Physical activity, genetic predisposition, and incident cardiovascular disease: Prospective analyses of the UK Biobank

• Published in: Journal of sport and health science Vol. 14; p. 101055
• Main Authors: Ahmadi, Matthew N., Mundell, Hamish D., Sutherland, Greg T., Hamer, Mark, Sillanpää, Elina, Blodgett, Joanna M., Cruz, Borja del Pozo, Stamatakis, Emmanuel
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.12.2025; Shanghai University of Sport; Elsevier
• Subjects: Cardiovascular disease; Coronary heart disease; Genetic risk; Original; Physical activity; Stroke; Cardiovascular disease; Stroke; Genetic risk; Physical activity; Coronary heart disease

•Among 303,950 UK Biobank participants (mean follow-up 11.6 years), higher MVPA was linked with lower CHD risk across genetic strata; in the high-risk group, low to medium vigorous intensity activity levels lowered CHD risk by 22% to 34% (HR: 0.78–0.66).•Stroke risk was inversely associated with mod...