Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction

The high prevalence of metabolic syndrome in persons with schizophrenia has spurred investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis dysfunction is present across multiple organ systems. On this account, schizophrenia may be a multisystem disorder in which...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of molecular sciences Vol. 23; no. 13; p. 7092
Main Authors Goh, Kah Kheng, Chen, Cynthia Yi-An, Wu, Tzu-Hua, Chen, Chun-Hsin, Lu, Mong-Liang
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.07.2022
MDPI
Subjects
Body fat
Insulin resistance
Mortality
Psychotropic drugs
Review
Online AccessGet full text

Cover

Abstract The high prevalence of metabolic syndrome in persons with schizophrenia has spurred investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis dysfunction is present across multiple organ systems. On this account, schizophrenia may be a multisystem disorder in which one organ system is predominantly affected and where other organ systems are also concurrently involved. Growing evidence of the overlapping neurobiological profiles of metabolic risk factors and psychiatric symptoms, such as an association with cognitive dysfunction, altered autonomic nervous system regulation, desynchrony in the resting-state default mode network, and shared genetic liability, suggest that metabolic syndrome and schizophrenia are connected via common pathways that are central to schizophrenia pathogenesis, which may be underpinned by oxytocin system dysfunction. Oxytocin, a hormone that involves in the mechanisms of food intake and metabolic homeostasis, may partly explain this piece of the puzzle in the mechanism underlying this association. Given its prosocial and anorexigenic properties, oxytocin has been administered intranasally to investigate its therapeutic potential in schizophrenia and obesity. Although the pathophysiology and mechanisms of oxytocinergic dysfunction in metabolic syndrome and schizophrenia are both complex and it is still too early to draw a conclusion upon, oxytocinergic dysfunction may yield a new mechanistic insight into schizophrenia pathogenesis and treatment.
AbstractList The high prevalence of metabolic syndrome in persons with schizophrenia has spurred investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis dysfunction is present across multiple organ systems. On this account, schizophrenia may be a multisystem disorder in which one organ system is predominantly affected and where other organ systems are also concurrently involved. Growing evidence of the overlapping neurobiological profiles of metabolic risk factors and psychiatric symptoms, such as an association with cognitive dysfunction, altered autonomic nervous system regulation, desynchrony in the resting-state default mode network, and shared genetic liability, suggest that metabolic syndrome and schizophrenia are connected via common pathways that are central to schizophrenia pathogenesis, which may be underpinned by oxytocin system dysfunction. Oxytocin, a hormone that involves in the mechanisms of food intake and metabolic homeostasis, may partly explain this piece of the puzzle in the mechanism underlying this association. Given its prosocial and anorexigenic properties, oxytocin has been administered intranasally to investigate its therapeutic potential in schizophrenia and obesity. Although the pathophysiology and mechanisms of oxytocinergic dysfunction in metabolic syndrome and schizophrenia are both complex and it is still too early to draw a conclusion upon, oxytocinergic dysfunction may yield a new mechanistic insight into schizophrenia pathogenesis and treatment.
The high prevalence of metabolic syndrome in persons with schizophrenia has spurred investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis dysfunction is present across multiple organ systems. On this account, schizophrenia may be a multisystem disorder in which one organ system is predominantly affected and where other organ systems are also concurrently involved. Growing evidence of the overlapping neurobiological profiles of metabolic risk factors and psychiatric symptoms, such as an association with cognitive dysfunction, altered autonomic nervous system regulation, desynchrony in the resting-state default mode network, and shared genetic liability, suggest that metabolic syndrome and schizophrenia are connected via common pathways that are central to schizophrenia pathogenesis, which may be underpinned by oxytocin system dysfunction. Oxytocin, a hormone that involves in the mechanisms of food intake and metabolic homeostasis, may partly explain this piece of the puzzle in the mechanism underlying this association. Given its prosocial and anorexigenic properties, oxytocin has been administered intranasally to investigate its therapeutic potential in schizophrenia and obesity. Although the pathophysiology and mechanisms of oxytocinergic dysfunction in metabolic syndrome and schizophrenia are both complex and it is still too early to draw a conclusion upon, oxytocinergic dysfunction may yield a new mechanistic insight into schizophrenia pathogenesis and treatment.The high prevalence of metabolic syndrome in persons with schizophrenia has spurred investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis dysfunction is present across multiple organ systems. On this account, schizophrenia may be a multisystem disorder in which one organ system is predominantly affected and where other organ systems are also concurrently involved. Growing evidence of the overlapping neurobiological profiles of metabolic risk factors and psychiatric symptoms, such as an association with cognitive dysfunction, altered autonomic nervous system regulation, desynchrony in the resting-state default mode network, and shared genetic liability, suggest that metabolic syndrome and schizophrenia are connected via common pathways that are central to schizophrenia pathogenesis, which may be underpinned by oxytocin system dysfunction. Oxytocin, a hormone that involves in the mechanisms of food intake and metabolic homeostasis, may partly explain this piece of the puzzle in the mechanism underlying this association. Given its prosocial and anorexigenic properties, oxytocin has been administered intranasally to investigate its therapeutic potential in schizophrenia and obesity. Although the pathophysiology and mechanisms of oxytocinergic dysfunction in metabolic syndrome and schizophrenia are both complex and it is still too early to draw a conclusion upon, oxytocinergic dysfunction may yield a new mechanistic insight into schizophrenia pathogenesis and treatment.
Author Goh, Kah Kheng
Lu, Mong-Liang
Chen, Chun-Hsin
Chen, Cynthia Yi-An
Wu, Tzu-Hua
AuthorAffiliation 1 Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan; havicson@gmail.com (K.K.G.); cyn.c@icloud.com (C.Y.-A.C.); chunhsin57@gmail.com (C.-H.C.)
3 Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
4 Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan
2 Psychiatric Research Center, Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan; thwu@tmu.edu.tw
AuthorAffiliation_xml – name: 2 Psychiatric Research Center, Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan; thwu@tmu.edu.tw
– name: 4 Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan
– name: 1 Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan; havicson@gmail.com (K.K.G.); cyn.c@icloud.com (C.Y.-A.C.); chunhsin57@gmail.com (C.-H.C.)
– name: 3 Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Author_xml – sequence: 1
  givenname: Kah Kheng
  orcidid: 0000-0003-2677-3944
  surname: Goh
  fullname: Goh, Kah Kheng
– sequence: 2
  givenname: Cynthia Yi-An
  surname: Chen
  fullname: Chen, Cynthia Yi-An
– sequence: 3
  givenname: Tzu-Hua
  orcidid: 0000-0002-3631-6248
  surname: Wu
  fullname: Wu, Tzu-Hua
– sequence: 4
  givenname: Chun-Hsin
  surname: Chen
  fullname: Chen, Chun-Hsin
– sequence: 5
  givenname: Mong-Liang
  surname: Lu
  fullname: Lu, Mong-Liang
BookMark eNptkU1rHDEMhk1IyVd7yw8w5NJDt9XYu-NxDoWyTT8gJZCkx2I8HjnrzYy9tT1ttr--HhJKGnKRBHr08ko6JLs-eCTkuIK3nEt459ZDYrziAiTbIQfVnLEZQC12H9X75DClNQDjbCH3yD5fNFCDrA_Ij2UMKWXd39IW829ET6_Myv0Jm1VE7zTVvqPfMOs29M7Qq63vYhjwlF6vkF6GHmmw9OJum4NxHuNNYT5ukx29yS74l-SF1X3CVw_5iHz_dHa9_DI7v_j8dfnhfGZ4I_PMzqFr59oYqWVXghCdhhYrKD4tLLhsmTW8kp3V1rRgRIcceVMJxpoKGsGPyPt73c3YDtgZ9DnqXm2iG3TcqqCd-r_j3UrdhF9KsrpecFYEXj8IxPBzxJTV4JLBvtcew5gUqxshGDRsQk-eoOswRl_Wm6i6mK5FU6g395SZ7hvR_jNTgZr-ph7_reDsCW5c1tMJi13XPz_0F_1RnrA
CitedBy_id crossref_primary_10_1016_j_plefa_2023_102604
crossref_primary_10_3389_fpsyt_2024_1520279
crossref_primary_10_1063_5_0172712
crossref_primary_10_3390_ijms241310430
crossref_primary_10_1192_bja_2024_52
crossref_primary_10_3892_mmr_2025_13479
crossref_primary_10_1016_j_psychres_2024_116126
crossref_primary_10_3389_fgene_2023_1150458
crossref_primary_10_3390_ijms24087104
crossref_primary_10_3892_etm_2023_12054
crossref_primary_10_3390_app14062351
crossref_primary_10_3389_fpsyt_2024_1451832
crossref_primary_10_3390_ijms232012180
crossref_primary_10_17116_jnevro202412408113
crossref_primary_10_1016_j_plefa_2025_102665
crossref_primary_10_7759_cureus_70803
crossref_primary_10_2147_NDT_S426481
crossref_primary_10_1016_j_plefa_2023_102578
crossref_primary_10_3389_fpsyt_2024_1496986
Cites_doi 10.1016/S0140-6736(19)31135-3
10.1007/s00213-021-05983-9
10.3390/ijerph17186700
10.1001/jamapsychiatry.2014.1314
10.1155/2020/9124520
10.5498/wjp.v11.i10.696
10.3389/fendo.2021.770145
10.3390/ijms22042146
10.1016/j.pnpbp.2010.06.011
10.1016/j.schres.2020.06.002
10.1016/S2215-0366(19)30416-X
10.3389/fpsyt.2020.00432
10.1080/13651501.2016.1197274
10.1016/j.pscychresns.2017.11.017
10.5888/pcd14.160287
10.1002/j.2051-5545.2009.tb00199.x
10.1016/j.scog.2021.100221
10.1002/wps.20204
10.4088/JCP.13m08820
10.3390/ph14030238
10.1097/NMD.0000000000000124
10.1016/j.schres.2007.12.476
10.4158/EP.9.S2.5
10.1093/arclin/acaa081
10.1136/bmj.38766.624097.1F
10.1111/j.1464-5491.2007.02092.x
10.1038/s41366-018-0124-z
10.1016/j.psychres.2021.114227
10.1038/s41380-018-0045-1
10.1016/j.psyneuen.2016.03.015
10.1152/ajpheart.00808.2015
10.1016/j.yfrne.2021.100930
10.1016/j.psyneuen.2015.11.013
10.1159/000341333
10.1038/ng.3749
10.1038/s41598-017-17674-7
10.3109/08039488.2013.839739
10.2147/NDT.S113099
10.1159/000495260
10.1016/j.jpsychires.2018.04.019
10.3389/fpsyt.2019.00217
10.1016/j.neulet.2016.12.005
10.1146/annurev-clinpsy-032813-153657
10.1016/j.plefa.2018.06.007
10.1007/s11886-021-01615-y
10.2337/db13-0663
10.1016/j.tem.2014.07.004
10.3389/fnins.2013.00048
10.1016/j.psyneuen.2012.09.009
10.3390/ijms21113966
10.1371/journal.pone.0249348
10.4274/jcrpe.3963
10.1016/j.tem.2017.02.007
10.1017/S0033291716003366
10.1002/oby.21790
10.1371/journal.pone.0059625
10.1016/j.euroneuro.2020.08.004
10.1038/npp.2017.226
10.1016/j.pnpbp.2012.12.007
10.1124/pr.120.019398
10.2174/1570159X15666170630163616
10.1016/j.schres.2017.09.041
10.1001/jamapsychiatry.2019.3360
10.1093/schbul/sbr148
10.1093/schbul/sbz091
10.1016/j.tics.2020.03.008
10.4088/JCP.14m09358
10.1101/2020.08.23.20180489
10.1016/j.clnu.2021.08.011
10.1001/jamapsychiatry.2015.2582
10.1177/0004867416679738
10.1210/jc.2007-1167
10.1016/j.biocel.2016.09.012
10.1016/j.schres.2018.12.007
10.1016/j.psyneuen.2015.09.026
10.1016/j.psychres.2018.03.048
10.1002/wps.20699
10.1016/S0304-3940(03)00718-3
10.3390/ijms18081689
10.1016/j.yhbeh.2020.104855
10.1016/j.schres.2018.07.003
10.1192/j.eurpsy.2019.17
10.1002/wps.20069
10.1186/s12944-020-01203-z
10.1016/j.yfrne.2016.12.004
10.1096/fj.15-279810
10.1111/jne.12805
10.3389/fpsyt.2021.702720
10.1038/s41398-017-0044-z
10.1016/j.jpsychires.2021.03.053
10.1192/bjp.2020.248
10.1001/jamapsychiatry.2015.1737
10.1093/schbul/sbq015
10.1016/j.psychres.2021.114233
10.1097/YIC.0b013e3283377850
10.1017/S1092852918001013
10.1093/ijnp/pyaa097
10.1016/j.schres.2019.11.050
10.1016/j.biopsych.2011.01.031
10.1016/j.schres.2010.08.022
10.1017/S1461145713001697
10.1016/j.npep.2021.102148
10.1016/j.diabres.2016.09.022
