Mucosa-Adhesive Water-Soluble Polymer Film for Treatment of Acute Radiation-Induced Oral Mucositis

• Published in: International journal of radiation oncology, biology, physics Vol. 40; no. 5; pp. 1033 - 1037
• Main Authors: Oguchi, Masahiko, Shikama, Naoto, Sasaki, Shigeru, Gomi, Koutarou, Katsuyama, Yoshihiko, Ohta, Shin, Hori, Miyoko, Takei, Kazuyoshi, Arakawa, Kazukiyo, Sone, Shusuke
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.03.1998; Elsevier
• Subjects: Acute radiation-induced mucositis; Administration, Buccal; Adult; Aged; Aged, 80 and over; Analgesics; Anesthetics, Local - administration & dosage; Anti-Bacterial Agents - administration & dosage; Antibiotic Prophylaxis - methods; Biological and medical sciences; Carcinoma, Squamous Cell - radiotherapy; Diseases of the upper aerodigestive tract; Ent and stomatology; Female; Humans; Male; Medical sciences; Middle Aged; Miscellaneous; Mouth Mucosa - radiation effects; Mouth Neoplasms - radiotherapy; Mucosa-adhesive film; Oral complication; Pain - drug therapy; Pain - etiology; Pharmacology. Drug treatments; Polymers - administration & dosage; Radiation Injuries - drug therapy; Radiation therapy; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Stomatitis - drug therapy; Stomatitis - etiology; Acute radiation-induced mucositis; Oral complication; Mucosa-adhesive film; Radiation therapy; Analgesics; Human; Carcinoma; Film; Treatment efficiency; Mucosa; Polymer; Malignant tumor; Radiotherapy; Antibiotic; Anesthetic; Radiation injury; Head and neck; ENT disease; Adhesive material

Purpose: To examine the usefulness and safety of a mucosa-adhesive water-soluble polymer film (AD film) containing anesthetics and antibiotics for the treatment of acute radiation-induced oral mucositis. Materials and Methods: To prepare AD films, 600 mg of hydroxy-propyl-cellulose was dissolved in...