A recombinant protein containing influenza viral conserved epitopes and superantigen induces broad-spectrum protection

• Published in: eLife Vol. 10
• Main Authors: Li, Yansheng, Xu, Mingkai, Li, Yongqiang, Gu, Wu, Halimu, Gulinare, Li, Yuqi, Zhang, Zhichun, Zhou, Libao, Liao, Hui, Yao, Songyuan, Zhang, Huiwen, Zhang, Chenggang
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 16.11.2021; eLife Sciences Publications, Ltd
• Subjects: Amino acids; Animals; Antibodies; Antigens; B-Lymphocytes - immunology; Bone marrow; CD4 antigen; CD8 antigen; Cell differentiation; cell-mediated immunity; Cross Protection; Cytokines; Cytotoxicity; Dendritic cells; Epidemiology and Global Health; Epitopes; Epitopes - immunology; Female; Genomes; Helper cells; Hemagglutinin Glycoproteins, Influenza Virus - immunology; hemagglutinin stalk; Hemagglutinins; Immune response (cell-mediated); Immunity, Cellular; Immunoglobulins; Immunology and Inflammation; Infections; Influenza; Influenza A virus - genetics; Influenza A virus - immunology; Influenza A Virus, H1N1 Subtype - immunology; Influenza Vaccines - immunology; Lymphocytes; Lymphocytes T; Mice; Mice, Inbred BALB C; Orthomyxoviridae; Orthomyxoviridae Infections - prevention & control; Pandemics; Phylogenetics; Proteins; Public health; Rabies; Recombinant Proteins - immunology; RNA polymerase; superantigen; Superantigens - immunology; T-Lymphocytes - immunology; Vaccination; Vaccines; Viruses; global health; epidemiology; mouse; hemagglutinin stalk; inflammation; superantigen; immunology; cross-protection; cell-mediated immunity

Influenza pandemics pose public health threats annually for lacking vaccine that provides cross-protection against novel and emerging influenza viruses. Combining conserved antigens that induce cross-protective antibody responses with epitopes that activate cross-protective T cell responses might be...