10.1016/j.physbeh.2018.03.008
10.3390/jcm9020537
10.1007/s11011-016-9882-2
10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
10.1093/ijnp/pyac023
10.1016/j.biopsych.2015.04.013
10.1111/eip.12457
10.1152/physrev.2001.81.2.629
10.1017/S0033291716001902
10.1016/j.neuron.2020.10.032
10.3389/fpsyt.2019.00251
10.1530/EJE-1450669
10.7326/0003-4819-152-2-201001190-00008
10.1111/bph.15451
10.1016/j.jpsychires.2019.02.017
10.3389/fendo.2021.585887
10.1038/s41380-018-0058-9
10.1038/oby.2009.12
10.1152/ajpgi.00176.2014
10.30773/pi.2018.01.18.1
10.1016/j.bbi.2018.03.013
10.1177/0706743716644765
10.1002/hup.2790
10.1097/WNR.0b013e3283021ca9
10.1016/j.schres.2010.07.012
10.3389/fnhum.2015.00009
10.1530/EJE-12-0869
10.1007/s11682-020-00409-0
10.3389/fendo.2020.573479
10.1155/2018/4864107
10.1016/j.pnpbp.2012.05.007
10.1016/S0140-6736(05)66378-7
10.1016/j.psyneuen.2015.03.012
10.1016/S0140-6736(21)01730-X
10.1016/j.schres.2011.07.025
10.1371/journal.pone.0094112
10.1002/jcp.24023
10.1016/S0924-9338(05)80187-7
10.1016/j.ejphar.2007.11.024
10.1016/S0140-6736(05)67402-8
10.1016/j.schres.2016.04.051
10.3389/fendo.2020.00335
10.1016/j.molmet.2015.03.005
10.1097/JCP.0000000000001367
10.1046/j.1464-5491.1999.00059.x
10.1038/ijo.2016.149
10.1038/s42003-019-0325-6
10.1016/j.schres.2018.11.036
10.1016/j.jfma.2022.03.008
10.1016/j.physbeh.2019.112704
10.3389/fpsyt.2020.00256
10.1001/jama.285.19.2486
10.3390/genes12020237
10.2147/DMSO.S226245
10.1007/s11906-018-0812-z
10.1017/S1461145710000167
10.1210/endrev/bnz012
10.1002/wps.20567
10.1016/j.psyneuen.2020.104744
10.1016/S0306-4522(01)00555-3
10.3389/fpsyt.2021.710498
10.1038/s41598-017-04600-0
10.1038/s41598-021-82398-8
10.5603/EP.a2019.0028
10.1016/j.psychres.2018.04.005
10.1016/j.neuroimage.2018.09.067
10.1159/000329028
10.1155/2015/341583
10.1016/S2215-0366(17)30078-0
10.3390/ijms22052639
10.1016/j.schres.2021.08.013
10.1111/j.1365-2826.2011.02263.x
10.1038/ncomms15904
10.1038/s41398-018-0304-6
10.1038/s41598-018-20963-4
10.1111/j.1467-789X.2006.00270.x
10.1016/j.psychres.2019.03.027
10.1007/s12264-016-0090-1
10.1080/17470910802319710
10.1016/S2215-0366(16)30262-0
10.3389/fendo.2020.564240
10.1038/s41598-018-28816-w
10.1016/j.neuropharm.2019.05.010
10.1016/j.schres.2015.11.011
10.1001/jama.2020.4501
10.1016/j.biopsycho.2010.11.006
10.1038/s41386-019-0417-5
10.1007/7854_2017_28
10.4103/tpsy.tpsy_14_21
10.1159/000492001
10.3389/fendo.2015.00090
10.1097/HRP.0b013e3182a75b7d
10.3109/15622975.2012.677547
10.1152/ajpregu.00441.2014
10.1111/jne.12268
10.1016/j.pnpbp.2010.08.009
10.1038/tp.2016.50
10.1038/s41380-019-0478-1
10.1093/ijnp/pyy075
10.1002/hbm.23308
10.1176/appi.ps.201000363
10.1210/jc.2019-00643
10.1002/oby.21069
10.1017/S0033291718002465
10.1093/ijnp/pyab020
10.1192/bjp.bp.108.052605
10.1159/000471488
10.1016/j.psyneuen.2013.07.010
10.1038/nn.4623
10.1016/j.physbeh.2019.112684
10.1093/schizbullopen/sgac001
10.1159/000103868
10.1016/j.neubiorev.2020.04.023
10.1038/s41598-017-09318-7
10.1016/S2215-0366(19)30132-4
10.1016/j.biopsych.2008.10.011
10.1038/nutd.2017.24
10.1017/S0033291721002853
10.1016/j.gene.2020.144913
10.1097/YCO.0000000000000733
10.1038/ijo.2011.97
10.1002/ajmg.b.32712
10.1111/cen.14387
10.1111/ejn.15370
10.1111/acps.12445
10.1016/j.ajp.2019.04.006
10.1038/tp.2016.282
10.1080/24750573.2017.1387405
10.1016/j.neuroimage.2016.12.062
10.1016/j.neuron.2006.08.023
10.1111/acps.12913
10.1210/jc.2014-2206
10.1111/dom.13289
10.1038/s41579-020-0433-9
10.3389/fphar.2018.00154
10.1111/obr.12757
10.1016/j.schres.2013.01.019
10.1186/s12888-018-1827-3
10.3389/fnins.2019.00454
10.1007/s00125-020-05332-z
10.1111/j.1601-5215.2011.00634.x
10.1016/j.archger.2019.103903
10.1016/j.schres.2010.01.033
10.1016/j.physbeh.2015.05.023
10.1111/dom.13527
10.1016/j.schres.2014.05.003
10.1016/j.npep.2020.102079
10.1016/j.schres.2018.11.003
10.1001/jamapsychiatry.2019.0304
10.1111/j.1440-1819.2012.02396.x
10.1152/ajpregu.00220.2015
10.1093/schbul/sbab042
10.4093/dmj.2021.0280
10.3390/ijms22147737
10.1016/j.biopsych.2020.03.008
10.1002/wps.20384
10.1016/j.pnpbp.2022.110561
10.1038/s41537-021-00151-6
10.1016/j.neubiorev.2019.05.018
10.1111/eip.12749
10.1016/j.npep.2019.101977
10.4088/PCC.18m02299
10.1016/j.neubiorev.2019.10.012
10.1097/WNR.0000000000000574
10.1152/ajpregu.00118.2014
10.1016/j.schres.2018.09.021
10.1016/j.psyneuen.2011.02.015
10.1017/S0033291713000226
10.1093/epirev/mxn001
10.3390/ijms23020786
10.3389/fpsyt.2022.804055
10.1530/JOE-13-0417
10.1192/j.eurpsy.2021.14
10.1016/j.psyneuen.2003.08.011
10.1038/s41398-021-01725-9
10.1161/CIRCULATIONAHA.109.192644
10.3389/fpsyt.2020.00480
10.1007/s13679-017-0261-z
10.1155/2020/1385138
10.1016/j.chc.2019.08.004
10.1016/S0140-6736(09)60995-8
10.1016/j.schres.2013.07.044
10.2147/NDT.S305200
10.1001/jamacardio.2020.6050
10.2337/diacare.29.04.06.dc05-1729
10.1007/s11011-021-00836-y
10.1038/s41366-019-0489-7
10.1016/j.jpsychores.2022.110789
10.3390/cells8111336
10.4239/wjd.v12.i10.1731
10.1016/j.schres.2020.07.011
10.1016/j.peptides.2019.170151
10.1017/S0033291715000562
10.1016/j.yhbeh.2020.104915
10.1038/s41582-020-0364-0
10.1177/0269881119885260
10.1210/jc.2018-02036
10.1152/ajpregu.00169.2017
10.3389/fendo.2015.00119
10.1001/jamapsychiatry.2016.3803
10.3390/ijms20010128
10.1007/978-3-319-63739-6
10.1111/eci.12997
10.1371/journal.pone.0061477
10.1016/j.psyneuen.2019.104536
10.1097/JCP.0b013e3181f0580e
10.1016/j.schres.2014.12.029
10.1177/070674370605100608
10.1111/j.1447-0349.2012.00821.x
10.1097/JCP.0b013e318234ee84
10.1017/S003329171400097X
10.1016/j.appet.2018.08.003
10.1002/ddr.21343
10.1126/science.aan4994
10.1016/j.jpsychires.2019.01.006
10.2174/1871530320666200520093730
10.2174/1871530319666190617160934
10.2337/db16-0569
10.1186/s12888-022-03746-0
10.3390/ijms222112077
10.1016/j.ajhg.2013.01.001
ContentType Journal Article
Copyright 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2022 by the authors. 2022
Copyright_xml – notice: 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2022 by the authors. 2022
DBID AAYXX
CITATION
3V.
7X7
7XB
88E
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
K9.
M0S
M1P
M2O
MBDVC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
Q9U
7X8
5PM
DOI 10.3390/ijms23137092
DatabaseName CrossRef
ProQuest Central (Corporate)
Health & Medical Collection (ProQuest)
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Research Library
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Medical Database
Research Library
Research Library (Corporate)
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Research Library
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
CrossRef
MEDLINE - Academic
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: BENPR
  name: ProQuest Central (New)
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1422-0067
ExternalDocumentID PMC9266532
10_3390_ijms23137092
GrantInformation_xml – fundername: Ministry of Science and Technology
  grantid: MOST110-2314-B-038-073
– fundername: Wan-Fang Hospital, Taipei Medical University
  grantid: 111-wf-eva-21; 111TMU-WFH-14
GroupedDBID ---
29J
2WC
53G
5GY
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
8G5
A8Z
AADQD
AAFWJ
AAHBH
AAYXX
ABDBF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
AEAQA
AENEX
AFKRA
AFZYC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BCNDV
BENPR
BPHCQ
BVXVI
CCPQU
CITATION
CS3
D1I
DIK
DU5
DWQXO
E3Z
EBD
EBS
EJD
ESX
F5P
FRP
FYUFA
GNUQQ
GUQSH
GX1
HH5
HMCUK
HYE
IAO
IHR
ITC
KQ8
LK8
M1P
M2O
M48
MODMG
O5R
O5S
OK1
OVT
P2P
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RPM
TR2
TUS
UKHRP
~8M
3V.
7XB
8FK
K9.
MBDVC
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
Q9U
7X8
5PM
ID FETCH-LOGICAL-c389t-f40db4acc9a9dc9a77da0be10358f0539b2fc319dfafcb0c7de3e381722810873
IEDL.DBID M48
ISSN 1422-0067
1661-6596
IngestDate Thu Aug 21 18:34:20 EDT 2025
Fri Jul 11 04:09:17 EDT 2025
Fri Jul 25 20:31:23 EDT 2025
Thu Apr 24 22:56:13 EDT 2025
Tue Jul 01 03:40:10 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 13
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c389t-f40db4acc9a9dc9a77da0be10358f0539b2fc319dfafcb0c7de3e381722810873
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0003-2677-3944
0000-0002-3631-6248
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3390/ijms23137092
PMID 35806096
PQID 2686103678
PQPubID 2032341
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_9266532
proquest_miscellaneous_2687720822
proquest_journals_2686103678
crossref_primary_10_3390_ijms23137092
crossref_citationtrail_10_3390_ijms23137092
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-07-01
PublicationDateYYYYMMDD 2022-07-01
PublicationDate_xml – month: 07
  year: 2022
  text: 2022-07-01
  day: 01
PublicationDecade 2020
PublicationPlace Basel
PublicationPlace_xml – name: Basel
PublicationTitle International journal of molecular sciences
PublicationYear 2022
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Merkestein (ref_78) 2012; 36
Szulc (ref_279) 2016; 122
Smith (ref_74) 2014; 157
Eckel (ref_31) 2005; 365
Fan (ref_43) 2021; 19
Alberti (ref_30) 2009; 120
Aulinas (ref_195) 2019; 104
Harris (ref_122) 2013; 38
(ref_134) 2016; 27
Nielsen (ref_65) 2016; 73
Otto (ref_92) 2001; 145
Chen (ref_120) 2016; 46
Iovino (ref_269) 2020; 20
Oakley (ref_10) 2018; 102
Welch (ref_265) 2014; 307
Carnethon (ref_308) 2006; 29
Stroup (ref_15) 2018; 17
Einhorn (ref_28) 2003; 9
Jurczyk (ref_163) 2016; 30
ref_247
Mitchell (ref_32) 2013; 39
ref_249
Lawson (ref_253) 2020; 32
Thorp (ref_306) 2015; 2015
Levy (ref_318) 2020; 11
Siafis (ref_67) 2018; 16
Lu (ref_97) 2021; 47
Blevins (ref_258) 2015; 308
(ref_218) 2021; 36
Dayabandara (ref_60) 2017; 13
Liao (ref_314) 2021; 35
Lind (ref_44) 2021; 11
Bresee (ref_52) 2012; 63
Spelman (ref_126) 2007; 24
Bradley (ref_242) 2021; 128
Kabasakalian (ref_272) 2018; 35
McGrath (ref_2) 2008; 30
Xiao (ref_282) 2018; 20
Gragnoli (ref_102) 2016; 6
Maejima (ref_261) 2017; 7
Tully (ref_220) 2018; 272
Perry (ref_19) 2016; 3
Ballon (ref_64) 2014; 25
Douglass (ref_257) 2017; 20
Blevins (ref_260) 2016; 310
Sasayama (ref_168) 2012; 38
Skinner (ref_280) 2019; 212
Solismaa (ref_76) 2021; 306
Tosato (ref_137) 2020; 113
Correll (ref_16) 2015; 14
Stanton (ref_321) 2020; 29
Zhao (ref_219) 2019; 184
Goossens (ref_33) 2017; 10
Endomba (ref_86) 2020; 19
Lefevre (ref_180) 2017; 7
Leng (ref_252) 2017; 28
Cao (ref_151) 2017; 7
Graham (ref_131) 2008; 101
Yu (ref_165) 2021; 12
Huhn (ref_56) 2019; 394
Navarrete (ref_176) 2020; 11
Misiak (ref_124) 2021; 62
Lundqvist (ref_309) 2021; 64
Ward (ref_53) 2022; 13
Quintana (ref_312) 2013; 7
Haring (ref_128) 2019; 13
Roberts (ref_251) 2017; 313
Fortea (ref_51) 2012; 21
Lysaker (ref_232) 2018; 270
Weingarten (ref_278) 2019; 104
Maurino (ref_50) 2015; 11
Laursen (ref_13) 2019; 206
ref_146
Makowski (ref_196) 2015; Volume 72
Zhao (ref_193) 2019; 88
Nakata (ref_217) 2021; 138
Zhu (ref_103) 2021; 237
Song (ref_138) 2013; 150
(ref_189) 2020; 114
Du (ref_274) 2019; 70
McCutcheon (ref_5) 2020; 77
Zhang (ref_95) 2013; 38
Moore (ref_34) 2017; 14
Obradovic (ref_88) 2021; 12
Chang (ref_327) 2019; 12
Venkatasubramanian (ref_73) 2010; 119
Li (ref_303) 2014; 202
Martins (ref_246) 2022; 179
Burmester (ref_284) 2019; 212
Gimpl (ref_177) 2001; 81
Strauss (ref_243) 2019; 49
Soontornniyomkij (ref_121) 2019; 10
Michalopoulou (ref_305) 2015; 162
Fan (ref_172) 2021; 17
Taipale (ref_18) 2020; 19
Misiak (ref_118) 2020; 223
Hirode (ref_35) 2020; 323
Wu (ref_213) 2017; 8
Tomasik (ref_113) 2019; 76
Lally (ref_109) 2015; 45
Yin (ref_158) 2021; 36
Montag (ref_224) 2013; 14
Donadon (ref_202) 2018; 9
Morgan (ref_313) 2017; 51
Tiwari (ref_79) 2010; 34
ref_208
ref_201
McGrath (ref_11) 2017; 4
Unamuno (ref_39) 2018; 48
Macdonald (ref_248) 2012; 24
Sapra (ref_82) 2016; 174
Zheng (ref_236) 2019; 206
Jameson (ref_268) 2016; 310
Liu (ref_23) 2017; 16
Balikci (ref_240) 2018; 28
Tahmi (ref_304) 2021; 23
Laursen (ref_4) 2014; 10
Oliveira (ref_136) 2012; 134
Swaab (ref_273) 1995; 80
Seeman (ref_197) 2019; 9
Zhang (ref_250) 2021; 109
Wang (ref_267) 2019; 13
Vandenberghe (ref_59) 2015; 76
Chao (ref_90) 2017; 25
Saklayen (ref_36) 2018; 20
