Regulation of ubiquitin-dependent processes by deubiquitinating enzymes

• Published in: The FASEB journal Vol. 11; no. 14; p. 1245
• Main Author: Wilkinson, K D
• Format: Journal Article
• Language: English
• Published: United States 01.12.1997
• Subjects: Amino Acid Sequence; Animals; Biopolymers - chemistry; Biopolymers - metabolism; Cell Transformation, Neoplastic; Endopeptidases - chemistry; Endopeptidases - genetics; Endopeptidases - metabolism; Growth; Humans; Molecular Sequence Data; Morphogenesis; Polyubiquitin; Protein Processing, Post-Translational; Protein Sorting Signals - chemistry; Protein Sorting Signals - metabolism; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Substrate Specificity; Thiolester Hydrolases - chemistry; Thiolester Hydrolases - genetics; Thiolester Hydrolases - metabolism; Ubiquitin Thiolesterase; Ubiquitins - chemistry; Ubiquitins - metabolism

An astounding number of important regulatory and structural proteins are subject to modification by the attachment of ubiquitin or ubiquitin-like proteins. This modification acts as a targeting signal, delivering the modified protein to different locations in the cell and modifying its activity, mac...