DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells

• Published in: Cellular signalling Vol. 28; no. 10; pp. 1593 - 1603
• Main Authors: Jacobsen, Rhîan G, Mazloumi Gavgani, Fatemeh, Mellgren, Gunnar, Lewis, Aurélia E
• Format: Journal Article
• Language: English
• Published: England 01.10.2016
• Subjects: 3T3-L1 Cells; Adipocytes - cytology; Adipocytes - metabolism; Adipogenesis; Animals; Biocatalysis; Cell Proliferation; Centris; Clone Cells; DNA - biosynthesis; DNA Topoisomerases, Type II - metabolism; Isoenzymes - metabolism; Mice; Mitosis; Phosphatidylinositol 3-Kinases - metabolism; PPAR gamma - metabolism; TOR Serine-Threonine Kinases - metabolism; Up-Regulation; DNA Topoisomerase II; Class I PI3K; PPARγ; Adipogenesis

DNA topoisomerases (Topo) are multifunctional enzymes resolving DNA topological problems such as those arising during DNA replication, transcription and mitosis. Mammalian cells express 2 class II isoforms, Topoisomerases IIα (Topo IIα) and IIβ (Topo IIβ), which have similar enzymatic properties but...