Agarwal (ref_123) 2020; 163
Bakos (ref_191) 2018; 2018
Hu (ref_317) 2017; 33
Jauhar (ref_1) 2022; 399
Kelesidis (ref_83) 2010; 152
Oldfield (ref_263) 2002; 110
Lee (ref_37) 2022; 46
Andreassen (ref_149) 2013; 92
Iovino (ref_178) 2021; 21
Parks (ref_63) 2018; 20
Huffmeijer (ref_200) 2013; 59
Zhang (ref_94) 2014; 17
Correll (ref_115) 2014; 71
Watanabe (ref_225) 2012; 66
Chan (ref_22) 2021; 219
Altirriba (ref_292) 2015; 6
Kennett (ref_204) 2012; 24
Warren (ref_298) 2018; 189
Ott (ref_286) 2013; 62
Norman (ref_311) 2011; 86
Richetto (ref_324) 2021; 89
Komossa (ref_54) 2010; 123
Borovcanin (ref_70) 2021; 12
ref_229
Rubin (ref_221) 2018; 202
Lis (ref_129) 2020; 11
Sabe (ref_244) 2021; 24
ref_100
Kuo (ref_170) 2011; 31
Rich (ref_211) 2015; 6
Erion (ref_119) 2017; 6
Barker (ref_203) 2020; 216
Schreurs (ref_48) 2009; 8
Bora (ref_301) 2017; 47
Manu (ref_68) 2015; 132
Ozsoy (ref_171) 2020; 756
Striepens (ref_287) 2016; 37
Pillinger (ref_20) 2017; 74
Rault (ref_181) 2016; 69
Pillinger (ref_57) 2020; 7
MacDonald (ref_235) 2011; 36
Rubin (ref_233) 2018; 195
Albayrak (ref_145) 2014; 68
Davis (ref_270) 2017; 7
Lawson (ref_185) 2013; 168
Blevins (ref_259) 2015; 152
Dasgupta (ref_105) 2010; 34
Plessow (ref_294) 2018; 43
Rybakowski (ref_142) 2013; 43
Dahoun (ref_164) 2017; 7
Lis (ref_71) 2020; 119
Postolache (ref_148) 2019; 180
Alberti (ref_25) 1998; 15
Zhang (ref_114) 2020; 25
Cochran (ref_216) 2013; 21
Quintana (ref_325) 2020; 24
Chen (ref_98) 2019; 22
Andari (ref_237) 2021; 41
Levkovitz (ref_239) 2014; 44
Firth (ref_21) 2019; 6
Klement (ref_290) 2017; 66
Yi (ref_262) 2015; 27
Noble (ref_264) 2014; 307
Samochowiec (ref_6) 2021; 34
Ding (ref_289) 2019; 20
ref_27
Chouinard (ref_117) 2019; 24
Nagalski (ref_153) 2016; 80
Olfson (ref_46) 2015; 72
McCormack (ref_183) 2020; 41
Strauss (ref_231) 2019; 112
Kilian (ref_157) 2016; 170
Lane (ref_150) 2017; 49
Ryan (ref_125) 2004; 29
Hung (ref_206) 2017; 357
Martorell (ref_132) 2019; 111
Kapur (ref_3) 2009; 374
Petrikis (ref_143) 2016; 20
Nadalin (ref_167) 2018; 135
Chang (ref_69) 2021; 11
Hommel (ref_133) 2006; 51
Lin (ref_238) 2019; 44
Zhang (ref_87) 2021; 12
Horta (ref_245) 2020; 108
Souza (ref_226) 2010; 13
Ebdrup (ref_75) 2014; 75
Maestrini (ref_275) 2018; 11
Jeong (ref_55) 2018; 15
Hu (ref_169) 2013; 43
Wigton (ref_223) 2022; 27
Daniels (ref_310) 2020; 39
Carter (ref_215) 2020; 72
Wu (ref_266) 2008; 580
Lunding (ref_323) 2021; 64
Ditzen (ref_194) 2009; 65
Bellivier (ref_155) 2005; 20
Oberweis (ref_104) 2012; 227
Mizuki (ref_156) 2021; 24
Lin (ref_154) 2010; 123
Klok (ref_91) 2007; 8
Pillinger (ref_329) 2019; 24
Spetter (ref_297) 2018; 8
Balkau (ref_26) 1999; 16
Wu (ref_96) 2020; 34
Zanardini (ref_130) 2018; 70
Misiak (ref_116) 2019; 102
Takayanagi (ref_254) 2008; 19
Kiss (ref_212) 2021; 87
Lawson (ref_285) 2015; 23
Tanskanen (ref_14) 2018; 138
Stahl (ref_7) 2018; 23
Binay (ref_209) 2017; 9
Stogios (ref_307) 2021; 7
ref_58
Yamamoto (ref_182) 2019; 2
Kiss (ref_234) 2009; 4
ref_175
Qian (ref_277) 2014; 99
Kucukgoncu (ref_111) 2019; 13
Kerem (ref_295) 2020; 44
Alberti (ref_29) 2005; 366
ref_299
Nogueiras (ref_89) 2015; 4
Basoglu (ref_77) 2010; 30
Foret (ref_316) 2021; 15
Abramova (ref_190) 2020; 83
Byberg (ref_45) 2006; 332
Petrikis (ref_84) 2022; 157
ref_61
Bernardo (ref_139) 2009; 194
Smeland (ref_147) 2020; 16
Burmester (ref_283) 2018; 130
Ferreira (ref_188) 2022; 117
ref_66
Liu (ref_205) 2020; 126
Grinevich (ref_256) 2016; 79
Thienel (ref_288) 2016; 40
ref_62
Tay (ref_81) 2019; 43
Basoglu (ref_99) 2010; 25
Winterton (ref_326) 2021; 11
Abram (ref_222) 2020; 46
ref_291
Schwetz (ref_101) 2017; 32
Badcock (ref_315) 2019; 204
Escurriola (ref_24) 2021; 306
Sun (ref_135) 2016; 64
Rubin (ref_241) 2013; 146
Hackinger (ref_152) 2018; 8
Moghaddam (ref_276) 2019; 122
Storosum (ref_140) 2008; 93
Liu (ref_166) 2020; 11
Zhang (ref_207) 2018; 8
Haro (ref_12) 2018; 267
Stubbs (ref_85) 2016; 63
Jacondino (ref_328) 2019; 84
Zhang (ref_112) 2021; 12
Zhang (ref_214) 2017; 638
Brambilla (ref_192) 2016; 77
Popovic (ref_72) 2007; 85
Haram (ref_228) 2015; 9
Godoy (ref_320) 2021; 6
Lawford (ref_161) 2016; 61
Womersley (ref_322) 2022; 55
ref_199
Miret (ref_227) 2020; 63
Alameda (ref_108) 2021; 51
Vancampfort (ref_47) 2013; 12
Gajdosechova (ref_186) 2014; 220
ref_38
Smith (ref_110) 2020; 11
Mazereel (ref_17) 2020; 11
Goetz (ref_93) 2019; 206
Perry (ref_160) 2022; 3
Liu (ref_230) 2019; 10
Bartoli (ref_80) 2015; 56
Mani (ref_198) 2015; 6
Quintana (ref_106) 2017; 45
Rybakowski (ref_174) 2012; 65
Fattakhov (ref_159) 2018; 42
Hansen (ref_162) 2011; 70
Brede (ref_281) 2019; 21
ref_42
ref_187
ref_41
Rosenfeld (ref_179) 2011; 37
ref_40
Cohn (ref_141) 2006; 51
Koch (ref_300) 2020; 222
Lang (ref_107) 2021; 238
Han (ref_127) 2020; 2020
Camerino (ref_255) 2009; 17
Bahchevanov (ref_302) 2021; 36
Wang (ref_319) 2017; 147
ref_49
Kagerbauer (ref_184) 2019; 78
ref_9
ref_8
Itokawa (ref_173) 2003; 347
Damen (ref_271) 2021; 94
Akalu (ref_210) 2020; 2020
Butjosa (ref_144) 2019; 276
Ziauddeen (ref_296) 2017; 7
Chen (ref_293) 2021; 40
References_xml – volume: 394
  start-page: 939
  year: 2019
  ident: ref_56
  article-title: Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: A systematic review and network meta-analysis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(19)31135-3
– volume: 238
  start-page: 3643
  year: 2021
  ident: ref_107
  article-title: The prevalence and clinical correlates of metabolic syndrome and cardiometabolic alterations in 430 drug-naive patients in their first episode of schizophrenia
  publication-title: Psychopharmacology
  doi: 10.1007/s00213-021-05983-9
– ident: ref_49
  doi: 10.3390/ijerph17186700
– volume: 71
  start-page: 1350
  year: 2014
  ident: ref_115
  article-title: Cardiometabolic risk in patients with first-episode schizophrenia spectrum disorders: Baseline results from the RAISE-ETP study
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2014.1314
– volume: 2020
  start-page: 9124520
  year: 2020
  ident: ref_127
  article-title: The Relationship of Functional Status of Cortisol, Testosterone, and Parameters of Metabolic Syndrome in Male Schizophrenics
  publication-title: Biomed. Res. Int.
  doi: 10.1155/2020/9124520
– volume: 11
  start-page: 696
  year: 2021
  ident: ref_69
  article-title: Metabolic disturbances associated with antipsychotic drug treatment in patients with schizophrenia: State-of-the-art and future perspectives
  publication-title: World J. Psychiatry
  doi: 10.5498/wjp.v11.i10.696
– volume: 12
  start-page: 770145
  year: 2021
  ident: ref_165
  article-title: The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2021.770145
– ident: ref_8
  doi: 10.3390/ijms22042146
– volume: 34
  start-page: 1202
  year: 2010
  ident: ref_105
  article-title: Insulin resistance and metabolic profile in antipsychotic naïve schizophrenia patients
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2010.06.011
– volume: 222
  start-page: 167
  year: 2020
  ident: ref_300
  article-title: Interactome overlap between schizophrenia and cognition
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2020.06.002
– volume: 7
  start-page: 64
  year: 2020
  ident: ref_57
  article-title: Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: A systematic review and network meta-analysis
  publication-title: Lancet Psychiatry
  doi: 10.1016/S2215-0366(19)30416-X
– volume: 11
  start-page: 432
  year: 2020
  ident: ref_176
  article-title: Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2020.00432
– volume: 20
  start-page: 165
  year: 2016
  ident: ref_143
  article-title: Prolactin levels in drug-naïve patients with schizophrenia and other psychotic disorders
  publication-title: Int. J. Psychiatry Clin. Pract.
  doi: 10.1080/13651501.2016.1197274
– volume: 272
  start-page: 17
  year: 2018
  ident: ref_220
  article-title: The effect of intranasal oxytocin on neural response to facial emotions in healthy adults as measured by functional MRI: A systematic review
  publication-title: Psychiatry Res. Neuroimaging
  doi: 10.1016/j.pscychresns.2017.11.017
– volume: 14
  start-page: E24
  year: 2017
  ident: ref_34
  article-title: Metabolic Syndrome Prevalence by Race/Ethnicity and Sex in the United States, National Health and Nutrition Examination Survey, 1988–2012
  publication-title: Prev. Chronic Dis.
  doi: 10.5888/pcd14.160287
– volume: 8
  start-page: 15
  year: 2009
  ident: ref_48
  article-title: Metabolic syndrome in people with schizophrenia: A review
  publication-title: World Psychiatry
  doi: 10.1002/j.2051-5545.2009.tb00199.x
– volume: 27
  start-page: 100221
  year: 2022
  ident: ref_223
  article-title: The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin
  publication-title: Schizophr. Res. Cogn.
  doi: 10.1016/j.scog.2021.100221
– volume: 14
  start-page: 119
  year: 2015
  ident: ref_16
  article-title: Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder
  publication-title: World Psychiatry
  doi: 10.1002/wps.20204
– volume: 75
  start-page: e899
  year: 2014
  ident: ref_75
  article-title: Glucometabolic hormones and cardiovascular risk markers in antipsychotic-treated patients
  publication-title: J. Clin. Psychiatry
  doi: 10.4088/JCP.13m08820
– ident: ref_66
  doi: 10.3390/ph14030238
– volume: 202
  start-page: 313
  year: 2014
  ident: ref_303
  article-title: Metabolic syndrome and its factors affect cognitive function in chronic schizophrenia complicated by metabolic syndrome
  publication-title: J. Nerv. Ment. Dis.
  doi: 10.1097/NMD.0000000000000124
– volume: 101
  start-page: 287
  year: 2008
  ident: ref_131
  article-title: Early treatment-related changes in diabetes and cardiovascular disease risk markers in first episode psychosis subjects
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2007.12.476
– volume: 9
  start-page: 237
  year: 2003
  ident: ref_28
  article-title: American College of Endocrinology position statement on the insulin resistance syndrome
  publication-title: Endocr. Pract.
  doi: 10.4158/EP.9.S2.5
– volume: 36
  start-page: 498
  year: 2021
  ident: ref_302
  article-title: Contribution of Components of Metabolic Syndrome to Cognitive Performance in Middle-Aged Adults
  publication-title: Arch. Clin. Neuropsychol.
  doi: 10.1093/arclin/acaa081
– volume: 332
  start-page: 878
  year: 2006
  ident: ref_45
  article-title: Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: Prospective, population based cohort study
  publication-title: BMJ
  doi: 10.1136/bmj.38766.624097.1F
– volume: 24
  start-page: 481
  year: 2007
  ident: ref_126
  article-title: Impaired glucose tolerance in first-episode drug-naïve patients with schizophrenia
  publication-title: Diabet. Med.
  doi: 10.1111/j.1464-5491.2007.02092.x
– volume: 42
  start-page: 2036
  year: 2018
  ident: ref_159
  article-title: Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and metabolic syndrome in healthy subjects and schizophrenia patients
  publication-title: Int. J. Obes.
  doi: 10.1038/s41366-018-0124-z
– volume: 306
  start-page: 114227
  year: 2021
  ident: ref_76
  article-title: Glucagon-like peptide-1 serum levels are associated with weight gain in patients treated with clozapine
  publication-title: Psychiatry Res.
  doi: 10.1016/j.psychres.2021.114227
– volume: 24
  start-page: 1513
  year: 2019
  ident: ref_117
  article-title: Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-018-0045-1
– volume: 69
  start-page: 60
  year: 2016
  ident: ref_181
  article-title: Effects of positive and negative human contacts and intranasal oxytocin on cerebrospinal fluid oxytocin
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2016.03.015
– volume: 310
  start-page: H1549
  year: 2016
  ident: ref_268
  article-title: Oxytocin neuron activation prevents hypertension that occurs with chronic intermittent hypoxia/hypercapnia in rats
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00808.2015
– volume: 62
  start-page: 100930
  year: 2021
  ident: ref_124
  article-title: A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals
  publication-title: Front. Neuroendocrinol.
