Stop Codon Usage as a Window into Genome Evolution: Mutation, Selection, Biased Gene Conversion and the TAG Paradox

• Published in: Genome biology and evolution Vol. 14; no. 8
• Main Authors: Ho, Alexander T, Hurst, Laurence D
• Format: Journal Article
• Language: English
• Published: Oxford University Press 03.08.2022
• Subjects: Review; stop codon usage; genome evolution; translational read-through; translation termination; stop codon read-through; molecular evolution

Abstract Protein coding genes terminate with one of three stop codons (TAA, TGA, or TAG) that, like synonymous codons, are not employed equally. With TGA and TAG having identical nucleotide content, analysis of their differential usage provides an unusual window into the forces operating on what are...