ω-3PUFA supplementation ameliorates adipose tissue inflammation and insulin-stimulated glucose disposal in subjects with obesity: a potential role for apolipoprotein E

• Published in: International Journal of Obesity Vol. 45; no. 6; pp. 1331 - 1341
• Main Authors: Hernandez, James D., Li, Ting, Rau, Cassandra M., LeSuer, William E., Wang, Panwen, Coletta, Dawn K., Madura, James A., Jacobsen, Elizabeth A., De Filippis, Eleanna
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2021; Nature Publishing Group
• Subjects: 38/61; 38/77; 631/250; 692/163/2743/2037; 692/163/2743/393; 692/700/2814; 82/51; 96/21; Adipose tissue; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Adult; Animal models; Anti-inflammatory agents; Apolipoprotein E; Apolipoproteins; Apolipoproteins E - genetics; Apolipoproteins E - metabolism; Biopsy; Blood Glucose - drug effects; Body fat; Body weight; Chromosome 3; Cytokines; Dietary supplements; DNA microarrays; Dosage; Epidemiology; Fatty acids; Fatty Acids, Omega-3 - administration & dosage; Fatty Acids, Omega-3 - pharmacology; Female; Gene expression; Glucose; Health Promotion and Disease Prevention; Humans; Inflammation; Inflammation - metabolism; Insulin; Insulin Resistance - physiology; Internal Medicine; Macrophages; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Obesity; Obesity - metabolism; Plasma levels; Polyunsaturated fatty acids; Public Health; Sensitivity; Stearic acid; Subcutaneous Fat - metabolism; Transcriptome - drug effects; Transcriptome - genetics

Background Long chain omega-3 polyunsaturated fatty acids (ω-3PUFA) supplementation in animal models of diet-induced obesity has consistently shown to improve insulin sensitivity. The same is not always reported in human studies with insulin resistant (IR) subjects with obesity. Objective We studied...