  doi: 10.1016/j.yfrne.2021.100930
– volume: 64
  start-page: 108
  year: 2016
  ident: ref_135
  article-title: Diurnal neurobiological alterations after exposure to clozapine in first-episode schizophrenia patients
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2015.11.013
– volume: 59
  start-page: 32
  year: 2013
  ident: ref_200
  article-title: Ageing and oxytocin: A call for extending human oxytocin research to ageing populations—A mini-review
  publication-title: Gerontology
  doi: 10.1159/000341333
– volume: 49
  start-page: 274
  year: 2017
  ident: ref_150
  article-title: Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3749
– volume: 7
  start-page: 17222
  year: 2017
  ident: ref_180
  article-title: A comparison of methods to measure central and peripheral oxytocin concentrations in human and non-human primates
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-17674-7
– volume: 68
  start-page: 341
  year: 2014
  ident: ref_145
  article-title: Increased serum prolactin levels in drug-naive first-episode male patients with schizophrenia
  publication-title: Nord. J. Psychiatry
  doi: 10.3109/08039488.2013.839739
– volume: 13
  start-page: 2231
  year: 2017
  ident: ref_60
  article-title: Antipsychotic-associated weight gain: Management strategies and impact on treatment adherence
  publication-title: Neuropsychiatr. Dis. Treat.
  doi: 10.2147/NDT.S113099
– volume: 88
  start-page: 125
  year: 2019
  ident: ref_193
  article-title: Oxytocin Enhancement of the Placebo Effect May Be a Novel Therapy for Working Memory Impairments
  publication-title: Psychother. Psychosom.
  doi: 10.1159/000495260
– volume: 102
  start-page: 245
  year: 2018
  ident: ref_10
  article-title: Increased mortality among people with schizophrenia and other non-affective psychotic disorders in the community: A systematic review and meta-analysis
  publication-title: J. Psychiatr. Res.
  doi: 10.1016/j.jpsychires.2018.04.019
– volume: 10
  start-page: 217
  year: 2019
  ident: ref_230
  article-title: Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2019.00217
– volume: 638
  start-page: 5
  year: 2017
  ident: ref_214
  article-title: Nicotine enhances GABAergic inhibition of oxytocin mRNA-expressing neuron in the hypothalamic paraventricular nucleus in vitro in rats
  publication-title: Neurosci. Lett.
  doi: 10.1016/j.neulet.2016.12.005
– volume: 10
  start-page: 425
  year: 2014
  ident: ref_4
  article-title: Excess early mortality in schizophrenia
  publication-title: Annu. Rev. Clin. Psychol.
  doi: 10.1146/annurev-clinpsy-032813-153657
– volume: 135
  start-page: 39
  year: 2018
  ident: ref_167
  article-title: An association between the BanI polymorphism of the PLA2G4A gene for calcium-dependent phospholipase A2 and plasma glucose levels among females with schizophrenia
  publication-title: Prostaglandins Leukot. Essent. Fat. Acids
  doi: 10.1016/j.plefa.2018.06.007
– volume: 23
  start-page: 180
  year: 2021
  ident: ref_304
  article-title: Metabolic Syndrome and Cognitive Function
  publication-title: Curr. Cardiol. Rep.
  doi: 10.1007/s11886-021-01615-y
– volume: 62
  start-page: 3418
  year: 2013
  ident: ref_286
  article-title: Oxytocin reduces reward-driven food intake in humans
  publication-title: Diabetes
  doi: 10.2337/db13-0663
– volume: 25
  start-page: 593
  year: 2014
  ident: ref_64
  article-title: Molecular pathophysiology of metabolic effects of antipsychotic medications
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2014.07.004
– volume: 7
  start-page: 48
  year: 2013
  ident: ref_312
  article-title: A role for autonomic cardiac control in the effects of oxytocin on social behavior and psychiatric illness
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2013.00048
– volume: 38
  start-page: 752
  year: 2013
  ident: ref_122
  article-title: Schizophrenia: Metabolic aspects of aetiology, diagnosis and future treatment strategies
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2012.09.009
– ident: ref_201
  doi: 10.3390/ijms21113966
– ident: ref_299
  doi: 10.1371/journal.pone.0249348
– volume: 9
  start-page: 124
  year: 2017
  ident: ref_209
  article-title: Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children
  publication-title: J. Clin. Res. Pediatr. Endocrinol.
  doi: 10.4274/jcrpe.3963
– volume: 28
  start-page: 365
  year: 2017
  ident: ref_252
  article-title: Oxytocin—The Sweet Hormone?
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2017.02.007
– volume: 47
  start-page: 1030
  year: 2017
  ident: ref_301
  article-title: The relationship between cognitive impairment in schizophrenia and metabolic syndrome: A systematic review and meta-analysis
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291716003366
– volume: 25
  start-page: 713
  year: 2017
  ident: ref_90
  article-title: Stress, cortisol, and other appetite-related hormones: Prospective prediction of 6-month changes in food cravings and weight
  publication-title: Obesity
  doi: 10.1002/oby.21790
– ident: ref_249
  doi: 10.1371/journal.pone.0059625
– volume: 39
  start-page: 87
  year: 2020
  ident: ref_310
  article-title: Oxytocin enhances the recovery of eye-contact induced autonomic arousal: A treatment mechanism study with placebo-controlled design
  publication-title: Eur. Neuropsychopharmacol.
  doi: 10.1016/j.euroneuro.2020.08.004
– volume: 43
  start-page: 638
  year: 2018
  ident: ref_294
  article-title: Effects of Intranasal Oxytocin on the Blood Oxygenation Level-Dependent Signal in Food Motivation and Cognitive Control Pathways in Overweight and Obese Men
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2017.226
– volume: 43
  start-page: 197
  year: 2013
  ident: ref_169
  article-title: Association study of NRXN3 polymorphisms with schizophrenia and risperid.done-induced bodyweight gain in Chinese Han population
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2012.12.007
– volume: 72
  start-page: 829
  year: 2020
  ident: ref_215
  article-title: Is Oxytocin “Nature’s Medicine”?
  publication-title: Pharmacol. Rev.
  doi: 10.1124/pr.120.019398
– volume: 16
  start-page: 1210
  year: 2018
  ident: ref_67
  article-title: Antipsychotic Drugs: From Receptor-binding Profiles to Metabolic Side Effects
  publication-title: Curr. Neuropharmacol.
  doi: 10.2174/1570159X15666170630163616
– volume: 195
  start-page: 409
  year: 2018
  ident: ref_233
  article-title: Peripheral oxytocin and vasopressin are associated with clinical symptom severity and cognitive functioning in midlife women with chronic schizophrenia
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2017.09.041
– volume: 77
  start-page: 201
  year: 2020
  ident: ref_5
  article-title: Schizophrenia-An Overview
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2019.3360
– volume: 39
  start-page: 306
  year: 2013
  ident: ref_32
  article-title: Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders—A systematic review and meta-analysis
  publication-title: Schizophr. Bull.
  doi: 10.1093/schbul/sbr148
– volume: 46
  start-page: 661
  year: 2020
  ident: ref_222
  article-title: Oxytocin Enhances an Amygdala Circuit Associated With Negative Symptoms in Schizophrenia: A Single-Dose, Placebo-Controlled, Crossover, Randomized Control Trial
  publication-title: Schizophr. Bull.
  doi: 10.1093/schbul/sbz091
– volume: 24
  start-page: 515
  year: 2020
  ident: ref_325
  article-title: An Allostatic Theory of Oxytocin
  publication-title: Trends Cogn. Sci.
  doi: 10.1016/j.tics.2020.03.008
– volume: 76
  start-page: e1417
  year: 2015
  ident: ref_59
  article-title: Importance of early weight changes to predict long-term weight gain during psychotropic drug treatment
  publication-title: J. Clin. Psychiatry
  doi: 10.4088/JCP.14m09358
– ident: ref_247
  doi: 10.1101/2020.08.23.20180489
– volume: 40
  start-page: 5407
  year: 2021
  ident: ref_293
  article-title: Effects of intranasal oxytocin in food intake and craving: A meta-analysis of clinical trials
  publication-title: Clin. Nutr.
  doi: 10.1016/j.clnu.2021.08.011
– volume: 73
  start-page: 121
  year: 2016
  ident: ref_65
  article-title: Striatal Reward Activity and Antipsychotic-Associated Weight Change in Patients with Schizophrenia Undergoing Initial Treatment
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2015.2582
– volume: 51
  start-page: 124
  year: 2017
  ident: ref_313
  article-title: Responding to challenges for people with psychotic illness: Updated evidence from the Survey of High Impact Psychosis
  publication-title: Aust. N. Z. J. Psychiatry
  doi: 10.1177/0004867416679738
– volume: 93
  start-page: 572
  year: 2008
  ident: ref_140
  article-title: Hepatic insulin resistance in antipsychotic naive schizophrenic patients: Stable isotope studies of glucose metabolism
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2007-1167
– volume: 80
  start-page: 19
  year: 2016
  ident: ref_153
  article-title: Metabolic pathways in the periphery and brain: Contribution to mental disorders?
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2016.09.012
– volume: 206
  start-page: 13
  year: 2019
  ident: ref_236
  article-title: Adjunctive intranasal oxytocin for schizophrenia: A meta-analysis of randomized, double-blind, placebo-controlled trials
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2018.12.007
– volume: 63
  start-page: 144
  year: 2016
  ident: ref_85
  article-title: Are leptin levels increased among people with schizophrenia versus controls? A systematic review and comparative meta-analysis
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2015.09.026
– volume: 270
  start-page: 1010
  year: 2018
  ident: ref_232
  article-title: Associations of oxytocin and vasopressin plasma levels with neurocognitive, social cognitive and meta cognitive function in schizophrenia
  publication-title: Psychiatry Res.
  doi: 10.1016/j.psychres.2018.03.048
– volume: 19
  start-page: 61
  year: 2020
  ident: ref_18
  article-title: 20-year follow-up study of physical morbidity and mortality in relationship to antipsychotic treatment in a nationwide cohort of 62,250 patients with schizophrenia (FIN20)
  publication-title: World Psychiatry
  doi: 10.1002/wps.20699
– volume: 347
  start-page: 202
  year: 2003
  ident: ref_173
  article-title: Association between a novel polymorphism in the promoter region of the neuropeptide Y gene and schizophrenia in humans
  publication-title: Neurosci. Lett.
  doi: 10.1016/S0304-3940(03)00718-3
– ident: ref_9
  doi: 10.3390/ijms18081689
– volume: 126
  start-page: 104855
  year: 2020
  ident: ref_205
  article-title: Central oxytocin signaling inhibits food reward-motivated behaviors and VTA dopamine responses to food-predictive cues in male rats
  publication-title: Horm. Behav.
  doi: 10.1016/j.yhbeh.2020.104855
– volume: 202
  start-page: 173
  year: 2018
  ident: ref_221
  article-title: Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2018.07.003
– volume: 63
  start-page: e15
  year: 2020
  ident: ref_227
  article-title: The role of schizotypal traits and the OXTR gene in theory of mind in schizophrenia: A family-based study
  publication-title: Eur. Psychiatry
  doi: 10.1192/j.eurpsy.2019.17
– volume: 12
  start-page: 240
  year: 2013
  ident: ref_47
  article-title: A meta-analysis of cardio-metabolic abnormalities in drug naïve, first-episode and multi-episode patients with schizophrenia versus general population controls
  publication-title: World Psychiatry
  doi: 10.1002/wps.20069
– volume: 19
  start-page: 22
  year: 2020
  ident: ref_86
  article-title: Leptin and psychiatric illnesses: Does leptin play a role in antipsychotic-induced weight gain?
  publication-title: Lipids Health Dis.
  doi: 10.1186/s12944-020-01203-z
– volume: 45
  start-page: 1
  year: 2017
  ident: ref_106
  article-title: Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders
  publication-title: Front. Neuroendocrinol.
  doi: 10.1016/j.yfrne.2016.12.004
– volume: 30
  start-page: 983
  year: 2016
  ident: ref_163
  article-title: Beyond the brain: Disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β
  publication-title: FASEB J.
  doi: 10.1096/fj.15-279810
– volume: 32
  start-page: e12805
  year: 2020
  ident: ref_253
  article-title: The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis
  publication-title: J. Neuroendocrinol.
  doi: 10.1111/jne.12805
– volume: 12
  start-page: 702720
  year: 2021
  ident: ref_112
  article-title: Unveiling the Metabolic Profile of First-Episode Drug-Naïve Schizophrenia Patients: Baseline Characteristics of a Longitudinal Study among Han Chinese
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2021.702720
– volume: 7
  start-page: 1295
  year: 2017
  ident: ref_151
  article-title: A polygenic score for schizophrenia predicts glycemic control
  publication-title: Transl. Psychiatry
  doi: 10.1038/s41398-017-0044-z
– volume: 138
  start-page: 219
  year: 2021
  ident: ref_217
  article-title: Oxytocin system dysfunction in patients with treatment-resistant schizophrenia: Alterations of blood oxytocin levels and effect of a genetic variant of OXTR
  publication-title: J. Psychiatr. Res.
  doi: 10.1016/j.jpsychires.2021.03.053
– volume: 219
  start-page: 375
  year: 2021
  ident: ref_22
  article-title: Risk of mortality and complications in patients with schizophrenia and diabetes mellitus: Population-based cohort study
  publication-title: Br. J. Psychiatry
  doi: 10.1192/bjp.2020.248
– volume: 72
  start-page: 1172
  year: 2015
  ident: ref_46
  article-title: Premature Mortality Among Adults with Schizophrenia in the United States
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2015.1737
– volume: 37
  start-page: 1077
  year: 2011
  ident: ref_179
  article-title: Oxytocin, dopamine, and the amygdala: A neurofunctional model of social cognitive deficits in schizophrenia
  publication-title: Schizophr. Bull.
  doi: 10.1093/schbul/sbq015
– volume: 306
  start-page: 114233
  year: 2021
  ident: ref_24
  article-title: Cardiovascular disease and mortality in people with schizophrenia or antipsychotic treatment: A cohort study in primary care
  publication-title: Psychiatry Res.
  doi: 10.1016/j.psychres.2021.114233
– volume: 25
  start-page: 165
  year: 2010
  ident: ref_99
  article-title: Plasma orexin A, ghrelin, cholecystokinin, visfatin, leptin and agouti-related protein levels during 6-week olanzapine treatment in first-episode male patients with psychosis
  publication-title: Int. Clin. Psychopharmacol.
