adherence with taking a mood stabilizer in bipolar disorder
URI https://api.istex.fr/ark:/67375/WNG-RJRMH390-6/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fhup.1077
https://www.ncbi.nlm.nih.gov/pubmed/20033908
https://search.proquest.com/docview/734221350
https://search.proquest.com/docview/746085306
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