A pH‐Triggered Polymer Degradation or Drug Delivery System by Light‐Mediated Cis/Trans Isomerization of o‐Hydroxy Cinnamates

• Published in: Macromolecular rapid communications. Vol. 42; no. 13; pp. e2100213 - n/a
• Main Authors: Abramov, Alex, Maiti, Binoy, Keridou, Ina, Puiggalí, Jordi, Reiser, Oliver, Díaz, David Díaz
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.07.2021
• Subjects: Chemical synthesis; Chromatography; coumarins; Degradation; Drug delivery; Drug delivery systems; E/Z‐double bond isomerization; Irradiation; Isomerization; Light irradiation; o‐hydroxy cinnamates; pH effects; Phenols; Polyethylene glycol; polymer degradation; Polymers; Spectroscopy; Stability; visible light photocatalysis

A new methodology for the pH‐triggered degradation of polymers or for the release of drugs under visible light irradiation based on the cyclization of ortho‐hydroxy‐cinnamates (oHC) to coumarins is described. The key oHC structural motif can be readily incorporated into the rational design of novel...