  doi: 10.1097/YIC.0b013e3283377850
– volume: 23
  start-page: 187
  year: 2018
  ident: ref_7
  article-title: Beyond the dopamine hypothesis of schizophrenia to three neural networks of psychosis: Dopamine, serotonin, and glutamate
  publication-title: CNS Spectr.
  doi: 10.1017/S1092852918001013
– volume: 24
  start-page: 367
  year: 2021
  ident: ref_156
  article-title: Mechanisms Underlying the Comorbidity of Schizophrenia and Type 2 Diabetes Mellitus
  publication-title: Int. J. Neuropsychopharmacol.
  doi: 10.1093/ijnp/pyaa097
– volume: Volume 72
  start-page: 1
  year: 2015
  ident: ref_196
  article-title: Chapter One—Metabolic Syndrome and Menopause: Pathophysiology, Clinical and Diagnostic Significance
  publication-title: Advances in Clinical Chemistry
– volume: 216
  start-page: 529
  year: 2020
  ident: ref_203
  article-title: Methylation of glucocorticoid receptor (NR3C1), BDNF and oxytocin receptor genes in association with childhood maltreatment in schizophrenia and schizoaffective disorder
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2019.11.050
– volume: 70
  start-page: 59
  year: 2011
  ident: ref_162
  article-title: At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2011.01.031
– volume: 123
  start-page: 234
  year: 2010
  ident: ref_154
  article-title: Rethinking the genetic basis for comorbidity of schizophrenia and type 2 diabetes
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2010.08.022
– volume: 17
  start-page: 807
  year: 2014
  ident: ref_94
  article-title: Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats
  publication-title: Int. J. Neuropsychopharmacol.
  doi: 10.1017/S1461145713001697
– volume: 87
  start-page: 102148
  year: 2021
  ident: ref_212
  article-title: The effect of amisulpride, olanzapine, quetiapine, and aripiprazole single administration on c-Fos expression in vasopressinergic and oxytocinergic neurons of the rat hypothalamic paraventricular nucleus
  publication-title: Neuropeptides
  doi: 10.1016/j.npep.2021.102148
– volume: 122
  start-page: 17
  year: 2016
  ident: ref_279
  article-title: High serum oxytocin is associated with metabolic syndrome in older men—The MINOS study
  publication-title: Diabetes Res. Clin. Pract.
  doi: 10.1016/j.diabres.2016.09.022
– volume: 189
  start-page: 86
  year: 2018
  ident: ref_298
  article-title: Effects of intranasal oxytocin on satiety signaling in people with schizophrenia
  publication-title: Physiol. Behav.
  doi: 10.1016/j.physbeh.2018.03.008
– ident: ref_199
  doi: 10.3390/jcm9020537
– volume: 32
  start-page: 155
  year: 2017
  ident: ref_101
  article-title: Treatment of hyperprolactinaemia reduces total cholesterol and LDL in patients with prolactinomas
  publication-title: Metab. Brain Dis.
  doi: 10.1007/s11011-016-9882-2
– volume: 15
  start-page: 539
  year: 1998
  ident: ref_25
  article-title: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
  publication-title: Diabet. Med.
  doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
– ident: ref_229
  doi: 10.1093/ijnp/pyac023
– volume: 79
  start-page: 155
  year: 2016
  ident: ref_256
  article-title: Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2015.04.013
– volume: 13
  start-page: 101
  year: 2019
  ident: ref_128
  article-title: Antipsychotic treatment is associated with inflammatory and metabolic biomarkers alterations among first-episode psychosis patients: A 7-month follow-up study
  publication-title: Early Interv. Psychiatry
  doi: 10.1111/eip.12457
– volume: 81
  start-page: 629
  year: 2001
  ident: ref_177
  article-title: The oxytocin receptor system: Structure, function, and regulation
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.2001.81.2.629
– volume: 46
  start-page: 3219
  year: 2016
  ident: ref_120
  article-title: Impaired glucose tolerance in first-episode drug-naïve patients with schizophrenia: Relationships with clinical phenotypes and cognitive deficits
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291716001902
– volume: 109
  start-page: 331
  year: 2021
  ident: ref_250
  article-title: Reconstruction of the Hypothalamo-Neurohypophysial System and Functional Dissection of Magnocellular Oxytocin Neurons in the Brain
  publication-title: Neuron
  doi: 10.1016/j.neuron.2020.10.032
– volume: 10
  start-page: 251
  year: 2019
  ident: ref_121
  article-title: Clinical Correlates of Insulin Resistance in Chronic Schizophrenia: Relationship to Negative Symptoms
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2019.00251
– volume: 145
  start-page: 669
  year: 2001
  ident: ref_92
  article-title: Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa
  publication-title: Eur. J. Endocrinol.
  doi: 10.1530/EJE-1450669
– volume: 152
  start-page: 93
  year: 2010
  ident: ref_83
  article-title: Narrative review: The role of leptin in human physiology: Emerging clinical applications
  publication-title: Ann. Intern. Med.
  doi: 10.7326/0003-4819-152-2-201001190-00008
– volume: 179
  start-page: 1525
  year: 2022
  ident: ref_246
  article-title: Heterogeneity in response to repeated intranasal oxytocin in schizophrenia and autism spectrum disorders: A meta-analysis of variance
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.15451
– volume: 112
  start-page: 38
  year: 2019
  ident: ref_231
  article-title: Endogenous oxytocin levels are associated with impaired social cognition and neurocognition in schizophrenia
  publication-title: J. Psychiatr. Res.
  doi: 10.1016/j.jpsychires.2019.02.017
– volume: 12
  start-page: 585887
  year: 2021
  ident: ref_88
  article-title: Leptin and Obesity: Role and Clinical Implication
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2021.585887
– volume: 24
  start-page: 776
  year: 2019
  ident: ref_329
  article-title: Is psychosis a multisystem disorder? A meta-review of central nervous system, immune, cardiometabolic, and endocrine alterations in first-episode psychosis and perspective on potential models
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-018-0058-9
– volume: 17
  start-page: 980
  year: 2009
  ident: ref_255
  article-title: Low sympathetic tone and obese phenotype in oxytocin-deficient mice
  publication-title: Obesity
  doi: 10.1038/oby.2009.12
– volume: 307
  start-page: G848
  year: 2014
  ident: ref_265
  article-title: Oxytocin regulates gastrointestinal motility, inflammation, macromolecular permeability, and mucosal maintenance in mice
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00176.2014
– volume: 15
  start-page: 628
  year: 2018
  ident: ref_55
  article-title: Long-Term Evolution of Metabolic Status in Patients with Schizophrenia Stably Maintained on Second-Generation Antipsychotics
  publication-title: Psychiatry Investig.
  doi: 10.30773/pi.2018.01.18.1
– volume: 70
  start-page: 315
  year: 2018
  ident: ref_130
  article-title: Immune and metabolic alterations in first episode psychosis (FEP) patients
  publication-title: Brain Behav. Immun.
  doi: 10.1016/j.bbi.2018.03.013
– volume: 61
  start-page: 291
  year: 2016
  ident: ref_161
  article-title: Dopamine 2 Receptor Genes Are Associated with Raised Blood Glucose in Schizophrenia
  publication-title: Can. J. Psychiatry
  doi: 10.1177/0706743716644765
– volume: 36
  start-page: e2790
  year: 2021
  ident: ref_158
  article-title: The type 2 diabetes mellitus susceptibility gene CDKAL1 polymorphism is associated with depressive symptom in first-episode drug-naive schizophrenic patients
  publication-title: Hum. Psychopharmacol.
  doi: 10.1002/hup.2790
– volume: 11
  start-page: 51
  year: 2015
  ident: ref_50
  article-title: Prevalence of metabolic syndrome according to the presence of negative symptoms in patients with schizophrenia
  publication-title: Neuropsychiatr. Dis. Treat.
– volume: 19
  start-page: 951
  year: 2008
  ident: ref_254
  article-title: Oxytocin receptor-deficient mice developed late-onset obesity
  publication-title: Neuroreport
  doi: 10.1097/WNR.0b013e3283021ca9
– volume: 123
  start-page: 225
  year: 2010
  ident: ref_54
  article-title: Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: A systematic review and meta-analysis
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2010.07.012
– volume: 9
  start-page: 9
  year: 2015
  ident: ref_228
  article-title: Association between Genetic Variation in the Oxytocin Receptor Gene and Emotional Withdrawal, but not between Oxytocin Pathway Genes and Diagnosis in Psychotic Disorders
  publication-title: Front. Hum. Neurosci.
  doi: 10.3389/fnhum.2015.00009
– volume: 168
  start-page: 457
  year: 2013
  ident: ref_185
  article-title: Nocturnal oxytocin secretion is lower in amenorrheic athletes than nonathletes and associated with bone microarchitecture and finite element analysis parameters
  publication-title: Eur. J. Endocrinol.
  doi: 10.1530/EJE-12-0869
– volume: 15
  start-page: 2139
  year: 2021
  ident: ref_316
  article-title: Metabolic syndrome components moderate the association between executive function and functional connectivity in the default mode network
  publication-title: Brain Imaging Behav.
  doi: 10.1007/s11682-020-00409-0
– volume: 11
  start-page: 573479
  year: 2020
  ident: ref_17
  article-title: Impact of Psychotropic Medication Effects on Obesity and the Metabolic Syndrome in People With Serious Mental Illness
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2020.573479
– volume: 2018
  start-page: 4864107
  year: 2018
  ident: ref_191
  article-title: Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection
  publication-title: Neural Plast.
  doi: 10.1155/2018/4864107
– volume: 38
  start-page: 341
  year: 2012
  ident: ref_168
  article-title: Possible impact of ADRB3 Trp64Arg polymorphism on BMI in patients with schizophrenia
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2012.05.007
– volume: 365
  start-page: 1415
  year: 2005
  ident: ref_31
  article-title: The metabolic syndrome
  publication-title: Lancet
  doi: 10.1016/S0140-6736(05)66378-7
– volume: 56
  start-page: 179
  year: 2015
  ident: ref_80
  article-title: Plasma adiponectin levels in schizophrenia and role of second-generation antipsychotics: A meta-analysis
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2015.03.012
– volume: 399
  start-page: 473
  year: 2022
  ident: ref_1
  article-title: Schizophrenia
  publication-title: Lancet
  doi: 10.1016/S0140-6736(21)01730-X
– volume: 134
  start-page: 16
  year: 2012
  ident: ref_136
  article-title: Prolactin concentrations in newly diagnosed, antipsychotic-naïve patients with nonaffective psychosis
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2011.07.025
– ident: ref_58
  doi: 10.1371/journal.pone.0094112
– volume: 227
  start-page: 3001
  year: 2012
  ident: ref_104
  article-title: Potential role of prolactin in antipsychotic-mediated association of schizophrenia and type 2 diabetes
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.24023
– volume: 20
  start-page: S335
  year: 2005
  ident: ref_155
  article-title: Schizophrenia, antipsychotics and diabetes: Genetic aspects
  publication-title: Eur. Psychiatry
  doi: 10.1016/S0924-9338(05)80187-7
– volume: 580
  start-page: 407
  year: 2008
  ident: ref_266
  article-title: Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2007.11.024
– volume: 366
  start-page: 1059
  year: 2005
  ident: ref_29
  article-title: The metabolic syndrome—A new worldwide definition
  publication-title: Lancet
  doi: 10.1016/S0140-6736(05)67402-8
– volume: 174
  start-page: 132
  year: 2016
  ident: ref_82
  article-title: Adiposity-independent hypoadiponectinemia as a potential marker of insulin resistance and inflammation in schizophrenia patients treated with second generation antipsychotics
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2016.04.051
– volume: 11
  start-page: 335
  year: 2020
  ident: ref_318
  article-title: Cumulative Risk on Oxytocin-Pathway Genes Impairs Default Mode Network Connectivity in Trauma-Exposed Youth
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2020.00335
– volume: 4
  start-page: 437
  year: 2015
  ident: ref_89
  article-title: Ghrelin
  publication-title: Mol. Metab.
  doi: 10.1016/j.molmet.2015.03.005
– volume: 41
  start-page: 103
  year: 2021
  ident: ref_237
  article-title: Effects of Oxytocin on Emotion Recognition in Schizophrenia: A Randomized Double-Blind Pilot Study
  publication-title: J. Clin. Psychopharmacol.
  doi: 10.1097/JCP.0000000000001367
– volume: 16
  start-page: 442
  year: 1999
  ident: ref_26
  article-title: Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR)
  publication-title: Diabet. Med.
  doi: 10.1046/j.1464-5491.1999.00059.x
– volume: 40
  start-page: 1707
  year: 2016
  ident: ref_288
  article-title: Oxytocin’s inhibitory effect on food intake is stronger in obese than normal-weight men
  publication-title: Int. J. Obes.
  doi: 10.1038/ijo.2016.149
– volume: 2
  start-page: 76
  year: 2019
  ident: ref_182
  article-title: Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice
  publication-title: Commun. Biol.
  doi: 10.1038/s42003-019-0325-6
– volume: 206
  start-page: 21
  year: 2019
  ident: ref_93
  article-title: Meta-analysis of ghrelin alterations in schizophrenia: Effects of olanzapine
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2018.11.036
– ident: ref_100
  doi: 10.1016/j.jfma.2022.03.008
– volume: 9
  start-page: 2045125319859973
  year: 2019
  ident: ref_197
  article-title: The association between hormones and antipsychotic use: A focus on postpartum and menopausal women
  publication-title: Ther. Adv. Psychopharmacol.
– volume: 212
  start-page: 112704
  year: 2019
  ident: ref_284
  article-title: Oxytocin reduces post-stress sweet snack intake in women without attenuating salivary cortisol
  publication-title: Physiol. Behav.
  doi: 10.1016/j.physbeh.2019.112704
– volume: 11
  start-page: 256
  year: 2020
  ident: ref_166
  article-title: Integrated Analysis of Summary Statistics to Identify Pleiotropic Genes and Pathways for the Comorbidity of Schizophrenia and Cardiometabolic Disease
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2020.00256
– ident: ref_27
  doi: 10.1001/jama.285.19.2486
– ident: ref_175
  doi: 10.3390/genes12020237
– volume: 12
  start-page: 2707
  year: 2019
  ident: ref_327
  article-title: The OXTR Polymorphism Stratified the Correlation of Oxytocin and Glucose Homeostasis in Non-Diabetic Subjects
  publication-title: Diabetes Metab. Syndr. Obes.
  doi: 10.2147/DMSO.S226245
– volume: 20
  start-page: 12
  year: 2018
  ident: ref_36
  article-title: The Global Epidemic of the Metabolic Syndrome
  publication-title: Curr. Hypertens Rep.
  doi: 10.1007/s11906-018-0812-z
– volume: 13
  start-page: 793
  year: 2010
  ident: ref_226
  article-title: Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes
  publication-title: Int. J. Neuropsychopharmacol.
  doi: 10.1017/S1461145710000167
– volume: 41
  start-page: 121
  year: 2020
  ident: ref_183
  article-title: Metabolic Effects of Oxytocin
  publication-title: Endocr. Rev.
  doi: 10.1210/endrev/bnz012
– volume: 17
  start-page: 341
  year: 2018
  ident: ref_15
  article-title: Management of common adverse effects of antipsychotic medications
  publication-title: World Psychiatry
  doi: 10.1002/wps.20567
– volume: 119
  start-page: 104744
  year: 2020
  ident: ref_71
  article-title: Impaired hormonal regulation of appetite in schizophrenia: A narrative review dissecting intrinsic mechanisms and the effects of antipsychotics
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2020.104744
– volume: 110
  start-page: 515
  year: 2002
  ident: ref_263
  article-title: The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat
  publication-title: Neuroscience
  doi: 10.1016/S0306-4522(01)00555-3
– volume: 12
  start-page: 710498
  year: 2021
  ident: ref_87
  article-title: Do Leptin Play a Role in Metabolism-Related Psychopathological Symptoms?
