The extrapolated reference values procedure: Theory, algorithm, and results in patients and control subjects

• Published in: Muscle & nerve Vol. 57; no. 1; pp. 90 - 95
• Main Authors: Nandedkar, Sanjeev D., Sanders, Donald B., Hobson‐Webb, Lisa D., Billakota, Santoshi, Barkhaus, Paul E., Stålberg, Erik V.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2018
• Subjects: Algorithms; CMAP amplitude; Computer simulation; Data Interpretation, Statistical; distal latency; Electrodiagnosis - statistics & numerical data; Electromyography - statistics & numerical data; extrapolated normal; Female; Humans; jitter; Male; Middle Aged; Muscles; Myasthenia; Myasthenia gravis; Myasthenia Gravis - physiopathology; Nerve conduction; Neural Conduction; Neuromuscular junctions; Normal Distribution; normal values; Patients; Reference Values; Reproducibility of Results; Vibration; normal values; reference values; jitter; CMAP amplitude; distal latency; extrapolated normal

ABSTRACT Introduction: Reference values (RVs) are required to separate normal from abnormal values obtained in electrodiagnostic (EDx) testing. However, it is frequently impractical to perform studies on control subjects to obtain RVs. The Extrapolated Reference Values (E‐Ref) procedure extracts RVs...