Validation of Radiolabeling of Drug Formulations for Aerosol Deposition Assessment of Orally Inhaled Products

• Published in: Journal of aerosol medicine Vol. 25; no. S1; pp. S-6 - S-9
• Main Authors: Devadason, Sunalene G., Chan, Hak-Kim, Haeussermann, Sabine, Kietzig, Claudius, Kuehl, Philip J., Newman, Stephen, Sommerer, Knut, Taylor, Glyn
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.12.2012
• Subjects: Administration, Inhalation; Aerosols; Drug Delivery Systems; Humans; Lung - diagnostic imaging; Lung - metabolism; Particle Size; Pharmaceutical Preparations - administration & dosage; Pharmaceutical Preparations - chemistry; Pharmaceutical Preparations - metabolism; Radionuclide Imaging - methods; Radiopharmaceuticals - administration & dosage; Radiopharmaceuticals - chemistry; Radiopharmaceuticals - pharmacokinetics; Tissue Distribution

Radiolabeling of inhaler formulations for imaging studies is an indirect method of determining lung deposition and regional distribution of drug in human subjects. Hence, ensuring that the radiotracer and drug exhibit similar aerodynamic characteristics when aerosolized, and that addition of the rad...