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2021.710498
– volume: 7
  start-page: 4266
  year: 2017
  ident: ref_296
  article-title: Oxytocin administration suppresses hypothalamic activation in response to visual food cues
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-04600-0
– volume: 11
  start-page: 2978
  year: 2021
  ident: ref_44
  article-title: A longitudinal study over 40 years to study the metabolic syndrome as a risk factor for cardiovascular diseases
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-82398-8
– volume: 70
  start-page: 417
  year: 2019
  ident: ref_274
  article-title: Associations of oxytocin with metabolic parameters in obese women of childbearing age
  publication-title: Endokrynol. Pol.
  doi: 10.5603/EP.a2019.0028
– volume: 267
  start-page: 56
  year: 2018
  ident: ref_12
  article-title: Understanding the course of persistent symptoms in schizophrenia: Longitudinal findings from the pattern study
  publication-title: Psychiatry Res.
  doi: 10.1016/j.psychres.2018.04.005
– volume: 184
  start-page: 781
  year: 2019
  ident: ref_219
  article-title: Oxytocin differentially modulates specific dorsal and ventral striatal functional connections with frontal and cerebellar regions
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2018.09.067
– volume: 65
  start-page: 41
  year: 2012
  ident: ref_174
  article-title: Functional-1149 g/t polymorphism of the prolactin gene in schizophrenia
  publication-title: Neuropsychobiology
  doi: 10.1159/000329028
– volume: 2015
  start-page: 341583
  year: 2015
  ident: ref_306
  article-title: Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome
  publication-title: J. Diabetes Res.
  doi: 10.1155/2015/341583
– volume: 4
  start-page: 295
  year: 2017
  ident: ref_11
  article-title: Years of potential life lost and life expectancy in schizophrenia: A systematic review and meta-analysis
  publication-title: Lancet Psychiatry
  doi: 10.1016/S2215-0366(17)30078-0
– ident: ref_40
  doi: 10.3390/ijms22052639
– volume: 237
  start-page: 20
  year: 2021
  ident: ref_103
  article-title: Prolactin levels influenced by antipsychotic drugs in schizophrenia: A systematic review and network meta-analysis
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2021.08.013
– volume: 24
  start-page: 403
  year: 2012
  ident: ref_204
  article-title: Oxytocin: An emerging regulator of prolactin secretion in the female rat
  publication-title: J. Neuroendocrinol.
  doi: 10.1111/j.1365-2826.2011.02263.x
– volume: 8
  start-page: 15904
  year: 2017
  ident: ref_213
  article-title: Caffeine inhibits hypothalamic A(1)R to excite oxytocin neuron and ameliorate dietary obesity in mice
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15904
– volume: 8
  start-page: 252
  year: 2018
  ident: ref_152
  article-title: Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia
  publication-title: Transl. Psychiatry
  doi: 10.1038/s41398-018-0304-6
– volume: 8
  start-page: 2736
  year: 2018
  ident: ref_297
  article-title: Oxytocin curbs calorie intake via food-specific increases in the activity of brain areas that process reward and establish cognitive control
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-20963-4
– volume: 8
  start-page: 21
  year: 2007
  ident: ref_91
  article-title: The role of leptin and ghrelin in the regulation of food intake and body weight in humans: A review
  publication-title: Obes. Rev.
  doi: 10.1111/j.1467-789X.2006.00270.x
– volume: 276
  start-page: 218
  year: 2019
  ident: ref_144
  article-title: Prolactin levels in drug-naïve first episode nonaffective psychosis patients compared with healthy controls. Sex differences
  publication-title: Psychiatry Res.
  doi: 10.1016/j.psychres.2019.03.027
– volume: 33
  start-page: 73
  year: 2017
  ident: ref_317
  article-title: A Review of the Functional and Anatomical Default Mode Network in Schizophrenia
  publication-title: Neurosci. Bull.
  doi: 10.1007/s12264-016-0090-1
– volume: 4
  start-page: 287
  year: 2009
  ident: ref_234
  article-title: Sharing secrets: Oxytocin and trust in schizophrenia
  publication-title: Soc. Neurosci.
  doi: 10.1080/17470910802319710
– volume: 3
  start-page: 1049
  year: 2016
  ident: ref_19
  article-title: The association between first-episode psychosis and abnormal glycaemic control: Systematic review and meta-analysis
  publication-title: Lancet Psychiatry
  doi: 10.1016/S2215-0366(16)30262-0
– volume: 11
  start-page: 564240
  year: 2020
  ident: ref_110
  article-title: Cardiometabolic Risk in First Episode Psychosis Patients
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2020.564240
– volume: 8
  start-page: 10415
  year: 2018
  ident: ref_207
  article-title: Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-28816-w
– volume: 163
  start-page: 107633
  year: 2020
  ident: ref_123
  article-title: Brain insulin action in schizophrenia: Something borrowed and something new
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2019.05.010
– volume: 170
  start-page: 1
  year: 2016
  ident: ref_157
  article-title: A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2015.11.011
– volume: 323
  start-page: 2526
  year: 2020
  ident: ref_35
  article-title: Trends in the Prevalence of Metabolic Syndrome in the United States, 2011–2016
  publication-title: JAMA
  doi: 10.1001/jama.2020.4501
– volume: 86
  start-page: 174
  year: 2011
  ident: ref_311
  article-title: Oxytocin increases autonomic cardiac control: Moderation by loneliness
  publication-title: Biol. Psychol.
  doi: 10.1016/j.biopsycho.2010.11.006
– volume: 44
  start-page: 1925
  year: 2019
  ident: ref_238
  article-title: Neural and behavioral effects of oxytocin administration during theory of mind in schizophrenia and controls: A randomized control trial
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-019-0417-5
– volume: 35
  start-page: 529
  year: 2018
  ident: ref_272
  article-title: Oxytocin and Prader-Willi Syndrome
  publication-title: Curr. Top. Behav. Neurosci.
  doi: 10.1007/7854_2017_28
– volume: 35
  start-page: 59
  year: 2021
  ident: ref_314
  article-title: Loneliness in patients with schizophrenia
  publication-title: Taiwan J. Psychiatry
  doi: 10.4103/tpsy.tpsy_14_21
– volume: 6
  start-page: 160
  year: 2015
  ident: ref_198
  article-title: Oxytocin and Estrogen Receptor β in the Brain: An Overview
  publication-title: Front. Endocrinol.
– volume: 11
  start-page: 429
  year: 2018
  ident: ref_275
  article-title: Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables
  publication-title: Obes. Facts
  doi: 10.1159/000492001
– volume: 6
  start-page: 90
  year: 2015
  ident: ref_211
  article-title: A Role for Oxytocin in the Etiology and Treatment of Schizophrenia
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2015.00090
– volume: 21
  start-page: 219
  year: 2013
  ident: ref_216
  article-title: The role of oxytocin in psychiatric disorders: A review of biological and therapeutic research findings
  publication-title: Harv. Rev. Psychiatry
  doi: 10.1097/HRP.0b013e3182a75b7d
– volume: 14
  start-page: 500
  year: 2013
  ident: ref_224
  article-title: Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case–control study
  publication-title: World J. Biol. Psychiatry
  doi: 10.3109/15622975.2012.677547
– volume: 308
  start-page: R431
  year: 2015
  ident: ref_258
  article-title: Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.00441.2014
– volume: 27
  start-page: 335
  year: 2015
  ident: ref_262
  article-title: The regulation of oxytocin receptor gene expression during adipogenesis
  publication-title: J. Neuroendocrinol.
  doi: 10.1111/jne.12268
– volume: 34
  start-page: 1484
  year: 2010
  ident: ref_79
  article-title: Association study of polymorphisms in cholecystokinin gene and its receptors with antipsychotic induced weight gain in schizophrenia patients
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2010.08.009
– volume: 6
  start-page: e785
  year: 2016
  ident: ref_102
  article-title: Dopamine-prolactin pathway potentially contributes to the schizophrenia and type 2 diabetes comorbidity
  publication-title: Transl. Psychiatry
  doi: 10.1038/tp.2016.50
– volume: 25
  start-page: 3220
  year: 2020
  ident: ref_114
  article-title: Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-019-0478-1
– volume: 22
  start-page: 28
  year: 2019
  ident: ref_98
  article-title: Orexin-A Levels in Relation to the Risk of Metabolic Syndrome in Patients with Schizophrenia Taking Antipsychotics
  publication-title: Int. J. Neuropsychopharmacol.
  doi: 10.1093/ijnp/pyy075
– volume: 37
  start-page: 4276
  year: 2016
  ident: ref_287
  article-title: Oxytocin enhances cognitive control of food craving in women
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.23308
– volume: 63
  start-page: 237
  year: 2012
  ident: ref_52
  article-title: Utilization of general and specialized cardiac care by people with schizophrenia
  publication-title: Psychiatr. Serv.
  doi: 10.1176/appi.ps.201000363
– volume: 104
  start-page: 5621
  year: 2019
  ident: ref_278
  article-title: Circulating Oxytocin Is Genetically Determined and Associated with Obesity and Impaired Glucose Tolerance
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2019-00643
– volume: 23
  start-page: 950
  year: 2015
  ident: ref_285
  article-title: Oxytocin reduces caloric intake in men
  publication-title: Obesity
  doi: 10.1002/oby.21069
– volume: 49
  start-page: 1731
  year: 2019
  ident: ref_243
  article-title: The effects of combined oxytocin and cognitive behavioral social skills training on social cognition in schizophrenia
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291718002465
– volume: 24
  start-page: 601
  year: 2021
  ident: ref_244
  article-title: Intranasal Oxytocin for Negative Symptoms of Schizophrenia: Systematic Review, Meta-Analysis, and Dose-Response Meta-Analysis of Randomized Controlled Trials
  publication-title: Int. J. Neuropsychopharmacol.
  doi: 10.1093/ijnp/pyab020
– volume: 194
  start-page: 434
  year: 2009
  ident: ref_139
  article-title: Metabolic profile of antipsychotic-naive individuals with non-affective psychosis
  publication-title: Br. J. Psychiatry
  doi: 10.1192/bjp.bp.108.052605
– volume: 10
  start-page: 207
  year: 2017
  ident: ref_33
  article-title: The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function
  publication-title: Obes. Facts
  doi: 10.1159/000471488
– volume: 38
  start-page: 2423
  year: 2013
  ident: ref_95
  article-title: The role of ghrelin signalling in second-generation antipsychotic-induced weight gain
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2013.07.010
– volume: 20
  start-page: 1384
  year: 2017
  ident: ref_257
  article-title: Central amygdala circuits modulate food consumption through a positive-valence mechanism
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4623
– volume: 212
  start-page: 112684
  year: 2019
  ident: ref_280
  article-title: Is weight status associated with peripheral levels of oxytocin? A pilot study in healthy women
  publication-title: Physiol. Behav.
  doi: 10.1016/j.physbeh.2019.112684
– volume: 3
  start-page: sgac001
  year: 2022
  ident: ref_160
  article-title: Evidence for Shared Genetic Aetiology between Schizophrenia, Cardiometabolic, and Inflammation-Related Traits: Genetic Correlation and Colocalization Analyses
  publication-title: Schizophr. Bull. Open
  doi: 10.1093/schizbullopen/sgac001
– volume: 85
  start-page: 249
  year: 2007
  ident: ref_72
  article-title: Changes in neuroendocrine and metabolic hormones induced by atypical antipsychotics in normal-weight patients with schizophrenia
  publication-title: Neuroendocrinology
  doi: 10.1159/000103868
– volume: 114
  start-page: 70
  year: 2020
  ident: ref_189
  article-title: Exogenous effects of oxytocin in five psychiatric disorders: A systematic review, meta-analyses and a personalized approach through the lens of the social salience hypothesis
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2020.04.023
– volume: 7
  start-page: 8599
  year: 2017
  ident: ref_261
  article-title: Impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-09318-7
– volume: 6
  start-page: 675
  year: 2019
  ident: ref_21
  article-title: The Lancet Psychiatry Commission: A blueprint for protecting physical health in people with mental illness
  publication-title: Lancet Psychiatry
  doi: 10.1016/S2215-0366(19)30132-4
– volume: 65
  start-page: 728
  year: 2009
  ident: ref_194
  article-title: Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2008.10.011
– volume: 7
  start-page: e279
  year: 2017
  ident: ref_270
  article-title: Polymorphisms of the oxytocin receptor gene and overeating: The intermediary role of endophenotypic risk factors
  publication-title: Nutr. Diabetes
  doi: 10.1038/nutd.2017.24
– volume: 51
  start-page: 2307
  year: 2021
  ident: ref_108
  article-title: Metabolic syndrome in antipsychotic-naïve patients with first-episode psychosis: A systematic review and meta-analysis
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291721002853
– volume: 756
  start-page: 144913
  year: 2020
  ident: ref_171
  article-title: Effect of AUTS2 gene rs6943555 variant in male patients with schizophrenia in a Turkish population
  publication-title: Gene
  doi: 10.1016/j.gene.2020.144913
– volume: 34
  start-page: 503
  year: 2021
  ident: ref_6
  article-title: Gut microbiota and microbiome in schizophrenia
  publication-title: Curr. Opin. Psychiatry
  doi: 10.1097/YCO.0000000000000733
– volume: 36
  start-page: 254
  year: 2012
  ident: ref_78
  article-title: The acute effects of olanzapine on ghrelin secretion, CCK sensitivity, meal size, locomotor activity and body temperature
  publication-title: Int. J. Obes.
  doi: 10.1038/ijo.2011.97
– volume: 180
  start-page: 186
  year: 2019
  ident: ref_148
  article-title: Co-shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic syndrome
  publication-title: Am. J. Med. Genet. B Neuropsychiatr. Genet.
