LMO2 attenuates glycolytic metabolism and facilitates cytotoxic T-lymphocyte infiltration in the tumor environment of lung and breast cancers

• Published in: Biochemical and biophysical research communications Vol. 675; pp. 170 - 176
• Main Authors: Wang, Wenhao, Meng, Yingying, Yu, Yanhong, Wang, Hang, Sun, Wei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2023
• Subjects: breast neoplasms; breasts; cytotoxicity; excretion; glucose; Glycolysis; Lactic acid; LMO2; lungs; T-lymphocytes; Tumor-infiltrating T Cells; Glycolysis; Lactic acid; LMO2; Tumor-infiltrating T Cells

Aerobic glycolysis preferentially exists in many cancer cells. LMO2 is an adaptor protein ubiquitously expressed in many epithelia and their malignancies, and it mediates broad-spectrum protein interactions. In this study, results showed that LMO2 directly interacted with glycolytic enzymes PGK1, PG...