DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia

• Published in: Scientific reports Vol. 8; no. 1; pp. 10163 - 14
• Main Authors: Keller, Simona, Punzo, Daniela, Cuomo, Mariella, Affinito, Ornella, Coretti, Lorena, Sacchi, Silvia, Florio, Ermanno, Lembo, Francesca, Carella, Massimo, Copetti, Massimiliano, Cocozza, Sergio, Balu, Darrick T., Errico, Francesco, Usiello, Alessandro, Chiariotti, Lorenzo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.07.2018; Nature Publishing Group
• Subjects: 38; 38/22; 38/23; 38/90; 45; 45/23; 45/77; 631/337/176; 631/378/2584; Amino acid oxidase; Amino acids; Brain; Cerebellum; CpG islands; D-Amino acids; D-Amino-acid oxidase; D-Aspartate oxidase; D-Serine; Deoxyribonucleic acid; DNA; DNA methylation; Gene expression; Gene regulation; Gene silencing; Genomes; Humanities and Social Sciences; Mental disorders; multidisciplinary; Prefrontal cortex; Regulatory sequences; Schizophrenia; Science; Science (multidisciplinary); Serine racemase; Temporal lobe

The spatio-temporal regulation of genes involved in the synthesis and degradation of D-serine and D-aspartate such as serine racemase ( SR ), D-amino acid oxidase ( DAO ), G72 and D-aspartate oxidase ( DDO ), play pivotal roles in determining the correct levels of these D-amino acids in the human br...