Extracellular microvesicles-derived from microglia treated with unaggregated α-synuclein attenuate mitochondrial fission and toxicity-induced by Parkinsonian toxin MPP

• Published in: Biochemical and biophysical research communications Vol. 517; no. 4; pp. 642 - 647
• Main Authors: Li, Na, Wu, Yufeng, Zhu, Liangyi, Huang, Yang, Liu, Zongran, Shi, Min, Soltys, David, Zhang, Jing, Chang, Qing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2019
• Subjects: Microglia-derived EVs; mitochondria; Mitochondrial fission/fusion; MPP; neuroglia; neurotoxicity; Parkinson disease; PD cell model; toxins; α-synuclein; EV(+); EV(−); Microglia-derived EVs; PD cell model; MPP; α-synuclein; Mitochondrial fission/fusion; MPP(+)

Biological functions of extracellular vesicles (EVs) are being discovered to be critical in neurodegenerative disorders, including Parkinson's disease (PD). A previous study using cellular models of PD has suggested that EVs derived from microglia exposed to aggregated α-synuclein (α-Syn) leads...