The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway

• Published in: Human molecular genetics Vol. 24; no. 9; pp. 2528 - 2538
• Main Authors: Gao, Feng, Chen, Dong, Si, Jianmin, Hu, Qingsong, Qin, Zhenghong, Fang, Ming, Wang, Guanghui
• Format: Journal Article
• Language: English
• Published: England 01.05.2015
• Subjects: Animals; Cell Line; Electron Transport Complex I - metabolism; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mitochondrial Degradation - genetics; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Models, Biological; Muscles - metabolism; Muscles - ultrastructure; Parkinson Disease - genetics; Parkinson Disease - metabolism; Protein Kinases - metabolism; Proteins - metabolism; Proteolysis; Signal Transduction; Substrate Specificity; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism

Mitochondrial dysfunction plays important roles in Parkinson's disease (PD) and the degradation of the damaged mitochondria by the mitochondria quality control system is important for dopaminergic (DA) neuronal survival. BNIP3L/Nix is a mitochondrial outer membrane protein that is required for...