The broad effects of the functional IL-10 promoter-592 polymorphism: modulation of IL-10, TIMP-3, and OPG expression and their association with periodontal disease outcome

• Published in: Journal of leukocyte biology Vol. 84; no. 6; pp. 1565 - 1573
• Main Authors: Marcela Claudino, Ana Paula F. Trombone, Cristina R. Cardoso, Samuel B. Ferreira, Jr, Walter Martins, Jr, Gerson F. Assis, Carlos F. Santos, Paula C. Trevilatto, Ana Paula Campanelli, João S. Silva, Gustavo P. Garlet
• Format: Journal Article
• Language: English
• Published: United States Society for Leukocyte Biology 01.12.2008
• Subjects: Adult; Case-Control Studies; Chronic Periodontitis - genetics; cytokine; Female; genetic polymorphism; Genotype; Gingiva - metabolism; Gingiva - pathology; Humans; immunoregulation; Interleukin-10 - genetics; interleukin‐10; Male; Middle Aged; osteoprotegerin; Osteoprotegerin - genetics; periodontal disease; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide - genetics; Promoter Regions, Genetic - genetics; Regulatory Sequences, Nucleic Acid; RNA, Messenger - genetics; RNA, Messenger - metabolism; single nucleotide polymorphism; Tissue Inhibitor of Metalloproteinase-3 - genetics

Periodontal diseases are infectious diseases, in which periodontopathogens trigger chronic inflammatory and immune responses that lead to tissue destruction. It occurs through the generation of metalloproteinases and the activation of bone resorption mechanisms. Anti‐inflammatory cytokines such as I...