The effect of ethanol on pancreatic enzymes – a dietary artefact?

• Published in: Biochimica et biophysica acta Vol. 1379; no. 3; pp. 314 - 324
• Main Authors: Apte, Minoti, Norton, Ian, Haber, Paul, Applegate, Tanya, Korsten, Mark, McCaughan, Geoffrey, Pirola, Romano, Wilson, Jeremy
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 02.03.1998
• Subjects: Alcoholic pancreatitis; Animals; Animals, Suckling; Cathepsin B - genetics; Cathepsin B - metabolism; Chymotrypsinogen - genetics; Chymotrypsinogen - metabolism; Diet; Dietary Carbohydrates - administration & dosage; Digestive enzyme; Ethanol; Ethanol - administration & dosage; Lipase - genetics; Lipase - metabolism; Lysosomal enzyme; Lysosomes - enzymology; Male; Pancreas - drug effects; Pancreas - enzymology; Rats; Rats, Sprague-Dawley; RNA, Messenger - metabolism; Trypsin - genetics; Trypsin - metabolism; SEM, standard error of the mean; Ethanol; RNA, ribonucleic acid; Lysosomal enzyme; PMSF, phenyl methyl sulfonyl fluoride; SDS, sodium dodecyl sulphate; DNA, deoxyribonucleic acid; DEPC, diethylpyrocarbonate; Alcoholic pancreatitis; Digestive enzyme; SSC, sodium chloride sodium citrate

The effects of ethanol on pancreatic digestive and lysosomal enzymes may be relevant to the pathogenesis of alcoholic pancreatitis since pancreatic enzymes are thought to play an important role in the development of pancreatic injury. Previous studies, using the Lieber–DeCarli pair-feeding model of...