Changes in apoptosis of human polymorphonuclear granulocytes with aging

• Published in: Mechanisms of ageing and development Vol. 96; no. 1-3; pp. 15 - 34
• Main Authors: Fülöp Jr, T, Fouquet, C, Allaire, P, Perrin, N, Lacombe, G, Stankova, J, Rola-Pleszczynski, M, Gagné, D, Wagner, J.R, Khalil, A, Dupuis, G
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.06.1997; Elsevier Science
• Subjects: Adult; Aged; Aged, 80 and over; Aging; Aging - immunology; Apoptosis; Apoptosis - drug effects; Biological and medical sciences; Cell Survival - drug effects; Cell Survival - immunology; Cells, Cultured; Development. Metamorphosis. Moult. Ageing; FMLP; Fundamental and applied biological sciences. Psychology; GM-CSF; Humans; Logistic Models; Neutrophils - drug effects; Neutrophils - pathology; PMNLs; Stimulation, Chemical; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Aging; PMNLs; FMLP; GM-CSF; Apoptosis; Human; Regulation(control); Senescence; Cell death; Granulocyte; Elderly; Age; Comparative study; Immune system

Many alterations with aging occur at the cellular and organic levels in the immune system ultimately leading to a decrease in the immune response. Our aim in the present work was to study apoptosis of polymorphonuclear granulocytes (PMN) with aging under various stimulations since apoptosis might pl...