Tryptophan prenyltransferases showing higher catalytic activities for Friedel–Crafts alkylation of o- and m-tyrosines than tyrosine prenyltransferases

• Published in: Organic & biomolecular chemistry Vol. 13; no. 27; pp. 7551 - 7557
• Main Authors: Fan, Aili, Xie, Xiulan, Li, Shu-Ming
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 21.07.2015
• Subjects: Alkylation; Biocatalysis; Carbon-13 Magnetic Resonance Spectroscopy; Chemistry; Chemistry, Organic; Chromatography, High Pressure Liquid; Dimethylallyltranstransferase - metabolism; Kinetics; Physical Sciences; Prenylation; Proton Magnetic Resonance Spectroscopy; Science & Technology; Tryptophan - metabolism; Tyrosine - metabolism; DIMETHYLALLYLTRYPTOPHAN SYNTHASE; ASPERGILLUS-FUMIGATUS; INDOLE PRENYLTRANSFERASES; OVERPRODUCTION; PRENYLATION; ENZYMES; PURIFICATION; BIOCHEMICAL-CHARACTERIZATION; SUPERFAMILY; DERIVATIVES

Tryptophan prenyltransferases FgaPT2, 5-DMATS, 6-DMATS Sv and 7-DMATS catalyse regiospecific C -prenylations on the indole ring, while tyrosine prenyltransferases SirD and TyrPT catalyse the O -prenylation of the phenolic hydroxyl group. In this study, we report the Friedel–Crafts alkylation of l -...