Muscone improves hypoxia/reoxygenation (H/R)-induced neuronal injury by blocking HMGB1/TLR4/NF-κB pathway via modulating microRNA-142

• Published in: PeerJ (San Francisco, CA) Vol. 10; p. e13523
• Main Authors: Ren, Weihua, Zhao, Fucheng, Han, Yanru, Liu, Zhenzhou, Zhai, Jianli, Jia, Kui
• Format: Journal Article
• Language: English
• Published: United States PeerJ, Inc 15.07.2022; PeerJ Inc
• Subjects: Alzheimer's disease; Annexin V; Apoptosis; Biochemistry; Bioinformatics; Biotechnology; Cell Biology; Cell culture; Cell injury; Cell viability; Cerebral hypoxia injury; Gene expression; HMGB1 protein; HMGB1 Protein - genetics; HMGB1/TLR4/NF-κB pathway; Hypoxia; Hypoxia - drug therapy; Hypoxia, Brain - metabolism; Inflammation; Laboratories; MicroRNA-142-5p; MicroRNAs; MicroRNAs - genetics; miRNA; Molecular Biology; Muscone; Neurons; Neurons - metabolism; Neuroprotection; Neuroprotective Agents - pharmacology; NF-kappa B - genetics; NF-κB protein; Oxidation; Oxidative stress; Penicillin; Signal transduction; TLR4 protein; Toll-Like Receptor 4 - genetics; Toll-like receptors; Traumatic brain injury; St Louis Missouri; United States > US; China; Japan; Cerebral hypoxia injury; MicroRNA-142-5p; HMGB1/TLR4/NF-κB pathway; Muscone

Previous reports have indicated that natural muscone has neuroprotective effects against cerebral hypoxia injury; however, little is known in regards to its pharmacological mechanism. In this study, we tried to evaluate the neuroprotective effects and mechanisms of muscone against cerebral hypoxia i...