Randomised clinical trial: sodium alginate oral suspension is non‐inferior to omeprazole in the treatment of patients with non‐erosive gastroesophageal disease

• Published in: Alimentary pharmacology & therapeutics Vol. 38; no. 9; pp. 1054 - 1064
• Main Authors: Chiu, C.‐T., Hsu, C.‐M., Wang, C.‐C., Chang, J.‐J., Sung, C.‐M., Lin, C.‐J., Chen, L.‐W., Su, M.‐Y., Chen, T.‐H.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.11.2013
• Subjects: Administration, Oral; Adult; Alginates - administration & dosage; Alginates - therapeutic use; Biological and medical sciences; Digestive system; Double-Blind Method; Female; Gastroesophageal Reflux - drug therapy; Gastroesophageal Reflux - pathology; Gastrointestinal Agents - administration & dosage; Gastrointestinal Agents - therapeutic use; Glucuronic Acid - administration & dosage; Glucuronic Acid - therapeutic use; Heartburn - drug therapy; Heartburn - etiology; Hexuronic Acids - administration & dosage; Hexuronic Acids - therapeutic use; Humans; Male; Medical sciences; Middle Aged; Omeprazole - administration & dosage; Omeprazole - therapeutic use; Patient Satisfaction; Pharmacology. Drug treatments; Proton Pump Inhibitors - administration & dosage; Proton Pump Inhibitors - therapeutic use; Surveys and Questionnaires; Suspensions; Treatment Outcome; Human; Gastroesophageal reflux; Enzyme; Esophageal disease; Oral administration; H; Enzyme inhibitor; Suspension; Antiulcer agent; K; Alginates; Proton pump inhibitor; Omeprazole; Treatment; Benzimidazole derivatives; Antisecretory agent; Dosage form; exchanging ATPase; Hydrolases; Digestive diseases; Clinical trial; Comparative study

Summary Background The burden of gastroesophageal reflux disease (GERD) is increasing in the Asia area and the majority of GERD patients have non‐erosive reflux disease (NERD). Aim To evaluate the efficacy and safety of sodium alginate suspension compared to omeprazole in adult subjects with NERD. M...