  doi: 10.1002/ajmg.b.32712
– volume: 94
  start-page: 774
  year: 2021
  ident: ref_271
  article-title: Oxytocin in young children with Prader-Willi syndrome: Results of a randomized, double-blind, placebo-controlled, crossover trial investigating 3 months of oxytocin
  publication-title: Clin. Endocrinol.
  doi: 10.1111/cen.14387
– volume: 55
  start-page: 2253
  year: 2022
  ident: ref_322
  article-title: Childhood trauma, the stress response and metabolic syndrome: A focus on DNA methylation
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/ejn.15370
– volume: 132
  start-page: 97
  year: 2015
  ident: ref_68
  article-title: Weight gain and obesity in schizophrenia: Epidemiology, pathobiology, and management
  publication-title: Acta Psychiatr. Scand.
  doi: 10.1111/acps.12445
– volume: 43
  start-page: 1
  year: 2019
  ident: ref_81
  article-title: The relationship between serum adiponectin levels, cardiometabolic indices and metabolic syndrome in schizophrenia
  publication-title: Asian J. Psychiatr.
  doi: 10.1016/j.ajp.2019.04.006
– volume: 7
  start-page: e1015
  year: 2017
  ident: ref_164
  article-title: The impact of Disrupted-in-Schizophrenia 1 (DISC1) on the dopaminergic system: A systematic review
  publication-title: Transl. Psychiatry
  doi: 10.1038/tp.2016.282
– volume: 28
  start-page: 123
  year: 2018
  ident: ref_240
  article-title: Oxytocin and social cognition in patients with schizophrenia: Comparison with healthy siblings and healthy controls
  publication-title: Psychiatry Clin. Psychopharmacol.
  doi: 10.1080/24750573.2017.1387405
– volume: 147
  start-page: 500
  year: 2017
  ident: ref_319
  article-title: Relationship of a common OXTR gene variant to brain structure and default mode network function in healthy humans
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2016.12.062
– volume: 51
  start-page: 801
  year: 2006
  ident: ref_133
  article-title: Leptin receptor signaling in midbrain dopamine neurons regulates feeding
  publication-title: Neuron
  doi: 10.1016/j.neuron.2006.08.023
– volume: 138
  start-page: 492
  year: 2018
  ident: ref_14
  article-title: Mortality in schizophrenia: 30-year nationwide follow-up study
  publication-title: Acta Psychiatr. Scand.
  doi: 10.1111/acps.12913
– volume: 99
  start-page: 4683
  year: 2014
  ident: ref_277
  article-title: Decreased circulating levels of oxytocin in obesity and newly diagnosed type 2 diabetic patients
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2014-2206
– volume: 80
  start-page: 573
  year: 1995
  ident: ref_273
  article-title: Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: A study of five cases
  publication-title: J. Clin. Endocrinol. Metab.
– volume: 20
  start-page: 1751
  year: 2018
  ident: ref_282
  article-title: Effects of intranasal insulin on endogenous glucose production in insulin-resistant men
  publication-title: Diabetes Obes. Metab.
  doi: 10.1111/dom.13289
– volume: 19
  start-page: 55
  year: 2021
  ident: ref_43
  article-title: Gut microbiota in human metabolic health and disease
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/s41579-020-0433-9
– volume: 9
  start-page: 154
  year: 2018
  ident: ref_202
  article-title: The Associations Between Oxytocin and Trauma in Humans: A Systematic Review
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2018.00154
– volume: 20
  start-page: 22
  year: 2019
  ident: ref_289
  article-title: Oxytocin in metabolic homeostasis: Implications for obesity and diabetes management
  publication-title: Obes. Rev.
  doi: 10.1111/obr.12757
– volume: 146
  start-page: 138
  year: 2013
  ident: ref_241
  article-title: Peripheral vasopressin but not oxytocin relates to severity of acute psychosis in women with acutely-ill untreated first-episode psychosis
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2013.01.019
– ident: ref_146
  doi: 10.1186/s12888-018-1827-3
– volume: 13
  start-page: 454
  year: 2019
  ident: ref_267
  article-title: Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2019.00454
– volume: 64
  start-page: 641
  year: 2021
  ident: ref_309
  article-title: Altered hormonal and autonomic nerve responses to hypo- and hyperglycaemia are found in overweight and insulin-resistant individuals and may contribute to the development of type 2 diabetes
  publication-title: Diabetologia
  doi: 10.1007/s00125-020-05332-z
– volume: 24
  start-page: 130
  year: 2012
  ident: ref_248
  article-title: Oxytocin in schizophrenia: A review of evidence for its therapeutic effects
  publication-title: Acta Neuropsychiatr.
  doi: 10.1111/j.1601-5215.2011.00634.x
– volume: 84
  start-page: 103903
  year: 2019
  ident: ref_328
  article-title: Association of oxytocin levels and oxytocin receptor gene polymorphism (rs2254298) with cardiovascular risk factors in Brazilian elderly from Primary Health Care
  publication-title: Arch. Gerontol. Geriatr.
  doi: 10.1016/j.archger.2019.103903
– volume: 119
  start-page: 131
  year: 2010
  ident: ref_73
  article-title: Effect of antipsychotic treatment on Insulin-like Growth Factor-1 and cortisol in schizophrenia: A longitudinal study
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2010.01.033
– volume: 152
  start-page: 438
  year: 2015
  ident: ref_259
  article-title: Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans
  publication-title: Physiol. Behav.
  doi: 10.1016/j.physbeh.2015.05.023
– volume: 21
  start-page: 424
  year: 2019
  ident: ref_281
  article-title: Intranasal oxytocin fails to acutely improve glucose metabolism in obese men
  publication-title: Diabetes Obes. Metab.
  doi: 10.1111/dom.13527
– volume: 157
  start-page: 128
  year: 2014
  ident: ref_74
  article-title: Clozapine directly increases insulin and glucagon secretion from islets: Implications for impairment of glucose tolerance
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2014.05.003
– volume: 83
  start-page: 102079
  year: 2020
  ident: ref_190
  article-title: The role of oxytocin and vasopressin dysfunction in cognitive impairment and mental disorders
  publication-title: Neuropeptides
  doi: 10.1016/j.npep.2020.102079
– volume: 206
  start-page: 284
  year: 2019
  ident: ref_13
  article-title: Cause-specific life years lost among persons diagnosed with schizophrenia: Is it getting better or worse?
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2018.11.003
– volume: 76
  start-page: 864
  year: 2019
  ident: ref_113
  article-title: Association of Insulin Resistance with Schizophrenia Polygenic Risk Score and Response to Antipsychotic Treatment
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2019.0304
– volume: 66
  start-page: 622
  year: 2012
  ident: ref_225
  article-title: Oxytocin receptor (OXTR) gene and risk of schizophrenia: Case-control and family-based analyses and meta-analysis in a Japanese population
  publication-title: Psychiatry Clin. Neurosci.
  doi: 10.1111/j.1440-1819.2012.02396.x
– volume: 310
  start-page: R640
  year: 2016
  ident: ref_260
  article-title: Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.00220.2015
– volume: 47
  start-page: 1310
  year: 2021
  ident: ref_97
  article-title: Changes of Hypocretin (Orexin) System in Schizophrenia: From Plasma to Brain
  publication-title: Schizophr. Bull.
  doi: 10.1093/schbul/sbab042
– volume: 46
  start-page: 15
  year: 2022
  ident: ref_37
  article-title: Insulin Resistance: From Mechanisms to Therapeutic Strategies
  publication-title: Diabetes Metab. J.
  doi: 10.4093/dmj.2021.0280
– ident: ref_42
  doi: 10.3390/ijms22147737
– volume: 89
  start-page: 215
  year: 2021
  ident: ref_324
  article-title: Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2020.03.008
– volume: 16
  start-page: 30
  year: 2017
  ident: ref_23
  article-title: Excess mortality in persons with severe mental disorders: A multilevel intervention framework and priorities for clinical practice, policy and research agendas
  publication-title: World Psychiatry
  doi: 10.1002/wps.20384
– volume: 117
  start-page: 110561
  year: 2022
  ident: ref_188
  article-title: Peripheral oxytocin concentrations in psychiatric disorders—A systematic review and methanalysis: Further evidence
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2022.110561
– volume: 7
  start-page: 22
  year: 2021
  ident: ref_307
  article-title: Autonomic nervous system dysfunction in schizophrenia: Impact on cognitive and metabolic health
  publication-title: NPJ Schizophr.
  doi: 10.1038/s41537-021-00151-6
– volume: 102
  start-page: 362
  year: 2019
  ident: ref_116
  article-title: Appetite regulating hormones in first-episode psychosis: A systematic review and meta-analysis
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2019.05.018
– volume: 13
  start-page: 1021
  year: 2019
  ident: ref_111
  article-title: Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta-analysis
  publication-title: Early Interv. Psychiatry
  doi: 10.1111/eip.12749
– volume: 78
  start-page: 101977
  year: 2019
  ident: ref_184
  article-title: Absence of a diurnal rhythm of oxytocin and arginine-vasopressin in human cerebrospinal fluid, blood and saliva
  publication-title: Neuropeptides
  doi: 10.1016/j.npep.2019.101977
– volume: 20
  start-page: 26587
  year: 2018
  ident: ref_63
  article-title: Acute Blood Pressure Changes Associated with Antipsychotic Administration to Psychiatric Inpatients
  publication-title: Prim. Care Companion CNS Disord.
  doi: 10.4088/PCC.18m02299
– volume: 108
  start-page: 1
  year: 2020
  ident: ref_245
  article-title: Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2019.10.012
– volume: 27
  start-page: 516
  year: 2016
  ident: ref_134
  article-title: Desensitization of leptin receptors is coincident with the upregulation of dopamine-related genes in the prefrontal cortex of adolescent mice
  publication-title: Neuroreport
  doi: 10.1097/WNR.0000000000000574
– volume: 307
  start-page: R737
  year: 2014
  ident: ref_264
  article-title: Oxytocin in the ventromedial hypothalamic nucleus reduces feeding and acutely increases energy expenditure
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.00118.2014
– volume: 204
  start-page: 90
  year: 2019
  ident: ref_315
  article-title: Loneliness in psychotic illness and its association with cardiometabolic disorders
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2018.09.021
– volume: 36
  start-page: 1114
  year: 2011
  ident: ref_235
  article-title: A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2011.02.015
– volume: 43
  start-page: 2571
  year: 2013
  ident: ref_142
  article-title: Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291713000226
– volume: 30
  start-page: 67
  year: 2008
  ident: ref_2
  article-title: Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality
  publication-title: Epidemiol. Rev.
  doi: 10.1093/epirev/mxn001
– ident: ref_38
  doi: 10.3390/ijms23020786
– volume: 13
  start-page: 804055
  year: 2022
  ident: ref_53
  article-title: Evidence for Schizophrenia-Specific Pathophysiology of Nicotine Dependence
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2022.804055
– volume: 220
  start-page: 333
  year: 2014
  ident: ref_186
  article-title: Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue
  publication-title: J. Endocrinol.
  doi: 10.1530/JOE-13-0417
– volume: 64
  start-page: e24
  year: 2021
  ident: ref_323
  article-title: Childhood trauma and cardiometabolic risk in severe mental disorders: The mediating role of cognitive control
  publication-title: Eur. Psychiatry
  doi: 10.1192/j.eurpsy.2021.14
– volume: 29
  start-page: 1065
  year: 2004
  ident: ref_125
  article-title: Evidence of basal pituitary-adrenal overactivity in first episode, drug naïve patients with schizophrenia
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2003.08.011
– volume: 11
  start-page: 599
  year: 2021
  ident: ref_326
  article-title: Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank
  publication-title: Transl. Psychiatry
  doi: 10.1038/s41398-021-01725-9
– volume: 120
  start-page: 1640
  year: 2009
  ident: ref_30
  article-title: Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.109.192644
– volume: 11
  start-page: 480
  year: 2020
  ident: ref_129
  article-title: Assessment of Appetite-Regulating Hormones Provides Further Evidence of Altered Adipoinsular Axis in Early Psychosis
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2020.00480
– volume: 6
  start-page: 178
  year: 2017
  ident: ref_119
  article-title: Hyperinsulinemia: A Cause of Obesity?
  publication-title: Curr. Obes. Rep.
  doi: 10.1007/s13679-017-0261-z
– volume: 2020
  start-page: 1385138
  year: 2020
  ident: ref_210
  article-title: Physiological Effect of Ghrelin on Body Systems
  publication-title: Int. J. Endocrinol.
  doi: 10.1155/2020/1385138
– volume: 29
  start-page: 115
  year: 2020
  ident: ref_321
  article-title: Childhood Trauma and Psychosis: An Updated Review
  publication-title: Child. Adolesc. Psychiatr. Clin. N. Am.
  doi: 10.1016/j.chc.2019.08.004
– volume: 374
  start-page: 635
  year: 2009
  ident: ref_3
  article-title: Schizophrenia
  publication-title: Lancet
  doi: 10.1016/S0140-6736(09)60995-8
– volume: 150
  start-page: 269
  year: 2013
  ident: ref_138
  article-title: Elevated levels of adiponectin and other cytokines in drug naïve, first episode schizophrenia patients with normal weight
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2013.07.044
– volume: 17
  start-page: 1289
  year: 2021
  ident: ref_172
  article-title: Association between ApoA1 Gene Polymorphisms and Antipsychotic Drug-Induced Dyslipidemia in Schizophrenia
  publication-title: Neuropsychiatr. Dis. Treat.
  doi: 10.2147/NDT.S305200
– volume: 6
  start-page: 228
  year: 2021
  ident: ref_320
  article-title: Association of Adverse Childhood Experiences with Cardiovascular Disease Later in Life: A Review
  publication-title: JAMA Cardiol.
  doi: 10.1001/jamacardio.2020.6050
– volume: 29
  start-page: 914
  year: 2006
  ident: ref_308
  article-title: The association among autonomic nervous system function, incident diabetes, and intervention arm in the Diabetes Prevention Program
  publication-title: Diabetes Care
  doi: 10.2337/diacare.29.04.06.dc05-1729
– volume: 36
  start-page: 2415
  year: 2021
  ident: ref_218
  article-title: Oxytocin levels in individuals with schizophrenia are high in cerebrospinal fluid but low in serum: A systematic review and meta-analysis
  publication-title: Metab. Brain Dis.
  doi: 10.1007/s11011-021-00836-y
– volume: 44
  start-page: 980
  year: 2020
  ident: ref_295
  article-title: Oxytocin reduces the functional connectivity between brain regions involved in eating behavior in men with overweight and obesity
  publication-title: Int. J. Obes.
  doi: 10.1038/s41366-019-0489-7
– volume: 157
  start-page: 110789
  year: 2022
  ident: ref_84
  article-title: Adiponectin, leptin and resistin levels in first-episode, drug-naïve patients with psychosis before and after short-term antipsychotic treatment
  publication-title: J. Psychosom. Res.
