Recasting Human Vδ1 Lymphocytes in an Adaptive Role

• Published in: Trends in immunology Vol. 39; no. 6; pp. 446 - 459
• Main Authors: Davey, Martin S., Willcox, Carrie R., Baker, Alfie T., Hunter, Stuart, Willcox, Benjamin E.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2018; Elsevier Limited; Elsevier Science Ltd
• Subjects: Adaptive Immunity - immunology; Animals; Antigens; Biology; Clone Cells - immunology; Clone Cells - metabolism; Clone Cells - microbiology; Cloning; Homing; Homing receptors; Humans; Hypotheses; Immunologic Surveillance - immunology; Infections; Ligands; Lipids; Lymphocytes; Lymphocytes T; Major histocompatibility complex; Major Histocompatibility Complex - immunology; Microorganisms; Paradigms; Phenotypes; Receptors; Receptors, Antigen, T-Cell, gamma-delta - immunology; Receptors, Antigen, T-Cell, gamma-delta - metabolism; T cell receptors; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; T-Lymphocytes - microbiology

γδ T cells are unconventional lymphocytes commonly described as ‘innate-like’ in function, which can respond in both a T cell receptor (TCR)-independent and also major histocompatibility complex (MHC)-unrestricted TCR-dependent manner. While the relative importance of TCR recognition had remained un...