Contractile elements in muscular fascial tissue – implications for in‐vitro contracture testing for malignant hyperthermia
Summary Malignant hyperthermia is a dreaded complication of general anaesthesia. Predisposed individuals can be identified using the standardised caffeine/halothane in‐vitro contracture test on a surgically dissected skeletal muscle specimen. Skeletal muscle is composed of muscle fibres and interwov...
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Published in | Anaesthesia Vol. 69; no. 9; pp. 1002 - 1008 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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England
Blackwell Publishing Ltd
01.09.2014
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Abstract | Summary
Malignant hyperthermia is a dreaded complication of general anaesthesia. Predisposed individuals can be identified using the standardised caffeine/halothane in‐vitro contracture test on a surgically dissected skeletal muscle specimen. Skeletal muscle is composed of muscle fibres and interwoven fascial components. Several malignant hyperthermia‐associated neuromuscular diseases are associated with an altered connective tissue composition. We analysed adjacent fascial components of skeletal muscle histologically and physiologically. We investigated whether the fascial tissue is sensitive to electrical or pharmacological stimulation in a way similar to the in‐vitro contracture test for diagnosing malignant hyperthermia. Using immunohistochemical staining, α‐smooth muscle actin‐positive cells (myofibroblasts) were detected in the epi‐, endo‐ and perimysium of human fascial tissue. Force measurements on isolated fascial strips after pharmacological challenge with mepyramin revealed that myofascial tissue is actively regulated by myofibroblasts, thereby influencing the biomechanical properties of skeletal muscle. Absence of electrical reactivity and insensitivity to caffeine and halothane suggests that, reassuringly, the malignant hyperthermia diagnostic in‐vitro contracture test is not influenced by the muscular fascial tissue. |
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AbstractList | Summary
Malignant hyperthermia is a dreaded complication of general anaesthesia. Predisposed individuals can be identified using the standardised caffeine/halothane in‐vitro contracture test on a surgically dissected skeletal muscle specimen. Skeletal muscle is composed of muscle fibres and interwoven fascial components. Several malignant hyperthermia‐associated neuromuscular diseases are associated with an altered connective tissue composition. We analysed adjacent fascial components of skeletal muscle histologically and physiologically. We investigated whether the fascial tissue is sensitive to electrical or pharmacological stimulation in a way similar to the in‐vitro contracture test for diagnosing malignant hyperthermia. Using immunohistochemical staining, α‐smooth muscle actin‐positive cells (myofibroblasts) were detected in the epi‐, endo‐ and perimysium of human fascial tissue. Force measurements on isolated fascial strips after pharmacological challenge with mepyramin revealed that myofascial tissue is actively regulated by myofibroblasts, thereby influencing the biomechanical properties of skeletal muscle. Absence of electrical reactivity and insensitivity to caffeine and halothane suggests that, reassuringly, the malignant hyperthermia diagnostic in‐vitro contracture test is not influenced by the muscular fascial tissue. Summary Malignant hyperthermia is a dreaded complication of general anaesthesia. Predisposed individuals can be identified using the standardised caffeine/halothane in-vitro contracture test on a surgically dissected skeletal muscle specimen. Skeletal muscle is composed of muscle fibres and interwoven fascial components. Several malignant hyperthermia-associated neuromuscular diseases are associated with an altered connective tissue composition. We analysed adjacent fascial components of skeletal muscle histologically and physiologically. We investigated whether the fascial tissue is sensitive to electrical or pharmacological stimulation in a way similar to the in-vitro contracture test for diagnosing malignant hyperthermia. Using immunohistochemical staining, [alpha]-smooth muscle actin-positive cells (myofibroblasts) were detected in the epi-, endo- and perimysium of human fascial tissue. Force measurements on isolated fascial strips after pharmacological challenge with mepyramin revealed that myofascial tissue is actively regulated by myofibroblasts, thereby influencing the biomechanical properties of skeletal muscle. Absence of electrical reactivity and insensitivity to caffeine and halothane suggests that, reassuringly, the malignant hyperthermia diagnostic in-vitro contracture test is not influenced by the muscular fascial tissue. [PUBLICATION ABSTRACT] Malignant hyperthermia is a dreaded complication of general anaesthesia. Predisposed individuals can be identified using the standardised caffeine/halothane in-vitro contracture test on a surgically dissected skeletal muscle specimen. Skeletal muscle is composed of muscle fibres and interwoven fascial components. Several malignant hyperthermia-associated neuromuscular diseases are associated with an altered connective tissue composition. We analysed adjacent fascial components of skeletal muscle histologically and physiologically. We investigated whether the fascial tissue is sensitive to electrical or pharmacological stimulation in a way similar to the in-vitro contracture test for diagnosing malignant hyperthermia. Using immunohistochemical staining, α-smooth muscle actin-positive cells (myofibroblasts) were detected in the epi-, endo- and perimysium of human fascial tissue. Force measurements on isolated fascial strips after pharmacological challenge with mepyramin revealed that myofascial tissue is actively regulated by myofibroblasts, thereby influencing the biomechanical properties of skeletal muscle. Absence of electrical reactivity and insensitivity to caffeine and halothane suggests that, reassuringly, the malignant hyperthermia diagnostic in-vitro contracture test is not influenced by the muscular fascial tissue. |
Author | Schleip, R. Lehmann‐Horn, F. Hoppe, K. Jäger, H. Klingler, W. |
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Cites_doi | 10.1002/jor.1100060112 10.1038/nrd3955 10.1152/ajpcell.00428.2002 10.1124/jpet.106.110635 10.1213/ANE.0b013e318222af2e 10.1111/aas.12126 10.1213/ane.0b013e3181a7c8e5 10.1126/science.273.5272.245 10.2174/156802609789044452 10.1152/ajpcell.00188.2002 10.1016/S1567-5769(01)00086-8 10.1111/j.1743-6109.2006.00126.x 10.1016/S0889-8537(02)00011-1 10.1242/jcs.066795 10.1111/j.1399-6576.1997.tb04820.x 10.1038/sj.bjp.0707457 10.1016/j.jbmt.2011.09.003 10.1093/bja/aeq243 10.1073/pnas.1119207109 10.1186/1471-2474-12-203 10.1023/A:1005496708505 10.1111/j.1460-9592.2011.03649.x 10.1213/00000539-198910000-00015 |
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Malignant hyperthermia is a dreaded complication of general anaesthesia. Predisposed individuals can be identified using the standardised... Malignant hyperthermia is a dreaded complication of general anaesthesia. Predisposed individuals can be identified using the standardised caffeine/halothane... Summary Malignant hyperthermia is a dreaded complication of general anaesthesia. Predisposed individuals can be identified using the standardised... |
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SubjectTerms | Anesthesia Anesthesia, General - adverse effects Anesthetics, General - adverse effects Animals Biopsy Caffeine Central Nervous System Stimulants Electric Stimulation Facial Muscles - drug effects Fever Fluorescent Antibody Technique Halothane Histamine H1 Antagonists - pharmacology Immunohistochemistry In Vitro Techniques Malignant Hyperthermia - diagnosis Mice Mice, Inbred BALB C Muscle Contraction - drug effects Muscular dystrophy Musculoskeletal system Neuromuscular diseases Pyrilamine - pharmacology Rats Rats, Wistar Side effects |
Title | Contractile elements in muscular fascial tissue – implications for in‐vitro contracture testing for malignant hyperthermia |
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