The pharmacodynamics of diphenhydramine-induced drowsiness and changes in mental performance

• Published in: Clinical pharmacology and therapeutics Vol. 45; no. 1; p. 15
• Main Authors: Gengo, F, Gabos, C, Miller, J K
• Format: Journal Article
• Language: English
• Published: United States 01.01.1989
• Subjects: Adult; Diphenhydramine - pharmacokinetics; Diphenhydramine - pharmacology; Humans; Male; Psychomotor Performance - drug effects; Reaction Time - drug effects; Sleep Stages - drug effects

The time course of diphenhydramine concentrations and effects on both mental performance and subjective feelings of drowsiness were assessed in 15 healthy men. Subjects received single oral doses of diphenhydramine, 50 mg, and placebo in this double-blind crossover study. Diphenhydramine plasma conc...