The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps - Antiochos, Brendan; Trejo-Zambrano, Daniela; Fenaroli, Paride; Rosenberg, Avi; Baer, Alan; Garg, Archit; Sohn, Jungsan; Li, Jessica; Petri, Michelle; Goldman, Daniel W; Mecoli, Christopher; Casciola-Rosen, Livia; et al. (eLife, 2022)
Keywords: Anti-DNA antibodies; Antibodies; Autoantibodies; Autoantigens; Autoantigens - metabolism; autoimmunity; Binding sites; Biopsy; Confocal microscopy; Deoxyribonuclease; Deoxyribonucleases - metabolism; Deoxyribonucleic acid; Disease; DNA; DNA-Binding Proteins - metabolism; Extracellular Traps - metabolism; Humans; Immunofluorescence; Immunology and Inflammation; Immunoprecipitation; Interferon; Interferon-inducible protein; Interferons - metabolism; Leukocytes (neutrophilic); Lupus; Lupus Erythematosus, Systemic; Medicine; Melanoma; Melanoma - metabolism; Mitochondrial DNA; neutrophil extracellular traps; Neutrophils; Nuclear Proteins - metabolism; Patients; Phosphoproteins - metabolism; Proteins; Rheumatology; Sensors; Short Report; Systemic lupus erythematosus; neutrophil extracellular traps; autoimmunity; inflammation; medicine; autoantibodies; human; immunology