  doi: 10.1016/j.jpsychores.2022.110789
– ident: ref_62
  doi: 10.3390/cells8111336
– volume: 12
  start-page: 1731
  year: 2021
  ident: ref_70
  article-title: Galectin-3 possible involvement in antipsychotic-induced metabolic changes of schizophrenia: A minireview
  publication-title: World J. Diabetes
  doi: 10.4239/wjd.v12.i10.1731
– volume: 223
  start-page: 2
  year: 2020
  ident: ref_118
  article-title: Glucose homeostasis in unaffected first-degree relatives of schizophrenia patients: A systematic review and meta-analysis
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2020.07.011
– volume: 122
  start-page: 170151
  year: 2019
  ident: ref_276
  article-title: The prevalence of food addiction and its associations with plasma oxytocin level and anthropometric and dietary measurements in Iranian women with obesity
  publication-title: Peptides
  doi: 10.1016/j.peptides.2019.170151
– volume: 45
  start-page: 2619
  year: 2015
  ident: ref_109
  article-title: Cardiovascular risk factors and metabolic syndrome in people with established psychotic illnesses: Baseline data from the IMPaCT randomized controlled trial
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291715000562
– volume: 128
  start-page: 104915
  year: 2021
  ident: ref_242
  article-title: Preliminary evidence that oxytocin does not improve mentalizing in women with schizophrenia
  publication-title: Horm. Behav.
  doi: 10.1016/j.yhbeh.2020.104915
– volume: 16
  start-page: 366
  year: 2020
  ident: ref_147
  article-title: The polygenic architecture of schizophrenia—Rethinking pathogenesis and nosology
  publication-title: Nat. Rev. Neurol.
  doi: 10.1038/s41582-020-0364-0
– volume: 34
  start-page: 86
  year: 2020
  ident: ref_96
  article-title: Relationship between metabolic syndrome and acylated/desacylated ghrelin ratio in patients with schizophrenia under olanzapine medication
  publication-title: J. Psychopharmacol.
  doi: 10.1177/0269881119885260
– volume: 104
  start-page: 1348
  year: 2019
  ident: ref_195
  article-title: Endogenous Oxytocin Levels in Relation to Food Intake, Menstrual Phase, and Age in Females
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2018-02036
– volume: 313
  start-page: R357
  year: 2017
  ident: ref_251
  article-title: Chronic hindbrain administration of oxytocin is sufficient to elicit weight loss in diet-induced obese rats
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.00169.2017
– volume: 6
  start-page: 119
  year: 2015
  ident: ref_292
  article-title: Chronic Oxytocin Administration as a Treatment Against Impaired Leptin Signaling or Leptin Resistance in Obesity
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2015.00119
– volume: 74
  start-page: 261
  year: 2017
  ident: ref_20
  article-title: Impaired Glucose Homeostasis in First-Episode Schizophrenia: A Systematic Review and Meta-analysis
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2016.3803
– ident: ref_41
  doi: 10.3390/ijms20010128
– ident: ref_208
  doi: 10.1007/978-3-319-63739-6
– volume: 48
  start-page: e12997
  year: 2018
  ident: ref_39
  article-title: Adipokine dysregulation and adipose tissue inflammation in human obesity
  publication-title: Eur. J. Clin. Investig.
  doi: 10.1111/eci.12997
– ident: ref_291
  doi: 10.1371/journal.pone.0061477
– volume: 113
  start-page: 104536
  year: 2020
  ident: ref_137
  article-title: Childhood trauma and glucose metabolism in patients with first-episode psychosis
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2019.104536
– volume: 30
  start-page: 636
  year: 2010
  ident: ref_77
  article-title: Association between symptom improvement and change of body mass index, lipid profile, and leptin, ghrelin, and cholecystokinin levels during 6-week olanzapine treatment in patients with first-episode psychosis
  publication-title: J. Clin. Psychopharmacol.
  doi: 10.1097/JCP.0b013e3181f0580e
– volume: 162
  start-page: 62
  year: 2015
  ident: ref_305
  article-title: The effects of a single dose of oxytocin on working memory in schizophrenia
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2014.12.029
– volume: 51
  start-page: 382
  year: 2006
  ident: ref_141
  article-title: Insulin resistance and adiponectin levels in drug-free patients with schizophrenia: A preliminary report
  publication-title: Can. J. Psychiatry
  doi: 10.1177/070674370605100608
– volume: 21
  start-page: 220
  year: 2012
  ident: ref_51
  article-title: Dietary habits of patients with schizophrenia: A self-reported questionnaire survey
  publication-title: Int. J. Ment. Health Nurs.
  doi: 10.1111/j.1447-0349.2012.00821.x
– volume: 31
  start-page: 705
  year: 2011
  ident: ref_170
  article-title: Polymorphisms of INSIG2, MC4R, and LEP are associated with obesity- and metabolic-related traits in schizophrenic patients
  publication-title: J. Clin. Psychopharmacol.
  doi: 10.1097/JCP.0b013e318234ee84
– volume: 44
  start-page: 3523
  year: 2014
  ident: ref_239
  article-title: The role of oxytocin in empathy to the pain of conflictual out-group members among patients with schizophrenia
  publication-title: Psychol. Med.
  doi: 10.1017/S003329171400097X
– volume: 130
  start-page: 104
  year: 2018
  ident: ref_283
  article-title: Rapid-onset anorectic effects of intranasal oxytocin in young men
  publication-title: Appetite
  doi: 10.1016/j.appet.2018.08.003
– volume: 77
  start-page: 479
  year: 2016
  ident: ref_192
  article-title: Effects of Intranasal Oxytocin on Long-Term Memory in Healthy Humans: A Systematic Review
  publication-title: Drug Dev. Res.
  doi: 10.1002/ddr.21343
– volume: 357
  start-page: 1406
  year: 2017
  ident: ref_206
  article-title: Gating of social reward by oxytocin in the ventral tegmental area
  publication-title: Science
  doi: 10.1126/science.aan4994
– volume: 111
  start-page: 24
  year: 2019
  ident: ref_132
  article-title: Increased levels of serum leptin in the early stages of psychosis
  publication-title: J. Psychiatr. Res.
  doi: 10.1016/j.jpsychires.2019.01.006
– volume: 21
  start-page: 91
  year: 2021
  ident: ref_178
  article-title: Oxytocin Signaling Pathway: From Cell Biology to Clinical Implications
  publication-title: Endocr. Metab. Immune Disord. Drug Targets
  doi: 10.2174/1871530320666200520093730
– volume: 20
  start-page: 15
  year: 2020
  ident: ref_269
  article-title: Brain Angiotensinergic Regulation of the Immune System: Implications for Cardiovascular and Neuroendocrine Responses
  publication-title: Endocr. Metab. Immune Disord. Drug Targets
  doi: 10.2174/1871530319666190617160934
– volume: 66
  start-page: 264
  year: 2017
  ident: ref_290
  article-title: Oxytocin Improves β-Cell Responsivity and Glucose Tolerance in Healthy Men
  publication-title: Diabetes
  doi: 10.2337/db16-0569
– ident: ref_61
  doi: 10.1186/s12888-022-03746-0
– ident: ref_187
  doi: 10.3390/ijms222112077
– volume: 92
  start-page: 197
  year: 2013
  ident: ref_149
  article-title: Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2013.01.001
SSID ssj0023259
Score 2.4567916
SecondaryResourceType review_article
Snippet The high prevalence of metabolic syndrome in persons with schizophrenia has spurred investigational efforts to study the mechanism beneath its pathophysiology....
SourceID pubmedcentral
proquest
crossref
SourceType Open Access Repository
Aggregation Database
Enrichment Source
Index Database
StartPage 7092
SubjectTerms Body fat
Insulin resistance
Mortality
Psychotropic drugs
Review
SummonAdditionalLinks – databaseName: Health & Medical Collection (ProQuest)
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LSwMxEA5aEbyIT6wvIuhJlm6T7GbjRcQHRVDBB_QiS16L1bpb7Rbsv3eyTV8HveSSYQMzmcw32ck3CB3HOmlyQ3UAoYoFTFIRKCVjGEiU2CRUkXH3kHf3ceuF3bajtr9w6_uyyvGZWB3UptDujrxB4gQiPYWz9bz3FbiuUe7vqm-hsYiWHHWZK-ni7WnCRUnVLK0JMSiIIxGPCt8ppPmNzvtnH6AN5aEg8yFpijPnqyRnws7NGlr1eBFfjAy8jhZsvoGWRx0kh5vo9dJ9EgD0B_YVV_hptowOy9zgO1uCqbsdjZ88P8EZhu2BH4uuxUWGH36GZaGrV4AgczXsu2DnDLaFXm6uny9bge-YEGgAHmWQsdAoJrUWUhgYODcyVBb0FiUZuJtQJNPgdCaTmVah5sZS6zj6CEmaYcLpNqrlRW53EGaABHQmqNWZYUxwxZmxSdNqgCix1LaOTsdKS7WnE3ddLboppBVOxemsiuvoZCLdG9Fo_CG3P9Z_6p2pn05NX0dHk2lwA_dvQ-a2GFQykCc4-vo64nN2m6zniLTnZ_LOW0WoLQClRJTs_r_4Hloh7u1DVau7j2rl98AeACIp1WG17X4B71nj3Q
  priority: 102
  providerName: ProQuest
Title Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction
URI https://www.proquest.com/docview/2686103678
https://www.proquest.com/docview/2687720822
https://pubmed.ncbi.nlm.nih.gov/PMC9266532
Volume 23
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dT9swED_xoSFepjFAdGOVJ21PKJAmThwjIcRXhyaVTUClvkyRvyIKXbLRINH_nrs0La3YXnjxi-1EvvPlfheffwfwJTZJS9jQeOiquMdVKD2tVYxNECUu8XVk6T9k5yI-7_Lvvai3AJNqo7UAh_8M7aieVPd-sPv4d3SIBn9AESeG7Hv9299DhCmh8CV-jJfRJwky0Q6fnicgbIjkOO39xYxVWKGjwNgn3v5Z3_QMOOfTJWf8T_sdvK2BIzsaa3oNFlz-Ht6MS0mO1uHXCT0SF3HH6tQrdjWbT8dUblnHlajzQd-wq5qoYJ_hPmGXxcCxImM_HkdlYarrgDjmdDQkr0ea24Bu--z65NyrSyd4BhFI6WXct5orY6SSFhshrPK1a_m41AztTuogM2h9NlOZ0b4R1oWOyPqCIGn5iQg3YSkvcrcFjCMkMJkMncks51Jowa1LWs4gVomVcQ3YmQgtNTWvOJW3GKQYX5C001lpN-DrdPSfMZ_Gf8ZtT-SfTjZFGsQJor0Q_WsDPk-70R7okEPlrnioxmDAQDz2DRBzepu-jxi153vy_k3FrC0RrkRh8OHVMz_CakD3I6p83m1YKu8f3CdELaVuwqLoCWyT9rcmLB-fXfy8bJIfiZrVVn0CgRr2Ow
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VVgguiPJQlxZqJHpCUbO2E8eVEEJ9aPvYItFW2gtK_Yq6sE1KNxXsn-I3Ms5jHwd668UXj2xp_NnfjD2eAfgQm6QrLDMBUhUPuGIy0FrF2NAocUmoI-vvIfunce-CHw2iwRL8bf_C-LDK9kysDmpbGH9Hvk3jBJme4dn6-eZX4KtG-dfVtoRGDYtjN_mNLtv40-Eeru8WpQf757u9oKkqEBgk5zLIeGg1V8ZIJS02QlgVaodjR0mGkJSaZgaBaTOVGR0aYR1zPo8dpUk3TATDcR_BChJv6HeUGMwcPEar4mxd5LwgjmRcB9ozJsPt4Y_rMZpSTISSLlLgzK5djMqco7mD5_CssU_JlxpQq7Dk8hfwuK5YOXkJ33f9kGiw_yRNhBc5mw_bIyq3pO9KhNZoaMhZkw9hhyAcybdi5EiRka9_JmVhql-HKLM3GXty9QB5BRcPosvXsJwXuVsDwtHyMJlkzmSWcym04NYlXWfQJIqVcR342CotNU36cl9FY5SiG-NVnM6ruANbU-mbOm3Hf-Q2Wv2nzeYdpzOodeD9tBu3nX9LUbkr7ioZ9Et8uvwOiIV1m87nE3cv9uTDqyqBt0SrKGL0zf2Tb8KT3nn_JD05PD1eh6fU_7uo4oQ3YLm8vXNv0Roq9bsKggQuHxrz_wCvESIH
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIhAXxFMsFDASPaFoE9uJYySEUJdVS2lBlEp7QcFPsbAkhU0F-9f4dYzz2McBbr344pEtjT97vrHHMwBPM5MnwjIToaniEVdMRlqrDBua5i6PdWrDPeTRcbZ_yt9M0skW_On_woSwyv5MbA5qW5lwRz6kWY6WnuHZOvRdWMT70fjl2Y8oVJAKL619OY0WIodu8Qvdt_mLgxGu9S6l49cf9_ajrsJAZNBQ15HnsdVcGSOVtNgIYVWsHc6T5h7hKTX1BkFqvfJGx0ZYx1zIaUdpnsS5YDjuJbgsWJqEPSYmK2eP0aZQW4L2L8pSmbVB94zJeDj9-n2OtIqJWNJNc7jiuJsRmmsmb3wDrndclbxqwXUTtlx5C6601SsXt-HTXhgSyfs30kV7kZP1ED6iSkuOXI0wm00NOelyIzwnCE3yoZo5Unny7veirkzzAxFlRot5MLQBLHfg9EJ0eRe2y6p094BwZCHGS-aMt5xLoQW3Lk-cQXqUKeMG8KxXWmG6VOahosasQJcmqLhYV_EAdpfSZ20Kj3_I7fT6L7qNPC9WsBvAk2U3bsHwrqJKV503MuijhNT5AxAb67acLyTx3uwpp1-aZN4SGVLK6P3_T_4YriLai7cHx4cP4BoNXzCakOEd2K5_nruHSIxq_ahBIIHPFw35v7xOJj0
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Crosstalk+between+Schizophrenia+and+Metabolic+Syndrome%3A+The+Role+of+Oxytocinergic+Dysfunction&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Goh%2C+Kah+Kheng&rft.au=Chen%2C+Cynthia+Yi-An&rft.au=Wu%2C+Tzu-Hua&rft.au=Chen%2C+Chun-Hsin&rft.date=2022-07-01&rft.pub=MDPI&rft.eissn=1422-0067&rft.volume=23&rft.issue=13&rft_id=info:doi/10.3390%2Fijms23137092&rft_id=info%3Apmid%2F35806096&rft.externalDocID=PMC9266532
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon